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Volume 39 Issue 5, May 2007

Cover art: "Culture" and DNA by Nina Bentley (http://www.ninabentley.com) From the exhibition 'Culture and DNA' at the Silvermine Guild Galleries http://www.silvermineart.org

Volume 39 Issue 5

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Editorial

  • Genome-wide association studies (GWAS or WGAS) have made the human the model organism of choice for discovery of genetic variants underlying common diseases and phenotypes. We have organized a conference to discuss the state of this research and the transition from detection to mechanisms and applications.

    Editorial

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Correspondence

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Book Review

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News & Views

  • Three new reports leverage genome-wide studies to localize and replicate multiple independent variants strongly associated with prostate cancer on chromosome 8q24. These findings provide a significant advance toward deciphering the genetic basis of this disease, although further work is needed to clarify the biological mechanisms underlying these associations.

    • John S Witte
    News & Views

  • The genetic basis of aggression may be conserved from lobsters to humans. A new study uses the genetics of Drosophila melanogaster to explore the underlying neurochemical mechanisms.

    • Anne F Simon
    • David E Krantz
    News & Views

  • Human cancers are characterized by widespread reduction in microRNA gene expression, but what role does this have in the pathobiology of the disease? A new study proves that reduction in microRNA expression does indeed promote tumorigenesis, changing the way we think about cancer.

    • Scott M Hammond
    News & Views

  • Understanding the molecular genetic mechanisms governing agronomic traits such as grain yield is important for genetics as well as agriculture. A newly discovered quantitative trait locus, GW2, which encodes a new RING-type E3 ubiquitin ligase, has been found to regulate rice grain width. This insight should prove useful for improving the yield of staple grains.

    • Makoto Matsuoka
    • Motoyuki Ashikari
    News & Views
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Meeting Report

  • Barcelona has long been known for its innovation, from the architectural genius of Gaudí to the culinary creations of its world-famous chefs. In recent years, it has reinvigorated Spanish science with the establishment of new, progressive research institutions. From 5 to 7 October 2006, Barcelona was host to a conference focusing on a new approach to human disease.

    • Juan Botas
    Meeting Report
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Brief Communication

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Article

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Letter

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Corrigendum

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