Browse Articles

  • Review Article |

    In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.

    • Johnna Doherty
    •  & Eric H. Baehrecke
  • News & Views |

    Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

    • Michael P. Murphy
  • Article |

    Zhu et al. show that the long noncoding RNA lncGata6 enhances Wnt signalling in intestinal stem cells by recruiting the NURF remodelling complex onto the Ehf promoter and initiating its transcription, which triggers expression of Lgr4/5.

    • Pingping Zhu
    • , Jiayi Wu
    • , Yanying Wang
    • , Xiaoxiao Zhu
    • , Tiankun Lu
    • , Benyu Liu
    • , Luyun He
    • , Buqing Ye
    • , Shuo Wang
    • , Shu Meng
    • , Dongdong Fan
    • , Jing Wang
    • , Liuliu Yang
    • , Xiwen Qin
    • , Ying Du
    • , Chong Li
    • , Lei He
    • , Weizheng Ren
    • , Xin Wu
    • , Yong Tian
    •  & Zusen Fan
  • Letter |

    Using super-resolution microscopy, tracking of single particle trajectories of endoplasmic reticulum (ER) luminal proteins traversing tubular ER, and measuring ER dynamics, Holcman et al. show that ER content is propelled by active luminal flow.

    • David Holcman
    • , Pierre Parutto
    • , Joseph E. Chambers
    • , Marcus Fantham
    • , Laurence J. Young
    • , Stefan J. Marciniak
    • , Clemens F. Kaminski
    • , David Ron
    •  & Edward Avezov
  • Article |

    Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.

    • J. Matthew Barnes
    • , Shelly Kaushik
    • , Russell O. Bainer
    • , Jason K. Sa
    • , Elliot C. Woods
    • , FuiBoon Kai
    • , Laralynne Przybyla
    • , Mijeong Lee
    • , Hye Won Lee
    • , Jason C. Tung
    • , Ori Maller
    • , Alexander S. Barrett
    • , Kan V. Lu
    • , Jonathon N. Lakins
    • , Kirk C. Hansen
    • , Kirsten Obernier
    • , Arturo Alvarez-Buylla
    • , Gabriele Bergers
    • , Joanna J. Phillips
    • , Do-Hyun Nam
    • , Carolyn R. Bertozzi
    •  & Valerie M. Weaver
  • Letter |

    Studying early Drosophila wing epithelium development, Singh et al. find that individual cells are mechanically autonomous, and that their elongation along the proximal–distal axis is driven by polarized microtubule-mediated pushing forces.

    • Amrita Singh
    • , Tanumoy Saha
    • , Isabell Begemann
    • , Andrea Ricker
    • , Harald Nüsse
    • , Oliver Thorn-Seshold
    • , Jürgen Klingauf
    • , Milos Galic
    •  & Maja Matis
  • Article |

    Zhang et al. show that BAP1 suppresses SLC7A11 expression and cystine uptake, thereby promoting ferroptosis and inhibiting tumour growth.

    • Yilei Zhang
    • , Jiejun Shi
    • , Xiaoguang Liu
    • , Li Feng
    • , Zihua Gong
    • , Pranavi Koppula
    • , Kapil Sirohi
    • , Xu Li
    • , Yongkun Wei
    • , Hyemin Lee
    • , Li Zhuang
    • , Gang Chen
    • , Zhen-Dong Xiao
    • , Mien-Chie Hung
    • , Junjie Chen
    • , Peng Huang
    • , Wei Li
    •  & Boyi Gan
  • Correction |

    • Rishi Raj Chhipa
    • , Qiang Fan
    • , Jane Anderson
    • , Ranjithmenon Muraleedharan
    • , Yan Huang
    • , Georgianne Ciraolo
    • , Xiaoting Chen
    • , Ronald Waclaw
    • , Lionel M. Chow
    • , Zaza Khuchua
    • , Matthew Kofron
    • , Matthew T. Weirauch
    • , Ady Kendler
    • , Christopher McPherson
    • , Nancy Ratner
    • , Ichiro Nakano
    • , Nupur Dasgupta
    • , Kakajan Komurov
    •  & Biplab Dasgupta
  • Article |

    Lenos et al. report that the spatiotemporal regulation of stem cell functionality is not intrinsically determined but environmentally defined during tumour growth and drug response in colon cancer.

    • Kristiaan J. Lenos
    • , Daniël M. Miedema
    • , Sophie C. Lodestijn
    • , Lisanne E. Nijman
    • , Tom van den Bosch
    • , Xavier Romero Ros
    • , Filipe C. Lourenço
    • , Maria C. Lecca
    • , Maartje van der Heijden
    • , Sanne M. van Neerven
    • , Anita van Oort
    • , Nicolas Leveille
    • , Ronja S. Adam
    • , Felipe de Sousa E Melo
    • , Joy Otten
    • , Patrick Veerman
    • , Guillaume Hypolite
    • , Lianne Koens
    • , Scott K. Lyons
    • , Giorgio Stassi
    • , Douglas J. Winton
    • , Jan Paul Medema
    • , Edward Morrissey
    • , Maarten F. Bijlsma
    •  & Louis Vermeulen
  • News & Views |

    Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    •  & Brendan D. Manning
  • Turning Points |

    Serena is a Cancer Research UK Advanced Clinician Scientist at the University of Cambridge. She studies mutation patterns in human DNA and finds ways to make it applicable in a clinical setting. Serena is a mother of two, loves music and being outdoors, and fights the forties with kung fu.

    • Serena Nik-Zainal
  • Editorial |

    Open discourse to identify challenges and devise solutions is essential to abolish gender inequalities globally and in science. In our ‘Focus on Women in Science’, we celebrate the achievements and consider the concerns of women researchers from around the world, who share some of the turning points of their scientific careers.

  • News & Views |

    Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

    • Michael Ebner
    •  & Volker Haucke
  • Turning Points |

    Melissa Little is an NHMRC Senior Principal Research Fellow and Cell Biology Theme Director at the Murdoch Children’s Research Institute in Melbourne, Australia. She also leads Stem Cells Australia, University of Melbourne. She studies kidney morphogenesis and regeneration using pluripotent stem cells.

    • Melissa Little
  • Turning Points |

    Melina Schuh did her PhD at the European Molecular Biology Laboratory with Jan Ellenberg. She became group leader at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, in 2009, and was appointed Director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, in 2016.

    • Melina Schuh
  • Turning Points |

    Shubha Tole obtained her BSc in Life Sciences and Biochemistry from St. Xavier’s College, Mumbai, India, in 1987. After a PhD from the California Institute of Technology in 1994, she did her postdoc at the University of Chicago. In 1999, she joined the Tata Institute of Fundamental Research, in Mumbai, as a faculty member.

    • Shubha Tole
  • Turning Points |

    M. Celeste Simon is Scientific Director of the Abramson Family Cancer Research Institute and Arthur H. Rubenstein, MBBCh Professor of Cell and Developmental Biology at the University of Pennsylvania. She studies tumour and stromal cell responses to variable oxygen and nutrient levels and is a devoted mentor of biomedical trainees.

    • M. Celeste Simon
  • Turning Points |

    Anne Simonsen is a Professor at the Department of Molecular Medicine at the Institute of Basic Medical Sciences of the University of Oslo, Norway. Her work focuses on lipid-binding proteins in membrane trafficking and autophagy, and their links to disease.

    • Anne Simonsen
  • Turning Points |

    Asifa Akhtar is Director at the Max Planck Institute of Immunobiology and Epigenetics. Her lab focuses on chromatin and epigenetic regulation. A member of the European Molecular Biology Organisation, she received the European Life Science Organization award in 2008 and the Wilhelm Feldberg Prize in 2017.

    • Asifa Akhtar
  • Turning Points |

    Nancy Y. Ip is Vice President for Research and Graduate Studies, the Morningside Professor of Life Science, and Director of the State Key Laboratory of Molecular Neuroscience at the Hong Kong University of Science and Technology, Hong Kong, China. Her career in the field of neuroscience spans over three decades.

    • Nancy Y. Ip
  • Turning Points |

    Professor Kum Kum Khanna heads the Signal Transduction Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia. She studies the role of the DNA damage response in tissue homeostasis and disease, including how to exploit its dysregulation in breast cancer to develop targeted therapeutic approaches.

    • Kum Kum Khanna
  • Turning Points |

    Mayana Zatz is Professor of Genetics and Director of the Human Genome and Stem-Cell Research Center at the University of São Paulo, Brazil. She works on neuromuscular disorders, ageing and, more recently, Zika virus and cancer. She has a prolific publication record and is actively involved in ethical aspects of genetic research.

    • Mayana Zatz
  • Turning Points |

    Sandrine Etienne-Manneville investigates the molecular mechanisms underlying cell migration in health and disease. She is Head of the Cell Polarity, Migration and Cancer laboratory, Director of the CNRS UMR3691 unit at the Institut Pasteur, Paris, France, a professor of cell biology and a mother of four.

    • Sandrine Etienne-Manneville
  • Turning Points |

    Maho Hamasaki is an associate professor at Osaka University, Japan. Maho’s laboratory focuses on investigating the mechanistic underpinnings of autophagy and the role of the autophagic process in disease.

    • Maho Hamasaki
  • Turning Points |

    Fiona Watt runs the Centre for Stem Cells and Regenerative Medicine at King’s College London and is an outspoken advocate for women scientists. Since April 2018, she has been on secondment as Executive Chair of the Medical Research Council, one of the major funders of biomedical research in the UK.

    • Fiona M. Watt
  • Review Article |

    In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.

    • Konstantinos Palikaras
    • , Eirini Lionaki
    •  & Nektarios Tavernarakis
  • Article |

    Liu et al. show that reduced m6A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m6A on their transcripts.

    • Jun Liu
    • , Mark A. Eckert
    • , Bryan T. Harada
    • , Song-Mei Liu
    • , Zhike Lu
    • , Kangkang Yu
    • , Samantha M. Tienda
    • , Agnieszka Chryplewicz
    • , Allen C. Zhu
    • , Ying Yang
    • , Jing-Tao Huang
    • , Shao-Min Chen
    • , Zhi-Gao Xu
    • , Xiao-Hua Leng
    • , Xue-Chen Yu
    • , Jie Cao
    • , Zezhou Zhang
    • , Jianzhao Liu
    • , Ernst Lengyel
    •  & Chuan He
  • Article |

    Using a small-molecule modulator of TORC2 signalling and a mechanosensitive probe, Riggi et al. reveal that decreased plasma membrane tension induces distinct PIP2-enriched domains that sequester and inactivate TORC2.

    • Margot Riggi
    • , Karolina Niewola-Staszkowska
    • , Nicolas Chiaruttini
    • , Adai Colom
    • , Beata Kusmider
    • , Vincent Mercier
    • , Saeideh Soleimanpour
    • , Michael Stahl
    • , Stefan Matile
    • , Aurélien Roux
    •  & Robbie Loewith
  • Article |

    Castaño et al. show that primary breast tumours drive an IL-1β -mediated inflammatory response that inhibits cellular plasticity and metastatic colonization of metastasis-initiating cells.

    • Zafira Castaño
    • , Beatriz P. San Juan
    • , Asaf Spiegel
    • , Ayush Pant
    • , Molly J. DeCristo
    • , Tyler Laszewski
    • , Jessalyn M. Ubellacker
    • , Susanne R. Janssen
    • , Anushka Dongre
    • , Ferenc Reinhardt
    • , Ayana Henderson
    • , Ana Garcia del Rio
    • , Ann M. Gifford
    • , Zachary T. Herbert
    • , John N. Hutchinson
    • , Robert A. Weinberg
    • , Christine L. Chaffer
    •  & Sandra S. McAllister
  • Article |

    Nichols et al. identify an SHP2 inhibitor that disrupts SOS1-mediated RAS–GTP loading with demonstrated efficacy in various types of tumour driven by mutant BRAF, NF1 or RAS.

    • Robert J. Nichols
    • , Franziska Haderk
    • , Carlos Stahlhut
    • , Christopher J. Schulze
    • , Golzar Hemmati
    • , David Wildes
    • , Christos Tzitzilonis
    • , Kasia Mordec
    • , Abby Marquez
    • , Jason Romero
    • , Tientien Hsieh
    • , Aubhishek Zaman
    • , Victor Olivas
    • , Caroline McCoach
    • , Collin M. Blakely
    • , Zhengping Wang
    • , Gert Kiss
    • , Elena S. Koltun
    • , Adrian L. Gill
    • , Mallika Singh
    • , Mark A. Goldsmith
    • , Jacqueline A. M. Smith
    •  & Trever G. Bivona
  • Publisher Correction |

    • Hery Urra
    • , Daniel R. Henriquez
    • , José Cánovas
    • , David Villarroel-Campos
    • , Amado Carreras-Sureda
    • , Eduardo Pulgar
    • , Emiliano Molina
    • , Younis M. Hazari
    • , Celia M. Limia
    • , Sebastián Alvarez-Rojas
    • , Ricardo Figueroa
    • , Rene L. Vidal
    • , Diego A. Rodriguez
    • , Claudia A. Rivera
    • , Felipe A. Court
    • , Andrés Couve
    • , Ling Qi
    • , Eric Chevet
    • , Ryoko Akai
    • , Takao Iwawaki
    • , Miguel L. Concha
    • , Álvaro Glavic
    • , Christian Gonzalez-Billault
    •  & Claudio Hetz
  • Publisher Correction |

    • Rishi Raj Chhipa
    • , Qiang Fan
    • , Jane Anderson
    • , Ranjithmenon Muraleedharan
    • , Yan Huang
    • , Georgianne Ciraolo
    • , Xiaoting Chen
    • , Ronald Waclaw
    • , Lionel M. Chow
    • , Zaza Khuchua
    • , Matthew Kofron
    • , Matthew T. Weirauch
    • , Ady Kendler
    • , Christopher McPherson
    • , Nancy Ratner
    • , Ichiro Nakano
    • , Nupur Dasgupta
    • , Kakajan Komurov
    •  & Biplab Dasgupta
  • Article |

    Almuedo-Castillo et al. show that extirpated embryos are reduced in size but exhibit normal proportions. Following a computational screen, the authors identify an increased concentration of the Nodal inhibitor Lefty to be responsible for the size scaling.

    • María Almuedo-Castillo
    • , Alexander Bläßle
    • , David Mörsdorf
    • , Luciano Marcon
    • , Gary H. Soh
    • , Katherine W. Rogers
    • , Alexander F. Schier
    •  & Patrick Müller
  • Letter |

    Chan Wah Hak et al. show how plasma membrane patches are primed for fast endophilin-mediated endocytosis and disassembly, in the absence of receptor stimulation, through FBP17 and CIP4 binding to SHIP2 and lamellipodin.

    • Laura Chan Wah Hak
    • , Shaheen Khan
    • , Ilaria Di Meglio
    • , Ah-Lai Law
    • , Safa Lucken-Ardjomande Häsler
    • , Leonor M. Quintaneiro
    • , Antonio P. A. Ferreira
    • , Matthias Krause
    • , Harvey T. McMahon
    •  & Emmanuel Boucrot
  • News & Views |

    During embryo development, concentration gradients of signalling molecules instruct formation of different cell types. How these gradients adapt to variable embryo sizes to form a properly scaled individual remains elusive. A simple system of an activator and an inhibitor, with different diffusion properties, may give an answer.

    • Laurence Garric
    •  & Jeroen Bakkers
  • Article |

    Madaro et al. show that denervation induces accumulation of IL-6–STAT3-activated fibro-adipogenic progenitors without inflammation or muscle regeneration, leading to muscle atrophy and fibrosis.

    • Luca Madaro
    • , Magda Passafaro
    • , David Sala
    • , Usue Etxaniz
    • , Francesca Lugarini
    • , Daisy Proietti
    • , Maria Vittoria Alfonsi
    • , Chiara Nicoletti
    • , Sole Gatto
    • , Marco De Bardi
    • , Ricardo Rojas-García
    • , Lorenzo Giordani
    • , Sara Marinelli
    • , Vittoria Pagliarini
    • , Claudio Sette
    • , Alessandra Sacco
    •  & Pier Lorenzo Puri
  • Editorial |

    Understanding the dynamics and complexity of tumour metastasis is crucial for improving clinical interventions and care for cancer patients. In this issue, we present the first of a Series of commissioned Review articles that discuss emerging concepts, technological advances and therapeutic implications in this exciting field.

  • Review Article |

    Stefano Piccolo and co-authors review recent insights into how YAP and TAZ transcription factors respond to the tissue environment, and how they mediate altered cell behaviour. Feedback mechanisms and crosstalk with other pathways are discussed, as are outstanding questions in the field.

    • Antonio Totaro
    • , Tito Panciera
    •  & Stefano Piccolo
  • News & Views |

    A previously unidentified protein complex termed Shieldin acts with the nucleosome-binding protein 53BP1 to limit end resection at DNA double-strand breaks, impacting myriad biological outcomes, from immunology to cancer therapy, and highlighting the importance of chromatin responses to DNA damage in vertebrates.

    • Roger A Greenberg
  • News & Views |

    Skeletal muscle denervation leads to myofibre atrophy with fibrosis and fatty infiltration of muscle-resident fibroadipogenic progenitors (FAPs). A study shows that on denervation, FAPs activate pathogenic STAT3–IL-6 signalling. Inhibition of this pathway prevents atrophy and points to potential therapeutic targets.

    • Giovanna Marazzi
    •  & David Sassoon
  • Review Article |

    Celia-Terrassa and Kang discuss specialized functions of distinct metastatic niches, and how the emerging knowledge can be leveraged for improved therapeutic opportunities.

    • Toni Celià-Terrassa
    •  & Yibin Kang
  • News & Views |

    Metastatic colonization of distant organs is the prime cause of mortality from cancer, and is governed by a series of steps that include survival and growth in the perivascular niche. A study now shows that L1CAM is necessary for tight physical interactions in this niche, involving a YAP–MRTF–β1-integrin mechanotransduction pathway.

    • Matthia A. Karreman
    •  & Frank Winkler
  • News & Views |

    Enteroendocrine (EE) cells secrete diverse peptide hormones, regulating food intake, digestion and metabolism. A study now challenges the traditional view that each hormone is the dominant product of a distinct EE cell type, showing that in response to local cues the same cell produces different hormones in different tissue compartments.

    • Ramesh A. Shivdasani