Nature Neuroscience - Issue - nature.com science feeds Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive. http://www.nature.com/neuro/current_issue/ Nature Publishing Group en © 2012 Nature Publishing Group Nature Neuroscience 1097-6256 1546-1726 © 2012 Nature Publishing Group permissions@nature.com Nature Neuroscience http://www.nature.com/includes/rj_globnavimages/nn_logo.gif http://www.nature.com/neuro/ Focus on social neuroscience http://feeds.nature.com/~r/neuro/rss/current/~3/p8kk7ut5CQg/nn0512-645 We present a special focus on social neuroscience, bringing together several strands of research to highlight recent progress in the field. Focus on social neuroscience

Nature Neuroscience 15, 645 (2012). doi:10.1038/nn0512-645

We present a special focus on social neuroscience, bringing together several strands of research to highlight recent progress in the field.

]]> Focus on social neuroscience doi:10.1038/nn0512-645 Nature Neuroscience 15, 645 (2012) 2012-04-25 Nature Neuroscience 2012-04-25 10.1038/nn0512-645 http://dx.doi.org/10.1038/nn0512-645 15 5 Editorial 645 645 http://dx.doi.org/10.1038/nn0512-645 Is the reward really worth it? http://feeds.nature.com/~r/neuro/rss/current/~3/MKYMzDiPzjA/nn.3096 How does the brain evaluate whether the benefits of a decision outweigh the costs? A study now reveals that neurons in the anterior cingulate cortex encode costs and benefits, and altering brain activity here biases choices away from negative outcomes. These results link anterior cingulate cortex with the regulation of emotional states. Is the reward really worth it?

Nature Neuroscience 15, 647 (2012). doi:10.1038/nn.3096

Author: Steven W Kennerley

How does the brain evaluate whether the benefits of a decision outweigh the costs? A study now reveals that neurons in the anterior cingulate cortex encode costs and benefits, and altering brain activity here biases choices away from negative outcomes. These results link anterior cingulate cortex with the regulation of emotional states.

]]> Is the reward really worth it? Steven W Kennerley doi:10.1038/nn.3096 Nature Neuroscience 15, 647 (2012) 2012-04-25 Nature Neuroscience 2012-04-25 10.1038/nn.3096 http://dx.doi.org/10.1038/nn.3096 15 5 News and Views 647 649 http://dx.doi.org/10.1038/nn.3096 Astrocytes join the plasticity party http://feeds.nature.com/~r/neuro/rss/current/~3/VqUsYrqZ0Uk/nn.3095 In the developing cortex, spike timing–dependent long-term depression requires cannabinoid-induced glutamate release from astrocytes. Astrocytes may be integral to the coincidence detection that guides plasticity and map formation. Astrocytes join the plasticity party

Nature Neuroscience 15, 649 (2012). doi:10.1038/nn.3095

Author: David J Rossi

In the developing cortex, spike timing–dependent long-term depression requires cannabinoid-induced glutamate release from astrocytes. Astrocytes may be integral to the coincidence detection that guides plasticity and map formation.

]]> Astrocytes join the plasticity party David J Rossi doi:10.1038/nn.3095 Nature Neuroscience 15, 649 (2012) 2012-04-25 Nature Neuroscience 2012-04-25 10.1038/nn.3095 http://dx.doi.org/10.1038/nn.3095 15 5 News and Views 649 651 http://dx.doi.org/10.1038/nn.3095 Fat incites tanycytes to neurogenesis http://feeds.nature.com/~r/neuro/rss/current/~3/hYTLKkHOPj0/nn.3091 Tanycytes in the hypothalamic median eminence have now been found to form a metabolically sensitive neurogenic niche in the brain. In adult mice, tanycytes give rise to hypothalamic regulatory neurons in response to a high-fat diet. Fat incites tanycytes to neurogenesis

Nature Neuroscience 15, 651 (2012). doi:10.1038/nn.3091

Authors: Marcelo O Dietrich & Tamas L Horvath

Tanycytes in the hypothalamic median eminence have now been found to form a metabolically sensitive neurogenic niche in the brain. In adult mice, tanycytes give rise to hypothalamic regulatory neurons in response to a high-fat diet.

]]> Fat incites tanycytes to neurogenesis Marcelo O Dietrich Tamas L Horvath doi:10.1038/nn.3091 Nature Neuroscience 15, 651 (2012) 2012-04-25 Nature Neuroscience 2012-04-25 10.1038/nn.3091 http://dx.doi.org/10.1038/nn.3091 15 5 News and Views 651 653 http://dx.doi.org/10.1038/nn.3091 On the scent of mitochondrial calcium http://feeds.nature.com/~r/neuro/rss/current/~3/ketluuF5I6w/nn.3090 Odorants are now shown to elevate mitochondrial Ca2+ in sensory neurons; moreover, blocking this Ca2+ sequestration impairs dynamic range. Acute stimulation rapidly recruits mitochondria from the soma to the dendritic knob. On the scent of mitochondrial calcium

Nature Neuroscience 15, 653 (2012). doi:10.1038/nn.3090

Author: Frank Zufall

Odorants are now shown to elevate mitochondrial Ca2+ in sensory neurons; moreover, blocking this Ca2+ sequestration impairs dynamic range. Acute stimulation rapidly recruits mitochondria from the soma to the dendritic knob.

]]> On the scent of mitochondrial calcium Frank Zufall doi:10.1038/nn.3090 Nature Neuroscience 15, 653 (2012) 2012-04-25 Nature Neuroscience 2012-04-25 10.1038/nn.3090 http://dx.doi.org/10.1038/nn.3090 15 5 News and Views 653 654 http://dx.doi.org/10.1038/nn.3090 The roots of modern justice: cognitive and neural foundations of social norms and their enforcement http://feeds.nature.com/~r/neuro/rss/current/~3/k97kh0R2H-s/nn.3087 This commentary reviews the neural processes underpinning the learning of social norms, as well the enforcement of these norms through second-party and third-party punishment. The authors suggest how these structures may have formed during our evolutionary history. The roots of modern justice: cognitive and neural foundations of social norms and their enforcement

Nature Neuroscience 15, 655 (2012). doi:10.1038/nn.3087

Authors: Joshua W Buckholtz & René Marois

]]> The roots of modern justice: cognitive and neural foundations of social norms and their enforcement Joshua W Buckholtz René Marois doi:10.1038/nn.3087 Nature Neuroscience 15, 655 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3087 http://dx.doi.org/10.1038/nn.3087 15 5 Commentary 655 661 http://dx.doi.org/10.1038/nn.3087 Neural mechanisms of social risk for psychiatric disorders http://feeds.nature.com/~r/neuro/rss/current/~3/fZi36lpvuoY/nn.3083 This review discusses how social factors modulate risks for mental disorders, and the neural systems that implement this modulation. Neural mechanisms of social risk for psychiatric disorders

Nature Neuroscience 15, 663 (2012). doi:10.1038/nn.3083

Authors: Andreas Meyer-Lindenberg & Heike Tost

]]> Neural mechanisms of social risk for psychiatric disorders Andreas Meyer-Lindenberg Heike Tost doi:10.1038/nn.3083 Nature Neuroscience 15, 663 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3083 http://dx.doi.org/10.1038/nn.3083 15 5 Perspective 663 668 http://dx.doi.org/10.1038/nn.3083 Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health http://feeds.nature.com/~r/neuro/rss/current/~3/PfOpoorYHWI/nn.3086 Although the relationship between social factors and physical health outcomes is well-recognized, the modulatory role of neural processing in this link is less well understood. This perspective describes the way in which neurophysiological processes respond to social connection and disconnection to influence health outcomes. Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health

Nature Neuroscience 15, 669 (2012). doi:10.1038/nn.3086

Authors: Naomi I Eisenberger & Steve W Cole

]]> Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health Naomi I Eisenberger Steve W Cole doi:10.1038/nn.3086 Nature Neuroscience 15, 669 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3086 http://dx.doi.org/10.1038/nn.3086 15 5 Perspective 669 674 http://dx.doi.org/10.1038/nn.3086 The neuroscience of empathy: progress, pitfalls and promise http://feeds.nature.com/~r/neuro/rss/current/~3/eSMA6_YjCDA/nn.3085 In this perspective, the authors critically evaluate the research on the neural systems supporting empathy. The neuroscience of empathy: progress, pitfalls and promise

Nature Neuroscience 15, 675 (2012). doi:10.1038/nn.3085

Authors: Jamil Zaki & Kevin Ochsner

]]> The neuroscience of empathy: progress, pitfalls and promise Jamil Zaki Kevin Ochsner doi:10.1038/nn.3085 Nature Neuroscience 15, 675 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3085 http://dx.doi.org/10.1038/nn.3085 15 5 Perspective 675 680 http://dx.doi.org/10.1038/nn.3085 The animal and human neuroendocrinology of social cognition, motivation and behavior http://feeds.nature.com/~r/neuro/rss/current/~3/ob85JBXVpaw/nn.3084 How does the neuroendocrine system modulate social behavior? The authors review animal as well as human work that aims to answer this question, and suggest ways to advance further research. The animal and human neuroendocrinology of social cognition, motivation and behavior

Nature Neuroscience 15, 681 (2012). doi:10.1038/nn.3084

Authors: Cade McCall & Tania Singer

]]> The animal and human neuroendocrinology of social cognition, motivation and behavior Cade McCall Tania Singer doi:10.1038/nn.3084 Nature Neuroscience 15, 681 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3084 http://dx.doi.org/10.1038/nn.3084 15 5 Review 681 688 http://dx.doi.org/10.1038/nn.3084 Social influences on neuroplasticity: stress and interventions to promote well-being http://feeds.nature.com/~r/neuro/rss/current/~3/nJ5D1nJ_-tk/nn.3093 This review describes how both negative and positive social factors, ranging from stress to meditation, affect brain structure and functioning. Social influences on neuroplasticity: stress and interventions to promote well-being

Nature Neuroscience 15, 689 (2012). doi:10.1038/nn.3093

Authors: Richard J Davidson & Bruce S McEwen

]]> Social influences on neuroplasticity: stress and interventions to promote well-being Richard J Davidson Bruce S McEwen doi:10.1038/nn.3093 Nature Neuroscience 15, 689 (2012) 2012-04-15 Nature Neuroscience 2012-04-15 10.1038/nn.3093 http://dx.doi.org/10.1038/nn.3093 15 5 Review 689 695 http://dx.doi.org/10.1038/nn.3093 microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons http://feeds.nature.com/~r/neuro/rss/current/~3/uld435tc_qk/nn.3082 This paper reports that microRNA-9 controls axonal extension and branching of cortical neurons via its actions on the MAP1B protein. microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons

Nature Neuroscience 15, 697 (2012). doi:10.1038/nn.3082

Authors: Federico Dajas-Bailador, Boyan Bonev, Patricia Garcez, Peter Stanley, Francois Guillemot & Nancy Papalopulu

The capacity of neurons to develop a long axon and multiple dendrites defines neuron connectivity in the CNS. The highly conserved microRNA-9 (miR-9) is expressed in both neuronal precursors and some post-mitotic neurons, and we detected miR-9 expression in the axons of primary cortical neurons. We found that miR-9 controlled axonal extension and branching by regulating the levels of Map1b, an important protein for microtubule stability. Following microfluidic separation of the axon and the soma, we found that miR-9 repressed Map1b translation and was a functional target for the BDNF-dependent control of axon extension and branching. We propose that miR-9 links regulatory signaling processes with dynamic translation mechanisms, controlling Map1b protein levels and axon development.

]]> microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons Federico Dajas-Bailador Boyan Bonev Patricia Garcez Peter Stanley Francois Guillemot Nancy Papalopulu doi:10.1038/nn.3082 Nature Neuroscience 15, 697 (2012) 2012-04-08 Nature Neuroscience 2012-04-08 10.1038/nn.3082 http://dx.doi.org/10.1038/nn.3082 15 5 Brief Communication 697 699 http://dx.doi.org/10.1038/nn.3082 Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche http://feeds.nature.com/~r/neuro/rss/current/~3/a4grLswMOZY/nn.3079 The authors describe a neurogenic niche in the postnatal hypothalamus of mice wherein β2-tanycytes generate neurons in response to high-fat diet. Blocking this neurogenesis leads to attenuated weight gain and increased activity levels. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Nature Neuroscience 15, 700 (2012). doi:10.1038/nn.3079

Authors: Daniel A Lee, Joseph L Bedont, Thomas Pak, Hong Wang, Juan Song, Ana Miranda-Angulo, Vani Takiar, Vanessa Charubhumi, Francesca Balordi, Hirohide Takebayashi, Susan Aja, Eric Ford, Gordon Fishell & Seth Blackshaw

Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

]]> Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche Daniel A Lee Joseph L Bedont Thomas Pak Hong Wang Juan Song Ana Miranda-Angulo Vani Takiar Vanessa Charubhumi Francesca Balordi Hirohide Takebayashi Susan Aja Eric Ford Gordon Fishell Seth Blackshaw doi:10.1038/nn.3079 Nature Neuroscience 15, 700 (2012) 2012-03-25 Nature Neuroscience 2012-03-25 10.1038/nn.3079 http://dx.doi.org/10.1038/nn.3079 15 5 Brief Communication 700 702 http://dx.doi.org/10.1038/nn.3079 NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans http://feeds.nature.com/~r/neuro/rss/current/~3/e68qXJJfMk0/nn.3070 In this study, the authors show that NgR1 and NgR3 can act as functional receptors for chondroitin sulfate proteoglycans (CSPGs), mediating inhibition of axonal growth and regeneration. This suggests a convergent mechanism for CSPG- and myelin-associated inhibitor activities after axonal injury in the CNS. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

Nature Neuroscience 15, 703 (2012). doi:10.1038/nn.3070

Authors: Travis L Dickendesher, Katherine T Baldwin, Yevgeniya A Mironova, Yoshiki Koriyama, Stephen J Raiker, Kim L Askew, Andrew Wood, Cédric G Geoffroy, Binhai Zheng, Claire D Liepmann, Yasuhiro Katagiri, Larry I Benowitz, Herbert M Geller & Roman J Giger

]]> NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans Travis L Dickendesher Katherine T Baldwin Yevgeniya A Mironova Yoshiki Koriyama Stephen J Raiker Kim L Askew Andrew Wood Cédric G Geoffroy Binhai Zheng Claire D Liepmann Yasuhiro Katagiri Larry I Benowitz Herbert M Geller Roman J Giger doi:10.1038/nn.3070 Nature Neuroscience 15, 703 (2012) 2012-03-11 Nature Neuroscience 2012-03-11 10.1038/nn.3070 http://dx.doi.org/10.1038/nn.3070 15 5 Article 703 712 http://dx.doi.org/10.1038/nn.3070 An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin http://feeds.nature.com/~r/neuro/rss/current/~3/PRC5tV3RvL8/nn.3080 In this paper, the authors show that, in the non-diseased state, the huntingtin protein promotes homotypic interactions between neuroepithelial cells, a process that is critical for proper neurulation. An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

Nature Neuroscience 15, 713 (2012). doi:10.1038/nn.3080

Authors: Valentina Lo Sardo, Chiara Zuccato, Germano Gaudenzi, Barbara Vitali, Catarina Ramos, Marzia Tartari, Michael A Myre, James A Walker, Anna Pistocchi, Luciano Conti, Marta Valenza, Binia Drung, Boris Schmidt, James Gusella, Scott Zeitlin, Franco Cotelli & Elena Cattaneo

]]> An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin Valentina Lo Sardo Chiara Zuccato Germano Gaudenzi Barbara Vitali Catarina Ramos Marzia Tartari Michael A Myre James A Walker Anna Pistocchi Luciano Conti Marta Valenza Binia Drung Boris Schmidt James Gusella Scott Zeitlin Franco Cotelli Elena Cattaneo doi:10.1038/nn.3080 Nature Neuroscience 15, 713 (2012) 2012-04-01 Nature Neuroscience 2012-04-01 10.1038/nn.3080 http://dx.doi.org/10.1038/nn.3080 15 5 Article 713 721 http://dx.doi.org/10.1038/nn.3080 Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury http://feeds.nature.com/~r/neuro/rss/current/~3/bH3KgCUNDmM/nn.3066 The engulfment receptor Draper is known to promote glial clearance of degenerating neurons in Drosophila, and this action of Draper is mediated by Src kinase. This study now shows that one of three Draper isoforms, namely Draper-II, negatively regulates glial clearance and acts in opposition to pro-clearance Draper-I. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

Nature Neuroscience 15, 722 (2012). doi:10.1038/nn.3066

Authors: Mary A Logan, Rachel Hackett, Johnna Doherty, Amy Sheehan, Sean D Speese & Marc R Freeman

]]> Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury Mary A Logan Rachel Hackett Johnna Doherty Amy Sheehan Sean D Speese Marc R Freeman doi:10.1038/nn.3066 Nature Neuroscience 15, 722 (2012) 2012-03-18 Nature Neuroscience 2012-03-18 10.1038/nn.3066 http://dx.doi.org/10.1038/nn.3066 15 5 Article 722 730 http://dx.doi.org/10.1038/nn.3066 Netrin (UNC-6) mediates dendritic self-avoidance http://feeds.nature.com/~r/neuro/rss/current/~3/O7n6uecNobU/nn.3065 Dendrites from the same neuron avoid each other through a mechanism involving cell surface proteins that trigger mutual repulsion. Here the authors show that the soluble axon guidance cue Netrin (UNC-6) drives sister dendrite self-avoidance in the PVD nociceptive neuron in C. elegans. Netrin (UNC-6) mediates dendritic self-avoidance

Nature Neuroscience 15, 731 (2012). doi:10.1038/nn.3065

Authors: Cody J Smith, Joseph D Watson, Miri K VanHoven, Daniel A Colón-Ramos & David M Miller

]]> Netrin (UNC-6) mediates dendritic self-avoidance Cody J Smith Joseph D Watson Miri K VanHoven Daniel A Colón-Ramos David M Miller doi:10.1038/nn.3065 Nature Neuroscience 15, 731 (2012) 2012-03-18 Nature Neuroscience 2012-03-18 10.1038/nn.3065 http://dx.doi.org/10.1038/nn.3065 15 5 Article 731 737 http://dx.doi.org/10.1038/nn.3065 VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission http://feeds.nature.com/~r/neuro/rss/current/~3/VBTxn-jWsYg/nn.3067 The authors show that the SNARE protein VAMP4 acts to maintain calcium-dependent asynchronous synaptic vesicle release. These findings suggest that VAMP4 is functionally distinct from synaptobrevin2, which primarily drives fast, synchronous release. VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission

Nature Neuroscience 15, 738 (2012). doi:10.1038/nn.3067

Authors: Jesica Raingo, Mikhail Khvotchev, Pei Liu, Frederic Darios, Ying C Li, Denise M O Ramirez, Megumi Adachi, Philippe Lemieux, Katalin Toth, Bazbek Davletov & Ege T Kavalali

]]> VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission Jesica Raingo Mikhail Khvotchev Pei Liu Frederic Darios Ying C Li Denise M O Ramirez Megumi Adachi Philippe Lemieux Katalin Toth Bazbek Davletov Ege T Kavalali doi:10.1038/nn.3067 Nature Neuroscience 15, 738 (2012) 2012-03-11 Nature Neuroscience 2012-03-11 10.1038/nn.3067 http://dx.doi.org/10.1038/nn.3067 15 5 Article 738 745 http://dx.doi.org/10.1038/nn.3067 Astrocyte signaling controls spike timing–dependent depression at neocortical synapses http://feeds.nature.com/~r/neuro/rss/current/~3/wtpLJRieq_w/nn.3075 This study shows that spike timing–dependent depression between excitatory neurons requires endocannabinoid-mediated calcium signaling and glutamate release from nearby astrocytes, revealing that they are key elements in cortical plasticity. Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

Nature Neuroscience 15, 746 (2012). doi:10.1038/nn.3075

Authors: Rogier Min & Thomas Nevian

]]> Astrocyte signaling controls spike timing–dependent depression at neocortical synapses Rogier Min Thomas Nevian doi:10.1038/nn.3075 Nature Neuroscience 15, 746 (2012) 2012-03-25 Nature Neuroscience 2012-03-25 10.1038/nn.3075 http://dx.doi.org/10.1038/nn.3075 15 5 Article 746 753 http://dx.doi.org/10.1038/nn.3075 Mitochondrial Ca2+ mobilization is a key element in olfactory signaling http://feeds.nature.com/~r/neuro/rss/current/~3/Fa6mGIj8nQ4/nn.3074 Cytosolic Ca2+ is known to control the gain and sensitivity of signaling in the olfactory sensory neurons (OSNs) through several molecular mechanisms. Here the authors find that mitochondrial Ca2+ mobilization is another critical component of OSN neuronal function, ensuring a broad dynamic response range and maintaining the sensitivity of the spike generation machinery. Mitochondrial Ca2+ mobilization is a key element in olfactory signaling

Nature Neuroscience 15, 754 (2012). doi:10.1038/nn.3074

Authors: Daniela Fluegge, Lisa M Moeller, Annika Cichy, Monika Gorin, Agnes Weth, Sophie Veitinger, Silvia Cainarca, Stefan Lohmer, Sabrina Corazza, Eva M Neuhaus, Werner Baumgartner, Jennifer Spehr & Marc Spehr

]]> Mitochondrial Ca2+ mobilization is a key element in olfactory signaling Daniela Fluegge Lisa M Moeller Annika Cichy Monika Gorin Agnes Weth Sophie Veitinger Silvia Cainarca Stefan Lohmer Sabrina Corazza Eva M Neuhaus Werner Baumgartner Jennifer Spehr Marc Spehr doi:10.1038/nn.3074 Nature Neuroscience 15, 754 (2012) 2012-03-25 Nature Neuroscience 2012-03-25 10.1038/nn.3074 http://dx.doi.org/10.1038/nn.3074 15 5 Article 754 762 http://dx.doi.org/10.1038/nn.3074 Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling http://feeds.nature.com/~r/neuro/rss/current/~3/quMd89K5b5g/nn.3081 This study examines the phase response curves of gamma oscillations induced by carbachol or optogenetic stimulation in the hippocampal CA3 network. The authors report that distinct inputs differentially entrain the gamma oscillation in accordance with the relative drive to excitatory and inhibitory neurons in the circuit. Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling

Nature Neuroscience 15, 763 (2012). doi:10.1038/nn.3081

Authors: Thomas Akam, Iris Oren, Laura Mantoan, Emily Ferenczi & Dimitri M Kullmann

]]> Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling Thomas Akam Iris Oren Laura Mantoan Emily Ferenczi Dimitri M Kullmann doi:10.1038/nn.3081 Nature Neuroscience 15, 763 (2012) 2012-04-01 Nature Neuroscience 2012-04-01 10.1038/nn.3081 http://dx.doi.org/10.1038/nn.3081 15 5 Article 763 768 http://dx.doi.org/10.1038/nn.3081 Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition http://feeds.nature.com/~r/neuro/rss/current/~3/aiX3zLbMohI/nn.3077 The authors conduct simultaneous recording and optogenetic silencing of PV or SOM interneurons in the CA1 region of the hippocampus in head-fixed mice actively moving a treadmill belt. They report that these interneurons have distinct roles in controlling the rate, burst and timing of hippocampal pyramidal cells. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition

Nature Neuroscience 15, 769 (2012). doi:10.1038/nn.3077

Authors: Sébastien Royer, Boris V Zemelman, Attila Losonczy, Jinhyun Kim, Frances Chance, Jeffrey C Magee & György Buzsáki

]]> Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition Sébastien Royer Boris V Zemelman Attila Losonczy Jinhyun Kim Frances Chance Jeffrey C Magee György Buzsáki doi:10.1038/nn.3077 Nature Neuroscience 15, 769 (2012) 2012-03-25 Nature Neuroscience 2012-03-25 10.1038/nn.3077 http://dx.doi.org/10.1038/nn.3077 15 5 Article 769 775 http://dx.doi.org/10.1038/nn.3077 Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making http://feeds.nature.com/~r/neuro/rss/current/~3/-JsUNb4iHbQ/nn.3088 In this paper, the authors present evidence for spatially overlapping populations of neurons representing positive and negative subjective value in the primate pregenual anterior cingulate cortex (pACC) during an approach-avoidance task. However, in one subzone of the pACC, negative coding predominated, and microstimulation in this subzone increased negative decision-making, a bias that was blocked by anti-anxiety drug treatment. Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making

Nature Neuroscience 15, 776 (2012). doi:10.1038/nn.3088

Authors: Ken-ichi Amemori & Ann M Graybiel

]]> Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making Ken-ichi Amemori Ann M Graybiel doi:10.1038/nn.3088 Nature Neuroscience 15, 776 (2012) 2012-04-08 Nature Neuroscience 2012-04-08 10.1038/nn.3088 http://dx.doi.org/10.1038/nn.3088 15 5 Article 776 785 http://dx.doi.org/10.1038/nn.3088 Mapping value based planning and extensively trained choice in the human brain http://feeds.nature.com/~r/neuro/rss/current/~3/Z8m7Wtmm3LM/nn.3068 Using a combination of fMRI in humans and computational modeling, the authors show that different striatal nuclei encode different kinds of decision-making information. The anterior caudate nucleus encodes the value of individual steps in a decision tree, whereas the putamen encodes values learnt during extensive training. Mapping value based planning and extensively trained choice in the human brain

Nature Neuroscience 15, 786 (2012). doi:10.1038/nn.3068

Authors: Klaus Wunderlich, Peter Dayan & Raymond J Dolan

]]> Mapping value based planning and extensively trained choice in the human brain Klaus Wunderlich Peter Dayan Raymond J Dolan doi:10.1038/nn.3068 Nature Neuroscience 15, 786 (2012) 2012-03-11 Nature Neuroscience 2012-03-11 10.1038/nn.3068 http://dx.doi.org/10.1038/nn.3068 15 5 Article 786 791 http://dx.doi.org/10.1038/nn.3068 A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing http://feeds.nature.com/~r/neuro/rss/current/~3/ih3kBJXH-E4/nn.3078 This study describes the generation of knock-in mouse lines that express optogenetic activators or silencers in a CRE recombinase–dependent manner, and demonstrates the reliability and utility of these tools with in vivo and ex vivo light-induced activation and silencing of neuronal activity. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

Nature Neuroscience 15, 793 (2012). doi:10.1038/nn.3078

Authors: Linda Madisen, Tianyi Mao, Henner Koch, Jia-min Zhuo, Antal Berenyi, Shigeyoshi Fujisawa, Yun-Wei A Hsu, Alfredo J Garcia, Xuan Gu, Sebastien Zanella, Jolene Kidney, Hong Gu, Yimei Mao, Bryan M Hooks, Edward S Boyden, György Buzsáki, Jan Marino Ramirez, Allan R Jones, Karel Svoboda, Xue Han, Eric E Turner & Hongkui Zeng

]]> A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing Linda Madisen Tianyi Mao Henner Koch Jia-min Zhuo Antal Berenyi Shigeyoshi Fujisawa Yun-Wei A Hsu Alfredo J Garcia Xuan Gu Sebastien Zanella Jolene Kidney Hong Gu Yimei Mao Bryan M Hooks Edward S Boyden György Buzsáki Jan Marino Ramirez Allan R Jones Karel Svoboda Xue Han Eric E Turner Hongkui Zeng doi:10.1038/nn.3078 Nature Neuroscience 15, 793 (2012) 2012-03-25 Nature Neuroscience 2012-03-25 10.1038/nn.3078 http://dx.doi.org/10.1038/nn.3078 15 5 Resource 793 802 http://dx.doi.org/10.1038/nn.3078