Browse Articles

  • Article |

    The authors measure evoked activity and perform dense reconstruction of the olfactory bulb wiring diagram in a zebrafish larva, uncovering a mechanism for whitening, a computation that decorrelates activity for pattern classification by memory networks.

    • Adrian A. Wanner
    •  & Rainer W. Friedrich
  • Brief Communication |

    Maes et al. use second-order conditioning, blocking and optogenetic inhibition to show that cue-evoked dopamine transients function as temporal-difference prediction errors rather than reward predictions.

    • Etienne J. P Maes
    • , Melissa J. Sharpe
    • , Alexandra A. Usypchuk
    • , Megan Lozzi
    • , Chun Yun Chang
    • , Matthew P. H. Gardner
    • , Geoffrey Schoenbaum
    •  & Mihaela D. Iordanova
  • Technical Report |

    A chemogenetic approach was developed for cell-type-specific drug-inducible protein synthesis inhibition in mice. It was used to show that consolidation of long-term aversive memories requires rapid neuronal protein synthesis in the amygdala.

    • Prerana Shrestha
    • , Pinar Ayata
    • , Pedro Herrero-Vidal
    • , Francesco Longo
    • , Alexandra Gastone
    • , Joseph E. LeDoux
    • , Nathaniel Heintz
    •  & Eric Klann
  • Article |

    Microglia in the aging hippocampus accumulate lipid droplets, and are functionally impaired and inflamed. Lipid droplet formation in microglia is regulated by genes linked to neurodegeneration such as progranulin.

    • Julia Marschallinger
    • , Tal Iram
    • , Macy Zardeneta
    • , Song E. Lee
    • , Benoit Lehallier
    • , Michael S. Haney
    • , John V. Pluvinage
    • , Vidhu Mathur
    • , Oliver Hahn
    • , David W. Morgens
    • , Justin Kim
    • , Julia Tevini
    • , Thomas K. Felder
    • , Heimo Wolinski
    • , Carolyn R. Bertozzi
    • , Michael C. Bassik
    • , Ludwig Aigner
    •  & Tony Wyss-Coray
  • Article |

    High concentrations of sodium are normally unpalatable. This study shows a neural population in the brainstem that suppresses appetite for sodium. Reducing the activity of these neurons can drive ingestion of high concentrations of sodium.

    • Seahyung Park
    • , Kevin W. Williams
    • , Chen Liu
    •  & Jong-Woo Sohn
  • News & Views |

    Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

    • Vivian Budnik
    •  & Travis Thomson
  • Article |

    In mice that have undergone Pavlovian reward conditioning, dopaminergic neurons regulate conditioned movements in a temporally restricted manner, consistent with a primary contribution to associative learning rather than online movement generation.

    • Kwang Lee
    • , Leslie D. Claar
    • , Ayaka Hachisuka
    • , Konstantin I. Bakhurin
    • , Jacquelyn Nguyen
    • , Jeremy M. Trott
    • , Jay L. Gill
    •  & Sotiris C. Masmanidis
  • Article |

    Munn et al. provide evidence that medial entorhinal speed signals scale to reflect the geometry of the environment, whereas entorhinal head direction signals reflect learned information about the geometric symmetry of the environment.

    • Robert G. K. Munn
    • , Caitlin S. Mallory
    • , Kiah Hardcastle
    • , Dane M. Chetkovich
    •  & Lisa M. Giocomo
  • Article |

    Rees et al. show that de novo mutations in the gene SLC6A1, and more broadly across evolutionary constrained genes and genes implicated in neurodevelopmental disorders, increase the risk for developing schizophrenia.

    • Elliott Rees
    • , Jun Han
    • , Joanne Morgan
    • , Noa Carrera
    • , Valentina Escott-Price
    • , Andrew J. Pocklington
    • , Madeleine Duffield
    • , Lynsey S. Hall
    • , Sophie E. Legge
    • , Antonio F. Pardiñas
    • , Alexander L. Richards
    • , Julian Roth
    • , Tatyana Lezheiko
    • , Nikolay Kondratyev
    • , Vasilii Kaleda
    • , Vera Golimbet
    • , Mara Parellada
    • , Javier González-Peñas
    • , Celso Arango
    • , Behrooz Z. Alizadeh
    • , Therese van Amelsvoort
    • , Richard Bruggeman
    • , Wiepke Cahn
    • , Lieuwe de Haan
    • , Jurjen J. Luykx
    • , Bart P. F. Rutten
    • , Jim van Os
    • , Ruud van Winkel
    • , Micha Gawlik
    • , George Kirov
    • , James T. R. Walters
    • , Peter Holmans
    • , Michael C. O’Donovan
    •  & Michael J. Owen
  • Article |

    Gao et al. provide evidence that two major classes of neurons exist in the paraventricular thalamus. One of these, termed type II PVT neurons, belongs to a previously ignored cell population that relays arousal information to the infralimbic cortex.

    • Claire Gao
    • , Yan Leng
    • , Jun Ma
    • , Victoria Rooke
    • , Shakira Rodriguez-Gonzalez
    • , Charu Ramakrishnan
    • , Karl Deisseroth
    •  & Mario A. Penzo
  • News & Views |

    Rewards direct behavioral adaptation through midbrain dopamine signaling, though the timing of those effects is often ambiguous. Lee and colleagues find that different subpopulations of dopamine neurons obey similar constraints, indirectly regulating reward-related behavior through learning mechanisms restricted to a brief time window following reward.

    • Luke T. Coddington
  • Resource |

    This resource comprises ultra-high-resolution MRI datasets and corresponding gray and white matter atlases of the marmoset brain to facilitate brain connectivity studies and the development of tractography algorithms in the primate brain.

    • Cirong Liu
    • , Frank Q. Ye
    • , John D. Newman
    • , Diego Szczupak
    • , Xiaoguang Tian
    • , Cecil Chern-Chyi Yen
    • , Piotr Majka
    • , Daniel Glen
    • , Marcello G. P. Rosa
    • , David A. Leopold
    •  & Afonso C. Silva
  • Article |

    In this study of protein-coding de novo mutations in schizophrenia, researchers found only a small contribution toward overall risk, coming predominantly from genes under negative selection and highly expressed in the brain.

    • Daniel P. Howrigan
    • , Samuel A. Rose
    • , Kaitlin E. Samocha
    • , Menachem Fromer
    • , Felecia Cerrato
    • , Wei J. Chen
    • , Claire Churchhouse
    • , Kimberly Chambert
    • , Sharon D. Chandler
    • , Mark J. Daly
    • , Ashley Dumont
    • , Giulio Genovese
    • , Hai-Gwo Hwu
    • , Nan Laird
    • , Jack A. Kosmicki
    • , Jennifer L. Moran
    • , Cheryl Roe
    • , Tarjinder Singh
    • , Shi-Heng Wang
    • , Stephen V. Faraone
    • , Stephen J. Glatt
    • , Steven A. McCarroll
    • , Ming Tsuang
    •  & Benjamin M. Neale
  • Article |

    Gallego, Perich et al. report that latent dynamics in the neural manifold across three cortical areas are stable throughout years of consistent behavior. The authors posit that these dynamics are fundamental building blocks of learned behavior.

    • Juan A. Gallego
    • , Matthew G. Perich
    • , Raeed H. Chowdhury
    • , Sara A. Solla
    •  & Lee E. Miller
  • Article |

    Shuman et al. report that epileptic mice harbor desynchronized hippocampal interneuron activity and unstable spatial representations, revealing that precise intrahippocampal synchronization is critical for spatial coding.

    • Tristan Shuman
    • , Daniel Aharoni
    • , Denise J. Cai
    • , Christopher R. Lee
    • , Spyridon Chavlis
    • , Lucia Page-Harley
    • , Lauren M. Vetere
    • , Yu Feng
    • , Chen Yi Yang
    • , Irene Mollinedo-Gajate
    • , Lingxuan Chen
    • , Zachary T. Pennington
    • , Jiannis Taxidis
    • , Sergio E. Flores
    • , Kevin Cheng
    • , Milad Javaherian
    • , Christina C. Kaba
    • , Naina Rao
    • , Mimi La-Vu
    • , Ioanna Pandi
    • , Matthew Shtrahman
    • , Konstantin I. Bakhurin
    • , Sotiris C. Masmanidis
    • , Baljit S. Khakh
    • , Panayiota Poirazi
    • , Alcino J. Silva
    •  & Peyman Golshani
  • Article |

    Yoo and colleagues find that while pursuing virtual prey, monkeys predict the prey’s upcoming movements, and neurons in the dorsal anterior cingulate cortex tracked prey position, velocity and acceleration to facilitate these predictions.

    • Seng Bum Michael Yoo
    • , Jiaxin Cindy Tu
    • , Steven T. Piantadosi
    •  & Benjamin Yost Hayden
  • Brief Communication |

    Arc, a master regulator of synaptic plasticity, can mediate intercellular RNA transfer. Arc evolved from retrotransposon genes. Erlendsson et al. present structures of retroviral-like Arc capsids as a basis to understand their function.

    • Simon Erlendsson
    • , Dustin R. Morado
    • , Harrison B. Cullen
    • , Cedric Feschotte
    • , Jason D. Shepherd
    •  & John A. G. Briggs
  • Brief Communication |

    Kodama et al. show that microglia from male and female adult mice have distinct microRNA profiles and that loss of microglial microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology.

    • Lay Kodama
    • , Elmer Guzman
    • , Jon I. Etchegaray
    • , Yaqiao Li
    • , Faten A. Sayed
    • , Lu Zhou
    • , Yungui Zhou
    • , Lihong Zhan
    • , David Le
    • , Joe C. Udeochu
    • , Claire D. Clelland
    • , Zuolin Cheng
    • , Guoqiang Yu
    • , Qingyun Li
    • , Kenneth S. Kosik
    •  & Li Gan
  • Article |

    Although Bayesian models provide good accounts of perceptual decisions, it is unclear how their components are represented in the brain. This paper addresses this question by showing that uncertainty decoded from visual cortex helps predict behavior.

    • Edgar Y. Walker
    • , R. James Cotton
    • , Wei Ji Ma
    •  & Andreas S. Tolias
  • Article |

    Gulli et al. record neurons in the monkey hippocampus during multiple tasks in a virtual reality environment and find that spatial coding is task-dependent. Their analyses reveal rich nonspatial sensory and mnemonic coding of task-related features.

    • Roberto A. Gulli
    • , Lyndon R. Duong
    • , Benjamin W. Corrigan
    • , Guillaume Doucet
    • , Sylvain Williams
    • , Stefano Fusi
    •  & Julio C. Martinez-Trujillo
  • Publisher Correction |

    • Sali M. K. Farhan
    • , Daniel P. Howrigan
    • , Liam E. Abbott
    • , Joseph R. Klim
    • , Simon D. Topp
    • , Andrea E. Byrnes
    • , Claire Churchhouse
    • , Hemali Phatnani
    • , Bradley N. Smith
    • , Evadnie Rampersaud
    • , Gang Wu
    • , Joanne Wuu
    • , Aleksey Shatunov
    • , Alfredo Iacoangeli
    • , Ahmad Al Khleifat
    • , Daniel A. Mordes
    • , Sulagna Ghosh
    • , Kevin Eggan
    • , Rosa Rademakers
    • , Jacob L. McCauley
    • , Rebecca Schüle
    • , Stephan Züchner
    • , Michael Benatar
    • , J. Paul Taylor
    • , Michael Nalls
    • , Marc Gotkine
    • , Pamela J. Shaw
    • , Karen E. Morrison
    • , Ammar Al-Chalabi
    • , Bryan Traynor
    • , Christopher E. Shaw
    • , David B. Goldstein
    • , Matthew B. Harms
    • , Mark J. Daly
    •  & Benjamin M. Neale
  • Publisher Correction |

    • Tobias Kaufmann
    • , Dennis van der Meer
    • , Nhat Trung Doan
    • , Emanuel Schwarz
    • , Martina J. Lund
    • , Ingrid Agartz
    • , Dag Alnæs
    • , Deanna M. Barch
    • , Ramona Baur-Streubel
    • , Alessandro Bertolino
    • , Francesco Bettella
    • , Mona K. Beyer
    • , Erlend Bøen
    • , Stefan Borgwardt
    • , Christine L. Brandt
    • , Jan Buitelaar
    • , Elisabeth G. Celius
    • , Simon Cervenka
    • , Annette Conzelmann
    • , Aldo Córdova-Palomera
    • , Anders M. Dale
    • , Dominique J. F. de Quervain
    • , Pasquale Di Carlo
    • , Srdjan Djurovic
    • , Erlend S. Dørum
    • , Sarah Eisenacher
    • , Torbjørn Elvsåshagen
    • , Thomas Espeseth
    • , Helena Fatouros-Bergman
    • , Lena Flyckt
    • , Barbara Franke
    • , Oleksandr Frei
    • , Beathe Haatveit
    • , Asta K. Håberg
    • , Hanne F. Harbo
    • , Catharina A. Hartman
    • , Dirk Heslenfeld
    • , Pieter J. Hoekstra
    • , Einar A. Høgestøl
    • , Terry L. Jernigan
    • , Rune Jonassen
    • , Erik G. Jönsson
    • , Lars Farde
    • , Lena Flyckt
    • , Göran Engberg
    • , Sophie Erhardt
    • , Helena Fatouros-Bergman
    • , Simon Cervenka
    • , Lilly Schwieler
    • , Fredrik Piehl
    • , Ingrid Agartz
    • , Karin Collste
    • , Pauliina Victorsson
    • , Anna Malmqvist
    • , Mikael Hedberg
    • , Funda Orhan
    • , Peter Kirsch
    • , Iwona Kłoszewska
    • , Knut K. Kolskår
    • , Nils Inge Landrø
    • , Stephanie Le Hellard
    • , Klaus-Peter Lesch
    • , Simon Lovestone
    • , Arvid Lundervold
    • , Astri J. Lundervold
    • , Luigi A. Maglanoc
    • , Ulrik F. Malt
    • , Patrizia Mecocci
    • , Ingrid Melle
    • , Andreas Meyer-Lindenberg
    • , Torgeir Moberget
    • , Linn B. Norbom
    • , Jan Egil Nordvik
    • , Lars Nyberg
    • , Jaap Oosterlaan
    • , Marco Papalino
    • , Andreas Papassotiropoulos
    • , Paul Pauli
    • , Giulio Pergola
    • , Karin Persson
    • , Geneviève Richard
    • , Jaroslav Rokicki
    • , Anne-Marthe Sanders
    • , Geir Selbæk
    • , Alexey A. Shadrin
    • , Olav B. Smeland
    • , Hilkka Soininen
    • , Piotr Sowa
    • , Vidar M. Steen
    • , Magda Tsolaki
    • , Kristine M. Ulrichsen
    • , Bruno Vellas
    • , Lei Wang
    • , Eric Westman
    • , Georg C. Ziegler
    • , Mathias Zink
    • , Ole A. Andreassen
    •  & Lars T. Westlye
  • Resource |

    By comparing neural responses to diverse visual stimuli measured with a standardized two-photon imaging pipeline, the authors reveal response specializations within the mouse visual cortex.

    • Saskia E. J. de Vries
    • , Jerome A. Lecoq
    • , Michael A. Buice
    • , Peter A. Groblewski
    • , Gabriel K. Ocker
    • , Michael Oliver
    • , David Feng
    • , Nicholas Cain
    • , Peter Ledochowitsch
    • , Daniel Millman
    • , Kate Roll
    • , Marina Garrett
    • , Tom Keenan
    • , Leonard Kuan
    • , Stefan Mihalas
    • , Shawn Olsen
    • , Carol Thompson
    • , Wayne Wakeman
    • , Jack Waters
    • , Derric Williams
    • , Chris Barber
    • , Nathan Berbesque
    • , Brandon Blanchard
    • , Nicholas Bowles
    • , Shiella D. Caldejon
    • , Linzy Casal
    • , Andrew Cho
    • , Sissy Cross
    • , Chinh Dang
    • , Tim Dolbeare
    • , Melise Edwards
    • , John Galbraith
    • , Nathalie Gaudreault
    • , Terri L. Gilbert
    • , Fiona Griffin
    • , Perry Hargrave
    • , Robert Howard
    • , Lawrence Huang
    • , Sean Jewell
    • , Nika Keller
    • , Ulf Knoblich
    • , Josh D. Larkin
    • , Rachael Larsen
    • , Chris Lau
    • , Eric Lee
    • , Felix Lee
    • , Arielle Leon
    • , Lu Li
    • , Fuhui Long
    • , Jennifer Luviano
    • , Kyla Mace
    • , Thuyanh Nguyen
    • , Jed Perkins
    • , Miranda Robertson
    • , Sam Seid
    • , Eric Shea-Brown
    • , Jianghong Shi
    • , Nathan Sjoquist
    • , Cliff Slaughterbeck
    • , David Sullivan
    • , Ryan Valenza
    • , Casey White
    • , Ali Williford
    • , Daniela M. Witten
    • , Jun Zhuang
    • , Hongkui Zeng
    • , Colin Farrell
    • , Lydia Ng
    • , Amy Bernard
    • , John W. Phillips
    • , R. Clay Reid
    •  & Christof Koch
  • Article |

    Kappes et al. report a new confirmation bias mechanism. When faced with disagreement, a reduction in the neural sensitivity to the confidence of others is observed leading to a subsequent failure to use others’ confidence to alter one’s own.

    • Andreas Kappes
    • , Ann H. Harvey
    • , Terry Lohrenz
    • , P. Read Montague
    •  & Tali Sharot
  • Brief Communication |

    Graves et al. demonstrate that as the neurotransmitter dopamine cycles through the cytosol at release sites, it can be metabolized by a mitochondrial enzyme to help generate the energy necessary to sustain synaptic function.

    • Steven M. Graves
    • , Zhong Xie
    • , Kristen A. Stout
    • , Enrico Zampese
    • , Lena F. Burbulla
    • , Jean C. Shih
    • , Jyothisri Kondapalli
    • , Tommaso Patriarchi
    • , Lin Tian
    • , Lars Brichta
    • , Paul Greengard
    • , Dimitri Krainc
    • , Paul T. Schumacker
    •  & D. James Surmeier
  • News & Views |

    A new study shows that the enzyme monoamine oxidase funnels a byproduct of dopamine metabolism, H2O2, directly into the mitochondrial electron transport chain, stimulating ATP production. This alternative energy pathway may protect dopaminergic neurons from the toxicity induced by dopamine metabolism while supporting phasic firing.

    • Rongmin Chen
    •  & Elizabeth A. Jonas
  • Article |

    Scheggia et al. show that a specific subpopulation of cortical neurons expressing somatostatin in the prefrontal cortex has a primary role in orchestrating the ability of mice to discriminate positive and negative affective states in others.

    • Diego Scheggia
    • , Francesca Managò
    • , Federica Maltese
    • , Stefania Bruni
    • , Marco Nigro
    • , Daniel Dautan
    • , Patrick Latuske
    • , Gabriella Contarini
    • , Marta Gomez-Gonzalo
    • , Linda Maria Requie
    • , Valentina Ferretti
    • , Giulia Castellani
    • , Daniele Mauro
    • , Alessandra Bonavia
    • , Giorgio Carmignoto
    • , Ofer Yizhar
    •  & Francesco Papaleo
  • News & Views |

    Humans and animals are drawn to others in an altered affective state, whether sad or happy. A study published in this issue of Nature Neuroscience shows that a specific population of interneurons in the brain is critical for discrimination of affective states.

    • Toni-Lee Sterley
    •  & Jaideep S. Bains
  • Article |

    Cummings and Clem demonstrate that cue-related activation and plasticity of prefrontal interneurons cause disinhibition of a distributed brain network that underlies fear memory.

    • Kirstie A. Cummings
    •  & Roger L. Clem
  • Article |

    Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

    • William J. Wright
    • , Nicholas M. Graziane
    • , Peter A. Neumann
    • , Peter J. Hamilton
    • , Hannah M. Cates
    • , Lauren Fuerst
    • , Alexander Spenceley
    • , Natalie MacKinnon-Booth
    • , Kartik Iyer
    • , Yanhua H. Huang
    • , Yavin Shaham
    • , Oliver M. Schlüter
    • , Eric J. Nestler
    •  & Yan Dong
  • Article |

    Lau et al. find that α-synuclein strains initiate distinct diseases when injected into mice, which provides a potential molecular explanation for the clinical and pathological differences between Parkinson’s disease and related neurodegenerative disorders.

    • Angus Lau
    • , Raphaella W. L. So
    • , Heather H. C. Lau
    • , Jason C. Sang
    • , Alejandro Ruiz-Riquelme
    • , Shelaine C. Fleck
    • , Erica Stuart
    • , Sindhu Menon
    • , Naomi P. Visanji
    • , Georg Meisl
    • , Rania Faidi
    • , Maria M. Marano
    • , Cian Schmitt-Ulms
    • , Zhilan Wang
    • , Paul E. Fraser
    • , Anurag Tandon
    • , Bradley T. Hyman
    • , Holger Wille
    • , Martin Ingelsson
    • , David Klenerman
    •  & Joel C. Watts
  • Article |

    DNA sequencing of 3,864 individuals with ALS and 7,839 controls identified a novel disease gene, DNAJC7, which encodes a heat-shock protein. As DNAJC7 is an essential part of cell maintenance, mutations in DNAJC7 may lead to neurodegeneration.

    • Sali M. K. Farhan
    • , Daniel P. Howrigan
    • , Liam E. Abbott
    • , Joseph R. Klim
    • , Simon D. Topp
    • , Andrea E. Byrnes
    • , Claire Churchhouse
    • , Hemali Phatnani
    • , Bradley N. Smith
    • , Evadnie Rampersaud
    • , Gang Wu
    • , Joanne Wuu
    • , Aleksey Shatunov
    • , Alfredo Iacoangeli
    • , Ahmad Al Khleifat
    • , Daniel A. Mordes
    • , Sulagna Ghosh
    • , Kevin Eggan
    • , Rosa Rademakers
    • , Jacob L. McCauley
    • , Rebecca Schüle
    • , Stephan Züchner
    • , Michael Benatar
    • , J. Paul Taylor
    • , Michael Nalls
    • , Marc Gotkine
    • , Pamela J. Shaw
    • , Karen E. Morrison
    • , Ammar Al-Chalabi
    • , Bryan Traynor
    • , Christopher E. Shaw
    • , David B. Goldstein
    • , Matthew B. Harms
    • , Mark J. Daly
    •  & Benjamin M. Neale
  • News & Views |

    Reitich-Stolero and Paz examined multineuron correlates of Pavlovian learning in the primate amygdala. They found repeating patterns of activity across neurons that may mediate synaptic-level plasticity mechanisms. This extends the notion of replay, often examined relative to navigation in the hippocampus, to aversive learning in the amygdala.

    • Bruno B. Averbeck
  • Resource |

    Grubman et al. generated a single-cell transcriptomic atlas of the entorhinal cortex from patients with Alzheimer’s disease and identified transcription factor networks predicted to control disease progression in a cell-subtype-specific way.

    • Alexandra Grubman
    • , Gabriel Chew
    • , John F. Ouyang
    • , Guizhi Sun
    • , Xin Yi Choo
    • , Catriona McLean
    • , Rebecca K. Simmons
    • , Sam Buckberry
    • , Dulce B. Vargas-Landin
    • , Daniel Poppe
    • , Jahnvi Pflueger
    • , Ryan Lister
    • , Owen J. L. Rackham
    • , Enrico Petretto
    •  & Jose M. Polo
  • Article |

    Using samples from the Danish Neonatal Screening Biobank, children with ASD and children with ADHD were found to have similar, significantly increased rates of rare protein-truncating variants in evolutionarily constrained genes.

    • F. Kyle Satterstrom
    • , Raymond K. Walters
    • , Tarjinder Singh
    • , Emilie M. Wigdor
    • , Francesco Lescai
    • , Ditte Demontis
    • , Jack A. Kosmicki
    • , Jakob Grove
    • , Christine Stevens
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Duncan S. Palmer
    • , Julian B. Maller
    • , Merete Nordentoft
    • , Ole Mors
    • , Elise B. Robinson
    • , David M. Hougaard
    • , Thomas M. Werge
    • , Preben Bo Mortensen
    • , Benjamin M. Neale
    • , Anders D. Børglum
    •  & Mark J. Daly
  • Article |

    Animals compose behaviors from both sensory cues and internal states. Calhoun et al. develop an unsupervised modeling framework to identify the dynamic internal states that shape social interactions in Drosophila and use the model to identify neurons that modulate the male’s internal state.

    • Adam J. Calhoun
    • , Jonathan W. Pillow
    •  & Mala Murthy
  • Article |

    This study shows that mouse prefrontal neurons differentially categorize social and nonsocial olfactory cues. Social cue representations are refined with experience and are disrupted in a mouse model of autism with elevated cortical noise.

    • Dana Rubi Levy
    • , Tal Tamir
    • , Maya Kaufman
    • , Ana Parabucki
    • , Aharon Weissbrod
    • , Elad Schneidman
    •  & Ofer Yizhar
  • News & Views |

    Behavior is more than the motor outputs that we can directly measure. Here Calhoun and colleagues devise a novel method for inferring the internal states that affect how fruit flies process sensory information during courtship, providing a new framework for understanding the neural encoding of behavior.

    • Kanishk Jain
    •  & Gordon J. Berman
  • Article |

    The authors show that spatiotemporal spike sequences across neurons in the primate amygdala serve as a coding mechanism and might aid memory formation via the rehearsal of a recently experienced aversive or pleasant tone–odor association.

    • Tamar Reitich-Stolero
    •  & Rony Paz
  • Article |

    Walking requires continual integrated information about the dynamic internal and external environment. This study reveals a pathway whereby the somatosensory cortex directly influences motor behavior based on integrated spatiotemporal information.

    • Spyridon K. Karadimas
    • , Kajana Satkunendrarajah
    • , Alex M. Laliberte
    • , Dene Ringuette
    • , Iliya Weisspapir
    • , Lijun Li
    • , Simon Gosgnach
    •  & Michael G. Fehlings
  • Review Article |

    This paper offers a primer on transcriptional enhancers in the CNS, using examples of enhancer regulation in the maturing brain and the role of non-coding variation in brain disorders to explain the concepts emerging from functional neurogenomics.

    • Alex S. Nord
    •  & Anne E. West
  • Resource |

    Sankowski et al. have combined high-throughput techniques to characterize human microglia, identifying a spectrum of microglia phenotypes that are determined by localization, aging and glioblastoma.

    • Roman Sankowski
    • , Chotima Böttcher
    • , Takahiro Masuda
    • , Laufey Geirsdottir
    • , Sagar
    • , Elena Sindram
    • , Tamara Seredenina
    • , Andreas Muhs
    • , Christian Scheiwe
    • , Mukesch Johannes Shah
    • , Dieter Henrik Heiland
    • , Oliver Schnell
    • , Dominic Grün
    • , Josef Priller
    •  & Marco Prinz