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AlphaFold is a breakthrough in protein structure prediction, but limitations in its application to computation- and structure-guided drug discovery remain. As with structure prediction, public-domain data and benchmarking initiatives will be essential to advance the field of computational drug design.
Hiroaki Suga’s research has made substantial contributions to the development of artificial ribozymes and their application in mRNA display libraries. In 2006, Professor Suga help found the biopharmaceutical company PeptiDream Inc. He spoke to Nature Chemical Biology about the future of mRNA display libraries and the advantages they offer.