Nature Immunology - Issue - nature.com science feeds Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation. http://www.nature.com/ni/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group Nature Immunology 1529-2908 1529-2916 © 2009 Nature Publishing Group permissions@nature.com Nature Immunology http://www.nature.com/includes/rj_globnavimages/ni_logo.gif http://www.nature.com/ni/ Science: a common language http://feeds.nature.com/~r/ni/rss/current/~3/-4tv84SkTgA/ni1209-1223 Science and technology can be used to build relations between countries. Thus, scientific diplomacy is becoming increasingly important. Advertisement

Science: a common language

Nature Immunology 10, 1223 (2009). doi:10.1038/ni1209-1223

Science and technology can be used to build relations between countries. Thus, scientific diplomacy is becoming increasingly important.

]]> Science: a common language doi:10.1038/ni1209-1223 Nature Immunology 10, 1223 (2009) Nature Immunology 10.1038/ni1209-1223 http://dx.doi.org/10.1038/ni1209-1223 10 12 Editorial 1223 1223 http://dx.doi.org/10.1038/ni1209-1223 Data management: it starts at the bench http://feeds.nature.com/~r/ni/rss/current/~3/ouHtrbyEj3k/ni1209-1225 Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench. Advertisement

Data management: it starts at the bench

Nature Immunology 10, 1225 (2009). doi:10.1038/ni1209-1225

Authors: Damien Chaussabel, Hideki Ueno, Jacques Banchereau & Charles Quinn

Data management has been neglected but should be made an integral activity in all research laboratories. Chaussabel and colleagues discuss how to implement this at the bench.

]]> Data management: it starts at the bench Damien Chaussabel Hideki Ueno Jacques Banchereau Charles Quinn doi:10.1038/ni1209-1225 Nature Immunology 10, 1225 (2009) Nature Immunology 10.1038/ni1209-1225 http://dx.doi.org/10.1038/ni1209-1225 10 12 Commentary 1225 1227 http://dx.doi.org/10.1038/ni1209-1225 MicroRNA-managing the TH-17 inflammatory response http://feeds.nature.com/~r/ni/rss/current/~3/iWnuOme8J2g/ni1209-1229 The differentiation of interleukin 17–producing helper T cells is controlled by a complex network of cytokines, signaling pathways and transcription factors. Regulation by microRNA particles can now be added to this list. Advertisement

MicroRNA-managing the TH-17 inflammatory response

Nature Immunology 10, 1229 (2009). doi:10.1038/ni1209-1229

Authors: Aaron J Martin, Liang Zhou & Stephen D Miller

The differentiation of interleukin 17–producing helper T cells is controlled by a complex network of cytokines, signaling pathways and transcription factors. Regulation by microRNA particles can now be added to this list.

]]> MicroRNA-managing the TH-17 inflammatory response Aaron J Martin Liang Zhou Stephen D Miller doi:10.1038/ni1209-1229 Nature Immunology 10, 1229 (2009) Nature Immunology 10.1038/ni1209-1229 http://dx.doi.org/10.1038/ni1209-1229 10 12 News and Views 1229 1231 http://dx.doi.org/10.1038/ni1209-1229 T cells need Nod too? http://feeds.nature.com/~r/ni/rss/current/~3/FV82QgQJMOo/ni1209-1231 Nucleotide-binding oligomerization domain 2 (Nod2) is required for sensing of intracellular bacteria and subsequent inflammatory responses. Unexpectedly, new evidence suggests that Nod2 influences T helper cell signaling, proliferation and differentiation and effector responses against Toxoplasma gondii. Advertisement

T cells need Nod too?

Nature Immunology 10, 1231 (2009). doi:10.1038/ni1209-1231

Authors: Shahram Salek-Ardakani & Michael Croft

Nucleotide-binding oligomerization domain 2 (Nod2) is required for sensing of intracellular bacteria and subsequent inflammatory responses. Unexpectedly, new evidence suggests that Nod2 influences T helper cell signaling, proliferation and differentiation and effector responses against Toxoplasma gondii.

]]> T cells need Nod too? Shahram Salek-Ardakani Michael Croft doi:10.1038/ni1209-1231 Nature Immunology 10, 1231 (2009) Nature Immunology 10.1038/ni1209-1231 http://dx.doi.org/10.1038/ni1209-1231 10 12 News and Views 1231 1233 http://dx.doi.org/10.1038/ni1209-1231 B cell memory: how to start and when to end http://feeds.nature.com/~r/ni/rss/current/~3/zGfVu4FhcCQ/ni1209-1233 Antigen-driven selection in germinal centers lays the foundation of effective B cell memory. Two reports in this issue reveal novel mechanisms that control effective formation of germinal centers and their long-term persistence in vivo. Advertisement

B cell memory: how to start and when to end

Nature Immunology 10, 1233 (2009). doi:10.1038/ni1209-1233

Authors: Nadege Pelletier & Michael G McHeyzer-Williams

Antigen-driven selection in germinal centers lays the foundation of effective B cell memory. Two reports in this issue reveal novel mechanisms that control effective formation of germinal centers and their long-term persistence in vivo.

]]> B cell memory: how to start and when to end Nadege Pelletier Michael G McHeyzer-Williams doi:10.1038/ni1209-1233 Nature Immunology 10, 1233 (2009) Nature Immunology 10.1038/ni1209-1233 http://dx.doi.org/10.1038/ni1209-1233 10 12 News and Views 1233 1235 http://dx.doi.org/10.1038/ni1209-1233 Research Highlights http://feeds.nature.com/~r/ni/rss/current/~3/36AyMBNyk1s/ni1209-1236 Advertisement

Research Highlights

Nature Immunology 10, 1236 (2009). doi:10.1038/ni1209-1236

]]> Research Highlights doi:10.1038/ni1209-1236 Nature Immunology 10, 1236 (2009) Nature Immunology 10.1038/ni1209-1236 http://dx.doi.org/10.1038/ni1209-1236 10 12 Research Highlights 1236 1236 http://dx.doi.org/10.1038/ni1209-1236 Dendritic cell subsets in primary and secondary T cell responses at body surfaces http://feeds.nature.com/~r/ni/rss/current/~3/6xZ7d9hiJs0/ni.1822 Advertisement

Dendritic cell subsets in primary and secondary T cell responses at body surfaces

Nature Immunology 10, 1237 (2009). doi:10.1038/ni.1822

Authors: William R Heath & Francis R Carbone

]]> Dendritic cell subsets in primary and secondary T cell responses at body surfaces William R Heath Francis R Carbone doi:10.1038/ni.1822 Nature Immunology 10, 1237 (2009) 2009-11-16 Nature Immunology 2009-11-16 10.1038/ni.1822 http://dx.doi.org/10.1038/ni.1822 10 12 Review 1237 1244 http://dx.doi.org/10.1038/ni.1822 Structural basis of receptor sharing by interleukin 17 cytokines http://feeds.nature.com/~r/ni/rss/current/~3/4wgM2tKW8Ek/ni.1813 The interleukin 17 (IL-17) family includes six cytokines and five receptors. Garcia and co-workers solve the crystal structure of the receptor IL-17RA bound to IL-17F and suggest that IL-17RA may act as a shared subunit among multiple IL-17 receptor complexes. Advertisement

Structural basis of receptor sharing by interleukin 17 cytokines

Nature Immunology 10, 1245 (2009). doi:10.1038/ni.1813

Authors: Lauren K Ely, Suzanne Fischer & K Christopher Garcia

]]> Structural basis of receptor sharing by interleukin 17 cytokines Lauren K Ely Suzanne Fischer K Christopher Garcia doi:10.1038/ni.1813 Nature Immunology 10, 1245 (2009) 2009-10-18 Nature Immunology 2009-10-18 10.1038/ni.1813 http://dx.doi.org/10.1038/ni.1813 10 12 Article 1245 1251 http://dx.doi.org/10.1038/ni.1813 MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis http://feeds.nature.com/~r/ni/rss/current/~3/veIrjl7YyfQ/ni.1798 Interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) are associated with the pathogenesis of multiple sclerosis. Pei and colleagues have now identified a TH-17 cell–associated microRNA, miR-326, whose expression correlates with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis. Advertisement

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Nature Immunology 10, 1252 (2009). doi:10.1038/ni.1798

Authors: Changsheng Du, Chang Liu, Jiuhong Kang, Guixian Zhao, Zhiqiang Ye, Shichao Huang, Zhenxin Li, Zhiying Wu & Gang Pei

]]> MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis Changsheng Du Chang Liu Jiuhong Kang Guixian Zhao Zhiqiang Ye Shichao Huang Zhenxin Li Zhiying Wu Gang Pei doi:10.1038/ni.1798 Nature Immunology 10, 1252 (2009) 2009-10-18 Nature Immunology 2009-10-18 10.1038/ni.1798 http://dx.doi.org/10.1038/ni.1798 10 12 Article 1252 1259 http://dx.doi.org/10.1038/ni.1798 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment http://feeds.nature.com/~r/ni/rss/current/~3/ywTQsF6zYV0/ni.1821 The molecular mediators responsible for directing T helper type 2 (TH2) differentiation remain incompletely defined. Dong and co-workers find that the transcription factor Dec2 promotes expression of the transcription factor JunB and is essential for the induction of TH2 responses. Advertisement

Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment

Nature Immunology 10, 1260 (2009). doi:10.1038/ni.1821

Authors: Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang, Bing Sun & Chen Dong

]]> Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment Xuexian O Yang Pornpimon Angkasekwinai Jinfang Zhu Juan Peng Zhiduo Liu Roza Nurieva Xikui Liu Yeonseok Chung Seon Hee Chang Bing Sun Chen Dong doi:10.1038/ni.1821 Nature Immunology 10, 1260 (2009) 2009-11-01 Nature Immunology 2009-11-01 10.1038/ni.1821 http://dx.doi.org/10.1038/ni.1821 10 12 Article 1260 1266 http://dx.doi.org/10.1038/ni.1821 T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii http://feeds.nature.com/~r/ni/rss/current/~3/p0A3bz5N280/ni.1816 Nod2 senses intracellular bacteria and is required for their eradication. Nuñez and co-workers now describe a T cell–intrinsic role for Nod2 in combating the intracellular parasite Toxoplasma gondii. Advertisement

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

Nature Immunology 10, 1267 (2009). doi:10.1038/ni.1816

Authors: Michael H Shaw, Thornik Reimer, Carmen Sánchez-Valdepeñas, Neil Warner, Yun-Gi Kim, Manuel Fresno & Gabriel Nuñez

]]> T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii Michael H Shaw Thornik Reimer Carmen Sánchez-Valdepeñas Neil Warner Yun-Gi Kim Manuel Fresno Gabriel Nuñez doi:10.1038/ni.1816 Nature Immunology 10, 1267 (2009) 2009-11-01 Nature Immunology 2009-11-01 10.1038/ni.1816 http://dx.doi.org/10.1038/ni.1816 10 12 Article 1267 1274 http://dx.doi.org/10.1038/ni.1816 Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels http://feeds.nature.com/~r/ni/rss/current/~3/0KhcDanS7fQ/ni.1793 T cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Cav1.4-β3 channels are needed for the survival and homeostasis of naive CD8+ T cells. Advertisement

Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

Nature Immunology 10, 1275 (2009). doi:10.1038/ni.1793

Authors: Mithilesh K Jha, Abdallah Badou, Marcel Meissner, John E McRory, Marc Freichel, Veit Flockerzi & Richard A Flavell

]]> Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels Mithilesh K Jha Abdallah Badou Marcel Meissner John E McRory Marc Freichel Veit Flockerzi Richard A Flavell doi:10.1038/ni.1793 Nature Immunology 10, 1275 (2009) 2009-10-18 Nature Immunology 2009-10-18 10.1038/ni.1793 http://dx.doi.org/10.1038/ni.1793 10 12 Article 1275 1282 http://dx.doi.org/10.1038/ni.1793 Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production http://feeds.nature.com/~r/ni/rss/current/~3/W3Ck8yfeEUA/ni.1820 High-affinity and isotype-switched antibodies arise from germinal center reactions. Goodnow and colleagues identify the Rho guanine nucleotide–exchange factor DOCK8 as being essential for sustained B cell immune synapse formation in germinal centers and mature antibody responses. Advertisement

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

Nature Immunology 10, 1283 (2009). doi:10.1038/ni.1820

Authors: Katrina L Randall, Teresa Lambe, Andy Johnson, Bebhinn Treanor, Edyta Kucharska, Heather Domaschenz, Belinda Whittle, Lina E Tze, Anselm Enders, Tanya L Crockford, Tiphaine Bouriez-Jones, Duncan Alston, Jason G Cyster, Michael J Lenardo, Fabienne Mackay, Elissa K Deenick, Stuart G Tangye, Tyani D Chan, Tahra Camidge, Robert Brink, Carola G Vinuesa, Facundo D Batista, Richard J Cornall & Christopher C Goodnow

]]> Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production Katrina L Randall Teresa Lambe Andy Johnson Bebhinn Treanor Edyta Kucharska Heather Domaschenz Belinda Whittle Lina E Tze Anselm Enders Tanya L Crockford Tiphaine Bouriez-Jones Duncan Alston Jason G Cyster Michael J Lenardo Fabienne Mackay Elissa K Deenick Stuart G Tangye Tyani D Chan Tahra Camidge Robert Brink Carola G Vinuesa Facundo D Batista Richard J Cornall Christopher C Goodnow doi:10.1038/ni.1820 Nature Immunology 10, 1283 (2009) 2009-11-08 Nature Immunology 2009-11-08 10.1038/ni.1820 http://dx.doi.org/10.1038/ni.1820 10 12 Article 1283 1291 http://dx.doi.org/10.1038/ni.1820 Multiple layers of B cell memory with different effector functions http://feeds.nature.com/~r/ni/rss/current/~3/smDFYHV5tRU/ni.1814 Immunization elicits B cell memory and short- and long-term antibody-secreting plasma cells. Weill and colleagues show that long-term IgM+ and IgG+ memory B cells can persist in germinal centers and undergo different fates after antigenic rechallenge. Advertisement

Multiple layers of B cell memory with different effector functions

Nature Immunology 10, 1292 (2009). doi:10.1038/ni.1814

Authors: Ismail Dogan, Barbara Bertocci, Valérie Vilmont, Frédéric Delbos, Jérome Mégret, Sébastien Storck, Claude-Agnès Reynaud & Jean-Claude Weill

]]> Multiple layers of B cell memory with different effector functions Ismail Dogan Barbara Bertocci Valérie Vilmont Frédéric Delbos Jérome Mégret Sébastien Storck Claude-Agnès Reynaud Jean-Claude Weill doi:10.1038/ni.1814 Nature Immunology 10, 1292 (2009) 2009-10-25 Nature Immunology 2009-10-25 10.1038/ni.1814 http://dx.doi.org/10.1038/ni.1814 10 12 Article 1292 1299 http://dx.doi.org/10.1038/ni.1814 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 http://feeds.nature.com/~r/ni/rss/current/~3/7KbaDeXuJgw/ni.1815 The mitochondrial adaptor MAVS is necessary for the transmission of RIG-I and Mda5 antiviral signals. Jiang and colleagues show that PCBP2 negatively regulates MAVS stability by recruiting the L48-ubiquitinating enzyme AIP4, thereby preventing excessive cytokine responses. Advertisement

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

Nature Immunology 10, 1300 (2009). doi:10.1038/ni.1815

Authors: Fuping You, Hui Sun, Xiang Zhou, Wenxiang Sun, Shimin Liang, Zhonghe Zhai & Zhengfan Jiang

]]> PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 Fuping You Hui Sun Xiang Zhou Wenxiang Sun Shimin Liang Zhonghe Zhai Zhengfan Jiang doi:10.1038/ni.1815 Nature Immunology 10, 1300 (2009) 2009-11-01 Nature Immunology 2009-11-01 10.1038/ni.1815 http://dx.doi.org/10.1038/ni.1815 10 12 Article 1300 1308 http://dx.doi.org/10.1038/ni.1815