Volume 40 Issue 4, April 2022

Editorial

Licensing for profit and for good

The Broad Institute’s enlightened licensing approach to CRISPR–Cas9 intellectual property stands out in the otherwise regrettable spat for patent rights over the foundational technology.

Editorial 04 Apr 2022

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News

First soluble TCR therapy opens ‘new universe’ of cancer targets

T cell receptor bispecific agents provide off-the-shelf therapies for targeting intracellular tumor antigens.

Elie Dolgin
News 24 Mar 2022
COVID vaccine IP waiver agreed

News in Brief 13 Apr 2022
In Antarctica, diesel is for dinner

Lisa Melton
News 13 Apr 2022
Broad defeats Berkeley CRISPR patent

A US decision to award a set of key patents related to CRISPR–Cas9 gene editing to the Broad Institute could spell the end for a long-running dispute over inventorship with the University of California and the University of Vienna.

Catherine Shaffer
News 14 Mar 2022
Glyco-immune checkpoints for cancer reach clinic

News in Brief 13 Apr 2022
Pyrukynd ushers in new era for rare cellular metabolic disease

The approval of the first oral pill to treat a rare anemia heralds the arrival of a new class of agents that could shake up enzyme replacement therapies for metabolic disease.

Charlotte Harrison
News 13 Apr 2022
CRISPR beef cattle get FDA green light

News in Brief 13 Apr 2022
Biotech news from around the world

News in Brief 13 Apr 2022
News Feature
- Innovators take cover as market bubble bursts
  
  Can biotech’s cash cushion soften the blow as public markets tumble?
  
  Melanie Senior
  News Feature 25 Mar 2022

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Bioentrepreneur

Building a Business
- Differentiated dollars
  
  Building your startup with venture philanthropy investment.
  
  Daniel L. Alvarez
  Andrew W. Lo
  Building a Business 17 Mar 2022

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Correspondence

Who will oversee the ethical limits of human embryo research?

Eli Y. Adashi
I. Glenn Cohen
Correspondence 31 Mar 2022

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Features

Patents
- European patent protection for medical uses of known products and drug repurposing
  
  Obtaining European patent protection for medical uses of known products is not a key factor limiting repurposing activity.
  
  Mateo Aboy
  Kathleen Liddell
  Johnathon Liddicoat
  Patents 13 Apr 2022
- Organoids and organs on a chip
  
  Recent patents relating to the manufacture and use of organoids and organs on a chip.
  
  Patents 13 Apr 2022

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News & Views

Enhanced cancer detection from cell-free DNA

A new assay for cell-free DNA fragmentation improves prediction of gene expression in liquid biopsies.

Peiyong Jiang
Y. M. Dennis Lo
News & Views 31 Mar 2022
Podcast
- First Rounders: Jay Keasling
  
  Podcast 13 Apr 2022

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Research

Brief Communications
- Super-resolved spatial transcriptomics by deep data fusion
  
  The low resolution of spatial transcriptomics is substantially improved by including histology images.
  
  Ludvig Bergenstråhle
  Bryan He
  Jonas Maaskola
  Brief Communication 29 Nov 2021
Articles
- Remote smartphone monitoring of Parkinson’s disease and individual response to therapy
  
  Smartphone sensors that monitor disease symptoms enable remote assessment of Parkinson’s patients.
  
  Larsson Omberg
  Elias Chaibub Neto
  Lara M. Mangravite
  Article 09 Aug 2021
- T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
  
  Engineered T cells kill leukemic cells with little off-target toxicity.
  
  Muhammad Ali
  Eirini Giannakopoulou
  Johanna Olweus
  Article Open Access 06 Dec 2021
- Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
  
  A combination of genomic and clinical features improves predictions of response to immune checkpoint blockade.
  
  Diego Chowell
  Seong-Keun Yoo
  Timothy A. Chan
  Article 01 Nov 2021
- Fast and accurate metagenotyping of the human gut microbiome with GT-Pro
  
  Alignment-free SNP calling from metagenomes reduces computational time by two orders of magnitude.
  
  Zhou Jason Shi
  Boris Dimitrov
  Katherine S. Pollard
  Article 23 Dec 2021
- Robust decomposition of cell type mixtures in spatial transcriptomics
  
  Cell type mapping in spatial transcriptomics is enabled by accounting for compositional mixtures and differences in sequencing technologies.
  
  Dylan M. Cable
  Evan Murray
  Rafael A. Irizarry
  Article 18 Feb 2021
- Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
  
  Bulk and single cell measurements are integrated to identify phenotype-associated subpopulations of cells.
  
  Duanchen Sun
  Xiangnan Guan
  Zheng Xia
  Article 11 Nov 2021
- RNA-responsive elements for eukaryotic translational control
  
  The translation of transgenes is regulated using RNA sensors.
  
  Evan M. Zhao
  Angelo S. Mao
  James J. Collins
  Article 28 Oct 2021
- Locus-specific expression of transposable elements in single cells with CELLO-seq
  
  Expression of transposable elements is mapped to unique genomic loci with CELLO-seq.
  
  Rebecca V. Berrens
  Andrian Yang
  John C. Marioni
  Article 15 Nov 2021
- Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
  
  Deep learning algorithms perform as well as humans in identifying cells in tissue images.
  
  Noah F. Greenwald
  Geneva Miller
  David Van Valen
  Article 18 Nov 2021
- Deep distributed computing to reconstruct extremely large lineage trees
  
  Cell lineage tracing is scaled up to hundreds of millions of simulated sequences with distributed computing.
  
  Naoki Konno
  Yusuke Kijima
  Nozomu Yachie
  Article 06 Jan 2022
- Personalized phosphoproteomics identifies functional signaling
  
  Functionally relevant phosphorylation sites are detected by integrating phosphoproteomic and phenotypic data.
  
  Elise J. Needham
  Janne R. Hingst
  Sean J. Humphrey
  Article 02 Dec 2021
- Inferring gene expression from cell-free DNA fragmentation profiles
  
  EPIC-seq predicts expression of individual genes from cell-free DNA.
  
  Mohammad Shahrokh Esfahani
  Emily G. Hamilton
  Ash A. Alizadeh
  Article 31 Mar 2022
- Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging
  
  Calcium and other analytes can be imaged at super-resolution and in vivo with photo-switchable sensors.
  
  Kanuj Mishra
  Juan Pablo Fuenzalida-Werner
  Andre C. Stiel
  Article Open Access 29 Nov 2021
- Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy
  
  The resolution of fluorescence microscopy is increased by incorporating prior information into deconvolution algorithms.
  
  Weisong Zhao
  Shiqun Zhao
  Liangyi Chen
  Article 15 Nov 2021

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Careers & Recruitment

Career Feature
- Helping others enhances graduate student wellness and mental health
  
  Actively engaging students in community-based educational outreach activities improves their mental health and will hopefully promote their retention and success in graduate school and beyond.
  
  Tracey O. Hermanstyne
  Lauren Johnson
  James B. Skeath
  Career Feature 13 Apr 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 13 Apr 2022

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Volume 40 Issue 4, April 2022

Phylogeny estimation at scale

Editorial

News

News Feature

Bioentrepreneur

Building a Business

Correspondence

Features

Patents

News & Views

Podcast

Research

Brief Communications

Articles

Careers & Recruitment

Career Feature

People

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