Volume 40 Issue 7, July 2022

Editorial

Revisiting checkpoint blockade

After over a decade of experience with immune checkpoint inhibitors in oncology, more effort needs to be spent unraveling why some patients respond — and why the majority do not — and integrating knowledge about biomarkers into patient selection in trials.

Editorial 05 Jul 2022

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News

RNA drugs lower lipoprotein(a) and genetically driven cholesterol

Companies are deploying siRNA and antisense oligonucleotides to tackle dangerously high cholesterol driven by genetics, betting that a wider population will benefit.

Cormac Sheridan
News 13 Jul 2022
Bluebird’s CALD gene therapy poised for approval

News in Brief 13 Jul 2022
PD-1 blockade works alone

News in Brief 13 Jul 2022
IL-2 upgrades show promise at ASCO

Companies pursue souped-up IL-2 candidates, undeterred by Nektar’s setback.

Elie Dolgin
News 13 Jul 2022
100,000 genomes — in Africa, for Africa

News in Brief 13 Jul 2022
Biotech news from around the world

News in Brief 13 Jul 2022
News Feature
- Diagnostics to take your breath away
  
  After decades of research and development, devices for detecting infectious agents in breath are finally maturing, with SARS-CoV-2 galvanizing progress. Carrie Arnold reports.
  
  Carrie Arnold
  News Feature 27 Jun 2022

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Correspondence

Standardized annotation of translated open reading frames

Jonathan M. Mudge
Jorge Ruiz-Orera
Sebastiaan van Heesch
Correspondence 13 Jul 2022
PRO-ACTive sharing of clinical data

Neta Zach
Melanie L. Leitner
Correspondence 01 Jul 2022

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Features

Patents
- The COVID-19 vaccine patent race
  
  The seemingly simple modular technology for making new mRNA vaccines could make vaccine developers a victim of their own success.
  
  Ulrich Storz
  Patents 13 Jul 2022
- Immuno-oncology checkpoint inhibitors
  
  Recent patents relating to checkpoint inhibitors and their use in treating cancers.
  
  Patents 13 Jul 2022

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News & Views

Sizing up beta cells made from stem cells

A thorough study of lab-made pancreatic beta cells reveals their differences from primary cells.

Kim-Vy Nguyen-Ngoc
Matthew Wortham
Maike Sander
News & Views 14 Mar 2022

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Research Briefings

Synthetic introns enable highly specific targeting of cancer cells

A new method uses synthetic introns to express therapeutic proteins selectively in cells bearing cancer-initiating mutations affecting RNA splicing factors, while healthy cells remain unaffected. This approach enabled the eradication of human leukemia, breast cancer and uveal melanoma cells in mouse models and significantly prolonged host survival.

Research Briefing 04 Mar 2022
Sustainable bioimaging using a fluorescent protein with unprecedented photostability

The jellyfish-derived green fluorescent protein StayGold is bright and hardly fades, contributing to improving spatiotemporal resolution and dramatically extending the observation period. To fully benefit from the rich photon budget, we tried some unusual illumination modalities for sustainable, quantitative live-cell or volumetric imaging.

Research Briefing 25 Apr 2022

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Research

Review Articles
- Smartphone apps in the COVID-19 pandemic
  
  An overview of apps for outbreak epidemiology, individual screening and contact tracing during the COVID-19 pandemic.
  
  Jay A. Pandit
  Jennifer M. Radin
  Eric J. Topol
  Review Article 20 Jun 2022
Brief Communications
- SignalP 6.0 predicts all five types of signal peptides using protein language models
  
  A new version of SignalP predicts all types of signal peptides.
  
  Felix Teufel
  José Juan Almagro Armenteros
  Henrik Nielsen
  Brief Communication Open Access 03 Jan 2022
- Fast nanopore sequencing data analysis with SLOW5
  
  Nanopore sequencing data are rapidly analyzed with parallel data access.
  
  Hasindu Gamaarachchi
  Hiruna Samarakoon
  Ira W. Deveson
  Brief Communication Open Access 03 Jan 2022
- Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations
  
  Clonal dynamics are inferred from mitochondrial variants in primary human cells.
  
  Tyler E. Miller
  Caleb A. Lareau
  Peter van Galen
  Brief Communication 24 Feb 2022
Articles
- Accelerated identification of disease-causing variants with ultra-rapid nanopore genome sequencing
  
  A streamlined sequencing process enables identification of disease-causing variants in the clinic within 8 hours.
  
  Sneha D. Goenka
  John E. Gorzynski
  Euan A. Ashley
  Article Open Access 28 Mar 2022
- Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
  
  Pancreatic islets derived from stem cells are benchmarked against primary cells.
  
  Diego Balboa
  Tom Barsby
  Timo Otonkoski
  Article Open Access 03 Mar 2022
- A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers
  
  Experimental and computational methods to detect enhancer RNAs are benchmarked.
  
  Li Yao
  Jin Liang
  Haiyuan Yu
  Article 17 Feb 2022
- CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information
  
  A computational algorithm integrates lineage tracing with single-cell RNA sequencing and improves early cell fate prediction.
  
  Shou-Wen Wang
  Michael J. Herriges
  Allon M. Klein
  Article 21 Feb 2022
- Multiplex de Bruijn graphs enable genome assembly from long, high-fidelity reads
  
  A multiplex de Bruijn graph algorithm allows high-accuracy genome assembly from long, high-fidelity reads.
  
  Anton Bankevich
  Andrey V. Bzikadze
  Pavel A. Pevzner
  Article 28 Feb 2022
- Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue
  
  Complete RNA isoforms are captured by a new single-nuclei sequencing method.
  
  Simon A. Hardwick
  Wen Hu
  Hagen U. Tilgner
  Article Open Access 07 Mar 2022
- Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides
  
  RNA in non-human primate liver is efficiently edited using short stereopure oligonucleotides.
  
  Prashant Monian
  Chikdu Shivalila
  Chandra Vargeese
  Article 07 Mar 2022
- Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells
  
  Synthetic introns tailored for specific splice-factor mutations enable targeted cancer gene therapy.
  
  Khrystyna North
  Salima Benbarche
  Robert K. Bradley
  Article 03 Mar 2022
- Learning protein fitness models from evolutionary and assay-labeled data
  
  A simple machine learning algorithm combines evolutionary and experimental data for improved protein fitness prediction.
  
  Chloe Hsu
  Hunter Nisonoff
  Jennifer Listgarten
  Article 17 Jan 2022
- Designing sensitive viral diagnostics with machine learning
  
  Viral diagnostics with maximum sensitivity are designed using machine learning and combinatorial optimization.
  
  Hayden C. Metsky
  Nicole L. Welch
  Pardis C. Sabeti
  
  Nature Outlook:
  
  Medical diagnostics
  Article Open Access 03 Mar 2022
- A highly photostable and bright green fluorescent protein
  
  StayGold is over one order of magnitude more photostable than current fluorescent proteins
  
  Masahiko Hirano
  Ryoko Ando
  Atsushi Miyawaki
  Article Open Access 25 Apr 2022
- Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression
  
  MRI detection of transgene expression in animals is expanded to two colors.
  
  Hyla Allouche-Arnon
  Olga Khersonsky
  Amnon Bar-Shir
  Article 31 Jan 2022

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Amendments & Corrections

Publisher Correction: Biotech patenting 2019

Brady Huggett
Kathryn Paisner
Publisher Correction 30 Jun 2022
Publisher Correction: Biotech patenting 2020

Brady Huggett
Kathryn Paisner
Publisher Correction 30 Jun 2022

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Careers & Recruitment

Career Feature
- What digitalization in biology R&D means for biotech companies and life scientists
  
  The digitalization of R&D can potentially transform the life sciences, but it cannot succeed without experts collaborating to develop a vision of what a better working environment can look like.
  
  Sybil Wong
  Mingke Pan
  Markus Gershater
  Career Feature 13 Jul 2022
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 13 Jul 2022

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Volume 40 Issue 7, July 2022

A fluorescent protein with staying power

Editorial

News

News Feature

Correspondence

Features

Patents

News & Views

Research Briefings

Research

Review Articles

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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