Browse Articles

  • Letter |

    The authors show that the transcription factors HNF4A and HNF4G regulate the transcriptome of the intestinal epithelium. HNF4 factors cooperate with BMP/SMAD signaling to promote enterocyte identity.

    • Lei Chen
    • , Natalie H. Toke
    • , Shirley Luo
    • , Roshan P. Vasoya
    • , Robert L. Fullem
    • , Aditya Parthasarathy
    • , Ansu O. Perekatt
    •  & Michael P. Verzi
  • Comment |

    The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

    • Pål Rasmus Njølstad
    • , Ole Andreas Andreassen
    • , Søren Brunak
    • , Anders D. Børglum
    • , Joakim Dillner
    • , Tõnu Esko
    • , Paul W. Franks
    • , Nelson Freimer
    • , Leif Groop
    • , Hakon Heimer
    • , David M. Hougaard
    • , Eivind Hovig
    • , Kristian Hveem
    • , Anu Jalanko
    • , Jaakko Kaprio
    • , Gun Peggy Knudsen
    • , Mads Melbye
    • , Andres Metspalu
    • , Preben Bo Mortensen
    • , Juni Palmgren
    • , Aarno Palotie
    • , Wenche Reed
    • , Hreinn Stefánsson
    • , Nathan O. Stitziel
    • , Patrick F. Sullivan
    • , Unnur Thorsteinsdóttir
    • , Marc Vaudel
    • , Eero Vuorio
    • , Thomas Werge
    • , Camilla Stoltenberg
    •  & Kári Stefánsson
  • Letter |

    A study of a stem cell receptor–ligand signaling module across tomato, maize and Arabidopsis identifies different genetic mechanisms of compensation that contribute to homeostasis.

    • Daniel Rodriguez-Leal
    • , Cao Xu
    • , Choon-Tak Kwon
    • , Cara Soyars
    • , Edgar Demesa-Arevalo
    • , Jarrett Man
    • , Lei Liu
    • , Zachary H. Lemmon
    • , Daniel S. Jones
    • , Joyce Van Eck
    • , David P. Jackson
    • , Madelaine E. Bartlett
    • , Zachary L. Nimchuk
    •  & Zachary B. Lippman
  • Technical Report |

    Signature Multivariate Analysis is a new computational tool that detects the mutational signature of homologous-recombination deficiency in clinical samples sequenced with targeted panels, enabling the identification of patients who are responsive to poly (ADP-ribose) polymerase inhibition therapy.

    • Doga C. Gulhan
    • , Jake June-Koo Lee
    • , Giorgio E. M. Melloni
    • , Isidro Cortés-Ciriano
    •  & Peter J. Park
  • Author Correction |

    • John A. Morris
    • , John P. Kemp
    • , Scott E. Youlten
    • , Laetitia Laurent
    • , John G. Logan
    • , Ryan C. Chai
    • , Nicholas A. Vulpescu
    • , Vincenzo Forgetta
    • , Aaron Kleinman
    • , Sindhu T. Mohanty
    • , C. Marcelo Sergio
    • , Julian Quinn
    • , Loan Nguyen-Yamamoto
    • , Aimee-Lee Luco
    • , Jinchu Vijay
    • , Marie-Michelle Simon
    • , Albena Pramatarova
    • , Carolina Medina-Gomez
    • , Katerina Trajanoska
    • , Elena J. Ghirardello
    • , Natalie C. Butterfield
    • , Katharine F. Curry
    • , Victoria D. Leitch
    • , Penny C. Sparkes
    • , Anne-Tounsia Adoum
    • , Naila S. Mannan
    • , Davide S. K. Komla-Ebri
    • , Andrea S. Pollard
    • , Hannah F. Dewhurst
    • , Thomas A. D. Hassall
    • , Michael-John G. Beltejar
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , Jennifer C. McCreight
    • , Karen E. Huber
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Douglas J. Adams
    • , Suzanne M. Vaillancourt
    • , Stephen Kaptoge
    • , Paul Baldock
    • , Cyrus Cooper
    • , Jonathan Reeve
    • , Evangelia E. Ntzani
    • , Evangelos Evangelou
    • , Claes Ohlsson
    • , David Karasik
    • , Fernando Rivadeneira
    • , Douglas P. Kiel
    • , Jonathan H. Tobias
    • , Celia L. Gregson
    • , Nicholas C. Harvey
    • , Elin Grundberg
    • , David Goltzman
    • , David J. Adams
    • , Christopher J. Lelliott
    • , David A. Hinds
    • , Cheryl L. Ackert-Bicknell
    • , Yi-Hsiang Hsu
    • , Matthew T. Maurano
    • , Peter I. Croucher
    • , Graham R. Williams
    • , J. H. Duncan Bassett
    • , David M. Evans
    •  & J. Brent Richards
  • Article | | open

    Genome assembly of durum wheat cultivar Svevo enables genome-wide genetic diversity analyses highlighting modifications imposed by thousands of years of empirical selection and breeding.

    • Marco Maccaferri
    • , Neil S. Harris
    • , Sven O. Twardziok
    • , Raj K. Pasam
    • , Heidrun Gundlach
    • , Manuel Spannagl
    • , Danara Ormanbekova
    • , Thomas Lux
    • , Verena M. Prade
    • , Sara G. Milner
    • , Axel Himmelbach
    • , Martin Mascher
    • , Paolo Bagnaresi
    • , Primetta Faccioli
    • , Paolo Cozzi
    • , Massimiliano Lauria
    • , Barbara Lazzari
    • , Alessandra Stella
    • , Andrea Manconi
    • , Matteo Gnocchi
    • , Marco Moscatelli
    • , Raz Avni
    • , Jasline Deek
    • , Sezgi Biyiklioglu
    • , Elisabetta Frascaroli
    • , Simona Corneti
    • , Silvio Salvi
    • , Gabriella Sonnante
    • , Francesca Desiderio
    • , Caterina Marè
    • , Cristina Crosatti
    • , Erica Mica
    • , Hakan Özkan
    • , Benjamin Kilian
    • , Pasquale De Vita
    • , Daniela Marone
    • , Reem Joukhadar
    • , Elisabetta Mazzucotelli
    • , Domenica Nigro
    • , Agata Gadaleta
    • , Shiaoman Chao
    • , Justin D. Faris
    • , Arthur T. O. Melo
    • , Mike Pumphrey
    • , Nicola Pecchioni
    • , Luciano Milanesi
    • , Krystalee Wiebe
    • , Jennifer Ens
    • , Ron P. MacLachlan
    • , John M. Clarke
    • , Andrew G. Sharpe
    • , Chu Shin Koh
    • , Kevin Y. H. Liang
    • , Gregory J. Taylor
    • , Ron Knox
    • , Hikmet Budak
    • , Anna M. Mastrangelo
    • , Steven S. Xu
    • , Nils Stein
    • , Iago Hale
    • , Assaf Distelfeld
    • , Matthew J. Hayden
    • , Roberto Tuberosa
    • , Sean Walkowiak
    • , Klaus F. X. Mayer
    • , Aldo Ceriotti
    • , Curtis J. Pozniak
    •  & Luigi Cattivelli
  • Perspective |

    This Perspective discusses how best to interpret pLI, a measure widely used to identify genes that are intolerant to a single copy of a truncating mutation, by relating this and related measures to the underlying population-genetic theory.

    • Zachary L. Fuller
    • , Jeremy J. Berg
    • , Hakhamanesh Mostafavi
    • , Guy Sella
    •  & Molly Przeworski
  • Perspective |

    This Perspective discusses scientific and ethical considerations regarding the clinical use of polygenic risk scores, highlighting the pressing need to diversify cohorts for genetic studies beyond European-ancestry populations.

    • Alicia R. Martin
    • , Masahiro Kanai
    • , Yoichiro Kamatani
    • , Yukinori Okada
    • , Benjamin M. Neale
    •  & Mark J. Daly
  • News & Views |

    Resolving variant-to-function relationships is a key challenge faced by human geneticists. A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.

    • Manuel Tardaguila
    •  & Nicole Soranzo
  • Article |

    Biallelic expansion of an intronic AAGGG repeat in RFC1 is identified here as a common cause of late-onset ataxia. This expansion occurs in the poly(A) tail of an AluSx3 element and is observed at a carrier frequency of 0.7% in populations of European ancestry.

    • Andrea Cortese
    • , Roberto Simone
    • , Roisin Sullivan
    • , Jana Vandrovcova
    • , Huma Tariq
    • , Yau Way Yan
    • , Jack Humphrey
    • , Zane Jaunmuktane
    • , Prasanth Sivakumar
    • , James Polke
    • , Muhammad Ilyas
    • , Eloise Tribollet
    • , Pedro J. Tomaselli
    • , Grazia Devigili
    • , Ilaria Callegari
    • , Maurizio Versino
    • , Vincenzo Salpietro
    • , Stephanie Efthymiou
    • , Diego Kaski
    • , Nick W. Wood
    • , Nadja S. Andrade
    • , Elena Buglo
    • , Adriana Rebelo
    • , Alexander M. Rossor
    • , Adolfo Bronstein
    • , Pietro Fratta
    • , Wilson J. Marques
    • , Stephan Züchner
    • , Mary M. Reilly
    •  & Henry Houlden
  • Article |

    Analysis of genomic and clinical features of acute erythroid leukemia in comparison to other myeloid disorders supports its distinct classification, defines subgroups and suggests therapeutic vulnerabilities.

    • Ilaria Iacobucci
    • , Ji Wen
    • , Manja Meggendorfer
    • , John K. Choi
    • , Lei Shi
    • , Stanley B. Pounds
    • , Catherine L. Carmichael
    • , Katherine E. Masih
    • , Sarah M. Morris
    • , R. Coleman Lindsley
    • , Laura J. Janke
    • , Thomas B. Alexander
    • , Guangchun Song
    • , Chunxu Qu
    • , Yongjin Li
    • , Debbie Payne-Turner
    • , Daisuke Tomizawa
    • , Nobutaka Kiyokawa
    • , Marcus Valentine
    • , Virginia Valentine
    • , Giuseppe Basso
    • , Franco Locatelli
    • , Eric J. Enemark
    • , Shirley K. Y. Kham
    • , Allen E. J. Yeoh
    • , Xiaotu Ma
    • , Xin Zhou
    • , Edgar Sioson
    • , Michael Rusch
    • , Rhonda E. Ries
    • , Elliot Stieglitz
    • , Stephen P. Hunger
    • , Andrew H. Wei
    • , L Bik To
    • , Ian D. Lewis
    • , Richard J. D’Andrea
    • , Benjamin T. Kile
    • , Anna L. Brown
    • , Hamish S. Scott
    • , Christopher N. Hahn
    • , Paula Marlton
    • , Deqing Pei
    • , Cheng Cheng
    • , Mignon L. Loh
    • , Benjamin L. Ebert
    • , Soheil Meshinchi
    • , Torsten Haferlach
    •  & Charles G. Mullighan
  • News & Views |

    More than one dozen hereditary ataxias are caused by repeat expansions. A newly discovered expansion may be the first known common genetic cause of late-onset ataxia.

    • Vikram Shakkottai
    •  & Henry Paulson
  • Editorial |

    Genetic resources and analyses overwhelmingly center on individuals of European ancestry. We encourage the community to embrace a global approach to genetic and genomic studies to address imbalances in the composition of cohorts and the subsequent translatability of findings.

  • Letter |

    A pan-cancer analysis identifies 129 transposable-element-driven promoter-activation events involving 106 oncogenes. At the AluJb-LIN28B locus, deletion of the transposable element eliminates oncogene expression.

    • Hyo Sik Jang
    • , Nakul M. Shah
    • , Alan Y. Du
    • , Zea Z. Dailey
    • , Erica C. Pehrsson
    • , Paula M. Godoy
    • , David Zhang
    • , Daofeng Li
    • , Xiaoyun Xing
    • , Sungsu Kim
    • , David O’Donnell
    • , Jeffrey I. Gordon
    •  & Ting Wang
  • Article |

    A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

    • Amy R. Bentley
    • , Yun J. Sung
    • , Michael R. Brown
    • , Thomas W. Winkler
    • , Aldi T. Kraja
    • , Ioanna Ntalla
    • , Karen Schwander
    • , Daniel I. Chasman
    • , Elise Lim
    • , Xuan Deng
    • , Xiuqing Guo
    • , Jingmin Liu
    • , Yingchang Lu
    • , Ching-Yu Cheng
    • , Xueling Sim
    • , Dina Vojinovic
    • , Jennifer E. Huffman
    • , Solomon K. Musani
    • , Changwei Li
    • , Mary F. Feitosa
    • , Melissa A. Richard
    • , Raymond Noordam
    • , Jenna Baker
    • , Guanjie Chen
    • , Hugues Aschard
    • , Traci M. Bartz
    • , Jingzhong Ding
    • , Rajkumar Dorajoo
    • , Alisa K. Manning
    • , Tuomo Rankinen
    • , Albert V. Smith
    • , Salman M. Tajuddin
    • , Wei Zhao
    • , Mariaelisa Graff
    • , Maris Alver
    • , Mathilde Boissel
    • , Jin Fang Chai
    • , Xu Chen
    • , Jasmin Divers
    • , Evangelos Evangelou
    • , Chuan Gao
    • , Anuj Goel
    • , Yanick Hagemeijer
    • , Sarah E. Harris
    • , Fernando P. Hartwig
    • , Meian He
    • , Andrea R. V. R. Horimoto
    • , Fang-Chi Hsu
    • , Yi-Jen Hung
    • , Anne U. Jackson
    • , Anuradhani Kasturiratne
    • , Pirjo Komulainen
    • , Brigitte Kühnel
    • , Karin Leander
    • , Keng-Hung Lin
    • , Jian’an Luan
    • , Leo-Pekka Lyytikäinen
    • , Nana Matoba
    • , Ilja M. Nolte
    • , Maik Pietzner
    • , Bram Prins
    • , Muhammad Riaz
    • , Antonietta Robino
    • , M. Abdullah Said
    • , Nicole Schupf
    • , Robert A. Scott
    • , Tamar Sofer
    • , Alena Stancáková
    • , Fumihiko Takeuchi
    • , Bamidele O. Tayo
    • , Peter J. van der Most
    • , Tibor V. Varga
    • , Tzung-Dau Wang
    • , Yajuan Wang
    • , Erin B. Ware
    • , Wanqing Wen
    • , Yong-Bing Xiang
    • , Lisa R. Yanek
    • , Weihua Zhang
    • , Jing Hua Zhao
    • , Adebowale Adeyemo
    • , Saima Afaq
    • , Najaf Amin
    • , Marzyeh Amini
    • , Dan E. Arking
    • , Zorayr Arzumanyan
    • , Tin Aung
    • , Christie Ballantyne
    • , R. Graham Barr
    • , Lawrence F. Bielak
    • , Eric Boerwinkle
    • , Erwin P. Bottinger
    • , Ulrich Broeckel
    • , Morris Brown
    • , Brian E. Cade
    • , Archie Campbell
    • , Mickaël Canouil
    • , Sabanayagam Charumathi
    • , Yii-Der Ida Chen
    • , Kaare Christensen
    • , Maria Pina Concas
    • , John M. Connell
    • , Lisa de las Fuentes
    • , H. Janaka de Silva
    • , Paul S. de Vries
    • , Ayo Doumatey
    • , Qing Duan
    • , Charles B. Eaton
    • , Ruben N. Eppinga
    • , Jessica D. Faul
    • , James S. Floyd
    • , Nita G. Forouhi
    • , Terrence Forrester
    • , Yechiel Friedlander
    • , Ilaria Gandin
    • , He Gao
    • , Mohsen Ghanbari
    • , Sina A. Gharib
    • , Bruna Gigante
    • , Franco Giulianini
    • , Hans J. Grabe
    • , C. Charles Gu
    • , Tamara B. Harris
    • , Sami Heikkinen
    • , Chew-Kiat Heng
    • , Makoto Hirata
    • , James E. Hixson
    • , M. Arfan Ikram
    • , Yucheng Jia
    • , Roby Joehanes
    • , Craig Johnson
    • , Jost Bruno Jonas
    • , Anne E. Justice
    • , Tomohiro Katsuya
    • , Chiea Chuen Khor
    • , Tuomas O. Kilpeläinen
    • , Woon-Puay Koh
    • , Ivana Kolcic
    • , Charles Kooperberg
    • , Jose E. Krieger
    • , Stephen B. Kritchevsky
    • , Michiaki Kubo
    • , Johanna Kuusisto
    • , Timo A. Lakka
    • , Carl D. Langefeld
    • , Claudia Langenberg
    • , Lenore J. Launer
    • , Benjamin Lehne
    • , Cora E. Lewis
    • , Yize Li
    • , Jingjing Liang
    • , Shiow Lin
    • , Ching-Ti Liu
    • , Jianjun Liu
    • , Kiang Liu
    • , Marie Loh
    • , Kurt K. Lohman
    • , Tin Louie
    • , Anna Luzzi
    • , Reedik Mägi
    • , Anubha Mahajan
    • , Ani W. Manichaikul
    • , Colin A. McKenzie
    • , Thomas Meitinger
    • , Andres Metspalu
    • , Yuri Milaneschi
    • , Lili Milani
    • , Karen L. Mohlke
    • , Yukihide Momozawa
    • , Andrew P. Morris
    • , Alison D. Murray
    • , Mike A. Nalls
    • , Matthias Nauck
    • , Christopher P. Nelson
    • , Kari E. North
    • , Jeffrey R. O’Connell
    • , Nicholette D. Palmer
    • , George J. Papanicolau
    • , Nancy L. Pedersen
    • , Annette Peters
    • , Patricia A. Peyser
    • , Ozren Polasek
    • , Neil Poulter
    • , Olli T. Raitakari
    • , Alex P. Reiner
    • , Frida Renström
    • , Treva K. Rice
    • , Stephen S. Rich
    • , Jennifer G. Robinson
    • , Lynda M. Rose
    • , Frits R. Rosendaal
    • , Igor Rudan
    • , Carsten O. Schmidt
    • , Pamela J. Schreiner
    • , William R. Scott
    • , Peter Sever
    • , Yuan Shi
    • , Stephen Sidney
    • , Mario Sims
    • , Jennifer A. Smith
    • , Harold Snieder
    • , John M. Starr
    • , Konstantin Strauch
    • , Heather M. Stringham
    • , Nicholas Y. Q. Tan
    • , Hua Tang
    • , Kent D. Taylor
    • , Yik Ying Teo
    • , Yih Chung Tham
    • , Henning Tiemeier
    • , Stephen T. Turner
    • , André G. Uitterlinden
    • , Diana van Heemst
    • , Melanie Waldenberger
    • , Heming Wang
    • , Lan Wang
    • , Lihua Wang
    • , Wen Bin Wei
    • , Christine A. Williams
    • , Gregory Wilson Sr
    • , Mary K. Wojczynski
    • , Jie Yao
    • , Kristin Young
    • , Caizheng Yu
    • , Jian-Min Yuan
    • , Jie Zhou
    • , Alan B. Zonderman
    • , Diane M. Becker
    • , Michael Boehnke
    • , Donald W. Bowden
    • , John C. Chambers
    • , Richard S. Cooper
    • , Ulf de Faire
    • , Ian J. Deary
    • , Paul Elliott
    • , Tõnu Esko
    • , Martin Farrall
    • , Paul W. Franks
    • , Barry I. Freedman
    • , Philippe Froguel
    • , Paolo Gasparini
    • , Christian Gieger
    • , Bernardo L. Horta
    • , Jyh-Ming Jimmy Juang
    • , Yoichiro Kamatani
    • , Candace M. Kammerer
    • , Norihiro Kato
    • , Jaspal S. Kooner
    • , Markku Laakso
    • , Cathy C. Laurie
    • , I-Te Lee
    • , Terho Lehtimäki
    • , Patrik K. E. Magnusson
    • , Albertine J. Oldehinkel
    • , Brenda W. J. H. Penninx
    • , Alexandre C. Pereira
    • , Rainer Rauramaa
    • , Susan Redline
    • , Nilesh J. Samani
    • , James Scott
    • , Xiao-Ou Shu
    • , Pim van der Harst
    • , Lynne E. Wagenknecht
    • , Jun-Sing Wang
    • , Ya Xing Wang
    • , Nicholas J. Wareham
    • , Hugh Watkins
    • , David R. Weir
    • , Ananda R. Wickremasinghe
    • , Tangchun Wu
    • , Eleftheria Zeggini
    • , Wei Zheng
    • , Claude Bouchard
    • , Michele K. Evans
    • , Vilmundur Gudnason
    • , Sharon L. R. Kardia
    • , Yongmei Liu
    • , Bruce M. Psaty
    • , Paul M. Ridker
    • , Rob M. van Dam
    • , Dennis O. Mook-Kanamori
    • , Myriam Fornage
    • , Michael A. Province
    • , Tanika N. Kelly
    • , Ervin R. Fox
    • , Caroline Hayward
    • , Cornelia M. van Duijn
    • , E. Shyong Tai
    • , Tien Yin Wong
    • , Ruth J. F. Loos
    • , Nora Franceschini
    • , Jerome I. Rotter
    • , Xiaofeng Zhu
    • , Laura J. Bierut
    • , W. James Gauderman
    • , Kenneth Rice
    • , Patricia B. Munroe
    • , Alanna C. Morrison
    • , Dabeeru C. Rao
    • , Charles N. Rotimi
    •  & L. Adrienne Cupples
  • Perspective |

    Transcriptome-wide association studies (TWAS) prioritize candidate causal genes at GWAS loci. This Perspective discusses the challenges to TWAS analysis, caveats to interpretation of results and opportunities for improvements to this class of methods.

    • Michael Wainberg
    • , Nasa Sinnott-Armstrong
    • , Nicholas Mancuso
    • , Alvaro N. Barbeira
    • , David A. Knowles
    • , David Golan
    • , Raili Ermel
    • , Arno Ruusalepp
    • , Thomas Quertermous
    • , Ke Hao
    • , Johan L. M. Björkegren
    • , Hae Kyung Im
    • , Bogdan Pasaniuc
    • , Manuel A. Rivas
    •  & Anshul Kundaje
  • Article |

    FOCUS (fine-mapping of causal gene sets) models correlation among TWAS signals to assign a probability for every gene in the risk region to explain the observed association signal while controlling for pleiotropic SNP effects and unmeasured causal expression.

    • Nicholas Mancuso
    • , Malika K. Freund
    • , Ruth Johnson
    • , Huwenbo Shi
    • , Gleb Kichaev
    • , Alexander Gusev
    •  & Bogdan Pasaniuc
  • Article |

    This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

    • Laura M. Huckins
    • , Amanda Dobbyn
    • , Douglas M. Ruderfer
    • , Gabriel Hoffman
    • , Weiqing Wang
    • , Antonio F. Pardiñas
    • , Veera M. Rajagopal
    • , Thomas D. Als
    • , Hoang T. Nguyen
    • , Kiran Girdhar
    • , James Boocock
    • , Panos Roussos
    • , Menachem Fromer
    • , Robin Kramer
    • , Enrico Domenici
    • , Eric R. Gamazon
    • , Shaun Purcell
    • , Jessica S. Johnson
    • , Hardik R. Shah
    • , Lambertus L. Klein
    • , Kristen K. Dang
    • , Benjamin A. Logsdon
    • , Milind C. Mahajan
    • , Lara M. Mangravite
    • , Hiroyoshi Toyoshiba
    • , Raquel E. Gur
    • , Chang-Gyu Hahn
    • , Eric Schadt
    • , David A. Lewis
    • , Vahram Haroutunian
    • , Mette A. Peters
    • , Barbara K. Lipska
    • , Joseph D. Buxbaum
    • , Keisuke Hirai
    • , Thanneer M. Perumal
    • , Laurent Essioux
    • , Stephan Ripke
    • , Benjamin M. Neale
    • , Aiden Corvin
    • , James T. R. Walters
    • , Kai-How Farh
    • , Peter A. Holmans
    • , Phil Lee
    • , Brendan Bulik-Sullivan
    • , David A. Collier
    • , Hailiang Huang
    • , Tune H. Pers
    • , Ingrid Agartz
    • , Esben Agerbo
    • , Margot Albus
    • , Madeline Alexander
    • , Farooq Amin
    • , Silviu A. Bacanu
    • , Martin Begemann
    • , Richard A. Belliveau Jr
    • , Judit Bene
    • , Sarah E. Bergen
    • , Elizabeth Bevilacqua
    • , Tim B. Bigdeli
    • , Donald W. Black
    • , Richard Bruggeman
    • , Nancy G. Buccola
    • , Randy L. Buckner
    • , William Byerley
    • , Wiepke Cahn
    • , Guiqing Cai
    • , Dominique Campion
    • , Rita M. Cantor
    • , Vaughan J. Carr
    • , Noa Carrera
    • , Stanley V. Catts
    • , Kimberly D. Chambert
    • , Raymond C. K. Chan
    • , Ronald Y. L. Chen
    • , Eric Y. H. Chen
    • , Wei Cheng
    • , Eric F. C. Cheung
    • , Siow Ann Chong
    • , C. Robert Cloninger
    • , David Cohen
    • , Nadine Cohen
    • , Paul Cormican
    • , Nick Craddock
    • , James J. Crowley
    • , David Curtis
    • , Michael Davidson
    • , Kenneth L. Davis
    • , Franziska Degenhardt
    • , Jurgen Del Favero
    • , Ditte Demontis
    • , Dimitris Dikeos
    • , Timothy Dinan
    • , Srdjan Djurovic
    • , Gary Donohoe
    • , Elodie Drapeau
    • , Jubao Duan
    • , Frank Dudbridge
    • , Naser Durmishi
    • , Peter Eichhammer
    • , Johan Eriksson
    • , Valentina Escott-Price
    • , Laurent Essioux
    • , Ayman H. Fanous
    • , Martilias S. Farrell
    • , Josef Frank
    • , Lude Franke
    • , Robert Freedman
    • , Nelson B. Freimer
    • , Marion Friedl
    • , Joseph I. Friedman
    • , Menachem Fromer
    • , Giulio Genovese
    • , Lyudmila Georgieva
    • , Ina Giegling
    • , Paola Giusti-Rodríguez
    • , Stephanie Godard
    • , Jacqueline I. Goldstein
    • , Vera Golimbet
    • , Srihari Gopal
    • , Jacob Gratten
    • , Lieuwe de Haan
    • , Christian Hammer
    • , Marian L. Hamshere
    • , Mark Hansen
    • , Thomas Hansen
    • , Vahram Haroutunian
    • , Annette M. Hartmann
    • , Frans A. Henskens
    • , Stefan Herms
    • , Joel N. Hirschhorn
    • , Per Hoffmann
    • , Andrea Hofman
    • , Mads V. Hollegaard
    • , David M. Hougaard
    • , Masashi Ikeda
    • , Inge Joa
    • , Antonio Julia
    • , Rene S. Kahn
    • , Luba Kalaydjieva
    • , Sena Karachanak-Yankova
    • , Juha Karjalainen
    • , David Kavanagh
    • , Matthew C. Keller
    • , James L. Kennedy
    • , Andrey Khrunin
    • , Yunjung Kim
    • , Janis Klovins
    • , James A. Knowles
    • , Bettina Konte
    • , Vaidutis Kucinskas
    • , Zita Ausrele Kucinskiene
    • , Hana Kuzelova-Ptackova
    • , Anna K. Kahler
    • , Claudine Laurent
    • , Jimmy Lee Chee Keong
    • , S. Hong Lee
    • , Sophie E. Legge
    • , Bernard Lerer
    • , Miaoxin Li
    • , Tao Li
    • , Kung-Yee Liang
    • , Jeffrey Lieberman
    • , Svetlana Limborska
    • , Carmel M. Loughland
    • , Jan Lubinski
    • , Jouko Lonnqvist
    • , Milan Macek Jr
    • , Patrik K. E. Magnusson
    • , Brion S. Maher
    • , Wolfgang Maier
    • , Jacques Mallet
    • , Sara Marsal
    • , Manuel Mattheisen
    • , Morten Mattingsdal
    • , Robert W. McCarley
    • , Colm McDonald
    • , Andrew M. McIntosh
    • , Sandra Meier
    • , Carin J. Meijer
    • , Bela Melegh
    • , Ingrid Melle
    • , Raquelle I. Mesholam-Gately
    • , Andres Metspalu
    • , Patricia T. Michie
    • , Lili Milani
    • , Vihra Milanova
    • , Younes Mokrab
    • , Derek W. Morris
    • , Ole Mors
    • , Kieran C. Murphy
    • , Robin M. Murray
    • , Inez Myin-Germeys
    • , Bertram Muller-Myhsok
    • , Mari Nelis
    • , Igor Nenadic
    • , Deborah A. Nertney
    • , Gerald Nestadt
    • , Kristin K. Nicodemus
    • , Liene Nikitina-Zake
    • , Laura Nisenbaum
    • , Annelie Nordin
    • , Eadbhard O’Callaghan
    • , Colm O’Dushlaine
    • , F. Anthony O’Neill
    • , Sang-Yun Oh
    • , Ann Olincy
    • , Line Olsen
    • , Jim Van Os
    • , Christos Pantelis
    • , George N. Papadimitriou
    • , Sergi Papiol
    • , Elena Parkhomenko
    • , Michele T. Pato
    • , Tiina Paunio
    • , Milica Pejovic-Milovancevic
    • , Diana O. Perkins
    • , Olli Pietiläinen
    • , Jonathan Pimm
    • , Andrew J. Pocklington
    • , John Powell
    • , Alkes Price
    • , Ann E. Pulver
    • , Shaun M. Purcell
    • , Digby Quested
    • , Henrik B. Rasmussen
    • , Abraham Reichenberg
    • , Mark A. Reimers
    • , Alexander L. Richards
    • , Joshua L. Roffman
    • , Panos Roussos
    • , Douglas M. Ruderfer
    • , Veikko Salomaa
    • , Alan R. Sanders
    • , Ulrich Schall
    • , Christian R. Schubert
    • , Thomas G. Schulze
    • , Sibylle G. Schwab
    • , Edward M. Scolnick
    • , Rodney J. Scott
    • , Larry J. Seidman
    • , Jianxin Shi
    • , Engilbert Sigurdsson
    • , Teimuraz Silagadze
    • , Jeremy M. Silverman
    • , Kang Sim
    • , Petr Slominsky
    • , Jordan W. Smoller
    • , Hon-Cheong So
    • , Chris C. A. Spencer
    • , Eli A. Stahl
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Elisabeth Stogmann
    • , Richard E. Straub
    • , Eric Strengman
    • , Jana Strohmaier
    • , T. Scott Stroup
    • , Mythily Subramaniam
    • , Jaana Suvisaari
    • , Dragan M. Svrakic
    • , Jin P. Szatkiewicz
    • , Erik Soderman
    • , Srinivas Thirumalai
    • , Draga Toncheva
    • , Sarah Tosato
    • , Juha Veijola
    • , John Waddington
    • , Dermot Walsh
    • , Dai Wang
    • , Qiang Wang
    • , Bradley T. Webb
    • , Mark Weiser
    • , Dieter B. Wildenauer
    • , Nigel M. Williams
    • , Stephanie Williams
    • , Stephanie H. Witt
    • , Aaron R. Wolen
    • , Emily H. M. Wong
    • , Brandon K. Wormley
    • , Hualin Simon Xi
    • , Clement C. Zai
    • , Xuebin Zheng
    • , Fritz Zimprich
    • , Naomi R. Wray
    • , Kari Stefansson
    • , Peter M. Visscher
    • , Rolf Adolfsson
    • , Ole A. Andreassen
    • , Douglas H. R. Blackwood
    • , Elvira Bramon
    • , Joseph D. Buxbaum
    • , Anders D. Børglum
    • , Sven Cichon
    • , Ariel Darvasi
    • , Enrico Domenici
    • , Hannelore Ehrenreich
    • , Tonu Esko
    • , Pablo V. Gejman
    • , Michael Gill
    • , Hugh Gurling
    • , Christina M. Hultman
    • , Nakao Iwata
    • , Assen V. Jablensky
    • , Erik G. Jonsson
    • , Kenneth S. Kendler
    • , George Kirov
    • , Jo Knight
    • , Todd Lencz
    • , Douglas F. Levinson
    • , Qingqin S. Li
    • , Jianjun Liu
    • , Anil K. Malhotra
    • , Steven A. McCarroll
    • , Andrew McQuillin
    • , Jennifer L. Moran
    • , Preben B. Mortensen
    • , Bryan J. Mowry
    • , Markus M. Nothen
    • , Roel A. Ophoff
    • , Michael J. Owen
    • , Aarno Palotie
    • , Carlos N. Pato
    • , Tracey L. Petryshen
    • , Danielle Posthuma
    • , Marcella Rietschel
    • , Brien P. Riley
    • , Dan Rujescu
    • , Pak C. Sham
    • , Pamela Sklar
    • , David St Clair
    • , Daniel R. Weinberger
    • , Jens R. Wendland
    • , Thomas Werge
    • , Mark J. Daly
    • , Patrick F. Sullivan
    • , Michael C. O’Donovan
    • , Anders D. Børglum
    • , Ditte Demontis
    • , Veera Manikandan Rajagopal
    • , Thomas D. Als
    • , Manuel Mattheisen
    • , Jakob Grove
    • , Thomas Werge
    • , Preben Bo Mortensen
    • , Carsten Bøcker Pedersen
    • , Esben Agerbo
    • , Marianne Giørtz Pedersen
    • , Ole Mors
    • , Merete Nordentoft
    • , David M. Hougaard
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Christine Søholm Hansen
    • , Ditte Demontis
    • , Anders D. Børglum
    • , James T. R. Walters
    • , Michael C. O’Donovan
    • , Patrick Sullivan
    • , Michael J. Owen
    • , Bernie Devlin
    • , Solveig K. Sieberts
    • , Nancy J. Cox
    • , Hae Kyung Im
    • , Pamela Sklar
    •  & Eli A. Stahl
  • Letter |

    Generation of a library of 62,389 mapped insertion mutants for the unicellular alga Chlamydomonas reinhardtii enables screening for genes required for photosynthesis and the identification of 303 candidate genes.

    • Xiaobo Li
    • , Weronika Patena
    • , Friedrich Fauser
    • , Robert E. Jinkerson
    • , Shai Saroussi
    • , Moritz T. Meyer
    • , Nina Ivanova
    • , Jacob M. Robertson
    • , Rebecca Yue
    • , Ru Zhang
    • , Josep Vilarrasa-Blasi
    • , Tyler M. Wittkopp
    • , Silvia Ramundo
    • , Sean R. Blum
    • , Audrey Goh
    • , Matthew Laudon
    • , Tharan Srikumar
    • , Paul A. Lefebvre
    • , Arthur R. Grossman
    •  & Martin C. Jonikas
  • Technical Report |

    Linked-read analysis is a method for analyzing single-cell DNA-sequencing data that accurately identifies somatic single-nucleotide variants by using read-level phasing with nearby germline variants, enabling the characterization of mutational signatures and estimation of somatic mutation rates in single cells.

    • Craig L. Bohrson
    • , Alison R. Barton
    • , Michael A. Lodato
    • , Rachel E. Rodin
    • , Lovelace J. Luquette
    • , Vinay V. Viswanadham
    • , Doga C. Gulhan
    • , Isidro Cortés-Ciriano
    • , Maxwell A. Sherman
    • , Minseok Kwon
    • , Michael E. Coulter
    • , Alon Galor
    • , Christopher A. Walsh
    •  & Peter J. Park
  • Article | | open

    High-quality de novo–assembled genomes of two cultivated allotetraploid cotton species and whole-genome comparative analyses provide insights into the evolution of cotton genomes and improvement of fiber quality and resilience to stress.

    • Yan Hu
    • , Jiedan Chen
    • , Lei Fang
    • , Zhiyuan Zhang
    • , Wei Ma
    • , Yongchao Niu
    • , Longzhen Ju
    • , Jieqiong Deng
    • , Ting Zhao
    • , Jinmin Lian
    • , Kobi Baruch
    • , David Fang
    • , Xia Liu
    • , Yong-ling Ruan
    • , Mehboob-ur Rahman
    • , Jinlei Han
    • , Kai Wang
    • , Qiong Wang
    • , Huaitong Wu
    • , Gaofu Mei
    • , Yihao Zang
    • , Zegang Han
    • , Chenyu Xu
    • , Weijuan Shen
    • , Duofeng Yang
    • , Zhanfeng Si
    • , Fan Dai
    • , Liangfeng Zou
    • , Fei Huang
    • , Yulin Bai
    • , Yugao Zhang
    • , Avital Brodt
    • , Hilla Ben-Hamo
    • , Xiefei Zhu
    • , Baoliang Zhou
    • , Xueying Guan
    • , Shuijin Zhu
    • , Xiaoya Chen
    •  & Tianzhen Zhang
  • Article |

    Fine-mapping of blood cell traits in the UK Biobank identifies putative causal variants and enrichment of fine-mapped variants in accessible chromatin of hematopoietic progenitor cells. The study provides an analytical framework for single-variant and single-cell analyses of genetic associations.

    • Jacob C. Ulirsch
    • , Caleb A. Lareau
    • , Erik L. Bao
    • , Leif S. Ludwig
    • , Michael H. Guo
    • , Christian Benner
    • , Ansuman T. Satpathy
    • , Vinay K. Kartha
    • , Rany M. Salem
    • , Joel N. Hirschhorn
    • , Hilary K. Finucane
    • , Martin J. Aryee
    • , Jason D. Buenrostro
    •  & Vijay G. Sankaran
  • Letter |

    This study uses SMARCA2/4-mutant variants to define catalytic activity–dependent and catalytic activity–independent contributions of the ATPase module to the targeting of BAF and PBAF complexes genome-wide.

    • Joshua Pan
    • , Zachary M. McKenzie
    • , Andrew R. D’Avino
    • , Nazar Mashtalir
    • , Caleb A. Lareau
    • , Roodolph St. Pierre
    • , Lu Wang
    • , Ali Shilatifard
    •  & Cigall Kadoch
  • Author Correction |

    • Patrick P. Edger
    • , Thomas J. Poorten
    • , Robert VanBuren
    • , Michael A. Hardigan
    • , Marivi Colle
    • , Michael R. McKain
    • , Ronald D. Smith
    • , Scott J. Teresi
    • , Andrew D. L. Nelson
    • , Ching Man Wai
    • , Elizabeth I. Alger
    • , Kevin A. Bird
    • , Alan E. Yocca
    • , Nathan Pumplin
    • , Shujun Ou
    • , Gil Ben-Zvi
    • , Avital Brodt
    • , Kobi Baruch
    • , Thomas Swale
    • , Lily Shiue
    • , Charlotte B. Acharya
    • , Glenn S. Cole
    • , Jeffrey P. Mower
    • , Kevin L. Childs
    • , Ning Jiang
    • , Eric Lyons
    • , Michael Freeling
    • , Joshua R. Puzey
    •  & Steven J. Knapp
  • Article |

    Cytogenetic and whole-genome-sequencing analyses using CEN-SELECT show that mitotic segregation errors generate a broad spectrum of chromosomal aberrations that recapitulate the complex structural features of cancer genomes.

    • Peter Ly
    • , Simon F. Brunner
    • , Ofer Shoshani
    • , Dong Hyun Kim
    • , Weijie Lan
    • , Tatyana Pyntikova
    • , Adrienne M. Flanagan
    • , Sam Behjati
    • , David C. Page
    • , Peter J. Campbell
    •  & Don W. Cleveland
  • Article |

    Transcriptional and epigenomic profiling of osteoblast and adipocyte differentiation shows that adipogenesis is driven by de novo activation of enhancers, whereas osteogenesis involves preestablished enhancers and depends on the activation of pro-osteogenic and antiadipogenic transcription factors.

    • Alexander Rauch
    • , Anders K. Haakonsson
    • , Jesper G. S. Madsen
    • , Mette Larsen
    • , Isabel Forss
    • , Martin R. Madsen
    • , Elvira L. Van Hauwaert
    • , Christian Wiwie
    • , Naja Z. Jespersen
    • , Michaela Tencerova
    • , Ronni Nielsen
    • , Bjørk D. Larsen
    • , Richard Röttger
    • , Jan Baumbach
    • , Camilla Scheele
    • , Moustapha Kassem
    •  & Susanne Mandrup
  • Article |

    Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

    • Brian W. Kunkle
    • , Benjamin Grenier-Boley
    • , Rebecca Sims
    • , Joshua C. Bis
    • , Vincent Damotte
    • , Adam C. Naj
    • , Anne Boland
    • , Maria Vronskaya
    • , Sven J. van der Lee
    • , Alexandre Amlie-Wolf
    • , Céline Bellenguez
    • , Aura Frizatti
    • , Vincent Chouraki
    • , Eden R. Martin
    • , Kristel Sleegers
    • , Nandini Badarinarayan
    • , Johanna Jakobsdottir
    • , Kara L. Hamilton-Nelson
    • , Sonia Moreno-Grau
    • , Robert Olaso
    • , Rachel Raybould
    • , Yuning Chen
    • , Amanda B. Kuzma
    • , Mikko Hiltunen
    • , Taniesha Morgan
    • , Shahzad Ahmad
    • , Badri N. Vardarajan
    • , Jacques Epelbaum
    • , Per Hoffmann
    • , Merce Boada
    • , Gary W. Beecham
    • , Jean-Guillaume Garnier
    • , Denise Harold
    • , Annette L. Fitzpatrick
    • , Otto Valladares
    • , Marie-Laure Moutet
    • , Amy Gerrish
    • , Albert V. Smith
    • , Liming Qu
    • , Delphine Bacq
    • , Nicola Denning
    • , Xueqiu Jian
    • , Yi Zhao
    • , Maria Del Zompo
    • , Nick C. Fox
    • , Seung-Hoan Choi
    • , Ignacio Mateo
    • , Joseph T. Hughes
    • , Hieab H. Adams
    • , John Malamon
    • , Florentino Sanchez-Garcia
    • , Yogen Patel
    • , Jennifer A. Brody
    • , Beth A. Dombroski
    • , Maria Candida Deniz Naranjo
    • , Makrina Daniilidou
    • , Gudny Eiriksdottir
    • , Shubhabrata Mukherjee
    • , David Wallon
    • , James Uphill
    • , Thor Aspelund
    • , Laura B. Cantwell
    • , Fabienne Garzia
    • , Daniela Galimberti
    • , Edith Hofer
    • , Mariusz Butkiewicz
    • , Bertrand Fin
    • , Elio Scarpini
    • , Chloe Sarnowski
    • , Will S. Bush
    • , Stéphane Meslage
    • , Johannes Kornhuber
    • , Charles C. White
    • , Yuenjoo Song
    • , Robert C. Barber
    • , Sebastiaan Engelborghs
    • , Sabrina Sordon
    • , Dina Voijnovic
    • , Perrie M. Adams
    • , Rik Vandenberghe
    • , Manuel Mayhaus
    • , L. Adrienne Cupples
    • , Marilyn S. Albert
    • , Peter P. De Deyn
    • , Wei Gu
    • , Jayanadra J. Himali
    • , Duane Beekly
    • , Alessio Squassina
    • , Annette M. Hartmann
    • , Adelina Orellana
    • , Deborah Blacker
    • , Eloy Rodriguez-Rodriguez
    • , Simon Lovestone
    • , Melissa E. Garcia
    • , Rachelle S. Doody
    • , Carmen Munoz-Fernadez
    • , Rebecca Sussams
    • , Honghuang Lin
    • , Thomas J. Fairchild
    • , Yolanda A. Benito
    • , Clive Holmes
    • , Hata Karamujić-Čomić
    • , Matthew P. Frosch
    • , Hakan Thonberg
    • , Wolfgang Maier
    • , Gena Roschupkin
    • , Bernardino Ghetti
    • , Vilmantas Giedraitis
    • , Amit Kawalia
    • , Shuo Li
    • , Ryan M. Huebinger
    • , Lena Kilander
    • , Susanne Moebus
    • , Isabel Hernández
    • , M. Ilyas Kamboh
    • , RoseMarie Brundin
    • , James Turton
    • , Qiong Yang
    • , Mindy J. Katz
    • , Letizia Concari
    • , Jenny Lord
    • , Alexa S. Beiser
    • , C. Dirk Keene
    • , Seppo Helisalmi
    • , Iwona Kloszewska
    • , Walter A. Kukull
    • , Anne Maria Koivisto
    • , Aoibhinn Lynch
    • , Lluís Tarraga
    • , Eric B. Larson
    • , Annakaisa Haapasalo
    • , Brian Lawlor
    • , Thomas H. Mosley
    • , Richard B. Lipton
    • , Vincenzo Solfrizzi
    • , Michael Gill
    • , W. T. Longstreth Jr
    • , Thomas J. Montine
    • , Vincenza Frisardi
    • , Monica Diez-Fairen
    • , Fernando Rivadeneira
    • , Ronald C. Petersen
    • , Vincent Deramecourt
    • , Ignacio Alvarez
    • , Francesca Salani
    • , Antonio Ciaramella
    • , Eric Boerwinkle
    • , Eric M. Reiman
    • , Nathalie Fievet
    • , Jerome I. Rotter
    • , Joan S. Reisch
    • , Olivier Hanon
    • , Chiara Cupidi
    • , A. G. Andre Uitterlinden
    • , Donald R. Royall
    • , Carole Dufouil
    • , Raffaele Giovanni Maletta
    • , Itziar de Rojas
    • , Mary Sano
    • , Alexis Brice
    • , Roberta Cecchetti
    • , Peter St George-Hyslop
    • , Karen Ritchie
    • , Magda Tsolaki
    • , Debby W. Tsuang
    • , Bruno Dubois
    • , David Craig
    • , Chuang-Kuo Wu
    • , Hilkka Soininen
    • , Despoina Avramidou
    • , Roger L. Albin
    • , Laura Fratiglioni
    • , Antonia Germanou
    • , Liana G. Apostolova
    • , Lina Keller
    • , Maria Koutroumani
    • , Steven E. Arnold
    • , Francesco Panza
    • , Olymbia Gkatzima
    • , Sanjay Asthana
    • , Didier Hannequin
    • , Patrice Whitehead
    • , Craig S. Atwood
    • , Paolo Caffarra
    • , Harald Hampel
    • , Inés Quintela
    • , Ángel Carracedo
    • , Lars Lannfelt
    • , David C. Rubinsztein
    • , Lisa L. Barnes
    • , Florence Pasquier
    • , Lutz Frölich
    • , Sandra Barral
    • , Bernadette McGuinness
    • , Thomas G. Beach
    • , Janet A. Johnston
    • , James T. Becker
    • , Peter Passmore
    • , Eileen H. Bigio
    • , Jonathan M. Schott
    • , Thomas D. Bird
    • , Jason D. Warren
    • , Bradley F. Boeve
    • , Michelle K. Lupton
    • , James D. Bowen
    • , Petra Proitsi
    • , Adam Boxer
    • , John F. Powell
    • , James R. Burke
    • , John S. K. Kauwe
    • , Jeffrey M. Burns
    • , Michelangelo Mancuso
    • , Joseph D. Buxbaum
    • , Ubaldo Bonuccelli
    • , Nigel J. Cairns
    • , Andrew McQuillin
    • , Chuanhai Cao
    • , Gill Livingston
    • , Chris S. Carlson
    • , Nicholas J. Bass
    • , Cynthia M. Carlsson
    • , John Hardy
    • , Regina M. Carney
    • , Jose Bras
    • , Minerva M. Carrasquillo
    • , Rita Guerreiro
    • , Mariet Allen
    • , Helena C. Chui
    • , Elizabeth Fisher
    • , Carlo Masullo
    • , Elizabeth A. Crocco
    • , Charles DeCarli
    • , Gina Bisceglio
    • , Malcolm Dick
    • , Li Ma
    • , Ranjan Duara
    • , Neill R. Graff-Radford
    • , Denis A. Evans
    • , Angela Hodges
    • , Kelley M. Faber
    • , Martin Scherer
    • , Kenneth B. Fallon
    • , Matthias Riemenschneider
    • , David W. Fardo
    • , Reinhard Heun
    • , Martin R. Farlow
    • , Heike Kölsch
    • , Steven Ferris
    • , Markus Leber
    • , Tatiana M. Foroud
    • , Isabella Heuser
    • , Douglas R. Galasko
    • , Ina Giegling
    • , Marla Gearing
    • , Michael Hüll
    • , Daniel H. Geschwind
    • , John R. Gilbert
    • , John Morris
    • , Robert C. Green
    • , Kevin Mayo
    • , John H. Growdon
    • , Thomas Feulner
    • , Ronald L. Hamilton
    • , Lindy E. Harrell
    • , Dmitriy Drichel
    • , Lawrence S. Honig
    • , Thomas D. Cushion
    • , Matthew J. Huentelman
    • , Paul Hollingworth
    • , Christine M. Hulette
    • , Bradley T. Hyman
    • , Rachel Marshall
    • , Gail P. Jarvik
    • , Alun Meggy
    • , Erin Abner
    • , Georgina E. Menzies
    • , Lee-Way Jin
    • , Ganna Leonenko
    • , Luis M. Real
    • , Gyungah R. Jun
    • , Clinton T. Baldwin
    • , Detelina Grozeva
    • , Anna Karydas
    • , Giancarlo Russo
    • , Jeffrey A. Kaye
    • , Ronald Kim
    • , Frank Jessen
    • , Neil W. Kowall
    • , Bruno Vellas
    • , Joel H. Kramer
    • , Emma Vardy
    • , Frank M. LaFerla
    • , Karl-Heinz Jöckel
    • , James J. Lah
    • , Martin Dichgans
    • , James B. Leverenz
    • , David Mann
    • , Allan I. Levey
    • , Stuart Pickering-Brown
    • , Andrew P. Lieberman
    • , Norman Klopp
    • , Kathryn L. Lunetta
    • , H-Erich Wichmann
    • , Constantine G. Lyketsos
    • , Kevin Morgan
    • , Daniel C. Marson
    • , Kristelle Brown
    • , Frank Martiniuk
    • , Christopher Medway
    • , Deborah C. Mash
    • , Markus M. Nöthen
    • , Eliezer Masliah
    • , Nigel M. Hooper
    • , Wayne C. McCormick
    • , Antonio Daniele
    • , Susan M. McCurry
    • , Anthony Bayer
    • , Andrew N. McDavid
    • , John Gallacher
    • , Ann C. McKee
    • , Hendrik van den Bussche
    • , Marsel Mesulam
    • , Carol Brayne
    • , Bruce L. Miller
    • , Steffi Riedel-Heller
    • , Carol A. Miller
    • , Joshua W. Miller
    • , Ammar Al-Chalabi
    • , John C. Morris
    • , Christopher E. Shaw
    • , Amanda J. Myers
    • , Jens Wiltfang
    • , Sid O’Bryant
    • , John M. Olichney
    • , Victoria Alvarez
    • , Joseph E. Parisi
    • , Andrew B. Singleton
    • , Henry L. Paulson
    • , John Collinge
    • , William R. Perry
    • , Simon Mead
    • , Elaine Peskind
    • , David H. Cribbs
    • , Martin Rossor
    • , Aimee Pierce
    • , Natalie S. Ryan
    • , Wayne W. Poon
    • , Benedetta Nacmias
    • , Huntington Potter
    • , Sandro Sorbi
    • , Joseph F. Quinn
    • , Eleonora Sacchinelli
    • , Ashok Raj
    • , Gianfranco Spalletta
    • , Murray Raskind
    • , Carlo Caltagirone
    • , Paola Bossù
    • , Maria Donata Orfei
    • , Barry Reisberg
    • , Robert Clarke
    • , Christiane Reitz
    • , A David Smith
    • , John M. Ringman
    • , Donald Warden
    • , Erik D. Roberson
    • , Gordon Wilcock
    • , Ekaterina Rogaeva
    • , Amalia Cecilia Bruni
    • , Howard J. Rosen
    • , Maura Gallo
    • , Roger N. Rosenberg
    • , Yoav Ben-Shlomo
    • , Mark A. Sager
    • , Patrizia Mecocci
    • , Andrew J. Saykin
    • , Pau Pastor
    • , Michael L. Cuccaro
    • , Jeffery M. Vance
    • , Julie A. Schneider
    • , Lori S. Schneider
    • , Susan Slifer
    • , William W. Seeley
    • , Amanda G. Smith
    • , Joshua A. Sonnen
    • , Salvatore Spina
    • , Robert A. Stern
    • , Russell H. Swerdlow
    • , Mitchell Tang
    • , Rudolph E. Tanzi
    • , John Q. Trojanowski
    • , Juan C. Troncoso
    • , Vivianna M. Van Deerlin
    • , Linda J. Van Eldik
    • , Harry V. Vinters
    • , Jean Paul Vonsattel
    • , Sandra Weintraub
    • , Kathleen A. Welsh-Bohmer
    • , Kirk C. Wilhelmsen
    • , Jennifer Williamson
    • , Thomas S. Wingo
    • , Randall L. Woltjer
    • , Clinton B. Wright
    • , Chang-En Yu
    • , Lei Yu
    • , Yasaman Saba
    • , Alberto Pilotto
    • , Maria J. Bullido
    • , Oliver Peters
    • , Paul K. Crane
    • , David Bennett
    • , Paola Bosco
    • , Eliecer Coto
    • , Virginia Boccardi
    • , Phil L. De Jager
    • , Alberto Lleo
    • , Nick Warner
    • , Oscar L. Lopez
    • , Martin Ingelsson
    • , Panagiotis Deloukas
    • , Carlos Cruchaga
    • , Caroline Graff
    • , Rhian Gwilliam
    • , Myriam Fornage
    • , Alison M. Goate
    • , Pascual Sanchez-Juan
    • , Patrick G. Kehoe
    • , Najaf Amin
    • , Nilifur Ertekin-Taner
    • , Claudine Berr
    • , Stéphanie Debette
    • , Seth Love
    • , Lenore J. Launer
    • , Steven G. Younkin
    • , Jean-Francois Dartigues
    • , Chris Corcoran
    • , M. Arfan Ikram
    • , Dennis W. Dickson
    • , Gael Nicolas
    • , Dominique Campion
    • , JoAnn Tschanz
    • , Helena Schmidt
    • , Hakon Hakonarson
    • , Jordi Clarimon
    • , Ron Munger
    • , Reinhold Schmidt
    • , Lindsay A. Farrer
    • , Christine Van Broeckhoven
    • , Michael C. O’Donovan
    • , Anita L. DeStefano
    • , Lesley Jones
    • , Jonathan L. Haines
    • , Jean-Francois Deleuze
    • , Michael J. Owen
    • , Vilmundur Gudnason
    • , Richard Mayeux
    • , Valentina Escott-Price
    • , Bruce M. Psaty
    • , Alfredo Ramirez
    • , Li-San Wang
    • , Agustin Ruiz
    • , Cornelia M. van Duijn
    • , Peter A. Holmans
    • , Sudha Seshadri
    • , Julie Williams
    • , Phillippe Amouyel
    • , Gerard D. Schellenberg
    • , Jean-Charles Lambert
    •  & Margaret A. Pericak-Vance
  • News & Views |

    The origin of strawberry is truly global, involving both natural processes and human intervention. The strawberry genome sequence provides support for an influential hypothesis of genome dominance.

    • David J. Bertioli
  • Editorial |

    The development of CRISPR–Cas technology and its applications in biomedical research have generated much excitement. If fully realized, this technology has the potential to help treat or prevent severe diseases. However, these tools also carry considerable risk if improperly used. The scientific community must promote constructive dialogue among its members and within society at large to ensure that research on genome editing is conducted responsibly.

  • Author Correction |

    • Miguel Verbitsky
    • , Rik Westland
    • , Alejandra Perez
    • , Krzysztof Kiryluk
    • , Qingxue Liu
    • , Priya Krithivasan
    • , Adele Mitrotti
    • , David A. Fasel
    • , Ekaterina Batourina
    • , Matthew G. Sampson
    • , Monica Bodria
    • , Max Werth
    • , Charlly Kao
    • , Jeremiah Martino
    • , Valentina P. Capone
    • , Asaf Vivante
    • , Shirlee Shril
    • , Byum Hee Kil
    • , Maddalena Marasa
    • , Jun Y. Zhang
    • , Young-Ji Na
    • , Tze Y. Lim
    • , Dina Ahram
    • , Patricia L. Weng
    • , Erin L. Heinzen
    • , Alba Carrea
    • , Giorgio Piaggio
    • , Loreto Gesualdo
    • , Valeria Manca
    • , Giuseppe Masnata
    • , Maddalena Gigante
    • , Daniele Cusi
    • , Claudia Izzi
    • , Francesco Scolari
    • , Joanna A. E. van Wijk
    • , Marijan Saraga
    • , Domenico Santoro
    • , Giovanni Conti
    • , Pasquale Zamboli
    • , Hope White
    • , Dorota Drozdz
    • , Katarzyna Zachwieja
    • , Monika Miklaszewska
    • , Marcin Tkaczyk
    • , Daria Tomczyk
    • , Anna Krakowska
    • , Przemyslaw Sikora
    • , Tomasz Jarmoliński
    • , Maria K. Borszewska-Kornacka
    • , Robert Pawluch
    • , Maria Szczepanska
    • , Piotr Adamczyk
    • , Malgorzata Mizerska-Wasiak
    • , Grazyna Krzemien
    • , Agnieszka Szmigielska
    • , Marcin Zaniew
    • , Mark G. Dobson
    • , John M. Darlow
    • , Prem Puri
    • , David E. Barton
    • , Susan L. Furth
    • , Bradley A. Warady
    • , Zoran Gucev
    • , Vladimir J. Lozanovski
    • , Velibor Tasic
    • , Isabella Pisani
    • , Landino Allegri
    • , Lida M. Rodas
    • , Josep M. Campistol
    • , Cécile Jeanpierre
    • , Shumyle Alam
    • , Pasquale Casale
    • , Craig S. Wong
    • , Fangming Lin
    • , Débora M. Miranda
    • , Eduardo A. Oliveira
    • , Ana Cristina Simoes-e-Silva
    • , Jonathan M. Barasch
    • , Brynn Levy
    • , Nan Wu
    • , Friedhelm Hildebrandt
    • , Gian Marco Ghiggeri
    • , Anna Latos-Bielenska
    • , Anna Materna-Kiryluk
    • , Feng Zhang
    • , Hakon Hakonarson
    • , Virginia E. Papaioannou
    • , Cathy L. Mendelsohn
    • , Ali G. Gharavi
    •  & Simone Sanna-Cherchi
  • Article |

    Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new. Integration of gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.

    • Phuwanat Sakornsakolpat
    • , Dmitry Prokopenko
    • , Maxime Lamontagne
    • , Nicola F. Reeve
    • , Anna L. Guyatt
    • , Victoria E. Jackson
    • , Nick Shrine
    • , Dandi Qiao
    • , Traci M. Bartz
    • , Deog Kyeom Kim
    • , Mi Kyeong Lee
    • , Jeanne C. Latourelle
    • , Xingnan Li
    • , Jarrett D. Morrow
    • , Ma’en Obeidat
    • , Annah B. Wyss
    • , Per Bakke
    • , R. Graham Barr
    • , Terri H. Beaty
    • , Steven A. Belinsky
    • , Guy G. Brusselle
    • , James D. Crapo
    • , Kim de Jong
    • , Dawn L. DeMeo
    • , Tasha E. Fingerlin
    • , Sina A. Gharib
    • , Amund Gulsvik
    • , Ian P. Hall
    • , John E. Hokanson
    • , Woo Jin Kim
    • , David A. Lomas
    • , Stephanie J. London
    • , Deborah A. Meyers
    • , George T. O’Connor
    • , Stephen I. Rennard
    • , David A. Schwartz
    • , Pawel Sliwinski
    • , David Sparrow
    • , David P. Strachan
    • , Ruth Tal-Singer
    • , Yohannes Tesfaigzi
    • , Jørgen Vestbo
    • , Judith M. Vonk
    • , Jae-Joon Yim
    • , Xiaobo Zhou
    • , Yohan Bossé
    • , Ani Manichaikul
    • , Lies Lahousse
    • , Edwin K. Silverman
    • , H. Marike Boezen
    • , Louise V. Wain
    • , Martin D. Tobin
    • , Brian D. Hobbs
    • , Michael H. Cho
    • , Nick Shrine
    • , Anna L. Guyatt
    • , Chiara Batini
    • , Jing Hua Zhao
    • , Matthias Wielscher
    • , Stefan Weiss
    • , Katherine A. Kentistou
    • , James P. Cook
    • , Jennie Hui
    • , Stefan Karrasch
    • , Medea Imboden
    • , Sarah E. Harris
    • , Jonathan Marten
    • , Stefan Enroth
    • , Shona M. Kerr
    • , Ida Surakka
    • , Veronique Vitart
    • , Terho Lehtimäki
    • , Ralf Ewert
    • , Christian Gieger
    • , Georg Homuth
    • , Peter K. Joshi
    • , Claudia Langenberg
    • , Lars Lind
    • , Jian’an Luan
    • , Anubha Mahajan
    • , Alison Murray
    • , David J. Porteous
    • , Rajesh Rawal
    • , Blair H. Smith
    • , Paul R. H. J. Timmers
    • , Olli T. Raitakari
    • , Mika Kähönen
    • , Ozren Polasek
    • , Ulf Gyllensten
    • , Igor Rudan
    • , Ian J. Deary
    • , Nicole M. Probst-Hensch
    • , Holger Schulz
    • , Alan L. James
    • , James F. Wilson
    • , Beate Stubbe
    • , Eleftheria Zeggini
    • , Marjo-Riitta Jarvelin
    • , Nick Wareham
    • , Caroline Hayward
    • , Andrew P. Morris
    • , David P. Strachan
    • , Ian P. Hall
    • , Martin D. Tobin
    • , Louise V. Wain
    • , Alvar Agusti
    • , Wayne Anderson
    • , Nawar Bakerly
    • , Per Bakke
    • , Robert Bals
    • , Kathleen C. Barnes
    • , R. Graham Barr
    • , Terri H. Beaty
    • , Eugene R. Bleecker
    • , H. Marike Boezen
    • , Yohan Bossé
    • , Russell Bowler
    • , Christopher Brightling
    • , Marleen de Bruijne
    • , Peter J. Castaldi
    • , Bartolome Celli
    • , Michael H. Cho
    • , Harvey O. Coxson
    • , James D. Crapo
    • , Ron Crystal
    • , Pim de Jong
    • , Asger Dirksen
    • , Jennifer Dy
    • , Marilyn Foreman
    • , Judith Garcia-Aymerich
    • , Pierre Gevenois
    • , Soumitra Ghosh
    • , Hester Gietema
    • , Amund Gulsvik
    • , Ian P. Hall
    • , Nadia Hansel
    • , Craig P. Hersh
    • , Brian D. Hobbs
    • , Eric Hoffman
    • , Noor Kalsheker
    • , Hans-Ulrich Kauczor
    • , Woo Jin Kim
    • , Deog Kyeom Kim
    • , Tarja Laitinen
    • , Diether Lambrechts
    • , Sang-Do Lee
    • , Augusto A. Litonjua
    • , David A. Lomas
    • , Stephanie J. London
    • , Daan W. Loth
    • , Sharon M. Lutz
    • , David Lynch
    • , William MacNee
    • , Merry-Lynn McDonald
    • , Deborah A. Meyers
    • , John D. Newell
    • , Borge G. Nordestgaard
    • , George T. O’Connor
    • , Ma’en Obeidat
    • , Yeon-Mok Oh
    • , Peter D. Paré
    • , Massimo Pistolesi
    • , Dirkje S. Postma
    • , Milo Puhan
    • , Elizabeth Regan
    • , Stephen S. Rich
    • , Joon Beom Seo
    • , Andrea Short
    • , Edwin K. Silverman
    • , David Sparrow
    • , Berend Stoel
    • , David P. Strachan
    • , Nicola Sverzellati
    • , Ruth Tal-Singer
    • , Gerben ter Riet
    • , Yohannes Tesfaigzi
    • , Martin D. Tobin
    • , Edwin J. R. Van Beek
    • , Bram van Ginneken
    • , Jørgen Vestbo
    • , Claus F. Vogelmeier
    • , Louise V. Wain
    • , Adam Wanner
    • , George Washko
    • , Els Wauters
    • , Emiel F. M. Wouters
    • , Robert P. Young
    •  & Loems Zeigler-Heitbrock
  • Article |

    Genome-wide analyses in >1 million individuals identify new loci and pathways associated with insomnia. The findings implicate key brain areas and cell types in the neurobiology of insomnia and highlight potential targets for developing new treatments.

    • Philip R. Jansen
    • , Kyoko Watanabe
    • , Sven Stringer
    • , Nathan Skene
    • , Julien Bryois
    • , Anke R. Hammerschlag
    • , Christiaan A. de Leeuw
    • , Jeroen S. Benjamins
    • , Ana B. Muñoz-Manchado
    • , Mats Nagel
    • , Jeanne E. Savage
    • , Henning Tiemeier
    • , Tonya White
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Jennifer C. McCreight
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Catherine H. Wilson
    • , Joyce Y. Tung
    • , David A. Hinds
    • , Vladimir Vacic
    • , Xin Wang
    • , Patrick F. Sullivan
    • , Sophie van der Sluis
    • , Tinca J. C. Polderman
    • , August B. Smit
    • , Jens Hjerling-Leffler
    • , Eus J. W. Van Someren
    •  & Danielle Posthuma
  • Article | | open

    Chromosome-scale assembly for the cultivated octoploid strawberry (Fragaria × ananassa) uncovers the origin and evolutionary processes that shaped this complex allopolyploid, providing a useful resource for genome-wide analyses and molecular breeding.

    • Patrick P. Edger
    • , Thomas J. Poorten
    • , Robert VanBuren
    • , Michael A. Hardigan
    • , Marivi Colle
    • , Michael R. McKain
    • , Ronald D. Smith
    • , Scott J. Teresi
    • , Andrew D. L. Nelson
    • , Ching Man Wai
    • , Elizabeth I. Alger
    • , Kevin A. Bird
    • , Alan E. Yocca
    • , Nathan Pumplin
    • , Shujun Ou
    • , Gil Ben-Zvi
    • , Avital Brodt
    • , Kobi Baruch
    • , Thomas Swale
    • , Lily Shiue
    • , Charlotte B. Acharya
    • , Glenn S. Cole
    • , Jeffrey P. Mower
    • , Kevin L. Childs
    • , Ning Jiang
    • , Eric Lyons
    • , Michael Freeling
    • , Joshua R. Puzey
    •  & Steven J. Knapp
  • Article |

    A genome-wide association study in more than 400,000 individuals identifies 139 new signals for lung function. These variants can predict chronic obstructive pulmonary disease in independent, transancestral cohorts.

    • Nick Shrine
    • , Anna L. Guyatt
    • , A. Mesut Erzurumluoglu
    • , Victoria E. Jackson
    • , Brian D. Hobbs
    • , Carl A. Melbourne
    • , Chiara Batini
    • , Katherine A. Fawcett
    • , Kijoung Song
    • , Phuwanat Sakornsakolpat
    • , Xingnan Li
    • , Ruth Boxall
    • , Nicola F. Reeve
    • , Ma’en Obeidat
    • , Jing Hua Zhao
    • , Matthias Wielscher
    • , Stefan Weiss
    • , Katherine A. Kentistou
    • , James P. Cook
    • , Benjamin B. Sun
    • , Jian Zhou
    • , Jennie Hui
    • , Stefan Karrasch
    • , Medea Imboden
    • , Sarah E Harris
    • , Jonathan Marten
    • , Stefan Enroth
    • , Shona M. Kerr
    • , Ida Surakka
    • , Veronique Vitart
    • , Terho Lehtimäki
    • , Richard J. Allen
    • , Per S. Bakke
    • , Terri H. Beaty
    • , Eugene R. Bleecker
    • , Yohan Bossé
    • , Corry-Anke Brandsma
    • , Zhengming Chen
    • , James D. Crapo
    • , John Danesh
    • , Dawn L. DeMeo
    • , Frank Dudbridge
    • , Ralf Ewert
    • , Christian Gieger
    • , Amund Gulsvik
    • , Anna L. Hansell
    • , Ke Hao
    • , Joshua D. Hoffman
    • , John E. Hokanson
    • , Georg Homuth
    • , Peter K. Joshi
    • , Philippe Joubert
    • , Claudia Langenberg
    • , Xuan Li
    • , Liming Li
    • , Kuang Lin
    • , Lars Lind
    • , Nicholas Locantore
    • , Jian’an Luan
    • , Anubha Mahajan
    • , Joseph C. Maranville
    • , Alison Murray
    • , David C. Nickle
    • , Richard Packer
    • , Margaret M. Parker
    • , Megan L. Paynton
    • , David J. Porteous
    • , Dmitry Prokopenko
    • , Dandi Qiao
    • , Rajesh Rawal
    • , Heiko Runz
    • , Ian Sayers
    • , Don D Sin
    • , Blair H Smith
    • , María Soler Artigas
    • , David Sparrow
    • , Ruth Tal-Singer
    • , Paul R. H. J. Timmers
    • , Maarten Van den Berge
    • , John C. Whittaker
    • , Prescott G. Woodruff
    • , Laura M. Yerges-Armstrong
    • , Olga G. Troyanskaya
    • , Olli T. Raitakari
    • , Mika Kähönen
    • , Ozren Polašek
    • , Ulf Gyllensten
    • , Igor Rudan
    • , Ian J. Deary
    • , Nicole M. Probst-Hensch
    • , Holger Schulz
    • , Alan L James
    • , James F. Wilson
    • , Beate Stubbe
    • , Eleftheria Zeggini
    • , Marjo-Riitta Jarvelin
    • , Nick Wareham
    • , Edwin K. Silverman
    • , Caroline Hayward
    • , Andrew P. Morris
    • , Adam S. Butterworth
    • , Robert A. Scott
    • , Robin G. Walters
    • , Deborah A. Meyers
    • , Michael H. Cho
    • , David P. Strachan
    • , Ian P. Hall
    • , Martin D. Tobin
    •  & Louise V. Wain
  • Article |

    A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

    • Jakob Grove
    • , Stephan Ripke
    • , Thomas D. Als
    • , Manuel Mattheisen
    • , Raymond K. Walters
    • , Hyejung Won
    • , Jonatan Pallesen
    • , Esben Agerbo
    • , Ole A. Andreassen
    • , Richard Anney
    • , Swapnil Awashti
    • , Rich Belliveau
    • , Francesco Bettella
    • , Joseph D. Buxbaum
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Felecia Cerrato
    • , Kimberly Chambert
    • , Jane H. Christensen
    • , Claire Churchhouse
    • , Karin Dellenvall
    • , Ditte Demontis
    • , Silvia De Rubeis
    • , Bernie Devlin
    • , Srdjan Djurovic
    • , Ashley L. Dumont
    • , Jacqueline I. Goldstein
    • , Christine S. Hansen
    • , Mads Engel Hauberg
    • , Mads V. Hollegaard
    • , Sigrun Hope
    • , Daniel P. Howrigan
    • , Hailiang Huang
    • , Christina M. Hultman
    • , Lambertus Klei
    • , Julian Maller
    • , Joanna Martin
    • , Alicia R. Martin
    • , Jennifer L. Moran
    • , Mette Nyegaard
    • , Terje Nærland
    • , Duncan S. Palmer
    • , Aarno Palotie
    • , Carsten Bøcker Pedersen
    • , Marianne Giørtz Pedersen
    • , Timothy dPoterba
    • , Jesper Buchhave Poulsen
    • , Beate St Pourcain
    • , Per Qvist
    • , Karola Rehnström
    • , Abraham Reichenberg
    • , Jennifer Reichert
    • , Elise B. Robinson
    • , Kathryn Roeder
    • , Panos Roussos
    • , Evald Saemundsen
    • , Sven Sandin
    • , F. Kyle Satterstrom
    • , George Davey Smith
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Christine R. Stevens
    • , Patrick F. Sullivan
    • , Patrick Turley
    • , G. Bragi Walters
    • , Xinyi Xu
    • , Naomi R. Wray
    • , Maciej Trzaskowski
    • , Enda M. Byrne
    • , Abdel Abdellaoui
    • , Mark J. Adams
    • , Tracy M. Air
    • , Till F. M. Andlauer
    • , Silviu-Alin Bacanu
    • , Aartjan T. F. Beekman
    • , Tim B. Bigdeli
    • , Elisabeth B. Binder
    • , Douglas H. R. Blackwood
    • , Julien Bryois
    • , Henriette N. Buttenschøn
    • , Na Cai
    • , Enrique Castelao
    • , Toni-Kim Clarke
    • , Jonathan R. I. Coleman
    • , Lucía Colodro-Conde
    • , Baptiste Couvy-Duchesne
    • , Nick Craddock
    • , Gregory E. Crawford
    • , Gail Davies
    • , Ian J. Deary
    • , Franziska Degenhardt
    • , Eske M. Derks
    • , Nese Direk
    • , Conor V. Dolan
    • , Erin C. Dunn
    • , Thalia C. Eley
    • , Valentina Escott-Price
    • , Farnush Farhadi Hassan Kiadeh
    • , Hilary K. Finucane
    • , Andreas J. Forstner
    • , Josef Frank
    • , Héléna A. Gaspar
    • , Michael Gill
    • , Fernando S. Goes
    • , Scott D. Gordon
    • , Lynsey S. Hall
    • , Thomas F. Hansen
    • , Stefan Herms
    • , Ian B. Hickie
    • , Per Hoffmann
    • , Georg Homuth
    • , Carsten Horn
    • , Jouke-Jan Hottenga
    • , Marcus Ising
    • , Rick Jansen
    • , Eric Jorgenson
    • , James A. Knowles
    • , Isaac S. Kohane
    • , Julia Kraft
    • , Warren W. Kretzschmar
    • , Jesper Krogh
    • , Zoltán Kutalik
    • , Yihan Li
    • , Penelope A. Lind
    • , Donald J. MacIntyre
    • , Dean F. MacKinnon
    • , Robert M. Maier
    • , Wolfgang Maier
    • , Jonathan Marchini
    • , Hamdi Mbarek
    • , Patrick McGrath
    • , Peter McGuffin
    • , Sarah E. Medland
    • , Divya Mehta
    • , Christel M. Middeldorp
    • , Evelin Mihailov
    • , Yuri Milaneschi
    • , Lili Milani
    • , Francis M. Mondimore
    • , Grant W. Montgomery
    • , Sara Mostafavi
    • , Niamh Mullins
    • , Matthias Nauck
    • , Bernard Ng
    • , Michel G. Nivard
    • , Dale R. Nyholt
    • , Paul F. O’Reilly
    • , Hogni Oskarsson
    • , Michael J. Owen
    • , Jodie N. Painter
    • , Roseann E. Peterson
    • , Erik Pettersson
    • , Wouter J. Peyrot
    • , Giorgio Pistis
    • , Danielle Posthuma
    • , Jorge A. Quiroz
    • , John P. Rice
    • , Brien P. Riley
    • , Margarita Rivera
    • , Saira Saeed Mirza
    • , Robert Schoevers
    • , Eva C. Schulte
    • , Ling Shen
    • , Jianxin Shi
    • , Stanley I. Shyn
    • , Engilbert Sigurdsson
    • , Grant C. B. Sinnamon
    • , Johannes H. Smit
    • , Daniel J. Smith
    • , Fabian Streit
    • , Jana Strohmaier
    • , Katherine E. Tansey
    • , Henning Teismann
    • , Alexander Teumer
    • , Wesley Thompson
    • , Pippa A. Thomson
    • , Thorgeir E. Thorgeirsson
    • , Matthew Traylor
    • , Jens Treutlein
    • , Vassily Trubetskoy
    • , André G. Uitterlinden
    • , Daniel Umbricht
    • , Sandra Van der Auwera
    • , Albert M. van Hemert
    • , Alexander Viktorin
    • , Peter M. Visscher
    • , Yunpeng Wang
    • , Bradley T. Webb
    • , Shantel Marie Weinsheimer
    • , Jürgen Wellmann
    • , Gonneke Willemsen
    • , Stephanie H. Witt
    • , Yang Wu
    • , Hualin S. Xi
    • , Jian Yang
    • , Futao Zhang
    • , Volker Arolt
    • , Bernhard T. Baune
    • , Klaus Berger
    • , Dorret I. Boomsma
    • , Sven Cichon
    • , Udo Dannlowski
    • , E. J. C. de Geus
    • , J. Raymond DePaulo
    • , Enrico Domenici
    • , Katharina Domschke
    • , Tõnu Esko
    • , Hans J. Grabe
    • , Steven P. Hamilton
    • , Caroline Hayward
    • , Andrew C. Heath
    • , Kenneth S. Kendler
    • , Stefan Kloiber
    • , Glyn Lewis
    • , Qingqin S. Li
    • , Susanne Lucae
    • , Pamela A. F. Madden
    • , Patrik K. Magnusson
    • , Nicholas G. Martin
    • , Andrew M. McIntosh
    • , Andres Metspalu
    • , Bertram Müller-Myhsok
    • , Markus M. Nöthen
    • , Michael C. O’Donovan
    • , Sara A. Paciga
    • , Nancy L. Pedersen
    • , Brenda W. J. H. Penninx
    • , Roy H. Perlis
    • , David J. Porteous
    • , James B. Potash
    • , Martin Preisig
    • , Marcella Rietschel
    • , Catherine Schaefer
    • , Thomas G. Schulze
    • , Jordan W. Smoller
    • , Henning Tiemeier
    • , Rudolf Uher
    • , Henry Völzke
    • , Myrna M. Weissman
    • , Cathryn M. Lewis
    • , Douglas F. Levinson
    • , Gerome Breen
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , Bethann S. Hromatka
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Kari Stefansson
    • , Daniel H. Geschwind
    • , Merete Nordentoft
    • , David M. Hougaard
    • , Thomas Werge
    • , Ole Mors
    • , Preben Bo Mortensen
    • , Benjamin M. Neale
    • , Mark J. Daly
    •  & Anders D. Børglum
  • Article |

    scRepli-seq measures DNA replication timing in single cells on the basis of copy number. Applying haplotype-resolved scRepli-seq to mESCs establishes basic principles of replication-timing conservation and heterogeneity among populations of cells.

    • Saori Takahashi
    • , Hisashi Miura
    • , Takahiro Shibata
    • , Koji Nagao
    • , Katsuzumi Okumura
    • , Masato Ogata
    • , Chikashi Obuse
    • , Shin-ichiro Takebayashi
    •  & Ichiro Hiratani
  • Letter |

    Genome-wide association analyses identify 57 loci associated with insomnia symptoms and provide evidence of shared genetic architecture between insomnia and cardiometabolic, behavioral, psychiatric and reproductive traits.

    • Jacqueline M. Lane
    • , Samuel E. Jones
    • , Hassan S. Dashti
    • , Andrew R. Wood
    • , Krishna G. Aragam
    • , Vincent T. van Hees
    • , Linn B. Strand
    • , Bendik S. Winsvold
    • , Heming Wang
    • , Jack Bowden
    • , Yanwei Song
    • , Krunal Patel
    • , Simon G. Anderson
    • , Robin N. Beaumont
    • , David A. Bechtold
    • , Brian E. Cade
    • , Mary Haas
    • , Sekar Kathiresan
    • , Max A. Little
    • , Annemarie I. Luik
    • , Andrew S. Loudon
    • , Shaun Purcell
    • , Rebecca C. Richmond
    • , Frank A. J. L. Scheer
    • , Barbara Schormair
    • , Jessica Tyrrell
    • , John W. Winkelman
    • , Juliane Winkelmann
    • , Amy E. Martinsen
    • , Anne H. Skogholt
    • , Ben Brumpton
    • , Bendik S. Winsvold
    • , Børge Sivertsen
    • , Cristen J. Willer
    • , Daniela Bragantini
    • , Håvard Kallestad
    • , Imre Janszky
    • , Ismail C. Guzey
    • , John-Anker Zwart
    • , Jonas B. Nielsen
    • , Kristian B. Nilsen
    • , Kristian Hveem
    • , Lars Fritsche
    • , Linda M. Pedersen
    • , Linn B. Strand
    • , Maiken E. Gabrielsen
    • , Marianne B. Johnsen
    • , Marie U. Lie
    • , Morten Engstrøm
    • , Trond Sand
    • , Wei Zhou
    • , Kristian Hveem
    • , Chen Zhao
    • , Jonas B. Nielsen
    • , Cristen J. Willer
    • , Susan Redline
    • , Kai Spiegelhalder
    • , Simon D. Kyle
    • , David W. Ray
    • , John-Anker Zwart
    • , Ben Brumpton
    • , Timothy M. Frayling
    • , Deborah A. Lawlor
    • , Martin K. Rutter
    • , Michael N. Weedon
    •  & Richa Saxena
  • Technical Report |

    UTMOST (unified test for molecular signatures) is a method for cross-tissue gene expression imputation for transcriptome-wide association analyses. Cross-tissue TWAS using UTMOST identifies new candidate genes for late-onset Alzheimer’s disease.

    • Yiming Hu
    • , Mo Li
    • , Qiongshi Lu
    • , Haoyi Weng
    • , Jiawei Wang
    • , Seyedeh M. Zekavat
    • , Zhaolong Yu
    • , Boyang Li
    • , Jianlei Gu
    • , Sydney Muchnik
    • , Yu Shi
    • , Brian W. Kunkle
    • , Shubhabrata Mukherjee
    • , Pradeep Natarajan
    • , Adam Naj
    • , Amanda Kuzma
    • , Yi Zhao
    • , Paul K. Crane
    • , Hui Lu
    •  & Hongyu Zhao
  • Article |

    Fate-mapping and clonal analysis show that bronchioalveolar stem cells (BASCs) become activated and respond distinctly to different lung injuries and differentiate into multiple cell types. Single-cell RNA-seq analysis identifies new BASC markers.

    • Qiaozhen Liu
    • , Kuo Liu
    • , Guizhong Cui
    • , Xiuzhen Huang
    • , Shun Yao
    • , Wenke Guo
    • , Zhen Qin
    • , Yan Li
    • , Rui Yang
    • , Wenjuan Pu
    • , Libo Zhang
    • , Lingjuan He
    • , Huan Zhao
    • , Wei Yu
    • , Muxue Tang
    • , Xueying Tian
    • , Dongqing Cai
    • , Yu Nie
    • , Shengshou Hu
    • , Tao Ren
    • , Zengyong Qiao
    • , Hefeng Huang
    • , Yi Arial Zeng
    • , Naihe Jing
    • , Guangdun Peng
    • , Hongbin Ji
    •  & Bin Zhou