Segal and colleagues identify a neuroprotective immature-like neutrophil subset that participates in dectin-1-dependent axon repair and regeneration in the central nervous system.

See Segal and N&Vs Voskuhl

The nervous and immune systems were long considered isolated from each other. Kipnis and colleagues find that the cytokine IL-17 influences survival-related behavioral traits that may be evolutionarily conserved.

See Kipnis and N&Vs Pujol

S proteins are shown in their closed inactive (yellow) and open active (orange) conformations. Based on fully-glycosylated models (PDBs 6VXX_1_1_1 and 6VSB_1_1_1, respectively) from CHARMM-GUI COVID-19 Proteins Library. Assembled and rendered by Austin Athman, Visual & Medical Arts, Research Technologies Branch (RTB), National Institute of Allergy and Infectious Diseases (NIAID), in collaboration with Cindi Schwartz, Electron Microscopy Unit, RTB, NIAID and the Bioinformatics & Computational Biology Branch, NIAID.

See Meeting Report Rosenberg

Di Domizio and colleagues show that CXCL10 facilitates the repair of injured skin by killing the commensal microbiota in skin wounds and by forming interferogenic complexes with bacterial and not host DNA.

See Article Gilliet and N&Vs Nagao

Geiger and colleagues use SILAC and mass spectrometry to study protein turnover in human T cells and examine how naive T cells both maintain their quiescence and transition to activated cells.

See article Geiger and N&Vs Cantrell

Twenty antibodies to reflect 20 years of Nature Immunology. To celebrate our anniversary, we have commissioned a series of Comments from some of our authors from the last 20 years that describe their landmark studies and how they drove immunology research forward.

See https://www.nature.com/collections/fddiddjdcj

Ludewig and colleagues use fate-mapping reporter cells, single-cell RNA-seq analysis and high-resolution microscopy to identify and track the spatial reorganization of follicular reticular cells within germinal centers during the course of an immune response.

See Ludewig and Clark and Klein N&Vs

Climate change is already affecting vector-borne and water-borne disease transmission and spread, and its impacts are likely to worsen.

See Dubrow and Semenza

Mucosa-associated invariant T (MAIT) cells recognize vitamin B metabolites presented by the molecule MR1. Rossjohn and colleagues generate multiple altered metabolite ligands and determine their structures in the context of MR1 and the TCR to develop a generalized framework for MAIT cell antigen recognition.

See Awad et al.

March is Women’s History Month. This month’s issue celebrates the contributions of women in immunology by presenting specially commissioned content, including World Views, from women across the globe.

See https://www.nature.com/collections/women-in-immunology

Seillet and colleagues demonstrate that the neurohormone VIP, produced by enteric neurons in response to feeding, activates VIPR2 on ILC3 to coordinate anticipatory defense mechanisms through IL-22 to protect mucosal tissues.

See Seillet et al.

Oxidized host-derived phospholipids such as oxPAPC can play important roles in atherosclerosis. Zanoni and colleagues demonstrate that oxPAPC potentiates the mitochondrial activity of macrophages and generates a distinctive metabolic and hyperinflammatory profile that can drive atherosclerosis in mice.

See Zanoni et al.