Nature Immunology Nature Immunology, ranked first out of more than 100 primary immunology research journals, brings together the most significant immunology research from every discipline. Nature Immunology’s scope is broad, covering all areas of immunology, including (but not limited to) innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity and tumor immunology, microbial immunopathology and transplantation. By presenting research that provides fundamental insight into the working of the immune system, Nature Immunology communicates the most significant and influential advances to a broad audience. http://feeds.nature.com/ni/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Immunology © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Immunology https://www.nature.com/uploads/product/ni/rss.gif http://feeds.nature.com/ni/rss/current <![CDATA[Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus]]> https://www.nature.com/articles/s41590-024-01786-0 Nature Immunology, Published online: 22 March 2024; doi:10.1038/s41590-024-01786-0

Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration.]]>
doi:10.1038/s41590-024-01786-0 Nature Immunology, Published online: 2024-03-22; | doi:10.1038/s41590-024-01786-0 2024-03-22 Nature Immunology 10.1038/s41590-024-01786-0 https://www.nature.com/articles/s41590-024-01786-0
<![CDATA[Mapping human hematopoiesis]]> https://www.nature.com/articles/s41590-024-01793-1 Nature Immunology, Published online: 21 March 2024; doi:10.1038/s41590-024-01793-1

Understanding normal hematopoiesis is critical to understanding disease. Technological advances are driving insight into human hematopoiesis at unprecedented resolution. Integrating ‘-omics’ datasets with machine learning has yielded a high-resolution map of primary human bone marrow hematopoietic progenitor cells that supports the study of immune cell development, as well as the origins of disease.]]>
Kathrin M. Bernt doi:10.1038/s41590-024-01793-1 Nature Immunology, Published online: 2024-03-21; | doi:10.1038/s41590-024-01793-1 2024-03-21 Nature Immunology 10.1038/s41590-024-01793-1 https://www.nature.com/articles/s41590-024-01793-1
<![CDATA[cGAS meets its demise in the nucleus]]> https://www.nature.com/articles/s41590-024-01794-0 Nature Immunology, Published online: 21 March 2024; doi:10.1038/s41590-024-01794-0

DNA sensing for the purposes of innate immunity is tricky when the DNA sensor can easily become stuck on chromosomes during cell division. The mechanism by which the trapped DNA sensor is degraded — and how this process can be balanced with added immune protection — is now reported.]]>
Calvin Jon A. LeonenHironori Funabiki doi:10.1038/s41590-024-01794-0 Nature Immunology, Published online: 2024-03-21; | doi:10.1038/s41590-024-01794-0 2024-03-21 Nature Immunology 10.1038/s41590-024-01794-0 https://www.nature.com/articles/s41590-024-01794-0
<![CDATA[Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell]]> https://www.nature.com/articles/s41590-024-01799-9 Nature Immunology, Published online: 21 March 2024; doi:10.1038/s41590-024-01799-9

Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell]]>
Yulong GaoFernando Souza-Fonseca-GuimaraesTobias BaldSusanna S. NgArabella YoungShin Foong NgiowJai RautelaJasmin StraubeNic WaddellStephen J. BlakeJuming YanLaurent BartholinJason S. LeeEric VivierKazuyoshi TakedaMeriem MessaoudeneLaurence ZitvogelMichele W. L. TengGabrielle T. BelzChristian R. EngwerdaNicholas D. HuntingtonKyohei NakamuraMichael HölzelMark J. Smyth doi:10.1038/s41590-024-01799-9 Nature Immunology, Published online: 2024-03-21; | doi:10.1038/s41590-024-01799-9 2024-03-21 Nature Immunology 10.1038/s41590-024-01799-9 https://www.nature.com/articles/s41590-024-01799-9
<![CDATA[An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors]]> https://www.nature.com/articles/s41590-024-01782-4 Nature Immunology, Published online: 21 March 2024; doi:10.1038/s41590-024-01782-4

In this Resource article, the authors integrate genomic, bioinformatic and flow cytometric data from human bone marrow to provide an atlas of hematopoietic progenitor cell states in health and disease.]]>
Xuan ZhangBaobao SongMaximillian J. CarlinoGuangyuan LiKyle FerchenMi ChenEvrett N. ThompsonBailee N. KainDan SchnellKairavee ThakkarMichal KourilKang JinStuart B. HaySidharth SenDavid BernardiciusSiyuan MaSierra N. BennettJosh CroteauOrnella SalvatoriMelvin H. LyeAustin E. GillenCraig T. JordanHarinder SinghDiane S. KrauseNathan SalomonisH. Leighton Grimes doi:10.1038/s41590-024-01782-4 Nature Immunology, Published online: 2024-03-21; | doi:10.1038/s41590-024-01782-4 2024-03-21 Nature Immunology 10.1038/s41590-024-01782-4 https://www.nature.com/articles/s41590-024-01782-4
<![CDATA[Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy]]> https://www.nature.com/articles/s41590-024-01792-2 Nature Immunology, Published online: 19 March 2024; doi:10.1038/s41590-024-01792-2

The spatial organization of cells in solid tumors is considered to be important for immune response and response to therapy. Here the authors use multiomics including spatial transcriptomics of human lung tumors prior to patients being treated and show among other things an association of stem-immunity hubs rich in stem-like CD8+ T cells with positive response to anti-PD-1 therapy.]]>
Jonathan H. ChenLinda T. NiemanMaxwell SpurrellVjola JorgjiLiad ElmelechPeter RichieriKatherine H. XuRoopa MadhuMilan ParikhIzabella ZamoraArnav MehtaChristopher S. NabelSamuel S. FreemanJoshua D. PirlChenyue LuCatherine B. MeadorJaimie L. BarthMustafa SakhiAlexander L. TangSiranush SarkizovaColles PriceNicolas F. FernandezGeorge EmanuelJiang HeKatrina Van RaayJason W. ReevesKeren YizhakMatan HofreeAngela ShihMoshe Sade-FeldmanGenevieve M. BolandKarin PelkaMartin J. AryeeMari Mino-KenudsonJustin F. GainorIlya KorsunskyNir Hacohen doi:10.1038/s41590-024-01792-2 Nature Immunology, Published online: 2024-03-19; | doi:10.1038/s41590-024-01792-2 2024-03-19 Nature Immunology 10.1038/s41590-024-01792-2 https://www.nature.com/articles/s41590-024-01792-2
<![CDATA[International nomenclature guidelines for the IL-1 family of cytokines and receptors]]> https://www.nature.com/articles/s41590-024-01777-1 Nature Immunology, Published online: 18 March 2024; doi:10.1038/s41590-024-01777-1

International nomenclature guidelines for the IL-1 family of cytokines and receptors]]>
Joseph M. GaballaJesper Falkesgaard HøjenDennis M. De GraafJesus Amo-AparicioCarlo MarchettiGiulio CavalliAlberto DinarelloSuzhao LiMichaele Francesco CorbisieroIsak W. TengesdalJasmina S. RedzicTania AzamWilliam S. Webber IIIKarl A. PankratzMakenna J. MayFabio CominelliElan Z. EisenmesserSoohyun KimCharles A. DinarelloDiana Boraschi doi:10.1038/s41590-024-01777-1 Nature Immunology, Published online: 2024-03-18; | doi:10.1038/s41590-024-01777-1 2024-03-18 Nature Immunology 10.1038/s41590-024-01777-1 https://www.nature.com/articles/s41590-024-01777-1
<![CDATA[A method for predicting drugs that can boost the efficacy of immune checkpoint blockade]]> https://www.nature.com/articles/s41590-024-01789-x Nature Immunology, Published online: 18 March 2024; doi:10.1038/s41590-024-01789-x

Here the authors present a method they call CM-Drug for the identification of combination drugs that can boost the efficacy of immune checkpoint blockade therapy. They validate this method with melanoma and lung cancer models in mice and explore in further depth one hit from their screen, the thyrotropin-releasing hormone (TRH) analog taltirelin.]]>
Yun XiaXin LiNana BieWen PanYa-Ru MiaoMei YangYan GaoChuang ChenHanqing LiuLu GanAn-Yuan Guo doi:10.1038/s41590-024-01789-x Nature Immunology, Published online: 2024-03-18; | doi:10.1038/s41590-024-01789-x 2024-03-18 Nature Immunology 10.1038/s41590-024-01789-x https://www.nature.com/articles/s41590-024-01789-x