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Volume 10 Issue 3, March 2008

Hypertrophy of the pericentriolar material (PCM) results in the formation of multiple daughter centrioles on the same mother. A montage is shown of triple-stained centrosomes from CHO cells arrested in S phase. SAS-6 (red) localizes to the proximal end of daughter centrioles; centrin localizes to the distal end of all centrioles (green) and the PCM is marked by g-tubulin (blue).

Volume 10 Issue 3

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  • Where a piece of research is published impacts on funding and career prospects. What is being done to ensure this journal's selection process is fair?

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  • The cell adhesion molecule TAG1 has been identified as the ligand that induces β-amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease.

    • Mark P. Mattson
    • Henriette van Praag
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  • How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a protein is misfolded. The basic strategy of glycan-based recognition, previously identified in yeast, is conserved in mammals but is expanded, possibly to accommodate a more complex client portfolio.

    • Songyu Wang
    • Davis T. W. Ng
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  • Hypoxia is a critical factor during tumour progression, regulating the expression of multiple factors implicated in tumour growth, epithelial to mesenchymal transition (EMT) and invasive cell behaviour. We now learn that the EMT inducer Twist operates under the control of hypoxia signalling in the tumour microenvironment.

    • Héctor Peinado
    • Amparo Cano
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  • Newly formed centrioles can spring forth from clouds of pericentriolar material, violating the precise regulation of centriole counting. These observations challenge the long-standing view that centriole number is determined by the periodic activation of an assembly template thought to reside on pre-existing centrioles.

    • Jeffrey L. Salisbury
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