Volume 36 Issue 1, January 2004

Editorial

Chance is a necessity

Editorial 01 Jan 2004

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Correspondence

A call for accurate phenotype definition in the study of complex disorders

Benoît Funalot
Olivier Varenne
Jean-Louis Mas
Correspondence 01 Jan 2004
Reply to “A call for accurate phenotype definition in the study of complex disorders”

Jeffrey R Gulcher
Solveig Gretarsdottir
Kari Stefansson
Correspondence 01 Jan 2004

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Book Review

A giant of genetics

Gunther S Stent
Book Review 01 Jan 2004

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News & Views

Conquering the complexity of p53

New evidence from a Trp53 'knock-in' mouse model suggests that p53-dependent cell cycle checkpoint control accompanied by maintenance of genome stability is important for keeping tumor growth in check.

Laura D Attardi
Ronald A DePinho
News & Views 01 Jan 2004
White meat or dark?

In zebrafish, slow twitch muscle is specified from a somitic muscle precursor pool by local Hedgehog (Hh) signals. A new study identifies the transcription factor Blimp-1 as a key downstream mediator in this process.

Ava E Brent
Clifford J Tabin
News & Views 01 Jan 2004
Two Pax are better than one

In fly eye development, new experiments suggest that two distinct Pax genes control tissue growth and identity, respectively. Notably, these two functions may be encoded by distinct isoforms of the human gene PAX6

Richard S Mann
News & Views 01 Jan 2004
Marking Xs, together and separately

A chromosome imprinting mark is sensitive to meiotic pairing in the gamete of origin and identified through the 'histone code'.

Mary Ann Handel
News & Views 01 Jan 2004
Diverse powerhouses

Mitochondria in different tissues vary in number, morphology, ultrastructure, respiratory capacity and involvement in specific metabolic pathways. A comparison of the proteome of mitochondria from different tissues has identified the extent of the underlying variation in protein composition and how this may be determined by tissue-specific networks of coregulated genes.

David R Thorburn
News & Views 01 Jan 2004
Touching base

News & Views 01 Jan 2004
Research notes

News & Views 01 Jan 2004

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Review Article

The four Rs of RNA-directed evolution

Alan Herbert
Review Article 30 Dec 2003

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Brief Communication

Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma

Kenro Oshima
Shigeyuki Kakizawa
Shigetou Namba
Brief Communication 07 Dec 2003

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Article

Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster

Maria Dominguez
Dolors Ferres-Marco
Monica Beneyto
Article 14 Dec 2003
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Article 21 Dec 2003
RPA regulates telomerase action by providing Est1p access to chromosome ends

Vera Schramke
Pierre Luciano
Vincent Géli
Article 21 Dec 2003
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Hiroshi Katayama
Kaori Sasai
Subrata Sen
Article 14 Dec 2003

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Letter

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

Geng Liu
John M Parant
Guillermina Lozano
Letter 21 Dec 2003
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex

Volney L Sheen
Vijay S Ganesh
Christopher A Walsh
Letter 30 Nov 2003
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

George Papanikolaou
Mark E Samuels
Y Paul Goldberg
Letter 30 Nov 2003
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

Ryo Sumazaki
Nobuyoshi Shiojiri
Akira Matsui
Letter 14 Dec 2003
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

Sarah Baxendale
Claire Davison
Sudipto Roy
Letter 21 Dec 2003
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

Marta García-Cao
Roderick O'Sullivan
María A Blasco
Letter 14 Dec 2003
Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans

Christopher J Bean
Christine E Schaner
William G Kelly
Letter 21 Dec 2003

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Erratum

Erratum: Chipping away at the chip bias: RNA degradation in microarray analysis

H Auer
S Lyianarachchi
K Kornacker
Erratum 01 Jan 2004
Erratum: Gene-culture coevolution between cattle milk protein genes and human lactase genes

A Beja-Pereira
G Luikart
G Erhardt
Erratum 01 Jan 2004

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Volume 36 Issue 1, January 2004

Editorial

Chance is a necessity

Correspondence

A call for accurate phenotype definition in the study of complex disorders

Reply to “A call for accurate phenotype definition in the study of complex disorders”

Book Review

A giant of genetics

News & Views

Conquering the complexity of p53

White meat or dark?

Two Pax are better than one

Marking Xs, together and separately

Diverse powerhouses

Touching base

Research notes

Review Article

The four Rs of RNA-directed evolution

Brief Communication

Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma

Article

Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster

Complete sequencing and characterization of 21,243 full-length human cDNAs

RPA regulates telomerase action by providing Est1p access to chromosome ends

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Letter

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans

Erratum

Erratum: Chipping away at the chip bias: RNA degradation in microarray analysis

Erratum: Gene-culture coevolution between cattle milk protein genes and human lactase genes

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