Browse Articles

  • Article |

    Klim et al. illuminate pathomechanisms of ALS using pluripotent stem cells to identify transcripts altered in human motor neurons by perturbations to ALS protein TDP-43, finding the microtubule regulator STMN2 highly sensitive to TDP-43 malfunctions.

    • Joseph R. Klim
    • , Luis A. Williams
    • , Francesco Limone
    • , Irune Guerra San Juan
    • , Brandi N. Davis-Dusenbery
    • , Daniel A. Mordes
    • , Aaron Burberry
    • , Michael J. Steinbaugh
    • , Kanchana K. Gamage
    • , Rory Kirchner
    • , Rob Moccia
    • , Seth H. Cassel
    • , Kuchuan Chen
    • , Brian J. Wainger
    • , Clifford J. Woolf
    •  & Kevin Eggan
  • Article |

    In the lateral entorhinal cortex, high-precision judgments related to timing were associated with greater blood-oxygen-level-dependent fMRI activity than low-precision time judgments. This brain region may be involved in memory for when events occur.

    • Maria E Montchal
    • , Zachariah M Reagh
    •  & Michael A Yassa
  • News & Views |

    Experience unfolds continuously in time, but we remember discrete sequences of events. In this issue of Nature Neuroscience, Montchal et al. describe brain activity patterns that predict how well people remember precisely when recent events occurred. Converging evidence suggests that homologous neural machinery structures temporal representations in rats and people.

    • Matthew L. Shapiro
  • Article |

    Concurrently recording neural spiking across cortical layers in a medial frontal area with EEG reveals the microcircuitry of error and reward signals, showing how neural circuits can realize executive control and produce error-related negativity.

    • Amirsaman Sajad
    • , David C. Godlove
    •  & Jeffrey D. Schall
  • Article |

    Prefrontal cortex can be flexibly engaged in many different tasks. Yang et al. trained an artificial neural network to solve 20 cognitive tasks. Functionally specialized modules and compositional representations emerged in the network after training.

    • Guangyu Robert Yang
    • , Madhura R. Joglekar
    • , H. Francis Song
    • , William T. Newsome
    •  & Xiao-Jing Wang
  • Article |

    The mRNA encoding stathmin-2, a protein implicated in axonal growth, is shown to be widely suppressed by premature polyadenylation in both sporadic and C9orf72 ALS through a mechanism directly dependent on loss of nuclear TDP-43 in motor neurons.

    • Ze’ev Melamed
    • , Jone López-Erauskin
    • , Michael W. Baughn
    • , Ouyang Zhang
    • , Kevin Drenner
    • , Ying Sun
    • , Fernande Freyermuth
    • , Moira A. McMahon
    • , Melinda S. Beccari
    • , Jon W. Artates
    • , Takuya Ohkubo
    • , Maria Rodriguez
    • , Nianwei Lin
    • , Dongmei Wu
    • , C. Frank Bennett
    • , Frank Rigo
    • , Sandrine Da Cruz
    • , John Ravits
    • , Clotilde Lagier-Tourenne
    •  & Don W. Cleveland
  • Resource |

    An extensive profile of DNA methylation in neuronal and non-neuronal cells across four brain regions is reported, showing that differential epigenetic marks are enriched for DNA variants associated with neuropsychiatric traits.

    • Lindsay F. Rizzardi
    • , Peter F. Hickey
    • , Varenka Rodriguez DiBlasi
    • , Rakel Tryggvadóttir
    • , Colin M. Callahan
    • , Adrian Idrizi
    • , Kasper D. Hansen
    •  & Andrew P. Feinberg
  • Article |

    Lieder et al show that individuals with dyslexia and individuals with ASD rely mostly on recent and earlier perceptual information, respectively, during perceptual tasks. This may explain the unique difficulties associated with the two conditions.

    • Itay Lieder
    • , Vincent Adam
    • , Or Frenkel
    • , Sagi Jaffe-Dax
    • , Maneesh Sahani
    •  & Merav Ahissar
  • Article |

    Loss of Trem2 function increases early amyloidogenesis by preventing microglial activation and clustering around amyloid seeds. As a consequence of reduced microglial ApoE production in the absence of Trem2 function, amyloid plaques contain less ApoE.

    • Samira Parhizkar
    • , Thomas Arzberger
    • , Matthias Brendel
    • , Gernot Kleinberger
    • , Maximilian Deussing
    • , Carola Focke
    • , Brigitte Nuscher
    • , Monica Xiong
    • , Alireza Ghasemigharagoz
    • , Natalie Katzmarski
    • , Susanne Krasemann
    • , Stefan F. Lichtenthaler
    • , Stephan A. Müller
    • , Alessio Colombo
    • , Laura Sebastian Monasor
    • , Sabina Tahirovic
    • , Jochen Herms
    • , Michael Willem
    • , Nadine Pettkus
    • , Oleg Butovsky
    • , Peter Bartenstein
    • , Dieter Edbauer
    • , Axel Rominger
    • , Ali Ertürk
    • , Stefan A. Grathwohl
    • , Jonas J. Neher
    • , David M. Holtzman
    • , Melanie Meyer-Luehmann
    •  & Christian Haass
  • Article |

    Using a dynamic time-course approach to model developmental trajectories in autism spectrum disorder, Schafer et al. identified aberrant gene network dynamics as a part of an ongoing process that is primed early in development.

    • Simon T. Schafer
    • , Apua C. M. Paquola
    • , Shani Stern
    • , David Gosselin
    • , Manching Ku
    • , Monique Pena
    • , Thomas J. M. Kuret
    • , Marvin Liyanage
    • , Abed AlFatah Mansour
    • , Baptiste N. Jaeger
    • , Maria C. Marchetto
    • , Christopher K. Glass
    • , Jerome Mertens
    •  & Fred H. Gage
  • News & Views |

    In 2008, Vyazovskiy et al. published a seminal study demonstrating that sleep induces a widespread downscaling of synapses that counters the synaptic upscaling that occurred during prior wakefulness. The study laid the groundwork for current research into the ‘where’ and ‘when’ of homeostatic neuronal network regulation during sleep.

    • Niels Niethard
    •  & Jan Born
  • Technical Report |

    A nanobody-based immunolabeling method, vDISCO, boosts the signal of fluorescent proteins and allows imaging of subcellular details in intact transparent mice. It uncovers neuronal projections and skull–meninges connections in whole adult mice.

    • Ruiyao Cai
    • , Chenchen Pan
    • , Alireza Ghasemigharagoz
    • , Mihail Ivilinov Todorov
    • , Benjamin Förstera
    • , Shan Zhao
    • , Harsharan S. Bhatia
    • , Arnaldo Parra-Damas
    • , Leander Mrowka
    • , Delphine Theodorou
    • , Markus Rempfler
    • , Anna L. R. Xavier
    • , Benjamin T. Kress
    • , Corinne Benakis
    • , Hanno Steinke
    • , Sabine Liebscher
    • , Ingo Bechmann
    • , Arthur Liesz
    • , Bjoern Menze
    • , Martin Kerschensteiner
    • , Maiken Nedergaard
    •  & Ali Ertürk
  • Article |

    Using a newly developed biochemical method for aggregated protein extraction, Laferrière and colleagues uncover different neurotoxic types of pathologic TDP-43 assemblies in the brains of subjects with distinct subtypes of frontotemporal dementia.

    • Florent Laferrière
    • , Zuzanna Maniecka
    • , Manuela Pérez-Berlanga
    • , Marian Hruska-Plochan
    • , Larissa Gilhespy
    • , Eva-Maria Hock
    • , Ulrich Wagner
    • , Tariq Afroz
    • , Paul J. Boersema
    • , Gery Barmettler
    • , Sandrine C. Foti
    • , Yasmine T. Asi
    • , Adrian M. Isaacs
    • , Ashraf Al-Amoudi
    • , Amanda Lewis
    • , Henning Stahlberg
    • , John Ravits
    • , Francesca De Giorgi
    • , François Ichas
    • , Erwan Bezard
    • , Paola Picotti
    • , Tammaryn Lashley
    •  & Magdalini Polymenidou
  • Article |

    Polanía et al. show that, similarly to sensory signals, subjective preferences guiding choice are represented by the brain in a manner that accounts for regularities of the environment, thereby optimizing use of limited neural processing resources.

    • Rafael Polanía
    • , Michael Woodford
    •  & Christian C. Ruff
  • Article |

    Neuron types vulnerable to tau accumulation (excitatory neurons) in AD brain are intrinsically less able to maintain tau homeostasis than neuron types that are resistant (inhibitory neurons).

    • Hongjun Fu
    • , Andrea Possenti
    • , Rosie Freer
    • , Yoshikazu Nakano
    • , Nancy C. Hernandez Villegas
    • , Maoping Tang
    • , Paula V. M. Cauhy
    • , Benjamin A. Lassus
    • , Shuo Chen
    • , Stephanie L. Fowler
    • , Helen Y. Figueroa
    • , Edward D. Huey
    • , Gail V. W. Johnson
    • , Michele Vendruscolo
    •  & Karen E. Duff
  • Article |

    CD133 and Notch1 double-positive GSCs were preferentially located along Jagged1-expressing white matter tracts, which exhibited a demyelinated phenotype. The NOTCH1SOX9SOX2 positive-feedback loop controls GSC invasion along white matter tracts.

    • Jun Wang
    • , Sen-Lin Xu
    • , Jiang-Jie Duan
    • , Liang Yi
    • , Yu-Feng Guo
    • , Yu Shi
    • , Lin Li
    • , Ze-Yu Yang
    • , Xue-Mei Liao
    • , Jiao Cai
    • , Yan-Qi Zhang
    • , Hua-Liang Xiao
    • , Li Yin
    • , Hao Wu
    • , Jing-Na Zhang
    • , Sheng-Qing Lv
    • , Qing-Kai Yang
    • , Xiao-Jun Yang
    • , Tao Jiang
    • , Xia Zhang
    • , Xiu-Wu Bian
    •  & Shi-Cang Yu
  • Article |

    Microscopic imaging of neurons in mouse models of Alzheimer’s disease shows that plaques increase activity while neurofibrillary tangles suppress activity. The combination of plaques and tangles, as in humans with Alzheimer’s disease, suppresses activity.

    • Marc Aurel Busche
    • , Susanne Wegmann
    • , Simon Dujardin
    • , Caitlin Commins
    • , Julia Schiantarelli
    • , Naomi Klickstein
    • , Tarun V. Kamath
    • , George A. Carlson
    • , Israel Nelken
    •  & Bradley T. Hyman
  • Article |

    Single-cell mass cytometry was applied to comprehensively characterize postmortem and fresh human microglia. Using a hybrid workflow for multidimensional data analysis, a core signature and regional heterogeneity were identified.

    • Chotima Böttcher
    • , Stephan Schlickeiser
    • , Marjolein A. M. Sneeboer
    • , Desiree Kunkel
    • , Anniki Knop
    • , Evdokia Paza
    • , Pawel Fidzinski
    • , Larissa Kraus
    • , Gijsje J. L. Snijders
    • , René S Kahn
    • , Axel R Schulz
    • , Henrik E Mei
    • , Elly M. Hol
    • , Britta Siegmund
    • , Rainer Glauben
    • , Eike J Spruth
    • , Lot D de Witte
    •  & Josef Priller
  • News & Views |

    TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

    • Edward M. Barbieri
    •  & James Shorter
  • News & Views |

    In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

    • Alexandra G. DiFeliceantonio
    •  & Dana M. Small
  • Article |

    Tau but not amyloid-beta pathology is associated with widespread alterations of histone 3 lysine 9 acetylation in the aged human cortex. Similar alterations of chromatin organization occur in iPSC-derived neurons after overexpression of tau.

    • Hans-Ulrich Klein
    • , Cristin McCabe
    • , Elizabeta Gjoneska
    • , Sarah E. Sullivan
    • , Belinda J. Kaskow
    • , Anna Tang
    • , Robert V. Smith
    • , Jishu Xu
    • , Andreas R. Pfenning
    • , Bradley E. Bernstein
    • , Alexander Meissner
    • , Julie A. Schneider
    • , Sara Mostafavi
    • , Li-Huei Tsai
    • , Tracy L. Young-Pearse
    • , David A. Bennett
    •  & Philip L. De Jager
  • Publisher Correction |

    • Xianjun Dong
    • , Zhixiang Liao
    • , David Gritsch
    • , Yavor Hadzhiev
    • , Yunfei Bai
    • , Joseph J. Locascio
    • , Boris Guennewig
    • , Ganqiang Liu
    • , Cornelis Blauwendraat
    • , Tao Wang
    • , Charles H. Adler
    • , John C. Hedreen
    • , Richard L. M. Faull
    • , Matthew P. Frosch
    • , Peter T. Nelson
    • , Patrizia Rizzu
    • , Antony A. Cooper
    • , Peter Heutink
    • , Thomas G. Beach
    • , John S. Mattick
    • , Ferenc Müller
    •  & Clemens R. Scherzer
  • News & Views |

    The locus coeruleus is known to be an essential source of neuromodulation that influences sensory processing, including the enhancement of feature selectivity associated with attentional focus. A new study shows that the primary sensory thalamus encompasses one circuit that underlies this enhancement.

    • Tingting Zhou
    •  & Michael M Halassa
  • Article |

    Yu, Li et al. show that VTA GABA and glutamate neurons induce sleep and waking, respectively, via projections to the lateral hypothalamus and nucleus accumbens. Thus, in addition to influencing reward-directed behaviors, the VTA regulates arousal.

    • Xiao Yu
    • , Wen Li
    • , Ying Ma
    • , Kyoko Tossell
    • , Julia J. Harris
    • , Edward C. Harding
    • , Wei Ba
    • , Giulia Miracca
    • , Dan Wang
    • , Long Li
    • , Juan Guo
    • , Ming Chen
    • , Yuqi Li
    • , Raquel Yustos
    • , Alexei L. Vyssotski
    • , Denis Burdakov
    • , Qianzi Yang
    • , Hailong Dong
    • , Nicholas P. Franks
    •  & William Wisden
  • Article |

    An overall downregulation of RNA editing was observed in postmortem brains from people with autism, which was consistent across brain regions and genetic disorder subtypes. These changes were regulated by the RNA-binding proteins FMRP and FXR1P.

    • Stephen S. Tran
    • , Hyun-Ik Jun
    • , Jae Hoon Bahn
    • , Adel Azghadi
    • , Gokul Ramaswami
    • , Eric L. Van Nostrand
    • , Thai B. Nguyen
    • , Yun-Hua E. Hsiao
    • , Changhoon Lee
    • , Gabriel A. Pratt
    • , Verónica Martínez-Cerdeño
    • , Randi J. Hagerman
    • , Gene W. Yeo
    • , Daniel H. Geschwind
    •  & Xinshu Xiao
  • Review Article |

    Knowledge of the role of glial–neuronal interactions in the physiology of food intake and energy metabolism is emerging. This review highlights the role of astrocytes, microglia, and tanycytes in central control of systemic metabolism.

    • Cristina García-Cáceres
    • , Eglantine Balland
    • , Vincent Prevot
    • , Serge Luquet
    • , Stephen C. Woods
    • , Marco Koch
    • , Tamas L. Horvath
    • , Chun-Xia Yi
    • , Julia A. Chowen
    • , Alexei Verkhratsky
    • , Alfonso Araque
    • , Ingo Bechmann
    •  & Matthias H. Tschöp
  • Review Article |

    A satisfactory understanding of how natural stimuli are encoded by neural circuits has remained elusive. Advances in machine learning provide new approaches to this problem by merging constraints imposed by stimulus statistics and behavioral goals.

    • Maxwell H. Turner
    • , Luis Gonzalo Sanchez Giraldo
    • , Odelia Schwartz
    •  & Fred Rieke
  • Article |

    How seizures emerge in epileptic brain remains an enigma. The authors show that the transition to seizure follows a ubiquitous dynamical principle inherent to many processes in nature characterized by repeated transitions between contrasting regimes.

    • Wei-Chih Chang
    • , Jan Kudlacek
    • , Jaroslav Hlinka
    • , Jan Chvojka
    • , Michal Hadrava
    • , Vojtech Kumpost
    • , Andrew D. Powell
    • , Radek Janca
    • , Matias I. Maturana
    • , Philippa J. Karoly
    • , Dean R. Freestone
    • , Mark J. Cook
    • , Milan Palus
    • , Jakub Otahal
    • , John G. R. Jefferys
    •  & Premysl Jiruska
  • News & Views |

    Landmark papers in 2005 and 2009 provided the first evidence of links between development, training, and white-matter plasticity in humans, contributing to a shift in our understanding of brain wiring that has inspired fundamental research into the role of genes, the environment, and the mechanisms underlying training-related plasticity.

    • Christopher J. Steele
    •  & Robert J. Zatorre
  • Article |

    Many behavioral tasks require fast, reliable switching of the shape and duration of cortical activity. Stroud et al. show that modulation of neural excitability in recurrent network models provides flexible spatiotemporal control of neural activity.

    • Jake P. Stroud
    • , Mason A. Porter
    • , Guillaume Hennequin
    •  & Tim P. Vogels
  • Brief Communication |

    Herman et al. exploit the reliable effects of perturbing superior colliculus (SC) neuronal activity on perceptual choice behavior to demonstrate a plausible mechanism by which SC may contribute to perceptual judgments during covert attention tasks.

    • James P. Herman
    • , Leor N. Katz
    •  & Richard J. Krauzlis
  • Article |

    Lombardo et al. find large-scale associations between the leukocyte transcriptome and neural responses to speech in toddlers, and these associations differ between toddlers with ASD who have good versus poor language outcomes.

    • Michael V. Lombardo
    • , Tiziano Pramparo
    • , Vahid Gazestani
    • , Varun Warrier
    • , Richard A. I. Bethlehem
    • , Cynthia Carter Barnes
    • , Linda Lopez
    • , Nathan E. Lewis
    • , Lisa Eyler
    • , Karen Pierce
    •  & Eric Courchesne
  • Article |

    Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

    • Raymond K. Walters
    • , Renato Polimanti
    • , Emma C. Johnson
    • , Jeanette N. McClintick
    • , Mark J. Adams
    • , Amy E. Adkins
    • , Fazil Aliev
    • , Silviu-Alin Bacanu
    • , Anthony Batzler
    • , Sarah Bertelsen
    • , Joanna M. Biernacka
    • , Tim B. Bigdeli
    • , Li-Shiun Chen
    • , Toni-Kim Clarke
    • , Yi-Ling Chou
    • , Franziska Degenhardt
    • , Anna R. Docherty
    • , Alexis C. Edwards
    • , Pierre Fontanillas
    • , Jerome C. Foo
    • , Louis Fox
    • , Josef Frank
    • , Ina Giegling
    • , Scott Gordon
    • , Laura M. Hack
    • , Annette M. Hartmann
    • , Sarah M. Hartz
    • , Stefanie Heilmann-Heimbach
    • , Stefan Herms
    • , Colin Hodgkinson
    • , Per Hoffmann
    • , Jouke Jan Hottenga
    • , Martin A. Kennedy
    • , Mervi Alanne-Kinnunen
    • , Bettina Konte
    • , Jari Lahti
    • , Marius Lahti-Pulkkinen
    • , Dongbing Lai
    • , Lannie Ligthart
    • , Anu Loukola
    • , Brion S. Maher
    • , Hamdi Mbarek
    • , Andrew M. McIntosh
    • , Matthew B. McQueen
    • , Jacquelyn L. Meyers
    • , Yuri Milaneschi
    • , Teemu Palviainen
    • , John F. Pearson
    • , Roseann E. Peterson
    • , Samuli Ripatti
    • , Euijung Ryu
    • , Nancy L. Saccone
    • , Jessica E. Salvatore
    • , Sandra Sanchez-Roige
    • , Melanie Schwandt
    • , Richard Sherva
    • , Fabian Streit
    • , Jana Strohmaier
    • , Nathaniel Thomas
    • , Jen-Chyong Wang
    • , Bradley T. Webb
    • , Robbee Wedow
    • , Leah Wetherill
    • , Amanda G. Wills
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Jennifer C. McCreight
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Jason D. Boardman
    • , Danfeng Chen
    • , Doo-Sup Choi
    • , William E. Copeland
    • , Robert C. Culverhouse
    • , Norbert Dahmen
    • , Louisa Degenhardt
    • , Benjamin W. Domingue
    • , Sarah L. Elson
    • , Mark A. Frye
    • , Wolfgang Gäbel
    • , Caroline Hayward
    • , Marcus Ising
    • , Margaret Keyes
    • , Falk Kiefer
    • , John Kramer
    • , Samuel Kuperman
    • , Susanne Lucae
    • , Michael T. Lynskey
    • , Wolfgang Maier
    • , Karl Mann
    • , Satu Männistö
    • , Bertram Müller-Myhsok
    • , Alison D. Murray
    • , John I. Nurnberger
    • , Aarno Palotie
    • , Ulrich Preuss
    • , Katri Räikkönen
    • , Maureen D Reynolds
    • , Monika Ridinger
    • , Norbert Scherbaum
    • , Marc A. Schuckit
    • , Michael Soyka
    • , Jens Treutlein
    • , Stephanie Witt
    • , Norbert Wodarz
    • , Peter Zill
    • , Daniel E. Adkins
    • , Joseph M. Boden
    • , Dorret I. Boomsma
    • , Laura J. Bierut
    • , Sandra A. Brown
    • , Kathleen K. Bucholz
    • , Sven Cichon
    • , E. Jane Costello
    • , Harriet de Wit
    • , Nancy Diazgranados
    • , Danielle M. Dick
    • , Johan G. Eriksson
    • , Lindsay A. Farrer
    • , Tatiana M. Foroud
    • , Nathan A. Gillespie
    • , Alison M. Goate
    • , David Goldman
    • , Richard A. Grucza
    • , Dana B. Hancock
    • , Kathleen Mullan Harris
    • , Andrew C. Heath
    • , Victor Hesselbrock
    • , John K. Hewitt
    • , Christian J. Hopfer
    • , John Horwood
    • , William Iacono
    • , Eric O. Johnson
    • , Jaakko A. Kaprio
    • , Victor M. Karpyak
    • , Kenneth S. Kendler
    • , Henry R. Kranzler
    • , Kenneth Krauter
    • , Paul Lichtenstein
    • , Penelope A. Lind
    • , Matt McGue
    • , James MacKillop
    • , Pamela A. F. Madden
    • , Hermine H. Maes
    • , Patrik Magnusson
    • , Nicholas G. Martin
    • , Sarah E. Medland
    • , Grant W. Montgomery
    • , Elliot C. Nelson
    • , Markus M. Nöthen
    • , Abraham A. Palmer
    • , Nancy L. Pedersen
    • , Brenda W. J. H. Penninx
    • , Bernice Porjesz
    • , John P. Rice
    • , Marcella Rietschel
    • , Brien P. Riley
    • , Richard Rose
    • , Dan Rujescu
    • , Pei-Hong Shen
    • , Judy Silberg
    • , Michael C. Stallings
    • , Ralph E. Tarter
    • , Michael M. Vanyukov
    • , Scott Vrieze
    • , Tamara L. Wall
    • , John B. Whitfield
    • , Hongyu Zhao
    • , Benjamin M. Neale
    • , Joel Gelernter
    • , Howard J. Edenberg
    •  & Arpana Agrawal
  • Article |

    Michaelson et al. report that human SYNGAP1 variation alters touch-related sensory processing. Studies in Syngap1 mice revealed circuit-specific impairments in the somatosensory cortex that underlie reduced cortical activation in response to touch.

    • Sheldon D. Michaelson
    • , Emin D. Ozkan
    • , Massimiliano Aceti
    • , Sabyasachi Maity
    • , Nerea Llamosas
    • , Monica Weldon
    • , Elisa Mizrachi
    • , Thomas Vaissiere
    • , Michael A. Gaffield
    • , Jason M. Christie
    • , J. Lloyd Holder Jr.
    • , Courtney A. Miller
    •  & Gavin Rumbaugh
  • Article |

    Mutations in SETD5 are a frequent cause of intellectual disability and autism. Deliu et al. describe that deletion of one mouse Setd5 allele leads to a disruption of the transcriptional program associated with development and learning.

    • Elena Deliu
    • , Niccolò Arecco
    • , Jasmin Morandell
    • , Christoph P. Dotter
    • , Ximena Contreras
    • , Charles Girardot
    • , Eva-Lotta Käsper
    • , Alena Kozlova
    • , Kasumi Kishi
    • , Ilaria Chiaradia
    • , Kyung-Min Noh
    •  & Gaia Novarino
  • Resource |

    Highly dynamic miRNA networks mediate developmental transitions during human brain development. Single-cell networks were detected by combining single-cell miRNA and mRNA profiling with HITS-CLIP analyzed with bipartite and co-expression networks.

    • Tomasz J. Nowakowski
    • , Neha Rani
    • , Mahdi Golkaram
    • , Hongjun R. Zhou
    • , Beatriz Alvarado
    • , Kylie Huch
    • , Jay A. West
    • , Anne Leyrat
    • , Alex A. Pollen
    • , Arnold R. Kriegstein
    • , Linda R. Petzold
    •  & Kenneth S. Kosik
  • Article |

    The authors develop a single-cell RNA-seq approach to distinguish cells expressing wild-type or mutant genes in mosaic individuals with X-linked disorders and find that cell-type-specific DNA methylation predicts gene misregulation in Rett syndrome.

    • William Renthal
    • , Lisa D. Boxer
    • , Sinisa Hrvatin
    • , Emmy Li
    • , Andrew Silberfeld
    • , M. Aurel Nagy
    • , Eric C. Griffith
    • , Thomas Vierbuchen
    •  & Michael E. Greenberg
  • News & Views |

    In an unfamiliar situation, animals display variable choice behavior. Based on computational modeling and empirical data, a new study suggests that the variability in decision-making across individuals is driven by differences in internal neural dynamics in the medial frontal cortex.

    • Huriye Atilgan
    •  & Alex C. Kwan
  • Article |

    Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.

    • Ying Cheng
    • , Zhi-Meng Wang
    • , Weiqi Tan
    • , Xiaona Wang
    • , Yujing Li
    • , Bing Bai
    • , Yuxin Li
    • , Shuang-Feng Zhang
    • , Hai-Liang Yan
    • , Zuo-Lun Chen
    • , Chang-Mei Liu
    • , Ting-Wei Mi
    • , Shuting Xia
    • , Zikai Zhou
    • , An Liu
    • , Gang-Bin Tang
    • , Cong Liu
    • , Zhi-Jie Dai
    • , Ying-Ying Wang
    • , Hong Wang
    • , Xusheng Wang
    • , Yunhee Kang
    • , Li Lin
    • , Zhenping Chen
    • , Nina Xie
    • , Qinmiao Sun
    • , Wei Xie
    • , Junmin Peng
    • , Dahua Chen
    • , Zhao-Qian Teng
    •  & Peng Jin