Volume 41 Issue 2, February 2023

Synthetic circRNA optimization

Circular RNA expression is affected by factors such as the placement of specific untranslated region and internal ribosome entry site features. Chen et. al. engineer and optimize synthetic circRNAs to allow robust translation of therapeutic proteins such as human erythropoietin.

See Chen et al.

Image: Xiaowei Yan, Stanford. Cover Design: Erin Dewalt.

Editorial

Generating ‘smarter’ biotechnology

Generative AI is moving full speed ahead in the biomedical space.

Editorial 02 Feb 2023

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News

Industry appetite for natural killer cells intensifies

Natural killer cells are attractive as cancer immunotherapy agents because — unlike T cells — they evade immune rejection and do not induce cytokine storms. But capturing their activity in effective therapies remains a work in progress.

Cormac Sheridan
News 15 Feb 2023
UK, BioNTech test mRNA against cancer

News in Brief 15 Feb 2023
Small innovators advance microbes as alternatives to chemical crop sprays

As farmers around the globe embrace microorganisms to treat and protect crops, ag giants sort out how they will participate in the industry, coming to different conclusions.

Emily Waltz
News 15 Feb 2023
First bee vaccine

News in Brief 15 Feb 2023
Putting CRISPR into African hands to future-proof crops

Scientists from seven countries embark on training to use gene editing tools to improve the continent’s neglected crops.

Linda Nordling
News 15 Feb 2023
Amgen pledges $8 million for diversity

News in Brief 15 Feb 2023
Biotech news from around the world

News in Brief 15 Feb 2023
Data Page
- Drug pipeline 4Q22 — sticking around
  
  John Hodgson
  Data Page 02 Feb 2023
- 2022 – toughing out the trough
  
  John Hodgson
  Data Page 02 Feb 2023
News Feature
- Fresh from the biotech pipeline: fewer approvals, but biologics gain share
  
  2022 saw a 25% drop in new drug approvals and a less predictable regulator.
  
  Melanie Senior
  News Feature 09 Jan 2023

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Comment

Delivering 3 billion doses of Comirnaty in 2021

Pfizer created a ‘light-speed’ approach to meet the challenge of vaccinating the world against COVID-19. It involved developing new strategies for all aspects of vaccine development, from sourcing materials and scaling up manufacturing to transportation and dosing.

Nicholas Warne
Margaret Ruesch
Mikael Dolsten
Comment 02 Feb 2023

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Features

Patents
- Drug licensing as evidence of evolution, diffusion and catch-up in East Asia
  
  Data-driven results map a holistic landscape of drug licensing and biotechnology diffusion in the last two decades.
  
  Jianan Huang
  Patents 15 Feb 2023
- Base editors
  
  Recent patents relating to compositions and methods for targeted editing of nucleic acids.
  
  Patents 15 Feb 2023

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Research Highlights

Capturing haplotype variation in populations using pangenome references

Jared B. Fudge
Research Highlight 15 Feb 2023
Consequences of cis-regulatory sequence variation

Jared B. Fudge
Research Highlight 15 Feb 2023
DISCO-MS combines spatial proteomics with whole-organ imaging

Anne Doerr
Research Highlight 15 Feb 2023

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Research Briefings

Capturing the diversity of protein modifications on presented tumor antigens

Post-translational modifications (PTMs) alter the structure, properties and functions of proteins in all aspects of biology. A new computational pipeline, termed protein modification integrated search engine (PROMISE), reveals the impact these modifications might have on the presentation of cancer antigens to T cells.

Research Briefing 10 Oct 2022

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Research

Brief Communications
- A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites
  
  A competitive CRISPR method discovers targets and phenotypic effects of the MYC oncogene.
  
  Päivi Pihlajamaa
  Otto Kauko
  Jussi Taipale
  Brief Communication Open Access 26 Sept 2022
Articles
- Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
  
  A mostly natural sequencing-by-synthesis method is effective for scRNA-seq, particularly in large-scale studies.
  
  Sean K. Simmons
  Gila Lithwick-Yanai
  Joshua Z. Levin
  Article Open Access 15 Sept 2022
- Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics
  
  Single-molecule imaging of cell-free nucleosomes detects colorectal cancer with high accuracy and sensitivity.
  
  Vadim Fedyuk
  Nir Erez
  Efrat Shema
  Article 08 Sept 2022
- Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH
  
  EEL FISH profiles spatial transcriptomes in single cells in large, complex tissue samples.
  
  Lars E. Borm
  Alejandro Mossi Albiach
  Sten Linnarsson
  Article Open Access 22 Sept 2022
- DeepConsensus improves the accuracy of sequences with a gap-aware sequence transformer
  
  Deep learning reduces errors in sequences from PacBio HiFi reads.
  
  Gunjan Baid
  Daniel E. Cook
  Andrew Carroll
  Article 01 Sept 2022
- Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors
  
  A computational pipeline identifies tumor antigen post-translational modifications guiding immune responses.
  
  Assaf Kacen
  Aaron Javitt
  Yifat Merbl
  Article 06 Oct 2022
- Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types
  
  Kidney collecting duct cells with physiologic functions are generated from human pluripotent stem cells.
  
  Min Shi
  Kyle W. McCracken
  Joseph V. Bonventre
  Article 29 Aug 2022
- Engineering circular RNA for enhanced protein production
  
  Protein expression from circular RNAs is enhanced several hundred-fold by optimizing vector design.
  
  Robert Chen
  Sean K. Wang
  Howard Y. Chang
  Article Open Access 18 Jul 2022
- Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins
  
  KineTACs are modular bispecific antibodies for degradation of extracellular and cell-surface proteins.
  
  Katarina Pance
  Josef A. Gramespacher
  James A. Wells
  Article Open Access 22 Sept 2022
- Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit
  
  DeepCAD-RT denoises fluorescence time-lapse images in real time.
  
  Xinyang Li
  Yixin Li
  Qionghai Dai
  Article Open Access 26 Sept 2022

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Amendments & Corrections

Author Correction: Engineering circular RNA for enhanced protein production

Robert Chen
Sean K. Wang
Howard Y. Chang
Author Correction Open Access 17 Aug 2022

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Careers & Recruitment

Career Feature
- Retaining postdocs by recognizing their worth
  
  Data from a postdoc salary and benefits survey may assist in retaining PhD holders interested in academia but considering alternate options owing to financial considerations.
  
  Esra Yalcin
  Rosa Martinez-Corral
  Mayank Chugh
  Career Feature 15 Feb 2023
- Fourth-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 15 Feb 2023
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 15 Feb 2023

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Volume 41 Issue 2, February 2023

Synthetic circRNA optimization

Editorial

News

Data Page

News Feature

Comment

Features

Patents

Research Highlights

Research Briefings

Research

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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