Browse Articles

  • Article |

    Using an inducible mouse model of sporadic ALS, Spiller et al. show that spinal microgliosis is not a major feature of TDP-43-triggered disease. Instead, microglia mediate TDP-43 clearance and motor recovery, suggesting a neuroprotective role in ALS.

    • Krista J. Spiller
    • , Clark R. Restrepo
    • , Tahiyana Khan
    • , Myrna A. Dominique
    • , Terry C. Fang
    • , Rebecca G. Canter
    • , Christopher J. Roberts
    • , Kelly R. Miller
    • , Richard M. Ransohoff
    • , John Q. Trojanowski
    •  & Virginia M.-Y. Lee
  • Article |

    New data reveal that the amygdala—a brain area specialized for emotion—also signals the hierarchical rank of peers in a social group. These neural signals likely mediate appropriate social and emotional behavior in many social settings.

    • Jérôme Munuera
    • , Mattia Rigotti
    •  & C. Daniel Salzman
  • Article |

    Bloss et al. show single axons form clustered inputs onto the dendrites of hippocampal pyramidal cells in a projection-specific manner. The spatial and temporal features inherent in these connections efficiently drive dendritic depolarization.

    • Erik B. Bloss
    • , Mark S. Cembrowski
    • , Bill Karsh
    • , Jennifer Colonell
    • , Richard D. Fetter
    •  & Nelson Spruston
  • Technical Report |

    This study describes single-nucleus ATAC-seq, a method to profile open chromatin in individual nuclei from frozen tissues. It is used to examine gene regulation in 15,000 nuclei comprising 20 distinct cell types in the developing mouse forebrain.

    • Sebastian Preissl
    • , Rongxin Fang
    • , Hui Huang
    • , Yuan Zhao
    • , Ramya Raviram
    • , David U. Gorkin
    • , Yanxiao Zhang
    • , Brandon C. Sos
    • , Veena Afzal
    • , Diane E. Dickel
    • , Samantha Kuan
    • , Axel Visel
    • , Len A. Pennacchio
    • , Kun Zhang
    •  & Bing Ren
  • Article |

    Addiction-related behaviors are believed to result from drug-evoked synaptic changes, but their causality is unclear. The authors show that bidirectional optogenetic modifications of synaptic strength distinctly alter alcohol-seeking behavior.

    • Tengfei Ma
    • , Yifeng Cheng
    • , Emily Roltsch Hellard
    • , Xuehua Wang
    • , Jiayi Lu
    • , Xinsheng Gao
    • , Cathy C. Y. Huang
    • , Xiao-Yan Wei
    • , Jun-Yuan Ji
    •  & Jun Wang
  • Article |

    Direct neuronal conversion of skin fibroblasts from individuals with Huntington’s disease (HD) generates a population of medium spiny neurons that recapitulate hallmarks of HD, including aggregation of mutant huntingtin protein, DNA damage and spontaneous cell death.

    • Matheus B. Victor
    • , Michelle Richner
    • , Hannah E. Olsen
    • , Seong Won Lee
    • , Alejandro M. Monteys
    • , Chunyu Ma
    • , Christine J. Huh
    • , Bo Zhang
    • , Beverly L. Davidson
    • , X. William Yang
    •  & Andrew S. Yoo
  • Perspective |

    Research in adolescent neurocognitive development has focussed largely on averages, but there is substantial individual variation in development. This Perspective proposes that the field should move towards studying individual differences.

    • Lucy Foulkes
    •  & Sarah-Jayne Blakemore
  • Article |

    Neurons in the ventral hippocampus project to parvalbumin inhibitory interneurons in the infralimbic (IL) region of medial prefrontal cortex. Activation of this projection produces feed-forward inhibition of IL and causes relapse of extinguished fear.

    • Roger Marek
    • , Jingji Jin
    • , Travis D. Goode
    • , Thomas F. Giustino
    • , Qian Wang
    • , Gillian M. Acca
    • , Roopashri Holehonnur
    • , Jonathan E. Ploski
    • , Paul J. Fitzgerald
    • , Timothy Lynagh
    • , Joseph W. Lynch
    • , Stephen Maren
    •  & Pankaj Sah
  • Article |

    Using longitudinal multimodal imaging data collected in healthy older individuals, Jacobs et al. provide in vivo evidence in humans that amyloid deposition facilitates tau spread along connected pathways and memory decline.

    • Heidi I. L. Jacobs
    • , Trey Hedden
    • , Aaron P. Schultz
    • , Jorge Sepulcre
    • , Rodrigo D. Perea
    • , Rebecca E. Amariglio
    • , Kathryn V. Papp
    • , Dorene M. Rentz
    • , Reisa A. Sperling
    •  & Keith A. Johnson
  • Brief Communication |

    The authors show that Mrgprs, vagal sensory neuron-expressing GPCRs, mediate bronchoconstriction and hyperresponsiveness, both of which are hallmark features of asthma. The results reveal novel potential neural mechanisms underlying asthma.

    • Liang Han
    • , Nathachit Limjunyawong
    • , Fei Ru
    • , Zhe Li
    • , Olivia J. Hall
    • , Haley Steele
    • , Yuyan Zhu
    • , Julie Wilson
    • , Wayne Mitzner
    • , Marian Kollarik
    • , Bradley J. Undem
    • , Brendan J. Canning
    •  & Xinzhong Dong
  • Technical Report |

    CRISPR interference-based gene silencing was adopted to achieve highly efficient multiple and conditional gene knockdown in the mouse brain with negligible off-target effects, providing a rapid gene interrogation tool in the mammalian brain.

    • Yi Zheng
    • , Wei Shen
    • , Jian Zhang
    • , Bo Yang
    • , Yao-Nan Liu
    • , Huihui Qi
    • , Xia Yu
    • , Si-Yao Lu
    • , Yun Chen
    • , Yu-Zhou Xu
    • , Yun Li
    • , Fred H. Gage
    • , Shuangli Mi
    •  & Jun Yao
  • Article |

    This study finds the key neurons that respond to 3D objects in the medial preoptic area (MPA). Their photostimulation induces hunting-like behaviors towards toys and prey, showing how the brain organizes behaviors to acquire useful resources.

    • Sae-Geun Park
    • , Yong-Cheol Jeong
    • , Dae-Gun Kim
    • , Min-Hyung Lee
    • , Anna Shin
    • , Geunhong Park
    • , Jia Ryoo
    • , Jiso Hong
    • , Seohui Bae
    • , Cheol-Hu Kim
    • , Phill-Seung Lee
    •  & Daesoo Kim
  • Article |

    Determining how to respond to others in distress is central to social cognition. In a new model, male rats approach stressed juveniles but avoid stressed adults; these behaviors require excitatory action of oxytocin within the insular cortex.

    • Morgan M. Rogers-Carter
    • , Juan A. Varela
    • , Katherine B. Gribbons
    • , Anne F. Pierce
    • , Morgan T. McGoey
    • , Maureen Ritchey
    •  & John P. Christianson
  • News & Views |

    Excessive dietary salt can impair cerebral blood flow regulation, resulting in cognitive dysfunction in mice. A ‘gut–brain’ pathway is implicated that links expansion of TH17 lymphocytes in small intestine to elevated bloodstream interleukin-17, which impairs brain perfusion by decreasing nitric oxide production in brain vascular endothelium.

    • Mohammed A. Shaik
    •  & Elizabeth M. C. Hillman
  • News & Views |

    Neuroimaging studies of human entorhinal cortex activity revealed 60-degree spatial periodicity, a hallmark of grid cells, as gaze movements were made throughout the visual field. This activity may serve as a framework for organizing visuospatial memory.

    • Nathaniel J. Killian
    •  & Elizabeth A. Buffalo
  • Obituary |

    Pamela Sklar, Chair of the Department of Genetics and Genomic Sciences and endowed Professor of Psychiatric Genetics at the Icahn School of Medicine at Mount Sinai in New York City, died 20 November 2017 after a long illness.

    • Patrick F. Sullivan
    • , Michael C. O’Donovan
    •  & Nick Craddock
  • Obituary |

    On 20 October 2017, John Lisman passed away at the age of 73. Neuroscience lost a great luminary.

    • Adam Kepecs
  • News & Views |

    An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the same differentiation path as embryonic neurogenesis, but the cell of origin differs. This work provides an invaluable resource with important implications for neuronal regeneration.

    • Ben W. Dulken
    •  & Anne Brunet
  • News & Views |

    Compromised compartmentalization of nucleus and cytoplasm has emerged as a central feature of aging and neurodegenerative diseases. Nucleocytoplasmic transport is disrupted, with widespread mislocalization of nuclear pore proteins, in TDP-43 proteinopathies such as, amyotrophic lateral sclerosis and frontotemporal dementia.

    • Nan Li
    •  & Clotilde Lagier-Tourenne
  • Article |

    The authors show that inhibitory interneurons in cortical layer 1 integrate topographically organized thalamic and neuromodulatory inputs to sculpt sound frequency maps in primary auditory cortex during a developmental critical period.

    • Anne E. Takesian
    • , Luke J. Bogart
    • , Jeff W. Lichtman
    •  & Takao K. Hensch
  • Article |

    How entorhinal grid cells control hippocampal coding and behavior remains elusive. The authors report that increasing the spatial scale of grid cells expands the scale and reduces the stability of place fields, impairing spatial memory in mice.

    • Caitlin S. Mallory
    • , Kiah Hardcastle
    • , Jason S. Bant
    •  & Lisa M. Giocomo
  • Technical Report |

    dCas9-mediated activation has been verified and widely used in vitro. Here the authors generated a potent in vivo activation platform and applied it to control the transcription of multiple genetic elements in the mammalian brain.

    • Haibo Zhou
    • , Junlai Liu
    • , Changyang Zhou
    • , Ni Gao
    • , Zhiping Rao
    • , He Li
    • , Xinde Hu
    • , Changlin Li
    • , Xuan Yao
    • , Xiaowen Shen
    • , Yidi Sun
    • , Yu Wei
    • , Fei Liu
    • , Wenqin Ying
    • , Junming Zhang
    • , Cheng Tang
    • , Xu Zhang
    • , Huatai Xu
    • , Linyu Shi
    • , Leping Cheng
    • , Pengyu Huang
    •  & Hui Yang