Nature Immunology - AOP - nature.com science feeds Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation. http://www.nature.com/ni/current_issue/ Nature Publishing Group en © Nature Publishing Group Nature Immunology 1529-2908 1529-2916 © Nature Publishing Group permissions@nature.com Nature Immunology http://www.nature.com/includes/rj_globnavimages/ni_logo.gif http://www.nature.com/ni/ Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells http://feeds.nature.com/~r/ni/rss/aop/~3/FhB9FN9i0Gc/ni.1826 Naive CD4+ T cells can differentiate into distinct polarized effector cells, but detailed characterization of physiologic CD4 memory is lacking. Jenkins and colleagues show that TH1 and TH17 memory cells differ in longevity and arise via different infection routes. Advertisement

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

Nature Immunology. doi:10.1038/ni.1826

Authors: Marion Pepper, Jonathan L Linehan, Antonio J Pagán, Traci Zell, Thamotharampillai Dileepan, P Patrick Cleary & Marc K Jenkins

]]> Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells Marion Pepper Jonathan L Linehan Antonio J Pagán Traci Zell Thamotharampillai Dileepan P Patrick Cleary Marc K Jenkins doi:10.1038/ni.1826 Nature Immunology 2009-11-22 Nature Immunology 2009-11-22 10.1038/ni.1826 http://dx.doi.org/10.1038/ni.1826 Article http://dx.doi.org/10.1038/ni.1826 Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production http://feeds.nature.com/~r/ni/rss/aop/~3/qFcOK6Mi0tk/ni.1824 Production of mature interleukin 1β (IL-1β) requires Il1b transcription and inflammasome-mediated processing of IL-1β protein. Ruland and colleagues show that the RNA virus sensor RIG-I signals via the adaptors CARD9 and Asc to facilitate both processes. Advertisement

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

Nature Immunology. doi:10.1038/ni.1824

Authors: Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth, Manuele Rebsamen, Nicole Hannesschläger, Martin Schlee, Simon Rothenfusser, Winfried Barchet, Hiroki Kato, Shizuo Akira, Satoshi Inoue, Stefan Endres, Christian Peschel, Gunther Hartmann, Veit Hornung & Jürgen Ruland

]]> Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production Hendrik Poeck Michael Bscheider Olaf Gross Katrin Finger Susanne Roth Manuele Rebsamen Nicole Hannesschläger Martin Schlee Simon Rothenfusser Winfried Barchet Hiroki Kato Shizuo Akira Satoshi Inoue Stefan Endres Christian Peschel Gunther Hartmann Veit Hornung Jürgen Ruland doi:10.1038/ni.1824 Nature Immunology 2009-11-15 Nature Immunology 2009-11-15 10.1038/ni.1824 http://dx.doi.org/10.1038/ni.1824 Article http://dx.doi.org/10.1038/ni.1824 Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry http://feeds.nature.com/~r/ni/rss/aop/~3/0B5CognjkQQ/ni.1823 Autophagy facilitates host defense against invading bacteria. Philpott and colleagues show that Nod1 and Nod2 link pathogen sensing to autophagy by recruiting the autophagy protein AGT16L1 to the site of pathogen entry. Advertisement

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Nature Immunology. doi:10.1038/ni.1823

Authors: Leonardo H Travassos, Leticia A M Carneiro, Mahendrasingh Ramjeet, Seamus Hussey, Yun-Gi Kim, João G Magalhães, Linda Yuan, Fraser Soares, Evelyn Chea, Lionel Le Bourhis, Ivo G Boneca, Abdelmounaaim Allaoui, Nicola L Jones, Gabriel Nuñez, Stephen E Girardin & Dana J Philpott

]]> Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry Leonardo H Travassos Leticia A M Carneiro Mahendrasingh Ramjeet Seamus Hussey Yun-Gi Kim João G Magalhães Linda Yuan Fraser Soares Evelyn Chea Lionel Le Bourhis Ivo G Boneca Abdelmounaaim Allaoui Nicola L Jones Gabriel Nuñez Stephen E Girardin Dana J Philpott doi:10.1038/ni.1823 Nature Immunology 2009-11-08 Nature Immunology 2009-11-08 10.1038/ni.1823 http://dx.doi.org/10.1038/ni.1823 Article http://dx.doi.org/10.1038/ni.1823 Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines http://feeds.nature.com/~r/ni/rss/aop/~3/Dfk3IwXtjEc/ni.1819 TLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ensuing immune response. Advertisement

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Nature Immunology. doi:10.1038/ni.1819

Authors: Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A A Vignali & Michael Karin

]]> Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Ping-Hui Tseng Atsushi Matsuzawa Weizhou Zhang Takashi Mino Dario A A Vignali Michael Karin doi:10.1038/ni.1819 Nature Immunology 2009-11-08 Nature Immunology 2009-11-08 10.1038/ni.1819 http://dx.doi.org/10.1038/ni.1819 Article http://dx.doi.org/10.1038/ni.1819 Enteric defensins are essential regulators of intestinal microbial ecology http://feeds.nature.com/~r/ni/rss/aop/~3/PjvDIecslaM/ni.1825 Defensins combat pathogenic bacteria invading the mammalian intestine. Salzman and co-workers find that defensins influence the composition of the small intestinal commensal microbiota and the presence of interleukin 17–producing T cells in the lamina propria. Advertisement

Enteric defensins are essential regulators of intestinal microbial ecology

Nature Immunology. doi:10.1038/ni.1825

Authors: Nita H Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood, Maaike Stoel, Yanjiao Zhou, Erica Sodergren, George M Weinstock, Charles L Bevins, Calvin B Williams & Nicolaas A Bos

]]> Enteric defensins are essential regulators of intestinal microbial ecology Nita H Salzman Kuiechun Hung Dipica Haribhai Hiutung Chu Jenny Karlsson-Sjöberg Elad Amir Paul Teggatz Melissa Barman Michael Hayward Daniel Eastwood Maaike Stoel Yanjiao Zhou Erica Sodergren George M Weinstock Charles L Bevins Calvin B Williams Nicolaas A Bos doi:10.1038/ni.1825 Nature Immunology 2009-10-22 Nature Immunology 2009-10-22 10.1038/ni.1825 http://dx.doi.org/10.1038/ni.1825 Article http://dx.doi.org/10.1038/ni.1825