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  • The nucleosome remodeling and deacetylase (NuRD) complex is a chromatin modifier with a key role in the switch from fetal to adult hemoglobin. In a new study, Vinjamur et al. identify a fetal hemoglobin repressor, ZNF410, which does not directly bind the γ-globin promoter but acts through highly specific regulation of CHD4, a protein subunit of the NuRD complex, thus presenting a potential approach for therapeutic reactivation of fetal hemoglobin.

    • Laxminath Tumburu
    • Swee Lay Thein
    News & Views
  • A CRISPR screen combined with in vivo data identify ZNF410 as an indirect repressor of fetal hemoglobin. ZNF410 binds to and regulates CHD4 expression, which in turn silences fetal hemoglobin.

    • Divya S. Vinjamur
    • Qiuming Yao
    • Daniel E. Bauer
  • Chromothripsis, a chromosomal shattering event, can be elicited by micronuclei and chromosome bridges formed by CRISPR–Cas9-generated double-stranded breaks. Extensive chromosomal rearrangements may thus be an on-target effect of genome editing.

    • Mitchell L. Leibowitz
    • Stamatis Papathanasiou
    • David Pellman
  • Cells resembling human fetal adrenal neuroblasts have been identified as major neuroblastoma cancer cells through single-cell mRNA comparison. Tumor risk stratification correlates with the differentiation of neuroblast-like neuroblastoma cells.

    • Hermann Rohrer
    News & Views
  • Case–case genome-wide association studies (GWAS) within a single genotyped cohort have proven useful in identifying genetic variants explaining different health outcomes, yet they are limited by data availability. A new study by Peyrot and Price proposes a clever statistical method to overcome this problem by inferring case–case GWAS results from a pair of standard case–control GWAS summary statistics that need not be from the same cohort.

    • Florian Privé
    • Zhihong Zhu
    • Bjarni J. Vilhjalmsson
    News & Views
  • Guided Open Access is a new publishing option offered at Nature Genetics. Authors can submit once and be simultaneously considered by three journals. Editorial collaboration and a single submission system combine to make the publication process easier and faster.

  • The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

    • Marie-Christine Birling
    • Atsushi Yoshiki
    • Stephen A. Murray
  • Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergenerational transmission of epigenetic information and gene regulation dynamics as embryos prepare for gastrulation.

    • Julien Richard Albert
    • Maxim V. C. Greenberg
    News & Views
  • A multivariate genome-wide association study highlighting loci that influence both face and brain shape suggesting shared developmental axes during early embryogenesis. These loci did not overlap with those governing behavioral–cognitive traits or neuropsychiatric risk indicating divergence between early brain development and cognitive function.

    • Sahin Naqvi
    • Yoeri Sleyp
    • Peter Claes
  • The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.

    • Tom Misteli
    • Elizabeth H. Finn
    News & Views