Browse Articles

  • News & Views |

    Detrimental levels of intracellular reactive oxygen species engage a caspase-independent and non-inflammatory cell death called ‘oxeiptosis’ that serves as an important mechanism in diminishing inflammation.

    • Sannula Kesavardhana
    •  & Thirumala-Devi Kanneganti
  • Review Article |

    Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.

    • Filippo Veglia
    • , Michela Perego
    •  & Dmitry Gabrilovich
  • News & Views |

    ERAdP, an endoplasmic reticulum (ER)-resident protein with similar mechanistic features as the innate immune adaptor STING, controls inflammatory cytokine release, but not that of type I interferon, in response to bacterial cyclic di-AMP.

    • Martin Roelsgaard Jakobsen
  • News & Views |

    The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.

    • Alexandra Bortnick
    •  & Cornelis Murre
  • News & Views |

    CD8+ tissue-resident memory T cells (TRM cells) in two mucosal tissues, the skin and the female reproductive tract, proliferate in situ to generate a secondary pool of TRM cells that does not exit into the circulation.

    • Jun Siong Low
    •  & Susan M. Kaech
  • Article |

    Crabtree and colleagues show that Aire has an intrinsic repressive function that restricts chromatin accessibility and restrains the amplitude of active transcription.

    • Andrew S. Koh
    • , Erik L. Miller
    • , Jason D. Buenrostro
    • , David M. Moskowitz
    • , Jing Wang
    • , William J. Greenleaf
    • , Howard Y. Chang
    •  & Gerald R. Crabtree
  • Article |

    Masopust and colleagues show that mucosal tissue-resident memory T cells proliferate in situ in response to local antigen and dominate the local recall response.

    • Lalit K. Beura
    • , Jason S. Mitchell
    • , Emily A. Thompson
    • , Jason M. Schenkel
    • , Javed Mohammed
    • , Sathi Wijeyesinghe
    • , Raissa Fonseca
    • , Brandon J. Burbach
    • , Heather D. Hickman
    • , Vaiva Vezys
    • , Brian T. Fife
    •  & David Masopust
  • Article |

    Mackay, Mueller and colleagues show that tissue-resident memory T cells proliferate in situ in response to local antigen and persist during subsequent antigen encounters.

    • Simone L. Park
    • , Ali Zaid
    • , Jyh Liang Hor
    • , Susan N. Christo
    • , Julia E. Prier
    • , Brooke Davies
    • , Yannick O. Alexandre
    • , Julia L. Gregory
    • , Tiffany A. Russell
    • , Thomas Gebhardt
    • , Francis R. Carbone
    • , David C. Tscharke
    • , William R. Heath
    • , Scott N. Mueller
    •  & Laura K. Mackay
  • Article |

    The bacterial secondary messenger c-di-AMP can be sensed by cytosolic receptors to activate innate immunity. Fan and colleagues show the ER-associated protein ERAdP to be a high-affinity receptor for c-di-AMP, linking it to downstream inflammatory responses.

    • Pengyan Xia
    • , Shuo Wang
    • , Zhen Xiong
    • , Xiaoxiao Zhu
    • , Buqing Ye
    • , Ying Du
    • , Shu Meng
    • , Yuan Qu
    • , Jing Liu
    • , Guangxia Gao
    • , Yong Tian
    •  & Zusen Fan
  • Article |

    Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.

    • Cathleen Holze
    • , Chloé Michaudel
    • , Claire Mackowiak
    • , Darya A. Haas
    • , Christian Benda
    • , Philipp Hubel
    • , Friederike L. Pennemann
    • , Daniel Schnepf
    • , Jennifer Wettmarshausen
    • , Marianne Braun
    • , Daisy W. Leung
    • , Gaya K. Amarasinghe
    • , Fabiana Perocchi
    • , Peter Staeheli
    • , Bernhard Ryffel
    •  & Andreas Pichlmair
  • News & Views |

    A previously unknown role is identified for a pathway that involves major histocompatibility complex class I and an inhibitory receptor, LILRB1, that regulates the phagocytosis of cancer cells by macrophages and contributes to resistance directed against the signal-regulatory protein CD47.

    • Cheng Cheng Zhang
    •  & Yang-Xin Fu
  • News & Views |

    A new ‘alarm mechanism’ of the innate immune system that signals the presence of nuclear viruses involves the sensing of host 5S rRNA by RIG-I.

    • Andrew G. Bowie