Browse Articles

  • Article |

    A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • , Jonathan Marten
    • , Victoria L. Halperin Kuhns
    • , Yong Li
    • , Matthias Wuttke
    • , Holger Kirsten
    • , Karsten B. Sieber
    • , Chengxiang Qiu
    • , Mathias Gorski
    • , Zhi Yu
    • , Ayush Giri
    • , Gardar Sveinbjornsson
    • , Man Li
    • , Audrey Y. Chu
    • , Anselm Hoppmann
    • , Luke J. O’Connor
    • , Bram Prins
    • , Teresa Nutile
    • , Damia Noce
    • , Masato Akiyama
    • , Massimiliano Cocca
    • , Sahar Ghasemi
    • , Peter J. van der Most
    • , Katrin Horn
    • , Yizhe Xu
    • , Christian Fuchsberger
    • , Sanaz Sedaghat
    • , Saima Afaq
    • , Najaf Amin
    • , Johan Ärnlöv
    • , Stephan J. L. Bakker
    • , Nisha Bansal
    • , Daniela Baptista
    • , Sven Bergmann
    • , Mary L. Biggs
    • , Ginevra Biino
    • , Eric Boerwinkle
    • , Erwin P. Bottinger
    • , Thibaud S. Boutin
    • , Marco Brumat
    • , Ralph Burkhardt
    • , Eric Campana
    • , Archie Campbell
    • , Harry Campbell
    • , Robert J. Carroll
    • , Eulalia Catamo
    • , John C. Chambers
    • , Marina Ciullo
    • , Maria Pina Concas
    • , Josef Coresh
    • , Tanguy Corre
    • , Daniele Cusi
    • , Sala Cinzia Felicita
    • , Martin H. de Borst
    • , Alessandro De Grandi
    • , Renée de Mutsert
    • , Aiko P. J. de Vries
    • , Graciela Delgado
    • , Ayşe Demirkan
    • , Olivier Devuyst
    • , Katalin Dittrich
    • , Kai-Uwe Eckardt
    • , Georg Ehret
    • , Karlhans Endlich
    • , Michele K. Evans
    • , Ron T. Gansevoort
    • , Paolo Gasparini
    • , Vilmantas Giedraitis
    • , Christian Gieger
    • , Giorgia Girotto
    • , Martin Gögele
    • , Scott D. Gordon
    • , Daniel F. Gudbjartsson
    • , Vilmundur Gudnason
    • , Toomas Haller
    • , Pavel Hamet
    • , Tamara B. Harris
    • , Caroline Hayward
    • , Andrew A. Hicks
    • , Edith Hofer
    • , Hilma Holm
    • , Wei Huang
    • , Nina Hutri-Kähönen
    • , Shih-Jen Hwang
    • , M. Arfan Ikram
    • , Raychel M. Lewis
    • , Erik Ingelsson
    • , Johanna Jakobsdottir
    • , Ingileif Jonsdottir
    • , Helgi Jonsson
    • , Peter K. Joshi
    • , Navya Shilpa Josyula
    • , Bettina Jung
    • , Mika Kähönen
    • , Yoichiro Kamatani
    • , Masahiro Kanai
    • , Shona M. Kerr
    • , Wieland Kiess
    • , Marcus E. Kleber
    • , Wolfgang Koenig
    • , Jaspal S. Kooner
    • , Antje Körner
    • , Peter Kovacs
    • , Bernhard K. Krämer
    • , Florian Kronenberg
    • , Michiaki Kubo
    • , Brigitte Kühnel
    • , Martina La Bianca
    • , Leslie A. Lange
    • , Benjamin Lehne
    • , Terho Lehtimäki
    • , Jun Liu
    • , Markus Loeffler
    • , Ruth J. F. Loos
    • , Leo-Pekka Lyytikäinen
    • , Reedik Magi
    • , Anubha Mahajan
    • , Nicholas G. Martin
    • , Winfried März
    • , Deborah Mascalzoni
    • , Koichi Matsuda
    • , Christa Meisinger
    • , Thomas Meitinger
    • , Andres Metspalu
    • , Yuri Milaneschi
    • , Christopher J. O’Donnell
    • , Otis D. Wilson
    • , J. Michael Gaziano
    • , Pashupati P. Mishra
    • , Karen L. Mohlke
    • , Nina Mononen
    • , Grant W. Montgomery
    • , Dennis O. Mook-Kanamori
    • , Martina Müller-Nurasyid
    • , Girish N. Nadkarni
    • , Mike A. Nalls
    • , Matthias Nauck
    • , Kjell Nikus
    • , Boting Ning
    • , Ilja M. Nolte
    • , Raymond Noordam
    • , Jeffrey R. O’Connell
    • , Isleifur Olafsson
    • , Sandosh Padmanabhan
    • , Brenda W. J. H. Penninx
    • , Thomas Perls
    • , Annette Peters
    • , Mario Pirastu
    • , Nicola Pirastu
    • , Giorgio Pistis
    • , Ozren Polasek
    • , Belen Ponte
    • , David J. Porteous
    • , Tanja Poulain
    • , Michael H. Preuss
    • , Ton J. Rabelink
    • , Laura M. Raffield
    • , Olli T. Raitakari
    • , Rainer Rettig
    • , Myriam Rheinberger
    • , Kenneth M. Rice
    • , Federica Rizzi
    • , Antonietta Robino
    • , Igor Rudan
    • , Alena Krajcoviechova
    • , Renata Cifkova
    • , Rico Rueedi
    • , Daniela Ruggiero
    • , Kathleen A. Ryan
    • , Yasaman Saba
    • , Erika Salvi
    • , Helena Schmidt
    • , Reinhold Schmidt
    • , Christian M. Shaffer
    • , Albert V. Smith
    • , Blair H. Smith
    • , Cassandra N. Spracklen
    • , Konstantin Strauch
    • , Michael Stumvoll
    • , Patrick Sulem
    • , Salman M. Tajuddin
    • , Andrej Teren
    • , Joachim Thiery
    • , Chris H. L. Thio
    • , Unnur Thorsteinsdottir
    • , Daniela Toniolo
    • , Anke Tönjes
    • , Johanne Tremblay
    • , André G. Uitterlinden
    • , Simona Vaccargiu
    • , Pim van der Harst
    • , Cornelia M. van Duijn
    • , Niek Verweij
    • , Uwe Völker
    • , Peter Vollenweider
    • , Gerard Waeber
    • , Melanie Waldenberger
    • , John B. Whitfield
    • , Sarah H. Wild
    • , James F. Wilson
    • , Qiong Yang
    • , Weihua Zhang
    • , Alan B. Zonderman
    • , Murielle Bochud
    • , James G. Wilson
    • , Sarah A. Pendergrass
    • , Kevin Ho
    • , Afshin Parsa
    • , Peter P. Pramstaller
    • , Bruce M. Psaty
    • , Carsten A. Böger
    • , Harold Snieder
    • , Adam S. Butterworth
    • , Yukinori Okada
    • , Todd L. Edwards
    • , Kari Stefansson
    • , Katalin Susztak
    • , Markus Scholz
    • , Iris M. Heid
    • , Adriana M. Hung
    • , Alexander Teumer
    • , Cristian Pattaro
    • , Owen M. Woodward
    • , Veronique Vitart
    •  & Anna Köttgen
  • Brief Communication |

    Postzygotic inactivating mutations in RHOA cause a mosaic neuroectodermal syndrome characterized by linear hypopigmentation, leukoencephalopathy and craniofacial anomalies, highlighting the role of RHOA in human development and disease.

    • Pierre Vabres
    • , Arthur Sorlin
    • , Stanislav S. Kholmanskikh
    • , Bénédicte Demeer
    • , Judith St-Onge
    • , Yannis Duffourd
    • , Paul Kuentz
    • , Jean-Benoît Courcet
    • , Virginie Carmignac
    • , Philippine Garret
    • , Didier Bessis
    • , Odile Boute
    • , Alain Bron
    • , Guillaume Captier
    • , Esther Carmi
    • , Bernard Devauchelle
    • , David Geneviève
    • , Catherine Gondry-Jouet
    • , Laurent Guibaud
    • , Arnaud Lafon
    • , Michèle Mathieu-Dramard
    • , Julien Thevenon
    • , William B. Dobyns
    • , Geneviève Bernard
    • , Satyamaanasa Polubothu
    • , Francesca Faravelli
    • , Veronica A. Kinsler
    • , Christel Thauvin
    • , Laurence Faivre
    • , M. Elizabeth Ross
    •  & Jean-Baptiste Rivière
  • Article
    | Open Access

    Analysis of the bracteatus pineapple genome provides insight into fiber production, color formation, sugar accumulation and fruit maturation. Resequencing of 89 Ananas genomes supports the coexistence of sexual recombination and a ‘one-step operation’ during domestication.

    • Li-Yu Chen
    • , Robert VanBuren
    • , Margot Paris
    • , Hongye Zhou
    • , Xingtan Zhang
    • , Ching Man Wai
    • , Hansong Yan
    • , Shuai Chen
    • , Michael Alonge
    • , Srividya Ramakrishnan
    • , Zhenyang Liao
    • , Juan Liu
    • , Jishan Lin
    • , Jingjing Yue
    • , Mahpara Fatima
    • , Zhicong Lin
    • , Jisen Zhang
    • , Lixian Huang
    • , Hao Wang
    • , Teh-Yang Hwa
    • , Shu-Min Kao
    • , Jae Young Choi
    • , Anupma Sharma
    • , Jian Song
    • , Lulu Wang
    • , Won C. Yim
    • , John C. Cushman
    • , Robert E. Paull
    • , Tracie Matsumoto
    • , Yuan Qin
    • , Qingsong Wu
    • , Jianping Wang
    • , Qingyi Yu
    • , Jun Wu
    • , Shaoling Zhang
    • , Peter Boches
    • , Chih-Wei Tung
    • , Ming-Li Wang
    • , Geo Coppens d’Eeckenbrugge
    • , Garth M. Sanewski
    • , Michael D. Purugganan
    • , Michael C. Schatz
    • , Jeffrey L. Bennetzen
    • , Christian Lexer
    •  & Ray Ming
  • Article |

    Natural variation of the F-box protein ZmFBL41 in maize confers resistance to Rhizoctonia solani, the causal fungus for banded leaf and sheath blight in maize, through decreased interaction of ZmFBL41 with the cinnamyl alcohol dehydrogenase ZmCAD.

    • Ning Li
    • , Bao Lin
    • , Hong Wang
    • , Xiaoming Li
    • , Fangfang Yang
    • , Xinhua Ding
    • , Jianbing Yan
    •  & Zhaohui Chu
  • Article |

    Analysis of iPSC-derived cardiomyocytes identifies variants associated with allele-specific effects on NKX2-5 binding. Fine-mapping and functional studies suggest that such variants underlie cardiac-specific expression quantitative trait loci and associations with electrocardiographic traits.

    • Paola Benaglio
    • , Agnieszka D’Antonio-Chronowska
    • , Wubin Ma
    • , Feng Yang
    • , William W. Young Greenwald
    • , Margaret K. R. Donovan
    • , Christopher DeBoever
    • , He Li
    • , Frauke Drees
    • , Sanghamitra Singhal
    • , Hiroko Matsui
    • , Jessica van Setten
    • , Nona Sotoodehnia
    • , Kyle J. Gaulton
    • , Erin N. Smith
    • , Matteo D’Antonio
    • , Michael G. Rosenfeld
    •  & Kelly A. Frazer
  • News & Views |

    A new study identifies germline NPM1 mutations in people with dyskeratosis congenita. These NPM1 mutations inhibit ribosomal RNA 2´-O-methylation by decreasing the binding of the rRNA methyltransferase FBL to small nucleolar RNAs. Thus, NPM1 influences ribosomal functions via epitranscriptomic regulation.

    • Fengbiao Zhou
    •  & Carsten Müller-Tidow
  • Article |

    Whole-genome sequencing of metastatic biopsies from 442 patients with breast cancer provides insights into metastatic disease, including associations of genomic features with prior treatments and identification of therapeutic vulnerabilities.

    • Lindsay Angus
    • , Marcel Smid
    • , Saskia M. Wilting
    • , Job van Riet
    • , Arne Van Hoeck
    • , Luan Nguyen
    • , Serena Nik-Zainal
    • , Tessa G. Steenbruggen
    • , Vivianne C. G. Tjan-Heijnen
    • , Mariette Labots
    • , Johanna M. G. H. van Riel
    • , Haiko J. Bloemendal
    • , Neeltje Steeghs
    • , Martijn P. Lolkema
    • , Emile E. Voest
    • , Harmen J. G. van de Werken
    • , Agnes Jager
    • , Edwin Cuppen
    • , Stefan Sleijfer
    •  & John W. M. Martens
  • Article |

    Analysis of gene expression and open chromatin regions in up to 32 immune cell populations under resting and stimulated conditions identifies widespread chromatin remodeling and shared response elements between stimulated B and T cells.

    • Diego Calderon
    • , Michelle L. T. Nguyen
    • , Anja Mezger
    • , Arwa Kathiria
    • , Fabian Müller
    • , Vinh Nguyen
    • , Ninnia Lescano
    • , Beijing Wu
    • , John Trombetta
    • , Jessica V. Ribado
    • , David A. Knowles
    • , Ziyue Gao
    • , Franziska Blaeschke
    • , Audrey V. Parent
    • , Trevor D. Burt
    • , Mark S. Anderson
    • , Lindsey A. Criswell
    • , William J. Greenleaf
    • , Alexander Marson
    •  & Jonathan K. Pritchard
  • Editorial |

    Understanding how to biologically interpret the loci identified in genome-wide association studies is a major goal of current genetics research. To achieve this goal, we need to understand where, when and how relevant genes are expressed in specific contexts, in order to explore the mechanistic links between genetic associations and diseases or complex traits.

  • Article |

    NPM1 regulates ribosomal RNA 2′-O-methylation by binding to small nucleolar RNAs, thereby modulating translation. NPM1 mutations lead to altered 2′-O-methylation and impaired ribosomal function, resulting in bone marrow failure and leukemia susceptibility.

    • Daphna Nachmani
    • , Anne H. Bothmer
    • , Silvia Grisendi
    • , Aldo Mele
    • , Dietmar Bothmer
    • , Jonathan D. Lee
    • , Emanuele Monteleone
    • , Ke Cheng
    • , Yang Zhang
    • , Assaf C. Bester
    • , Alison Guzzetti
    • , Caitlin A. Mitchell
    • , Lourdes M. Mendez
    • , Olga Pozdnyakova
    • , Paolo Sportoletti
    • , Maria-Paola Martelli
    • , Tom J. Vulliamy
    • , Modi Safra
    • , Schraga Schwartz
    • , Lucio Luzzatto
    • , Olivier Bluteau
    • , Jean Soulier
    • , Robert B. Darnell
    • , Brunangelo Falini
    • , Inderjeet Dokal
    • , Keisuke Ito
    • , John G. Clohessy
    •  & Pier Paolo Pandolfi
  • Comment |

    To increase the utility of Gene Ontology (GO) annotations for interpretation of genome-wide experimental data, we have developed GO-CAM, a structured framework for linking multiple GO annotations into an integrated model of a biological system. We expect that GO-CAM will enable new applications in pathway and network analysis, as well as improve standard GO annotations for traditional GO-based applications.

    • Paul D. Thomas
    • , David P. Hill
    • , Huaiyu Mi
    • , David Osumi-Sutherland
    • , Kimberly Van Auken
    • , Seth Carbon
    • , James P. Balhoff
    • , Laurent-Philippe Albou
    • , Benjamin Good
    • , Pascale Gaudet
    • , Suzanna E. Lewis
    •  & Christopher J. Mungall
  • Article |

    Integration of immune-disease GWAS variants with open chromatin and enhancer profiling in T cells and macrophages stimulated with different cytokines and analyzed at different time points reveals cell-state-specific enrichments for 12 complex diseases.

    • Blagoje Soskic
    • , Eddie Cano-Gamez
    • , Deborah J. Smyth
    • , Wendy C. Rowan
    • , Nikolina Nakic
    • , Jorge Esparza-Gordillo
    • , Lara Bossini-Castillo
    • , David F. Tough
    • , Christopher G. C. Larminie
    • , Paola G. Bronson
    • , David Willé
    •  & Gosia Trynka
  • Correspondence |

    • Mariano J. Alvarez
    • , Pengrong Yan
    • , Mary L. Alpaugh
    • , Michaela Bowden
    • , Ewa Sicinska
    • , Chensheng W. Zhou
    • , Charles Karan
    • , Ronald B. Realubit
    • , Prabhjot S. Mundi
    • , Adina Grunn
    • , Dirk Jäger
    • , John A. Chabot
    • , Antonio T. Fojo
    • , Paul E. Oberstein
    • , Hanina Hibshoosh
    • , Jeffrey W. Milsom
    • , Matthew H. Kulke
    • , Massimo Loda
    • , Gabriela Chiosis
    • , Diane L. Reidy-Lagunes
    •  & Andrea Califano
  • Article |

    Large-scale genomic analyses in wheat identify regions associated with 50 agronomic traits evaluated in South Asia, Africa and the Americas. This genotype–phenotype map can be used to enhance wheat productivity and stress resilience.

    • Philomin Juliana
    • , Jesse Poland
    • , Julio Huerta-Espino
    • , Sandesh Shrestha
    • , José Crossa
    • , Leonardo Crespo-Herrera
    • , Fernando Henrique Toledo
    • , Velu Govindan
    • , Suchismita Mondal
    • , Uttam Kumar
    • , Sridhar Bhavani
    • , Pawan K. Singh
    • , Mandeep S. Randhawa
    • , Xinyao He
    • , Carlos Guzman
    • , Susanne Dreisigacker
    • , Matthew N. Rouse
    • , Yue Jin
    • , Paulino Pérez-Rodríguez
    • , Osval A. Montesinos-López
    • , Daljit Singh
    • , Mohammad Mokhlesur Rahman
    • , Felix Marza
    •  & Ravi Prakash Singh
  • Article |

    Combinatorial perturbation of schizophrenia risk loci in human induced pluripotent stem cell–derived neuronal cells demonstrates a synergistic effect converging on synaptic function.

    • Nadine Schrode
    • , Seok-Man Ho
    • , Kazuhiko Yamamuro
    • , Amanda Dobbyn
    • , Laura Huckins
    • , Marliette R. Matos
    • , Esther Cheng
    • , P. J. Michael Deans
    • , Erin Flaherty
    • , Natalie Barretto
    • , Aaron Topol
    • , Khaled Alganem
    • , Sonya Abadali
    • , James Gregory
    • , Emily Hoelzli
    • , Hemali Phatnani
    • , Vineeta Singh
    • , Deeptha Girish
    • , Bruce Aronow
    • , Robert Mccullumsmith
    • , Gabriel E. Hoffman
    • , Eli A. Stahl
    • , Hirofumi Morishita
    • , Pamela Sklar
    •  & Kristen J. Brennand
  • News & Views |

    Common genetic variants increase the risk of schizophrenia, but the downstream biological mechanisms are largely unknown. A new study demonstrates that schizophrenia risk genes cause neuronal dysfunction and have synergistic effects on gene expression.

    • Jane H. Christensen
    •  & Anders D. Børglum
  • Letter |

    Mapping long-range chromatin interactions in 27 human cell/tissue types identifies candidate target genes of 70,329 putative regulatory elements. Further analysis suggests potential regulatory function for 27,325 noncoding variants associated with 2,117 traits and diseases.

    • Inkyung Jung
    • , Anthony Schmitt
    • , Yarui Diao
    • , Andrew J. Lee
    • , Tristin Liu
    • , Dongchan Yang
    • , Catherine Tan
    • , Junghyun Eom
    • , Marilynn Chan
    • , Sora Chee
    • , Zachary Chiang
    • , Changyoun Kim
    • , Eliezer Masliah
    • , Cathy L. Barr
    • , Bin Li
    • , Samantha Kuan
    • , Dongsup Kim
    •  & Bing Ren
  • Article
    | Open Access

    The first annotated chromosome-level reference genome assembly for pea, Gregor Mendel’s original genetic model, provides insights into legume genome evolution and the molecular basis of agricultural traits for pea improvement.

    • Jonathan Kreplak
    • , Mohammed-Amin Madoui
    • , Petr Cápal
    • , Petr Novák
    • , Karine Labadie
    • , Grégoire Aubert
    • , Philipp E. Bayer
    • , Krishna K. Gali
    • , Robert A. Syme
    • , Dorrie Main
    • , Anthony Klein
    • , Aurélie Bérard
    • , Iva Vrbová
    • , Cyril Fournier
    • , Leo d’Agata
    • , Caroline Belser
    • , Wahiba Berrabah
    • , Helena Toegelová
    • , Zbyněk Milec
    • , Jan Vrána
    • , HueyTyng Lee
    • , Ayité Kougbeadjo
    • , Morgane Térézol
    • , Cécile Huneau
    • , Chala J. Turo
    • , Nacer Mohellibi
    • , Pavel Neumann
    • , Matthieu Falque
    • , Karine Gallardo
    • , Rebecca McGee
    • , Bunyamin Tar’an
    • , Abdelhafid Bendahmane
    • , Jean-Marc Aury
    • , Jacqueline Batley
    • , Marie-Christine Le Paslier
    • , Noel Ellis
    • , Thomas D. Warkentin
    • , Clarice J. Coyne
    • , Jérome Salse
    • , David Edwards
    • , Judith Lichtenzveig
    • , Jiří Macas
    • , Jaroslav Doležel
    • , Patrick Wincker
    •  & Judith Burstin
  • News & Views |

    Inferring adaptation, migration and population history would be profoundly easier if we could use the genomes that we sequence to infer the true genealogical history of each locus. Two new papers bring us close to achieving this goal.

    • Kelley Harris
  • Article |

    A new method for inferring genealogical histories from large-scale genetic data is used to characterize population structure using data from the 1000 Genomes Project, the UK Biobank and the Simons Genome Diversity Project.

    • Jerome Kelleher
    • , Yan Wong
    • , Anthony W. Wohns
    • , Chaimaa Fadil
    • , Patrick K. Albers
    •  & Gil McVean
  • Editorial |

    The genome of the model genetic organism Pisum sativum, or pea plant, links nineteenth-century genetics to twenty-first-century genomics, serving as a symbol of how far the genetics field has developed and how greatly technologies have advanced. Almost every student’s introduction to genetics currently involves learning Mendel’s laws; we envision that genomics and genome sequencing will become just as foundational in the education of future geneticists.

  • Article |

    An approach to estimate the contribution of all alleles to phenotypic variation is applied to transcription regulation using whole-genome sequencing and transcriptome data. Ultrarare variants contribute approximately 46% of cis heritability across genes.

    • Ryan D. Hernandez
    • , Lawrence H. Uricchio
    • , Kevin Hartman
    • , Chun Ye
    • , Andrew Dahl
    •  & Noah Zaitlen
  • Article |

    A new technique called NET-CAGE identifies 5′ ends of nascent RNAs with high sensitivity, including enhancer-derived RNAs. This approach shows that enhancer–promoter pairs are generally activated simultaneously.

    • Shigeki Hirabayashi
    • , Shruti Bhagat
    • , Yu Matsuki
    • , Yujiro Takegami
    • , Takuya Uehata
    • , Ai Kanemaru
    • , Masayoshi Itoh
    • , Kotaro Shirakawa
    • , Akifumi Takaori-Kondo
    • , Osamu Takeuchi
    • , Piero Carninci
    • , Shintaro Katayama
    • , Yoshihide Hayashizaki
    • , Juha Kere
    • , Hideya Kawaji
    •  & Yasuhiro Murakawa
  • Article |

    Genetic deletion or transcriptional silencing of HERV-H elements in human pluripotent stem cells (hPSCs) eliminates nearby topologically associating domain boundaries, while de novo insertion of HERV-H elements can introduce new ones. Mutations of specific HERV-H elements can impact hPSC differentiation.

    • Yanxiao Zhang
    • , Ting Li
    • , Sebastian Preissl
    • , Maria Luisa Amaral
    • , Jonathan D. Grinstein
    • , Elie N. Farah
    • , Eugin Destici
    • , Yunjiang Qiu
    • , Rong Hu
    • , Ah Young Lee
    • , Sora Chee
    • , Kaiyue Ma
    • , Zhen Ye
    • , Quan Zhu
    • , Hui Huang
    • , Rongxin Fang
    • , Leqian Yu
    • , Juan Carlos Izpisua Belmonte
    • , Jun Wu
    • , Sylvia M. Evans
    • , Neil C. Chi
    •  & Bing Ren
  • Article |

    The authors generate cell lines deficient for 22 BAF subunits, studying effects on complex composition, chromatin accessibility and gene expression. They identify synthetic lethal interactions between SMARCA4–ARID2, SMARCA4–ACTB and SMARCC1–SMARCC2.

    • Sandra Schick
    • , André F. Rendeiro
    • , Kathrin Runggatscher
    • , Anna Ringler
    • , Bernd Boidol
    • , Melanie Hinkel
    • , Peter Májek
    • , Loan Vulliard
    • , Thomas Penz
    • , Katja Parapatics
    • , Christian Schmidl
    • , Jörg Menche
    • , Guido Boehmelt
    • , Mark Petronczki
    • , André C. Müller
    • , Christoph Bock
    •  & Stefan Kubicek
  • Article |

    Systematic analyses of large-scale genome-wide association data provide an overview of pleiotropy and genetic architecture for hundreds of human complex traits and diseases.

    • Kyoko Watanabe
    • , Sven Stringer
    • , Oleksandr Frei
    • , Maša Umićević Mirkov
    • , Christiaan de Leeuw
    • , Tinca J. C. Polderman
    • , Sophie van der Sluis
    • , Ole A. Andreassen
    • , Benjamin M. Neale
    •  & Danielle Posthuma
  • News & Views |

    Far from being junk DNA, the pervasive retrotransposons that populate the genome have a powerful capacity to influence genes and chromatin. A new study demonstrates how the transcription of one such element, HERV-H, can modify the higher-order 3D structure of chromatin during early primate development.

    • Michael I. Robson
    •  & Stefan Mundlos
  • Author Correction |

    • Brian W. Kunkle
    • , Benjamin Grenier-Boley
    • , Rebecca Sims
    • , Joshua C. Bis
    • , Vincent Damotte
    • , Adam C. Naj
    • , Anne Boland
    • , Maria Vronskaya
    • , Sven J. van der Lee
    • , Alexandre Amlie-Wolf
    • , Céline Bellenguez
    • , Aura Frizatti
    • , Vincent Chouraki
    • , Eden R. Martin
    • , Kristel Sleegers
    • , Nandini Badarinarayan
    • , Johanna Jakobsdottir
    • , Kara L. Hamilton-Nelson
    • , Sonia Moreno-Grau
    • , Robert Olaso
    • , Rachel Raybould
    • , Yuning Chen
    • , Amanda B. Kuzma
    • , Mikko Hiltunen
    • , Taniesha Morgan
    • , Shahzad Ahmad
    • , Badri N. Vardarajan
    • , Jacques Epelbaum
    • , Per Hoffmann
    • , Merce Boada
    • , Gary W. Beecham
    • , Jean-Guillaume Garnier
    • , Denise Harold
    • , Annette L. Fitzpatrick
    • , Otto Valladares
    • , Marie-Laure Moutet
    • , Amy Gerrish
    • , Albert V. Smith
    • , Liming Qu
    • , Delphine Bacq
    • , Nicola Denning
    • , Xueqiu Jian
    • , Yi Zhao
    • , Maria Del Zompo
    • , Nick C. Fox
    • , Seung-Hoan Choi
    • , Ignacio Mateo
    • , Joseph T. Hughes
    • , Hieab H. Adams
    • , John Malamon
    • , Florentino Sanchez-Garcia
    • , Yogen Patel
    • , Jennifer A. Brody
    • , Beth A. Dombroski
    • , Maria Candida Deniz Naranjo
    • , Makrina Daniilidou
    • , Gudny Eiriksdottir
    • , Shubhabrata Mukherjee
    • , David Wallon
    • , James Uphill
    • , Thor Aspelund
    • , Laura B. Cantwell
    • , Fabienne Garzia
    • , Daniela Galimberti
    • , Edith Hofer
    • , Mariusz Butkiewicz
    • , Bertrand Fin
    • , Elio Scarpini
    • , Chloe Sarnowski
    • , Will S. Bush
    • , Stéphane Meslage
    • , Johannes Kornhuber
    • , Charles C. White
    • , Yuenjoo Song
    • , Robert C. Barber
    • , Sebastiaan Engelborghs
    • , Sabrina Sordon
    • , Dina Voijnovic
    • , Perrie M. Adams
    • , Rik Vandenberghe
    • , Manuel Mayhaus
    • , L. Adrienne Cupples
    • , Marilyn S. Albert
    • , Peter P. De Deyn
    • , Wei Gu
    • , Jayanadra J. Himali
    • , Duane Beekly
    • , Alessio Squassina
    • , Annette M. Hartmann
    • , Adelina Orellana
    • , Deborah Blacker
    • , Eloy Rodriguez-Rodriguez
    • , Simon Lovestone
    • , Melissa E. Garcia
    • , Rachelle S. Doody
    • , Carmen Munoz-Fernadez
    • , Rebecca Sussams
    • , Honghuang Lin
    • , Thomas J. Fairchild
    • , Yolanda A. Benito
    • , Clive Holmes
    • , Hata Karamujić-Čomić
    • , Matthew P. Frosch
    • , Hakan Thonberg
    • , Wolfgang Maier
    • , Gennady Roshchupkin
    • , Bernardino Ghetti
    • , Vilmantas Giedraitis
    • , Amit Kawalia
    • , Shuo Li
    • , Ryan M. Huebinger
    • , Lena Kilander
    • , Susanne Moebus
    • , Isabel Hernández
    • , M. Ilyas Kamboh
    • , RoseMarie Brundin
    • , James Turton
    • , Qiong Yang
    • , Mindy J. Katz
    • , Letizia Concari
    • , Jenny Lord
    • , Alexa S. Beiser
    • , C. Dirk Keene
    • , Seppo Helisalmi
    • , Iwona Kloszewska
    • , Walter A. Kukull
    • , Anne Maria Koivisto
    • , Aoibhinn Lynch
    • , Lluís Tarraga
    • , Eric B. Larson
    • , Annakaisa Haapasalo
    • , Brian Lawlor
    • , Thomas H. Mosley
    • , Richard B. Lipton
    • , Vincenzo Solfrizzi
    • , Michael Gill
    • , W. T. Longstreth Jr
    • , Thomas J. Montine
    • , Vincenza Frisardi
    • , Monica Diez-Fairen
    • , Fernando Rivadeneira
    • , Ronald C. Petersen
    • , Vincent Deramecourt
    • , Ignacio Alvarez
    • , Francesca Salani
    • , Antonio Ciaramella
    • , Eric Boerwinkle
    • , Eric M. Reiman
    • , Nathalie Fievet
    • , Jerome I. Rotter
    • , Joan S. Reisch
    • , Olivier Hanon
    • , Chiara Cupidi
    • , A. G. Andre Uitterlinden
    • , Donald R. Royall
    • , Carole Dufouil
    • , Raffaele Giovanni Maletta
    • , Itziar de Rojas
    • , Mary Sano
    • , Alexis Brice
    • , Roberta Cecchetti
    • , Peter St George-Hyslop
    • , Karen Ritchie
    • , Magda Tsolaki
    • , Debby W. Tsuang
    • , Bruno Dubois
    • , David Craig
    • , Chuang-Kuo Wu
    • , Hilkka Soininen
    • , Despoina Avramidou
    • , Roger L. Albin
    • , Laura Fratiglioni
    • , Antonia Germanou
    • , Liana G. Apostolova
    • , Lina Keller
    • , Maria Koutroumani
    • , Steven E. Arnold
    • , Francesco Panza
    • , Olymbia Gkatzima
    • , Sanjay Asthana
    • , Didier Hannequin
    • , Patrice Whitehead
    • , Craig S. Atwood
    • , Paolo Caffarra
    • , Harald Hampel
    • , Inés Quintela
    • , Ángel Carracedo
    • , Lars Lannfelt
    • , David C. Rubinsztein
    • , Lisa L. Barnes
    • , Florence Pasquier
    • , Lutz Frölich
    • , Sandra Barral
    • , Bernadette McGuinness
    • , Thomas G. Beach
    • , Janet A. Johnston
    • , James T. Becker
    • , Peter Passmore
    • , Eileen H. Bigio
    • , Jonathan M. Schott
    • , Thomas D. Bird
    • , Jason D. Warren
    • , Bradley F. Boeve
    • , Michelle K. Lupton
    • , James D. Bowen
    • , Petra Proitsi
    • , Adam Boxer
    • , John F. Powell
    • , James R. Burke
    • , John S. K. Kauwe
    • , Jeffrey M. Burns
    • , Michelangelo Mancuso
    • , Joseph D. Buxbaum
    • , Ubaldo Bonuccelli
    • , Nigel J. Cairns
    • , Andrew McQuillin
    • , Chuanhai Cao
    • , Gill Livingston
    • , Chris S. Carlson
    • , Nicholas J. Bass
    • , Cynthia M. Carlsson
    • , John Hardy
    • , Regina M. Carney
    • , Jose Bras
    • , Minerva M. Carrasquillo
    • , Rita Guerreiro
    • , Mariet Allen
    • , Helena C. Chui
    • , Elizabeth Fisher
    • , Carlo Masullo
    • , Elizabeth A. Crocco
    • , Charles DeCarli
    • , Gina Bisceglio
    • , Malcolm Dick
    • , Li Ma
    • , Ranjan Duara
    • , Neill R. Graff-Radford
    • , Denis A. Evans
    • , Angela Hodges
    • , Kelley M. Faber
    • , Martin Scherer
    • , Kenneth B. Fallon
    • , Matthias Riemenschneider
    • , David W. Fardo
    • , Reinhard Heun
    • , Martin R. Farlow
    • , Heike Kölsch
    • , Steven Ferris
    • , Markus Leber
    • , Tatiana M. Foroud
    • , Isabella Heuser
    • , Douglas R. Galasko
    • , Ina Giegling
    • , Marla Gearing
    • , Michael Hüll
    • , Daniel H. Geschwind
    • , John R. Gilbert
    • , John Morris
    • , Robert C. Green
    • , Kevin Mayo
    • , John H. Growdon
    • , Thomas Feulner
    • , Ronald L. Hamilton
    • , Lindy E. Harrell
    • , Dmitriy Drichel
    • , Lawrence S. Honig
    • , Thomas D. Cushion
    • , Matthew J. Huentelman
    • , Paul Hollingworth
    • , Christine M. Hulette
    • , Bradley T. Hyman
    • , Rachel Marshall
    • , Gail P. Jarvik
    • , Alun Meggy
    • , Erin Abner
    • , Georgina E. Menzies
    • , Lee-Way Jin
    • , Ganna Leonenko
    • , Luis M. Real
    • , Gyungah R. Jun
    • , Clinton T. Baldwin
    • , Detelina Grozeva
    • , Anna Karydas
    • , Giancarlo Russo
    • , Jeffrey A. Kaye
    • , Ronald Kim
    • , Frank Jessen
    • , Neil W. Kowall
    • , Bruno Vellas
    • , Joel H. Kramer
    • , Emma Vardy
    • , Frank M. LaFerla
    • , Karl-Heinz Jöckel
    • , James J. Lah
    • , Martin Dichgans
    • , James B. Leverenz
    • , David Mann
    • , Allan I. Levey
    • , Stuart Pickering-Brown
    • , Andrew P. Lieberman
    • , Norman Klopp
    • , Kathryn L. Lunetta
    • , H-Erich Wichmann
    • , Constantine G. Lyketsos
    • , Kevin Morgan
    • , Daniel C. Marson
    • , Kristelle Brown
    • , Frank Martiniuk
    • , Christopher Medway
    • , Deborah C. Mash
    • , Markus M. Nöthen
    • , Eliezer Masliah
    • , Nigel M. Hooper
    • , Wayne C. McCormick
    • , Antonio Daniele
    • , Susan M. McCurry
    • , Anthony Bayer
    • , Andrew N. McDavid
    • , John Gallacher
    • , Ann C. McKee
    • , Hendrik van den Bussche
    • , Marsel Mesulam
    • , Carol Brayne
    • , Bruce L. Miller
    • , Steffi Riedel-Heller
    • , Carol A. Miller
    • , Joshua W. Miller
    • , Ammar Al-Chalabi
    • , John C. Morris
    • , Christopher E. Shaw
    • , Amanda J. Myers
    • , Jens Wiltfang
    • , Sid O’Bryant
    • , John M. Olichney
    • , Victoria Alvarez
    • , Joseph E. Parisi
    • , Andrew B. Singleton
    • , Henry L. Paulson
    • , John Collinge
    • , William R. Perry
    • , Simon Mead
    • , Elaine Peskind
    • , David H. Cribbs
    • , Martin Rossor
    • , Aimee Pierce
    • , Natalie S. Ryan
    • , Wayne W. Poon
    • , Benedetta Nacmias
    • , Huntington Potter
    • , Sandro Sorbi
    • , Joseph F. Quinn
    • , Eleonora Sacchinelli
    • , Ashok Raj
    • , Gianfranco Spalletta
    • , Murray Raskind
    • , Carlo Caltagirone
    • , Paola Bossù
    • , Maria Donata Orfei
    • , Barry Reisberg
    • , Robert Clarke
    • , Christiane Reitz
    • , A David Smith
    • , John M. Ringman
    • , Donald Warden
    • , Erik D. Roberson
    • , Gordon Wilcock
    • , Ekaterina Rogaeva
    • , Amalia Cecilia Bruni
    • , Howard J. Rosen
    • , Maura Gallo
    • , Roger N. Rosenberg
    • , Yoav Ben-Shlomo
    • , Mark A. Sager
    • , Patrizia Mecocci
    • , Andrew J. Saykin
    • , Pau Pastor
    • , Michael L. Cuccaro
    • , Jeffery M. Vance
    • , Julie A. Schneider
    • , Lori S. Schneider
    • , Susan Slifer
    • , William W. Seeley
    • , Amanda G. Smith
    • , Joshua A. Sonnen
    • , Salvatore Spina
    • , Robert A. Stern
    • , Russell H. Swerdlow
    • , Mitchell Tang
    • , Rudolph E. Tanzi
    • , John Q. Trojanowski
    • , Juan C. Troncoso
    • , Vivianna M. Van Deerlin
    • , Linda J. Van Eldik
    • , Harry V. Vinters
    • , Jean Paul Vonsattel
    • , Sandra Weintraub
    • , Kathleen A. Welsh-Bohmer
    • , Kirk C. Wilhelmsen
    • , Jennifer Williamson
    • , Thomas S. Wingo
    • , Randall L. Woltjer
    • , Clinton B. Wright
    • , Chang-En Yu
    • , Lei Yu
    • , Yasaman Saba
    • , Alberto Pilotto
    • , Maria J. Bullido
    • , Oliver Peters
    • , Paul K. Crane
    • , David Bennett
    • , Paola Bosco
    • , Eliecer Coto
    • , Virginia Boccardi
    • , Phil L. De Jager
    • , Alberto Lleo
    • , Nick Warner
    • , Oscar L. Lopez
    • , Martin Ingelsson
    • , Panagiotis Deloukas
    • , Carlos Cruchaga
    • , Caroline Graff
    • , Rhian Gwilliam
    • , Myriam Fornage
    • , Alison M. Goate
    • , Pascual Sanchez-Juan
    • , Patrick G. Kehoe
    • , Najaf Amin
    • , Nilifur Ertekin-Taner
    • , Claudine Berr
    • , Stéphanie Debette
    • , Seth Love
    • , Lenore J. Launer
    • , Steven G. Younkin
    • , Jean-Francois Dartigues
    • , Chris Corcoran
    • , M. Arfan Ikram
    • , Dennis W. Dickson
    • , Gael Nicolas
    • , Dominique Campion
    • , JoAnn Tschanz
    • , Helena Schmidt
    • , Hakon Hakonarson
    • , Jordi Clarimon
    • , Ron Munger
    • , Reinhold Schmidt
    • , Lindsay A. Farrer
    • , Christine Van Broeckhoven
    • , Michael C. O’Donovan
    • , Anita L. DeStefano
    • , Lesley Jones
    • , Jonathan L. Haines
    • , Jean-Francois Deleuze
    • , Michael J. Owen
    • , Vilmundur Gudnason
    • , Richard Mayeux
    • , Valentina Escott-Price
    • , Bruce M. Psaty
    • , Alfredo Ramirez
    • , Li-San Wang
    • , Agustin Ruiz
    • , Cornelia M. van Duijn
    • , Peter A. Holmans
    • , Sudha Seshadri
    • , Julie Williams
    • , Phillippe Amouyel
    • , Gerard D. Schellenberg
    • , Jean-Charles Lambert
    •  & Margaret A. Pericak-Vance
  • Letter |

    Genomic analysis of 906 Clostridium difficile strains shows that this enteropathogen is undergoing speciation, which is linked to the selection of genes involved in sporulation and in the metabolism of simple dietary sugars.

    • Nitin Kumar
    • , Hilary P. Browne
    • , Elisa Viciani
    • , Samuel C. Forster
    • , Simon Clare
    • , Katherine Harcourt
    • , Mark D. Stares
    • , Gordon Dougan
    • , Derek J. Fairley
    • , Paul Roberts
    • , Munir Pirmohamed
    • , Martha R. J. Clokie
    • , Mie Birgitte Frid Jensen
    • , Katherine R. Hargreaves
    • , Margaret Ip
    • , Lothar H. Wieler
    • , Christian Seyboldt
    • , Torbjörn Norén
    • , Thomas V. Riley
    • , Ed J. Kuijper
    • , Brendan W. Wren
    •  & Trevor D. Lawley
  • Letter |

    A mutation in RAS oncogene family-like 3 (RABL3) is discovered in a family with multiple cases of pancreatic cancer. Zebrafish modeling and biochemical approaches suggest that truncated RABL3 elevates KRAS activity via accelerated prenylation.

    • Sahar Nissim
    • , Ignaty Leshchiner
    • , Joseph D. Mancias
    • , Matthew B. Greenblatt
    • , Ophélia Maertens
    • , Christopher A. Cassa
    • , Jill A. Rosenfeld
    • , Andrew G. Cox
    • , John Hedgepeth
    • , Julia I. Wucherpfennig
    • , Andrew J. Kim
    • , Jake E. Henderson
    • , Patrick Gonyo
    • , Anthony Brandt
    • , Ellen Lorimer
    • , Bethany Unger
    • , Jeremy W. Prokop
    • , Jerry R. Heidel
    • , Xiao-Xu Wang
    • , Chinedu I. Ukaegbu
    • , Benjamin C. Jennings
    • , Joao A. Paulo
    • , Sebastian Gableske
    • , Carol A. Fierke
    • , Gad Getz
    • , Shamil R. Sunyaev
    • , J. Wade Harper
    • , Karen Cichowski
    • , Alec C. Kimmelman
    • , Yariv Houvras
    • , Sapna Syngal
    • , Carol Williams
    •  & Wolfram Goessling
  • Article |

    An integrative three-dimensional genomic and transcriptional profiling of four human neural cell types links regulatory elements to their target genes and elucidates the function of noncoding variants in neuropsychiatric disorders.

    • Michael Song
    • , Xiaoyu Yang
    • , Xingjie Ren
    • , Lenka Maliskova
    • , Bingkun Li
    • , Ian R. Jones
    • , Chao Wang
    • , Fadi Jacob
    • , Kenneth Wu
    • , Michela Traglia
    • , Tsz Wai Tam
    • , Kirsty Jamieson
    • , Si-Yao Lu
    • , Guo-Li Ming
    • , Yun Li
    • , Jun Yao
    • , Lauren A. Weiss
    • , Jesse R. Dixon
    • , Luke M. Judge
    • , Bruce R. Conklin
    • , Hongjun Song
    • , Li Gan
    •  & Yin Shen
  • Editorial |

    Record high temperatures are being seen worldwide, thus placing strains on human health and disrupting the availability of essential resources such as food and water. Aberrant weather patterns in the form of intense storms or prolonged drought have put pressure on our agricultural systems and underscored the need for adaptation to a changing climate across many sectors. Complex problems require complex solutions, and genetic approaches could be a powerful tool for helping to mitigate the effects of climate change.

  • Article |

    Removal of boundary and intra-TAD CTCF-binding sites at the Sox9–Kcnj2 locus in mice leads to TAD fusion but no major changes in gene expression. Gene misexpression and disease phenotypes were obtained through inversions and/or repositioning of TAD boundaries.

    • Alexandra Despang
    • , Robert Schöpflin
    • , Martin Franke
    • , Salaheddine Ali
    • , Ivana Jerković
    • , Christina Paliou
    • , Wing-Lee Chan
    • , Bernd Timmermann
    • , Lars Wittler
    • , Martin Vingron
    • , Stefan Mundlos
    •  & Daniel M. Ibrahim
  • Article |

    The authors use theoretical justifications coupled with extensive simulations to accurately estimate SNP-heritability for 22 complex traits and diseases from the UK Biobank data, irrespective of the underlying genetic architecture of the trait.

    • Kangcheng Hou
    • , Kathryn S. Burch
    • , Arunabha Majumdar
    • , Huwenbo Shi
    • , Nicholas Mancuso
    • , Yue Wu
    • , Sriram Sankararaman
    •  & Bogdan Pasaniuc
  • Article |

    Exome sequencing identifies loss-of-function CELA2A mutations in families with early-onset atherosclerosis and metabolic syndrome. Functional studies show that CELA2A is a circulating enzyme that reduces platelet activation, triggers insulin secretion and degradation, and increases insulin sensitivity.

    • Fatemehsadat Esteghamat
    • , James S. Broughton
    • , Emily Smith
    • , Rebecca Cardone
    • , Tarun Tyagi
    • , Mateus Guerra
    • , András Szabó
    • , Nelson Ugwu
    • , Mitra V. Mani
    • , Bani Azari
    • , Gerald Kayingo
    • , Sunny Chung
    • , Mohsen Fathzadeh
    • , Ephraim Weiss
    • , Jeffrey Bender
    • , Shrikant Mane
    • , Richard P. Lifton
    • , Adebowale Adeniran
    • , Michael H. Nathanson
    • , Fred S. Gorelick
    • , John Hwa
    • , Miklós Sahin-Tóth
    • , Renata Belfort-DeAguiar
    • , Richard G. Kibbey
    •  & Arya Mani
  • News & Views |

    Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.

    • Elizabeth H. Finn
    •  & Tom Misteli
  • Article |

    Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and oculopharyngeal myopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.

    • Hiroyuki Ishiura
    • , Shota Shibata
    • , Jun Yoshimura
    • , Yuta Suzuki
    • , Wei Qu
    • , Koichiro Doi
    • , M. Asem Almansour
    • , Junko Kanda Kikuchi
    • , Makiko Taira
    • , Jun Mitsui
    • , Yuji Takahashi
    • , Yaeko Ichikawa
    • , Tatsuo Mano
    • , Atsushi Iwata
    • , Yasuo Harigaya
    • , Miho Kawabe Matsukawa
    • , Takashi Matsukawa
    • , Masaki Tanaka
    • , Yuichiro Shirota
    • , Ryo Ohtomo
    • , Hisatomo Kowa
    • , Hidetoshi Date
    • , Aki Mitsue
    • , Hiroyuki Hatsuta
    • , Satoru Morimoto
    • , Shigeo Murayama
    • , Yasushi Shiio
    • , Yuko Saito
    • , Akihiko Mitsutake
    • , Mizuho Kawai
    • , Takuya Sasaki
    • , Yusuke Sugiyama
    • , Masashi Hamada
    • , Gaku Ohtomo
    • , Yasuo Terao
    • , Yoshihiko Nakazato
    • , Akitoshi Takeda
    • , Yoshio Sakiyama
    • , Yumi Umeda-Kameyama
    • , Jun Shinmi
    • , Katsuhisa Ogata
    • , Yutaka Kohno
    • , Shen-Yang Lim
    • , Ai Huey Tan
    • , Jun Shimizu
    • , Jun Goto
    • , Ichizo Nishino
    • , Tatsushi Toda
    • , Shinichi Morishita
    •  & Shoji Tsuji
  • Letter |

    Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder. The expansion results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.

    • Jun Sone
    • , Satomi Mitsuhashi
    • , Atsushi Fujita
    • , Takeshi Mizuguchi
    • , Kohei Hamanaka
    • , Keiko Mori
    • , Haruki Koike
    • , Akihiro Hashiguchi
    • , Hiroshi Takashima
    • , Hiroshi Sugiyama
    • , Yutaka Kohno
    • , Yoshihisa Takiyama
    • , Kengo Maeda
    • , Hiroshi Doi
    • , Shigeru Koyano
    • , Hideyuki Takeuchi
    • , Michi Kawamoto
    • , Nobuo Kohara
    • , Tetsuo Ando
    • , Toshiaki Ieda
    • , Yasushi Kita
    • , Norito Kokubun
    • , Yoshio Tsuboi
    • , Kazutaka Katoh
    • , Yoshihiro Kino
    • , Masahisa Katsuno
    • , Yasushi Iwasaki
    • , Mari Yoshida
    • , Fumiaki Tanaka
    • , Ikuo K. Suzuki
    • , Martin C. Frith
    • , Naomichi Matsumoto
    •  & Gen Sobue
  • Author Correction |

    • Mark R. Davies
    • , Liam McIntyre
    • , Ankur Mutreja
    • , Jake A. Lacey
    • , John A. Lees
    • , Rebecca J. Towers
    • , Sebastián Duchêne
    • , Pierre R. Smeesters
    • , Hannah R. Frost
    • , David J. Price
    • , Matthew T. G. Holden
    • , Sophia David
    • , Philip M. Giffard
    • , Kate A. Worthing
    • , Anna C. Seale
    • , James A. Berkley
    • , Simon R. Harris
    • , Tania Rivera-Hernandez
    • , Olga Berking
    • , Amanda J. Cork
    • , Rosângela S. L. A. Torres
    • , Trevor Lithgow
    • , Richard A. Strugnell
    • , Rene Bergmann
    • , Patric Nitsche-Schmitz
    • , Gusharan S. Chhatwal
    • , Stephen D. Bentley
    • , John D. Fraser
    • , Nicole J. Moreland
    • , Jonathan R. Carapetis
    • , Andrew C. Steer
    • , Julian Parkhill
    • , Allan Saul
    • , Deborah A. Williamson
    • , Bart J. Currie
    • , Steven Y. C. Tong
    • , Gordon Dougan
    •  & Mark J. Walker