Browse Articles

  • News & Views |

    Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

    • Saskia Hutten
    •  & Dorothee Dormann
  • Article |

    Researchers identify a transcriptional network engaged in stress-resilient mice that is regulated by a previously unstudied transcription factor, Zfp189, and elucidate molecular mechanisms controlling this network and resilience behavior.

    • Zachary S. Lorsch
    • , Peter J. Hamilton
    • , Aarthi Ramakrishnan
    • , Eric M. Parise
    • , Marine Salery
    • , William J. Wright
    • , Ashley E. Lepack
    • , Philipp Mews
    • , Orna Issler
    • , Andrew McKenzie
    • , Xianxiao Zhou
    • , Lyonna F. Parise
    • , Stephen T. Pirpinias
    • , Idelisse Ortiz Torres
    • , Hope G. Kronman
    • , Sarah E. Montgomery
    • , Yong-Hwee Eddie Loh
    • , Benoit Labonté
    • , Andrew Conkey
    • , Ann E. Symonds
    • , Rachael L. Neve
    • , Gustavo Turecki
    • , Ian Maze
    • , Yan Dong
    • , Bin Zhang
    • , Li Shen
    • , Rosemary C. Bagot
    •  & Eric J. Nestler
  • Article |

    Neural populations often encode unknown variables. Chaudhuri et al. develop a method to decode unknown variables by finding shapes in neural data. They show that a mammalian brain circuit of thousands of neurons constructs a navigational compass with only a one-dimensional ring of stable activity states.

    • Rishidev Chaudhuri
    • , Berk Gerçek
    • , Biraj Pandey
    • , Adrien Peyrache
    •  & Ila Fiete
  • Article |

    Using data from rats and humans, the authors study the time it takes to make sensory judgments. The authors define the new regularity as the time–intensity equivalence in discrimination (TIED), which provides a mechanistic basis of Weber’s law.

    • Jose L. Pardo-Vazquez
    • , Juan R. Castiñeiras-de Saa
    • , Mafalda Valente
    • , Iris Damião
    • , Tiago Costa
    • , M. Inês Vicente
    • , André G. Mendonça
    • , Zachary F. Mainen
    •  & Alfonso Renart
  • Article |

    Like humans, songbirds learn to communicate vocally early in life. Moore and Woolley taught birds the songs of a different species to identify how vocal experience and auditory tuning mechanisms create neural representations of communication sounds.

    • Jordan M. Moore
    •  & Sarah M. N. Woolley
  • Article |

    Everyday decisions require choosing among multiple options. This work derives the optimal decision policy and shows how it can be approximated by a biologically plausible neural circuit and how this circuit can reproduce observed behavior.

    • Satohiro Tajima
    • , Jan Drugowitsch
    • , Nisheet Patel
    •  & Alexandre Pouget
  • Article |

    This study identifies eight significant genetic associations with intrusive reexperiencing of trauma in post-traumatic stress disorder (PTSD) from the Million Veteran Program (MVP), a large biobank focused on US veterans.

    • Joel Gelernter
    • , Ning Sun
    • , Renato Polimanti
    • , Robert. Pietrzak
    • , Daniel F. Levey
    • , Julien Bryois
    • , Qiongshi Lu
    • , Yiming Hu
    • , Boyang Li
    • , Krishnan Radhakrishnan
    • , Mihaela Aslan
    • , Kei-Hoi Cheung
    • , Yuli Li
    • , Nallakkandi Rajeevan
    • , Frederick Sayward
    • , Kelly Harrington
    • , Quan Chen
    • , Kelly Cho
    • , Saiju Pyarajan
    • , Patrick F. Sullivan
    • , Rachel Quaden
    • , Yunling Shi
    • , Haley Hunter-Zinck
    • , J. Michael Gaziano
    • , John Concato
    • , Hongyu Zhao
    •  & Murray B. Stein
  • Brief Communication |

    Tost et al. show that urban green space exposure improves well-being, particularly in people dwelling in relatively deprived areas and showing less prefrontal activity during emotion processing, a neural signature that is linked to mental health risk.

    • Heike Tost
    • , Markus Reichert
    • , Urs Braun
    • , Iris Reinhard
    • , Robin Peters
    • , Sven Lautenbach
    • , Andreas Hoell
    • , Emanuel Schwarz
    • , Ulrich Ebner-Priemer
    • , Alexander Zipf
    •  & Andreas Meyer-Lindenberg
  • Brief Communication |

    A nucleotide repeat expansion in the C9orf72 gene is the most common cause of amyotrophic lateral sclerosis. The mutation causes production of aberrant proteins by an enigmatic form of translation. Yamada et al. identify that RPS25 is required for this form of translation.

    • Shizuka B. Yamada
    • , Tania F. Gendron
    • , Teresa Niccoli
    • , Naomi R. Genuth
    • , Rosslyn Grosely
    • , Yingxiao Shi
    • , Idoia Glaria
    • , Nicholas J. Kramer
    • , Lisa Nakayama
    • , Shirleen Fang
    • , Tai J. I. Dinger
    • , Annora Thoeng
    • , Gabriel Rocha
    • , Maria Barna
    • , Joseph D. Puglisi
    • , Linda Partridge
    • , Justin K. Ichida
    • , Adrian M. Isaacs
    • , Leonard Petrucelli
    •  & Aaron D. Gitler
  • Article |

    Detecting and responding to noxious stimuli is essential for survival. Wee et al. show that noxious stimuli elicit intense and widespread activity in zebrafish oxytocin neurons, which promote defensive behavior by activating hindbrain premotor neurons.

    • Caroline L. Wee
    • , Maxim Nikitchenko
    • , Wei-Chun Wang
    • , Sasha J. Luks-Morgan
    • , Erin Song
    • , James A. Gagnon
    • , Owen Randlett
    • , Isaac H. Bianco
    • , Alix M. B. Lacoste
    • , Elena Glushenkova
    • , Joshua P. Barrios
    • , Alexander F. Schier
    • , Samuel Kunes
    • , Florian Engert
    •  & Adam D. Douglass
  • News & Views |

    Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

    • Ellen Kuhl
  • News & Views |

    Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.

    • Karen Krukowski
    •  & Susanna Rosi
  • Article |

    Henderson et al. use quantitative pathology mapping and network modeling to show that α-synuclein pathology spreads through a neuroanatomically connected network, guided by selective vulnerability and genetic risk factors.

    • Michael X. Henderson
    • , Eli J. Cornblath
    • , Adam Darwich
    • , Bin Zhang
    • , Hannah Brown
    • , Ronald J. Gathagan
    • , Raizel M. Sandler
    • , Danielle S. Bassett
    • , John Q. Trojanowski
    •  & Virginia M. Y. Lee
  • Q&A |

    There is disagreement on how best to define and investigate fear. Nature Neuroscience asked Dean Mobbs to lead experts from the fields of human and animal affective neuroscience to discuss their viewpoints on how to define fear and how to move forward with the study of fear.

    • Dean Mobbs
    • , Ralph Adolphs
    • , Michael S. Fanselow
    • , Lisa Feldman Barrett
    • , Joseph E. LeDoux
    • , Kerry Ressler
    •  & Kay M. Tye
  • Article |

    Guo et al. show that synaptic alterations in ACC pyramidal neurons underlie social impairments in Shank3 mutant mice and that selective activation of ACC pyramidal neurons or enhancing AMPAR function improves social behavior in these mice.

    • Baolin Guo
    • , Jing Chen
    • , Qian Chen
    • , Keke Ren
    • , Dayun Feng
    • , Honghui Mao
    • , Han Yao
    • , Jing Yang
    • , Haiying Liu
    • , Yingying Liu
    • , Fan Jia
    • , Chuchu Qi
    • , Taylor Lynn-Jones
    • , Hailan Hu
    • , Zhanyan Fu
    • , Guoping Feng
    • , Wenting Wang
    •  & Shengxi Wu
  • Article |

    Green et al. find that, when their internal heading estimate is rotated via neural stimulation, flies turn their body in a direction that aims to return their heading estimate back to its previous value. This suggests the heading estimate is compared with an internal goal to guide navigation.

    • Jonathan Green
    • , Vikram Vijayan
    • , Peter Mussells Pires
    • , Atsuko Adachi
    •  & Gaby Maimon
  • Article |

    Laboy-Juárez et al. show that barrel cortex neurons in mice are tuned for elementary multi-whisker sequences that represent tactile motion, using a computation similar to motion direction selectivity in vision. These findings provide a novel view of columnar organization.

    • Keven J. Laboy-Juárez
    • , Tomer Langberg
    • , Seoiyoung Ahn
    •  & Daniel E. Feldman
  • Article |

    The authors find that olfactory bulb inputs and outputs sample overlapping but distinct odor subspaces. Physical–chemical properties used to characterize odorants are not well represented in bulb activity, urging further search for better descriptors of odor space.

    • Honggoo Chae
    • , Daniel R. Kepple
    • , Walter G. Bast
    • , Venkatesh N. Murthy
    • , Alexei A. Koulakov
    •  & Dinu F. Albeanu
  • Article |

    SFRP1, an ADAM10 inhibitor, is elevated in the brains of patients with Alzheimer’s disease (AD). Antibody-mediated neutralization of its activity stalls brain alterations and cognitive loss in AD-like mice, supporting SFRP1 as a potential target for disease therapy.

    • Pilar Esteve
    • , Javier Rueda-Carrasco
    • , María Inés Mateo
    • , María Jesús Martin-Bermejo
    • , Jonathan Draffin
    • , Guadalupe Pereyra
    • , África Sandonís
    • , Inmaculada Crespo
    • , Inmaculada Moreno
    • , Ester Aso
    • , Paula Garcia-Esparcia
    • , Estrella Gomez-Tortosa
    • , Alberto Rábano
    • , Juan Fortea
    • , Daniel Alcolea
    • , Alberto Lleo
    • , Michael T. Heneka
    • , José M. Valpuesta
    • , José A. Esteban
    • , Isidro Ferrer
    • , Mercedes Domínguez
    •  & Paola Bovolenta
  • Resource |

    Targeting genes to specific cell types is valuable for basic science and gene therapy. The authors describe a collection of AAVs containing synthetic promoters targeting a broad range of neuronal cell types in mice, non-human primates and humans.

    • Josephine Jüttner
    • , Arnold Szabo
    • , Brigitte Gross-Scherf
    • , Rei K. Morikawa
    • , Santiago B. Rompani
    • , Peter Hantz
    • , Tamas Szikra
    • , Federico Esposti
    • , Cameron S. Cowan
    • , Arjun Bharioke
    • , Claudia P. Patino-Alvarez
    • , Özkan Keles
    • , Akos Kusnyerik
    • , Thierry Azoulay
    • , Dominik Hartl
    • , Arnaud R. Krebs
    • , Dirk Schübeler
    • , Rozina I. Hajdu
    • , Akos Lukats
    • , Janos Nemeth
    • , Zoltan Z. Nagy
    • , Kun-Chao Wu
    • , Rong-Han Wu
    • , Lue Xiang
    • , Xiao-Long Fang
    • , Zi-Bing Jin
    • , David Goldblum
    • , Pascal W. Hasler
    • , Hendrik P. N. Scholl
    • , Jacek Krol
    •  & Botond Roska
  • Resource |

    Using a large task battery spanning motor, cognitive, social and affective domains, this functional MRI (fMRI) study provides a comprehensive functional map of the human cerebellum, along with a comparison to maps derived from anatomy and resting-state fMRI data.

    • Maedbh King
    • , Carlos R. Hernandez-Castillo
    • , Russell A. Poldrack
    • , Richard B. Ivry
    •  & Jörn Diedrichsen
  • Resource |

    Sun et al. built a comprehensive atlas of inputs to major types of GABAergic interneurons in the prefrontal cortex of mice. Through three-dimensional reconstruction of neural morphology, the authors classified input neurons and identified novel neural circuits.

    • Qingtao Sun
    • , Xiangning Li
    • , Miao Ren
    • , Mengting Zhao
    • , Qiuyuan Zhong
    • , Yuqi Ren
    • , Pan Luo
    • , Hong Ni
    • , Xiaoyu Zhang
    • , Chen Zhang
    • , Jing Yuan
    • , Anan Li
    • , Minmin Luo
    • , Hui Gong
    •  & Qingming Luo
  • Article |

    Genetic techniques to manipulate autonomic nerves in a tumor- and fiber-type-specific manner in rodent models of breast cancer reveal that sympathetic nerve denervation or parasympathetic nerve stimulation suppresses breast cancer growth and progression.

    • Atsunori Kamiya
    • , Yohsuke Hayama
    • , Shigeki Kato
    • , Akihiko Shimomura
    • , Takushi Shimomura
    • , Katsumasa Irie
    • , Ryosuke Kaneko
    • , Yuchio Yanagawa
    • , Kazuto Kobayashi
    •  & Takahiro Ochiya
  • Article |

    Parietal neurons encode the information gains that saccades are expected to bring for subsequent actions independently of economic utility, consistent with a boost in neural gain to facilitate the implementation of sampling policies.

    • Mattias Horan
    • , Nabil Daddaoua
    •  & Jacqueline Gottlieb
  • Obituary |

    On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • , Myriam Heiman
    •  & Anne Schaefer
  • News & Views |

    The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

    • Andrée-Anne Berthiaume
    •  & Andy Y. Shih
  • Article |

    T cell-derived interferon-γ signaling to microglia underlies spatial-learning deficits associated with West Nile virus and Zika virus via the loss of hippocampal presynaptic termini or neurons with elimination of postsynaptic termini, respectively.

    • Charise Garber
    • , Allison Soung
    • , Lauren L. Vollmer
    • , Marlene Kanmogne
    • , Aisling Last
    • , Jasmine Brown
    •  & Robyn S. Klein
  • Article |

    Using pericyte-specific Cre and ablation mouse lines, the authors show that loss of brain pericytes leads to circulatory failure and reduced pleiotrophin causing rapid neuron loss. These findings link pericyte loss to a rapid neurodegeneration cascade.

    • Angeliki M. Nikolakopoulou
    • , Axel Montagne
    • , Kassandra Kisler
    • , Zhonghua Dai
    • , Yaoming Wang
    • , Mikko T. Huuskonen
    • , Abhay P. Sagare
    • , Divna Lazic
    • , Melanie D. Sweeney
    • , Pan Kong
    • , Min Wang
    • , Nelly Chuqui Owens
    • , Erica J. Lawson
    • , Xiaochun Xie
    • , Zhen Zhao
    •  & Berislav V. Zlokovic
  • Article |

    This paper elucidates the mechanism regulating the subcellular localization of UBE3A and demonstrates that abrogation of UBE3A nuclear localization leads to electrophysiological and behavioral impairments in mice and to Angelman syndrome in humans.

    • Rossella Avagliano Trezza
    • , Monica Sonzogni
    • , Stijn N. V. Bossuyt
    • , F. Isabella Zampeta
    • , A. Mattijs Punt
    • , Marlene van den Berg
    • , Diana C. Rotaru
    • , Linda M. C. Koene
    • , Shashini T. Munshi
    • , Jeffrey Stedehouder
    • , Johan M. Kros
    • , Mark Williams
    • , Helen Heussler
    • , Femke M. S. de Vrij
    • , Edwin J. Mientjes
    • , Geeske M. van Woerden
    • , Steven A. Kushner
    • , Ben Distel
    •  & Ype Elgersma
  • Article |

    Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.

    • Sarah H. Shahmoradian
    • , Amanda J. Lewis
    • , Christel Genoud
    • , Jürgen Hench
    • , Tim E. Moors
    • , Paula P. Navarro
    • , Daniel Castaño-Díez
    • , Gabriel Schweighauser
    • , Alexandra Graff-Meyer
    • , Kenneth N. Goldie
    • , Rosmarie Sütterlin
    • , Evelien Huisman
    • , Angela Ingrassia
    • , Yvonne de Gier
    • , Annemieke J. M. Rozemuller
    • , Jing Wang
    • , Anne De Paepe
    • , Johannes Erny
    • , Andreas Staempfli
    • , Joerg Hoernschemeyer
    • , Frederik Großerüschkamp
    • , Daniel Niedieker
    • , Samir F. El-Mashtoly
    • , Marialuisa Quadri
    • , Wilfred F. J. Van IJcken
    • , Vincenzo Bonifati
    • , Klaus Gerwert
    • , Bernd Bohrmann
    • , Stephan Frank
    • , Markus Britschgi
    • , Henning Stahlberg
    • , Wilma D. J. Van de Berg
    •  & Matthias E. Lauer
  • News & Views |

    Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

    • Tim Bartels
  • Brief Communication |

    A new study reveals that complete loss of TREM2 function or expression of the TREM2R47H Alzheimer’s disease risk variant hinders amyloid-β plaque-associated microglia, leaving peri-plaque neurites susceptible to tau seeding and spreading.

    • Cheryl E. G. Leyns
    • , Maud Gratuze
    • , Sneha Narasimhan
    • , Nimansha Jain
    • , Lauren J. Koscal
    • , Hong Jiang
    • , Melissa Manis
    • , Marco Colonna
    • , Virginia M. Y. Lee
    • , Jason D. Ulrich
    •  & David M. Holtzman
  • Article |

    Chondroitinase injections into monkey spinal cords 4 weeks after hemisection injury increased corticospinal axon growth and corticospinal synapse formation and improved functional outcomes.

    • Ephron S. Rosenzweig
    • , Ernesto A. Salegio
    • , Justine J. Liang
    • , Janet L. Weber
    • , Chase A. Weinholtz
    • , John H. Brock
    • , Rod Moseanko
    • , Stephanie Hawbecker
    • , Roger Pender
    • , Christina L. Cruzen
    • , Jennifer F. Iaci
    • , Anthony O. Caggiano
    • , Andrew R. Blight
    • , Barbara Haenzi
    • , J. Russell Huie
    • , Leif A. Havton
    • , Yvette S. Nout-Lomas
    • , James W. Fawcett
    • , Adam R. Ferguson
    • , Michael S. Beattie
    • , Jacqueline C. Bresnahan
    •  & Mark H. Tuszynski
  • Brief Communication |

    Optogenetics has revolutionized neuroscience, but intracranial illumination can cause off-target effects. Owen et al. identify a temperature-sensitive potassium current that modulates neuronal activity and behavior independent of opsin expression.

    • Scott F. Owen
    • , Max H. Liu
    •  & Anatol C. Kreitzer
  • Article |

    The study reports a genome-wide significant locus for cannabis use disorder, replicating in an independent cohort, and implicates CHRNA2, which encodes an acetylcholine receptor subunit, in the disorder by analyses of genetically regulated gene expression.

    • Ditte Demontis
    • , Veera Manikandan Rajagopal
    • , Thorgeir E. Thorgeirsson
    • , Thomas D. Als
    • , Jakob Grove
    • , Kalle Leppälä
    • , Daniel F. Gudbjartsson
    • , Jonatan Pallesen
    • , Carsten Hjorthøj
    • , Gunnar W. Reginsson
    • , Thorarinn Tyrfingsson
    • , Valgerdur Runarsdottir
    • , Per Qvist
    • , Jane Hvarregaard Christensen
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Laura M. Huckins
    • , Eli A. Stahl
    • , Allan Timmermann
    • , Esben Agerbo
    • , David M. Hougaard
    • , Thomas Werge
    • , Ole Mors
    • , Preben Bo Mortensen
    • , Merete Nordentoft
    • , Mark J. Daly
    • , Hreinn Stefansson
    • , Kari Stefansson
    • , Mette Nyegaard
    •  & Anders D. Børglum
  • Article |

    Microglia are resident immune cells of the CNS. Here the authors show that neurons communicate to microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of synapses in the brain after sensory loss.

    • Georgia Gunner
    • , Lucas Cheadle
    • , Kasey M. Johnson
    • , Pinar Ayata
    • , Ana Badimon
    • , Erica Mondo
    • , M. Aurel Nagy
    • , Liwang Liu
    • , Shane M. Bemiller
    • , Ki-Wook Kim
    • , Sergio A. Lira
    • , Bruce T. Lamb
    • , Andrew R. Tapper
    • , Richard M. Ransohoff
    • , Michael E. Greenberg
    • , Anne Schaefer
    •  & Dorothy P. Schafer
  • Brief Communication |

    The authors show that decreased synaptic efficacy onto raphe-projecting lateral habenula neurons supports opiate withdrawal-induced sociability deficits, and they demonstrate a role for TNF-α signaling in this process.

    • Kristina Valentinova
    • , Anna Tchenio
    • , Massimo Trusel
    • , Joseph A. Clerke
    • , Arnaud L. Lalive
    • , Stamatina Tzanoulinou
    • , Alessandro Matera
    • , Imane Moutkine
    • , Luc Maroteaux
    • , Rosa C. Paolicelli
    • , Andrea Volterra
    • , Camilla Bellone
    •  & Manuel Mameli
  • News & Views |

    A new study by Owen et al. shows that widely used optogenetic light delivery can heat brain tissue and produce changes in neural activity and behavior in the absence of opsins. How will this finding influence experimental design in the optical age of neuroscience?

    • Daniel F. Cardozo Pinto
    •  & Stephan Lammel
  • Resource |

    Gouwens et al. established a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features from 1,938 neurons available online at the Allen Cell Types Database.

    • Nathan W. Gouwens
    • , Staci A. Sorensen
    • , Jim Berg
    • , Changkyu Lee
    • , Tim Jarsky
    • , Jonathan Ting
    • , Susan M. Sunkin
    • , David Feng
    • , Costas A. Anastassiou
    • , Eliza Barkan
    • , Kris Bickley
    • , Nicole Blesie
    • , Thomas Braun
    • , Krissy Brouner
    • , Agata Budzillo
    • , Shiella Caldejon
    • , Tamara Casper
    • , Dan Castelli
    • , Peter Chong
    • , Kirsten Crichton
    • , Christine Cuhaciyan
    • , Tanya L. Daigle
    • , Rachel Dalley
    • , Nick Dee
    • , Tsega Desta
    • , Song-Lin Ding
    • , Samuel Dingman
    • , Alyse Doperalski
    • , Nadezhda Dotson
    • , Tom Egdorf
    • , Michael Fisher
    • , Rebecca A. de Frates
    • , Emma Garren
    • , Marissa Garwood
    • , Amanda Gary
    • , Nathalie Gaudreault
    • , Keith Godfrey
    • , Melissa Gorham
    • , Hong Gu
    • , Caroline Habel
    • , Kristen Hadley
    • , James Harrington
    • , Julie A. Harris
    • , Alex Henry
    • , DiJon Hill
    • , Sam Josephsen
    • , Sara Kebede
    • , Lisa Kim
    • , Matthew Kroll
    • , Brian Lee
    • , Tracy Lemon
    • , Katherine E. Link
    • , Xiaoxiao Liu
    • , Brian Long
    • , Rusty Mann
    • , Medea McGraw
    • , Stefan Mihalas
    • , Alice Mukora
    • , Gabe J. Murphy
    • , Lindsay Ng
    • , Kiet Ngo
    • , Thuc Nghi Nguyen
    • , Philip R. Nicovich
    • , Aaron Oldre
    • , Daniel Park
    • , Sheana Parry
    • , Jed Perkins
    • , Lydia Potekhina
    • , David Reid
    • , Miranda Robertson
    • , David Sandman
    • , Martin Schroedter
    • , Cliff Slaughterbeck
    • , Gilberto Soler-Llavina
    • , Josef Sulc
    • , Aaron Szafer
    • , Bosiljka Tasic
    • , Naz Taskin
    • , Corinne Teeter
    • , Nivretta Thatra
    • , Herman Tung
    • , Wayne Wakeman
    • , Grace Williams
    • , Rob Young
    • , Zhi Zhou
    • , Colin Farrell
    • , Hanchuan Peng
    • , Michael J. Hawrylycz
    • , Ed Lein
    • , Lydia Ng
    • , Anton Arkhipov
    • , Amy Bernard
    • , John W. Phillips
    • , Hongkui Zeng
    •  & Christof Koch
  • Author Correction |

    • Maisa C. Takenaka
    • , Galina Gabriely
    • , Veit Rothhammer
    • , Ivan D. Mascanfroni
    • , Michael A. Wheeler
    • , Chun-Cheih Chao
    • , Cristina Gutiérrez-Vázquez
    • , Jessica Kenison
    • , Emily C. Tjon
    • , Andreia Barroso
    • , Tyler Vandeventer
    • , Kalil Alves de Lima
    • , Sonja Rothweiler
    • , Lior Mayo
    • , Soufiene Ghannam
    • , Stephanie Zandee
    • , Luke Healy
    • , David Sherr
    • , Mauricio F. Farez
    • , Alexandre Prat
    • , Jack Antel
    • , David A. Reardon
    • , Hailei Zhang
    • , Simon C. Robson
    • , Gad Getz
    • , Howard L. Weiner
    •  & Francisco J. Quintana
  • Brief Communication |

    Lloyd et al. find that regeneration of CNS myelin requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state, revealing new therapeutic targets for neurodegenerative disease.

    • Amy F. Lloyd
    • , Claire L. Davies
    • , Rebecca K. Holloway
    • , Yasmine Labrak
    • , Graeme Ireland
    • , Dario Carradori
    • , Alessandra Dillenburg
    • , Eva Borger
    • , Daniel Soong
    • , Jill C. Richardson
    • , Tanja Kuhlmann
    • , Anna Williams
    • , Jeffrey W. Pollard
    • , Anne des Rieux
    • , Josef Priller
    •  & Veronique E. Miron
  • Article |

    The role of persistent spiking activity in working memory has recently come under debate. Here the authors use biologically realistic recurrent neural networks to explain why the strength of persistent activity can vary markedly between tasks.

    • Nicolas Y. Masse
    • , Guangyu R. Yang
    • , H. Francis Song
    • , Xiao-Jing Wang
    •  & David J. Freedman