Browse Articles

  • Article |

    Beas et al. show that stress exposure drives disinhibition of PVT projection neurons. This process involves an LC-mediated rise in extracellular DA in the midline thalamus, requires D2 receptors on PVT neurons, and increases stress sensitivity.

    • B. Sofia Beas
    • , Brandon J. Wright
    • , Miguel Skirzewski
    • , Yan Leng
    • , Jung Ho Hyun
    • , Omar Koita
    • , Nicholas Ringelberg
    • , Hyung-Bae Kwon
    • , Andres Buonanno
    •  & Mario A. Penzo
  • Article |

    Circuit assembly relies on several developmental processes that are often considered independently. Lim and colleagues now reveal that cell migration and axon targeting may be mechanistically linked for Martinotti cells during cortical development.

    • Lynette Lim
    • , Janelle M. P. Pakan
    • , Martijn M. Selten
    • , André Marques-Smith
    • , Alfredo Llorca
    • , Sung Eun Bae
    • , Nathalie L. Rochefort
    •  & Oscar Marín
  • Article |

    The authors identify a CA3 new pyramidal cell type with unique morphofunctional characteristics and distinct synaptic inputs and describe how these cells contribute to sharp-wave synchronization events, which are vital to hippocampal memory function.

    • David L. Hunt
    • , Daniele Linaro
    • , Bailu Si
    • , Sandro Romani
    •  & Nelson Spruston
  • Article |

    Ascl1 and Sox2 convert human brain pericytes into the two major neuronal subclasses of GABA- and glutamatergic neurons. Unexpectedly, despite the lack of cell division, this conversion requires passage through a neural stem cell-like state.

    • Marisa Karow
    • , J. Gray Camp
    • , Sven Falk
    • , Tobias Gerber
    • , Abhijeet Pataskar
    • , Malgorzata Gac-Santel
    • , Jorge Kageyama
    • , Agnieska Brazovskaja
    • , Angela Garding
    • , Wenqiang Fan
    • , Therese Riedemann
    • , Antonella Casamassa
    • , Andrej Smiyakin
    • , Christian Schichor
    • , Magdalena Götz
    • , Vijay K. Tiwari
    • , Barbara Treutlein
    •  & Benedikt Berninger
  • Article |

    This study shows that tonic firing of centromedial thalamic neurons triggers rapid arousal, whereas burst firing triggers brain-wide propagating cortical slow waves and promotes sleep recovery, indicative of a midline thalamus sleep–wake hub.

    • Thomas C. Gent
    • , Mojtaba Bandarabadi
    • , Carolina Gutierrez Herrera
    •  & Antoine R. Adamantidis
  • Publisher Correction |

    • Thomas Gstrein
    • , Andrew Edwards
    • , Anna Přistoupilová
    • , Ines Leca
    • , Martin Breuss
    • , Sandra Pilat-Carotta
    • , Andi H. Hansen
    • , Ratna Tripathy
    • , Anna K. Traunbauer
    • , Tobias Hochstoeger
    • , Gavril Rosoklija
    • , Marco Repic
    • , Lukas Landler
    • , Viktor Stránecký
    • , Gerhard Dürnberger
    • , Thomas M. Keane
    • , Johannes Zuber
    • , David J. Adams
    • , Jonathan Flint
    • , Tomas Honzik
    • , Marta Gut
    • , Sergi Beltran
    • , Karl Mechtler
    • , Elliott Sherr
    • , Stanislav Kmoch
    • , Ivo Gut
    •  & David A. Keays
  • Publisher Correction |

    • Matthew A. White
    • , Eosu Kim
    • , Amanda Duffy
    • , Robert Adalbert
    • , Benjamin U. Phillips
    • , Owen M. Peters
    • , Jodie Stephenson
    • , Sujeong Yang
    • , Francesca Massenzio
    • , Ziqiang Lin
    • , Simon Andrews
    • , Anne Segonds-Pichon
    • , Jake Metterville
    • , Lisa M. Saksida
    • , Richard Mead
    • , Richard R. Ribchester
    • , Youssef Barhomi
    • , Thomas Serre
    • , Michael P. Coleman
    • , Justin R. Fallon
    • , Timothy J. Bussey
    • , Robert H. Brown Jr
    •  & Jemeen Sreedharan
  • Brief Communication |

    Whether MeCP2 competes with linker histone H1 for DNA binding has never been tested in vivo. Ito-Ishida et al. performed ChIP-seq on MeCP2 and Flag-H1.0 in mouse forebrain neurons and reveal that their genomic distributions are largely independent.

    • Aya Ito-Ishida
    • , Hari Krishna Yamalanchili
    • , Yingyao Shao
    • , Steven A. Baker
    • , Laura D. Heckman
    • , Laura A. Lavery
    • , Ji-yoen Kim
    • , Laura M. Lombardi
    • , Yaling Sun
    • , Zhandong Liu
    •  & Huda Y. Zoghbi
  • News & Views |

    New techniques enable simultaneous optogenetic stimulation and calcium imaging from ensembles of tens of neurons in vivo. Improved opsins are localized to the cell body, minimizing spurious activation of the optically unresolvable neuropil. Two-photon light pulses are sculpted in space, time, and wavelength to efficiently target the desired cells.

    • Adam E. Cohen
    •  & Samouil L. Farhi
  • Article |

    The authors constructed and validated a molecular network of the aging human cortex from RNA sequencing data from 478 individuals and identified genes that affect cognitive decline or neuropathology in Alzheimer’s disease.

    • Sara Mostafavi
    • , Chris Gaiteri
    • , Sarah E. Sullivan
    • , Charles C. White
    • , Shinya Tasaki
    • , Jishu Xu
    • , Mariko Taga
    • , Hans-Ulrich Klein
    • , Ellis Patrick
    • , Vitalina Komashko
    • , Cristin McCabe
    • , Robert Smith
    • , Elizabeth M. Bradshaw
    • , David E. Root
    • , Aviv Regev
    • , Lei Yu
    • , Lori B. Chibnik
    • , Julie A. Schneider
    • , Tracy L. Young-Pearse
    • , David A. Bennett
    •  & Philip L. De Jager
  • Article |

    Social rank determines access to feeding and breeding opportunities. Stagkourakis et al. identify an intrinsically amplifying hypothalamic circuit that can generate intermale attack and aggression reward to influence hierarchical status among males.

    • Stefanos Stagkourakis
    • , Giada Spigolon
    • , Paul Williams
    • , Jil Protzmann
    • , Gilberto Fisone
    •  & Christian Broberger
  • Brief Communication |

    mTORC1 was posited as required for hippocampal mGluR-LTD at CA1 synapses based on its pharmacological inhibition with rapamycin. Using molecular genetics, the authors show that mTORC2 but not mTORC1 is required for mGluR-LTD and associated behaviors.

    • Ping Jun Zhu
    • , Chien-Ju Chen
    • , Jacqunae Mays
    • , Loredana Stoica
    •  & Mauro Costa-Mattioli
  • Article |

    Khan et al. simultaneously measured activity from excitatory cells and three classes of inhibitory interneurons in visual cortex and show that learning differentially shapes the stimulus selectivity and interactions of multiple cell classes.

    • Adil G. Khan
    • , Jasper Poort
    • , Angus Chadwick
    • , Antonin Blot
    • , Maneesh Sahani
    • , Thomas D. Mrsic-Flogel
    •  & Sonja B. Hofer
  • News & Views |

    In 2004, Weaver et al. published evidence in Nature Neuroscience for the lasting epigenetic impact of maternal care within the hippocampus of rat offspring. This conceptual and methodological leap contributed to the evolution of environmental and behavioral epigenetics and continues to inspire challenging questions about genes, environments, and their legacy.

    • Frances A. Champagne
  • Brief Communication |

    The neuropeptide CRH is believed to induce aversive, stress-like behavioral responses. Here the authors describe a distinct population of CRH neurons in the extended amygdala that act to suppress anxiety by positively modulating dopamine release.

    • Nina Dedic
    • , Claudia Kühne
    • , Mira Jakovcevski
    • , Jakob Hartmann
    • , Andreas J. Genewsky
    • , Karina S. Gomes
    • , Elmira Anderzhanova
    • , Max L. Pöhlmann
    • , Simon Chang
    • , Adam Kolarz
    • , Annette M. Vogl
    • , Julien Dine
    • , Michael W. Metzger
    • , Bianca Schmid
    • , Rafael C. Almada
    • , Kerry J. Ressler
    • , Carsten T. Wotjak
    • , Valery Grinevich
    • , Alon Chen
    • , Mathias V. Schmidt
    • , Wolfgang Wurst
    • , Damian Refojo
    •  & Jan M. Deussing
  • Perspective |

    In this Perspective, Josh Berke discusses recent developments in the study of dopamine function. He proposes a model that explains how dopamine can serve as both a learning signal and as a critical modulator of motivated decision-making.

    • Joshua D. Berke
  • Article |

    The authors revise the classical view that homeostasis of neuronal activity is achieved by negative firing rate feedback: during sensory deprivation, homeostasis occurs via the sliding threshold, which acts via firing patterns rather than rates.

    • Michelle C. D. Bridi
    • , Roberto de Pasquale
    • , Crystal L. Lantz
    • , Yu Gu
    • , Andrew Borrell
    • , Se-Young Choi
    • , Kaiwen He
    • , Trinh Tran
    • , Su Z. Hong
    • , Andrew Dykman
    • , Hey-Kyoung Lee
    • , Elizabeth M. Quinlan
    •  & Alfredo Kirkwood
  • News & Views |

    Synaptic connections adapt homeostatically to changes in experience to maintain optimal circuit function. A study demonstrates that different forms of synaptic homeostasis respond to distinct aspects of circuit activity, suggesting that neurons can gauge and adapt to the both the quality and quantity of circuit activity.

    • Kimberly M. Huber