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Volume 7 Issue 8, August 2006

Toll-like receptor 5 (TLR5) recognizes bacterial flagellin. Akira and colleagues demonstrate that CD11c+ lamina propria cells have high expression of TLR5 and may help the immune system distinguish between pathogenic and commensal bacteria. The original immunofluorescence image (by Satoshi Uematsu and Myoung Ho Jang) shows CD11c+ cells (red) expressing TLR5 (green) in the lamina propria of the small intestine. Artwork by Lewis Long.

Volume 7 Issue 8

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Essay

  • Envisioning how T cells might recognize antigen presented by major histocompatibility complex molecules proved to be a formidable challenge. Pamela Bjorkman describes her journey to provide structural insights into how such recognition is achieved.

    • Pamela J Bjorkman
    Essay
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News & Views

  • Networks of transcription factors regulate cell fate 'decisions'. The forkhead protein Foxp1 is now identified as a key regulator of B cell development that influences the expression of recombination-activating genes.

    • Fabio Savarese
    • Rudolf Grosschedl
    News & Views

  • Viruses have evolved several strategies to subvert host defenses. New evidence indicates that herpes simplex virus 1 prevents glycolipid antigen presentation to natural killer T cells by downregulating CD1d expression.

    • Luc Van Kaer
    • Sebastian Joyce
    News & Views

  • The recently deduced structures of amphioxus immune-like receptors provide new insights on what is actually required for antigen recognition by antigen receptors.

    • Neil S Greenspan
    • Harry W Schroeder Jr
    News & Views

  • Many aspects of the CD8+ T lymphocyte response are 'programmed' by inductive stimuli during primary activation. A recent Nature paper shows that interleukin 2 signals endow CD8 T cells with the capacity for secondary population expansion during priming.

    • Stephen P Schoenberger
    • Edith M Janssen
    News & Views
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