Nature Neuroscience Nature Neuroscience provides the international neuroscience community with a highly visible forum in which the most exciting developments in all areas of neuroscience can be communicated to a broad readership. A lively front half, including News &amp; Views, Reviews, Perspectives and editorials, helps place the primary research in context, providing readers with a broad perspective on the entire field. Nature Neuroscience aims to provide readers with authoritative, accessible and timely information on the most important advances in understanding the nervous system. Areas covered include molecular, cellular, systems, behavioral, cognitive and computational studies. http://feeds.nature.com/neuro/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Neuroscience © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Neuroscience https://www.nature.com/uploads/product/neuro/rss.gif http://feeds.nature.com/neuro/rss/current <![CDATA[Natural language instructions induce compositional generalization in networks of neurons]]> https://www.nature.com/articles/s41593-024-01607-5 Nature Neuroscience, Published online: 18 March 2024; doi:10.1038/s41593-024-01607-5

Riveland and Pouget model instructed action, showing that shared structure in task and semantic representations allows language to compose practiced skills in novel settings. Models make predictions for neural activity in human language areas.]]>
Reidar RivelandAlexandre Pouget doi:10.1038/s41593-024-01607-5 Nature Neuroscience, Published online: 2024-03-18; | doi:10.1038/s41593-024-01607-5 2024-03-18 Nature Neuroscience 10.1038/s41593-024-01607-5 https://www.nature.com/articles/s41593-024-01607-5
<![CDATA[The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions]]> https://www.nature.com/articles/s41593-024-01598-3 Nature Neuroscience, Published online: 18 March 2024; doi:10.1038/s41593-024-01598-3

Chen et al. show that transitions to innate behaviors, such as feeding and social interaction, rely on their encoding during beta oscillations by neuron populations in the lateral hypothalamus, coordinated with the medial prefrontal cortex and ventral tegmental area.]]>
Changwan ChenMahsa AltafiMihaela-Anca CorbuAleksandra TrenkHanna van den MunkhofKristin WeineckFranziska BenderMarta Carus-CadaviecoAlisa BakharevaTatiana KorotkovaAlexey Ponomarenko doi:10.1038/s41593-024-01598-3 Nature Neuroscience, Published online: 2024-03-18; | doi:10.1038/s41593-024-01598-3 2024-03-18 Nature Neuroscience 10.1038/s41593-024-01598-3 https://www.nature.com/articles/s41593-024-01598-3
<![CDATA[Local origin of excitatory–inhibitory tuning equivalence in a cortical network]]> https://www.nature.com/articles/s41593-024-01588-5 Nature Neuroscience, Published online: 15 March 2024; doi:10.1038/s41593-024-01588-5

Cortical excitatory neurons are narrowly tuned to sensory inputs, but the tuning of interneurons is perceived as broad and irregular. Duszkiewicz et al. demonstrate that interneuron tuning is structured and reflects the sum of local excitatory inputs.]]>
Adrian J. DuszkiewiczPierre OrhanSofia Skromne CarrascoEleanor H. BrownEliott OwczarekGilberto R. ViteEmma R. WoodAdrien Peyrache doi:10.1038/s41593-024-01588-5 Nature Neuroscience, Published online: 2024-03-15; | doi:10.1038/s41593-024-01588-5 2024-03-15 Nature Neuroscience 10.1038/s41593-024-01588-5 https://www.nature.com/articles/s41593-024-01588-5
<![CDATA[In conversation with Igor Adameyko]]> https://www.nature.com/articles/s41593-024-01614-6 Nature Neuroscience, Published online: 12 March 2024; doi:10.1038/s41593-024-01614-6

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Igor Adameyko (Department Chair at the Center for Brain Research of the Medical University of Vienna, Austria, and a group leader at the Karolinska Institutet, Sweden), a developmental biologist by training with research interests ranging from neural crest cell fate to aquatic life and a champion of a positive research culture.]]>
Elisa Floriddia doi:10.1038/s41593-024-01614-6 Nature Neuroscience, Published online: 2024-03-12; | doi:10.1038/s41593-024-01614-6 2024-03-12 Nature Neuroscience 10.1038/s41593-024-01614-6 https://www.nature.com/articles/s41593-024-01614-6
<![CDATA[Liprin-α proteins are master regulators of human presynapse assembly]]> https://www.nature.com/articles/s41593-024-01592-9 Nature Neuroscience, Published online: 12 March 2024; doi:10.1038/s41593-024-01592-9

This paper identifies the evolutionarily conserved liprin-α protein family as key mediators of presynaptic assembly in human neurons. Their recruitment to sites formed by contacting neurons is the critical initial step that triggers presynaptic differentiation.]]>
Berta Marcó de la CruzJoaquín CamposAngela MolinaroXingqiao XieGaowei JinZhiyi WeiClaudio AcunaFredrik H. Sterky doi:10.1038/s41593-024-01592-9 Nature Neuroscience, Published online: 2024-03-12; | doi:10.1038/s41593-024-01592-9 2024-03-12 Nature Neuroscience 10.1038/s41593-024-01592-9 https://www.nature.com/articles/s41593-024-01592-9
<![CDATA[Identification of a cold sensor in peripheral somatosensory neurons]]> https://www.nature.com/articles/s41593-024-01606-6 Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01606-6

Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-sensing chemoreceptor that mediates synaptic transmission in the brain, mediates the sensing of cold but not cool temperatures in mouse dorsal root ganglia neurons in the periphery. Thus, we identify GluK2 as a cold-sensing thermoreceptor.]]>
doi:10.1038/s41593-024-01606-6 Nature Neuroscience, Published online: 2024-03-11; | doi:10.1038/s41593-024-01606-6 2024-03-11 Nature Neuroscience 10.1038/s41593-024-01606-6 https://www.nature.com/articles/s41593-024-01606-6
<![CDATA[The kainate receptor GluK2 mediates cold sensing in mice]]> https://www.nature.com/articles/s41593-024-01585-8 Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01585-8

The identity of receptors sensing cold temperatures in peripheral somatosensory neurons remains obscure. Cai et al. report that GluK2, a kainate receptor mediating synaptic transmission in the brain, is co-opted as a cold sensor in the periphery.]]>
Wei CaiWenwen ZhangQin ZhengChia Chun HorTong PanMahar FatimaXinzhong DongBo DuanX. Z. Shawn Xu doi:10.1038/s41593-024-01585-8 Nature Neuroscience, Published online: 2024-03-11; | doi:10.1038/s41593-024-01585-8 2024-03-11 Nature Neuroscience 10.1038/s41593-024-01585-8 https://www.nature.com/articles/s41593-024-01585-8
<![CDATA[Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics]]> https://www.nature.com/articles/s41593-024-01595-6 Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01595-6

A real-time analysis system was developed for an up to 500-megabyte-per-second image stream. This system can extract activities from up to 100,000 neurons in larval zebrafish brains and enables closed-loop perturbations of brain-wide neural dynamics at cellular resolution.]]>
Chun-Feng ShangYu-Fan WangMei-Ting ZhaoQiu-Xiang FanShan ZhaoYu QianSheng-Jin XuYu MuJie HaoJiu-Lin Du doi:10.1038/s41593-024-01595-6 Nature Neuroscience, Published online: 2024-03-11; | doi:10.1038/s41593-024-01595-6 2024-03-11 Nature Neuroscience 10.1038/s41593-024-01595-6 https://www.nature.com/articles/s41593-024-01595-6