Browse Articles

  • Publisher Correction |

    • Elaine T. Lim
    • , Mohammed Uddin
    • , Silvia De Rubeis
    • , Yingleong Chan
    • , Anne S. Kamumbu
    • , Xiaochang Zhang
    • , Alissa M. D’Gama
    • , Sonia N. Kim
    • , Robert Sean Hill
    • , Arthur P. Goldberg
    • , Christopher Poultney
    • , Nancy J. Minshew
    • , Itaru Kushima
    • , Branko Aleksic
    • , Norio Ozaki
    • , Mara Parellada
    • , Celso Arango
    • , Maria J. Penzol
    • , Angel Carracedo
    • , Alexander Kolevzon
    • , Christina M. Hultman
    • , Lauren A. Weiss
    • , Menachem Fromer
    • , Andreas G. Chiocchetti
    • , Christine M. Freitag
    • , George M. Church
    • , Stephen W. Scherer
    • , Joseph D. Buxbaum
    •  & Christopher A. Walsh
  • Article |

    Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

    • Elyza Kelly
    • , Fantao Meng
    • , Hirofumi Fujita
    • , Felipe Morgado
    • , Yasaman Kazemi
    • , Laura C. Rice
    • , Chongyu Ren
    • , Christine Ochoa Escamilla
    • , Jennifer M. Gibson
    • , Sanaz Sajadi
    • , Robert J. Pendry
    • , Tommy Tan
    • , Jacob Ellegood
    • , M. Albert Basson
    • , Randy D. Blakely
    • , Scott V. Dindot
    • , Christelle Golzio
    • , Maureen K. Hahn
    • , Nicholas Katsanis
    • , Diane M. Robins
    • , Jill L. Silverman
    • , Karun K. Singh
    • , Rachel Wevrick
    • , Margot J. Taylor
    • , Christopher Hammill
    • , Evdokia Anagnostou
    • , Brad E. Pfeiffer
    • , Catherine J. Stoodley
    • , Jason P. Lerch
    • , Sascha du Lac
    •  & Peter T. Tsai
  • Article |

    Most studies of autism spectrum disorder (ASD) have focused on neuronal mechanisms. Here, the authors describe vascular impairments in a mouse model of 16p11.2 deletion syndrome using physiological and genetic approaches to examine endothelial-dependent phenotypes.

    • Julie Ouellette
    • , Xavier Toussay
    • , Cesar H. Comin
    • , Luciano da F. Costa
    • , Mirabelle Ho
    • , María Lacalle-Aurioles
    • , Moises Freitas-Andrade
    • , Qing Yan Liu
    • , Sonia Leclerc
    • , Youlian Pan
    • , Ziying Liu
    • , Jean-François Thibodeau
    • , Melissa Yin
    • , Micael Carrier
    • , Cameron J. Morse
    • , Peter Van Dyken
    • , Christopher J. Bergin
    • , Sylvain Baillet
    • , Christopher R. Kennedy
    • , Marie-Ève Tremblay
    • , Yannick D. Benoit
    • , William L. Stanford
    • , Dylan Burger
    • , Duncan J. Stewart
    •  & Baptiste Lacoste
  • Technical Report |

    Deschloroclozapine (DCZ) is a broadly useful chemogenetic agonist for studies using nonhuman primates and mice. DCZ rapidly and reversibly activates DREADDs, and its binding can be visualized noninvasively by positron emission tomography.

    • Yuji Nagai
    • , Naohisa Miyakawa
    • , Hiroyuki Takuwa
    • , Yukiko Hori
    • , Kei Oyama
    • , Bin Ji
    • , Manami Takahashi
    • , Xi-Ping Huang
    • , Samuel T. Slocum
    • , Jeffrey F. DiBerto
    • , Yan Xiong
    • , Takuya Urushihata
    • , Toshiyuki Hirabayashi
    • , Atsushi Fujimoto
    • , Koki Mimura
    • , Justin G. English
    • , Jing Liu
    • , Ken-ichi Inoue
    • , Katsushi Kumata
    • , Chie Seki
    • , Maiko Ono
    • , Masafumi Shimojo
    • , Ming-Rong Zhang
    • , Yutaka Tomita
    • , Jin Nakahara
    • , Tetsuya Suhara
    • , Masahiko Takada
    • , Makoto Higuchi
    • , Jian Jin
    • , Bryan L. Roth
    •  & Takafumi Minamimoto
  • News & Views |

    Poll and colleagues examined the historical activity of hippocampal CA1 neurons during learning and memory recall using longitudinal two-photon in vivo imaging, providing evidence that extra neural ensemble activity disrupts memory recall in a mouse model of early Alzheimer’s disease.

    • Ryang Kim
    • , Naoki Yamamoto
    •  & Takashi Kitamura
  • News & Views |

    Citation count has become one of the most important methods to evaluate a scientist’s contributions. In an extensive analysis of citations from a number of leading neuroscience journals, Dworkin and colleagues find evidence of gender bias in citation practices that can have an adverse impact on women’s careers.

    • Adrienne L. Fairhall
    •  & Eve Marder
  • Editorial |

    An overlooked bias in research practices and current global events call for a broader approach to addressing issues of diversity.

  • Article |

    Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution.

    • Tamás Laszlovszky
    • , Dániel Schlingloff
    • , Panna Hegedüs
    • , Tamás F. Freund
    • , Attila Gulyás
    • , Adam Kepecs
    •  & Balázs Hangya
  • Article |

    Lovett-Barron et al. register in situ gene expression to cellular-level neural dynamics in behaving zebrafish and find threat-selective populations spanning multiple hypothalamic peptidergic neuron classes, which converge on brainstem defensive action premotor neurons.

    • Matthew Lovett-Barron
    • , Ritchie Chen
    • , Susanna Bradbury
    • , Aaron S. Andalman
    • , Mahendra Wagle
    • , Su Guo
    •  & Karl Deisseroth
  • Article |

    Barbosa, Stein et al. show that rather than operating independently, PFC persistent activity and ‘activity-silent’ mechanisms interact dynamically to produce serial effects in working memory, consistent with attractor models with synaptic plasticity.

    • Joao Barbosa
    • , Heike Stein
    • , Rebecca L. Martinez
    • , Adrià Galan-Gadea
    • , Sihai Li
    • , Josep Dalmau
    • , Kirsten C. S. Adam
    • , Josep Valls-Solé
    • , Christos Constantinidis
    •  & Albert Compte
  • Article |

    Using data from top neuroscience journals, this study finds that women-led work tends to be undercited relative to expectations. This imbalance is driven largely by the citation practices of men and is increasing over time as the field diversifies.

    • Jordan D. Dworkin
    • , Kristin A. Linn
    • , Erin G. Teich
    • , Perry Zurn
    • , Russell T. Shinohara
    •  & Danielle S. Bassett
  • News & Views |

    Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors induced by mistimed light input in mice, implicating the nucleus accumbens as the downstream target of the neural pathway between intrinsically photosensitive retinal ganglion cells and the perihabenular nucleus.

    • Tara A. LeGates
    •  & Mark D. Kvarta
  • Review Article |

    Recent studies separately address the neural representation of stimuli and its dynamics in networks that model neural interactions. Ju and Bassett review such recent advances and discuss the integration of neural representations and network models.

    • Harang Ju
    •  & Danielle S. Bassett
  • Article |

    Mice with AD-like pathology and memory impairments surprisingly have memory engrams in their hippocampus. However, interference with novelty-like cells prevents proper recall, erroneously letting mice perceive a previously learned context as novel.

    • Stefanie Poll
    • , Manuel Mittag
    • , Fabrizio Musacchio
    • , Lena C. Justus
    • , Eleonora Ambrad Giovannetti
    • , Julia Steffen
    • , Jens Wagner
    • , Lioba Zohren
    • , Susanne Schoch
    • , Boris Schmidt
    • , Walker S. Jackson
    • , Dan Ehninger
    •  & Martin Fuhrmann
  • Article |

    Andreone, Przybyla et al. used induced pluripotent stem cell-derived human microglia to show that TREM2-dependent phagocytosis and lipid metabolism require the Alzheimer’s risk factor PLCγ2, which can also mediate TREM2-independent inflammatory signaling via Toll-like receptors.

    • Benjamin J. Andreone
    • , Laralynne Przybyla
    • , Ceyda Llapashtica
    • , Anil Rana
    • , Sonnet S. Davis
    • , Bettina van Lengerich
    • , Karin Lin
    • , Ju Shi
    • , Yuan Mei
    • , Giuseppe Astarita
    • , Gilbert Di Paolo
    • , Thomas Sandmann
    • , Kathryn M. Monroe
    •  & Joseph W. Lewcock
  • Brief Communication |

    Brain connectivity and normalized wiring costs are conserved across mammals independently of brain size according to a common principle: species with fewer interhemispheric connections exhibit better intrahemispheric connectivity.

    • Yaniv Assaf
    • , Arieli Bouznach
    • , Omri Zomet
    • , Assaf Marom
    •  & Yossi Yovel
  • Article |

    Wimmer et al. show that successful recall of an extended episode of experience in humans is associated with temporally compressed replay of neural patterns associated with the memory, and that the direction of replay depends on task goals.

    • G. Elliott Wimmer
    • , Yunzhe Liu
    • , Neža Vehar
    • , Timothy E. J. Behrens
    •  & Raymond J. Dolan
  • Article |

    Cellular imaging reveals that visual cue-evoked activity patterns in visual association cortex are reactivated during subsequent quiet waking. Reactivation rates scale with cue salience and predict next-day changes in functional connectivity and behavior.

    • Arthur U. Sugden
    • , Jeffrey D. Zaremba
    • , Lauren A. Sugden
    • , Kelly L. McGuire
    • , Andrew Lutas
    • , Rohan N. Ramesh
    • , Osama Alturkistani
    • , Kristian K. Lensjø
    • , Christian R. Burgess
    •  & Mark L. Andermann
  • Article |

    An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.

    • Kai An
    • , Huan Zhao
    • , Ying Miao
    • , Qi Xu
    • , Yu-Fei Li
    • , Yu-Qian Ma
    • , Yi-Ming Shi
    • , Jia-Wei Shen
    • , Jian-Jun Meng
    • , Yong-Gang Yao
    • , Zhi Zhang
    • , Ju-Tao Chen
    • , Jin Bao
    • , Mei Zhang
    •  & Tian Xue
  • Article |

    A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

    • Hang Zhou
    • , Julia M. Sealock
    • , Sandra Sanchez-Roige
    • , Toni-Kim Clarke
    • , Daniel F. Levey
    • , Zhongshan Cheng
    • , Boyang Li
    • , Renato Polimanti
    • , Rachel L. Kember
    • , Rachel Vickers Smith
    • , Johan H. Thygesen
    • , Marsha Y. Morgan
    • , Stephen R. Atkinson
    • , Mark R. Thursz
    • , Mette Nyegaard
    • , Manuel Mattheisen
    • , Anders D. Børglum
    • , Emma C. Johnson
    • , Amy C. Justice
    • , Abraham A. Palmer
    • , Andrew McQuillin
    • , Lea K. Davis
    • , Howard J. Edenberg
    • , Arpana Agrawal
    • , Henry R. Kranzler
    •  & Joel Gelernter
  • Article |

    Assessing residual consciousness in unresponsive patients is a major clinical concern. Gui et al. demonstrate that EEG-based language assessment can objectively characterize states of consciousness and predict outcomes in individual patients.

    • Peng Gui
    • , Yuwei Jiang
    • , Di Zang
    • , Zengxin Qi
    • , Jiaxing Tan
    • , Hiromi Tanigawa
    • , Jian Jiang
    • , Yunqing Wen
    • , Long Xu
    • , Jizong Zhao
    • , Ying Mao
    • , Mu-ming Poo
    • , Nai Ding
    • , Stanislas Dehaene
    • , Xuehai Wu
    •  & Liping Wang
  • Article |

    This study elucidates how long-range chromatin loops are altered during short- and long-term changes in neural activity, and analyzes the interplay between the 3D genome and the linear epigenome during activity-dependent transcriptional responses.

    • Jonathan A. Beagan
    • , Elissa D. Pastuzyn
    • , Lindsey R. Fernandez
    • , Michael H. Guo
    • , Kelly Feng
    • , Katelyn R. Titus
    • , Harshini Chandrashekar
    • , Jason D. Shepherd
    •  & Jennifer E. Phillips-Cremins
  • Article |

    Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

    • Qing Shen
    • , Zhuo Chen
    • , Faming Zhao
    • , Susu Pan
    • , Tingting Zhang
    • , Xueer Cheng
    • , Lei Zhang
    • , Shanshan Zhang
    • , Junxia Qi
    • , Juxue Li
    • , Dongsheng Cai
    •  & Guo Zhang
  • News & Views |

    Hardening of the arteries (atherosclerosis) was linked to dementia long ago, but subsequently, Alzheimer’s plaques and tangles have received more attention. A new proteome-wide association study unveils molecular links between intracranial atherosclerosis and dementia, independent of other pathologies, providing new evidence for one of the oldest suspected causes of dementia.

    • Costantino Iadecola
  • News & Views |

    General anesthetics during surgery are presumed to block pain by dampening brain activity and promoting loss-of-consciousness. A new study shows that anesthetics activate an endogenous analgesia neural ensemble in the central nucleus of the amygdala.

    • Nora M. McCall
    • , Jessica A. Wojick
    •  & Gregory Corder
  • Brief Communication |

    Greater novelty and diversity in one’s daily physical environment is associated with positive affect, and functional connectivity within a hippocampal–striatal circuit is related to the strength of this effect.

    • Aaron S. Heller
    • , Tracey C. Shi
    • , C. E. Chiemeka Ezie
    • , Travis R. Reneau
    • , Lara M. Baez
    • , Conor J. Gibbons
    •  & Catherine A. Hartley
  • Article |

    Precisely timed motor learning promotes remyelination in the motor cortex by enhancing oligodendrogenesis and stimulating mature oligodendrocytes to generate new myelin, presenting mature oligodendrocytes as new targets in remyelinating therapies.

    • Clara M. Bacmeister
    • , Helena J. Barr
    • , Crystal R. McClain
    • , Michael A. Thornton
    • , Dailey Nettles
    • , Cristin G. Welle
    •  & Ethan G. Hughes
  • Article |

    Hua and Chen et al. show that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the brain.

    • Thuy Hua
    • , Bin Chen
    • , Dongye Lu
    • , Katsuyasu Sakurai
    • , Shengli Zhao
    • , Bao-Xia Han
    • , Jiwoo Kim
    • , Luping Yin
    • , Yong Chen
    • , Jinghao Lu
    •  & Fan Wang
  • Article |

    Medulloblastomas lacking p53 do not express surface class I major histocompatibility complex (MHC-I) and are resistant to immune rejection. Tumor necrosis factor rescues MHC-I expression and synergizes with immune checkpoint inhibitors to promote rejection.

    • Alexandra Garancher
    • , Hiromichi Suzuki
    • , Svasti Haricharan
    • , Lianne Q. Chau
    • , Meher Beigi Masihi
    • , Jessica M. Rusert
    • , Paula S. Norris
    • , Florent Carrette
    • , Megan M. Romero
    • , Sorana A. Morrissy
    • , Patryk Skowron
    • , Florence M. G. Cavalli
    • , Hamza Farooq
    • , Vijay Ramaswamy
    • , Steven J. M. Jones
    • , Richard A. Moore
    • , Andrew J. Mungall
    • , Yussanne Ma
    • , Nina Thiessen
    • , Yisu Li
    • , Alaide Morcavallo
    • , Lin Qi
    • , Mari Kogiso
    • , Yuchen Du
    • , Patricia Baxter
    • , Jacob J. Henderson
    • , John R. Crawford
    • , Michael L. Levy
    • , James M. Olson
    • , Yoon-Jae Cho
    • , Aniruddha J. Deshpande
    • , Xiao-Nan Li
    • , Louis Chesler
    • , Marco A. Marra
    • , Harald Wajant
    • , Oren J. Becher
    • , Linda M. Bradley
    • , Carl F. Ware
    • , Michael D. Taylor
    •  & Robert J. Wechsler-Reya
  • Brief Communication |

    Proteome-wide association studies of brain samples from older adults revealed effects of cerebral atherosclerosis and Alzheimer’s disease. A subset of proteins and protein co-expression modules were associated with both, suggesting shared mechanisms.

    • Aliza P. Wingo
    • , Wen Fan
    • , Duc M. Duong
    • , Ekaterina S. Gerasimov
    • , Eric B. Dammer
    • , Yue Liu
    • , Nadia V. Harerimana
    • , Bartholomew White
    • , Madhav Thambisetty
    • , Juan C. Troncoso
    • , Namhee Kim
    • , Julie A. Schneider
    • , Ihab M. Hajjar
    • , James J. Lah
    • , David A. Bennett
    • , Nicholas T. Seyfried
    • , Allan I. Levey
    •  & Thomas S. Wingo
  • News & Views |

    One hallmark of sleep is the slow oscillation, which is often synchronous across the neocortical mantle. How this synchrony is achieved remains unclear. A new study by Narikiyo et al. demonstrates how the claustrum may play a key role in the global control of this rhythm.

    • Igor Timofeev
    •  & Sylvain Chauvette
  • Article |

    Cregg et al. find that a specific population of brainstem neurons act to control left–right turning of locomotor movements in mammals through distinct axial- and limb-based mechanisms. This turning pathway is the dominant system for natural directional movements.

    • Jared M. Cregg
    • , Roberto Leiras
    • , Alexia Montalant
    • , Paulina Wanken
    • , Ian R. Wickersham
    •  & Ole Kiehn
  • Article |

    The authors establish the claustrum-Cre transgenic mouse line and demonstrate that the claustrum orchestrates cortical slow-wave activity by synchronously driving the inhibitory interneurons in widespread cortical areas.

    • Kimiya Narikiyo
    • , Rumiko Mizuguchi
    • , Ayako Ajima
    • , Momoko Shiozaki
    • , Hiroki Hamanaka
    • , Joshua P. Johansen
    • , Kensaku Mori
    •  & Yoshihiro Yoshihara
  • Article |

    Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that binding of Adar1 reduces Z-DNA during extinction learning, which is required for memory flexibility.

    • Paul R. Marshall
    • , Qiongyi Zhao
    • , Xiang Li
    • , Wei Wei
    • , Ambika Periyakaruppiah
    • , Esmi L. Zajaczkowski
    • , Laura J. Leighton
    • , Sachithrani U. Madugalle
    • , Dean Basic
    • , Ziqi Wang
    • , Jiayu Yin
    • , Wei-Siang Liau
    • , Ankita Gupte
    • , Carl R. Walkley
    •  & Timothy W. Bredy
  • Brief Communication |

    A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer’s disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.

    • Naomi Habib
    • , Cristin McCabe
    • , Sedi Medina
    • , Miriam Varshavsky
    • , Daniel Kitsberg
    • , Raz Dvir-Szternfeld
    • , Gilad Green
    • , Danielle Dionne
    • , Lan Nguyen
    • , Jamie L. Marshall
    • , Fei Chen
    • , Feng Zhang
    • , Tommy Kaplan
    • , Aviv Regev
    •  & Michal Schwartz
  • Resource |

    Single-nucleus transcriptomics reveal brain alterations associated with major depression. Deep layer excitatory cells and immature oligodendrocytes showed most changes, involving synaptic plasticity, immune function and steroid hormones.

    • Corina Nagy
    • , Malosree Maitra
    • , Arnaud Tanti
    • , Matthew Suderman
    • , Jean-Francois Théroux
    • , Maria Antonietta Davoli
    • , Kelly Perlman
    • , Volodymyr Yerko
    • , Yu Chang Wang
    • , Shreejoy J. Tripathy
    • , Paul Pavlidis
    • , Naguib Mechawar
    • , Jiannis Ragoussis
    •  & Gustavo Turecki
  • Obituary
    | Open Access

    Ronald S. Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry, Professor of Neuroscience at the Yale University School of Medicine and Director of the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center, died unexpectedly of a heart attack on 1 February 2020 while hiking near his home in Guilford, CT. Dr Duman was about to turn 65 years old. He was a member of the US National Academy of Medicine and received many honors for his research on mood disorders, including the Colvin Prize, from the Brain and Behavior Research Foundation, and the Anna-Monika Foundation Prize.

    • Jane R. Taylor
    • , Ralph J. DiLeone
    •  & Marina R. Picciotto
  • News & Views |

    At the heart of C9ORF72-related amyotrophic lateral sclerosis and frontotemporal dementia (ALS /FTD) research lies the mechanistic question of whether disease is caused by toxic gain of function related to the repeat expansion, loss of endogenous C9ORF72 expression, or both. New findings provide insights to this question.

    • Cathleen Lutz