Browse Articles

  • Article |

    Microsatellite instability and Epstein–Barr virus positivity represent novel biomarkers of clinical response to PD-1 blockade in patients with metastatic gastric cancer.

    • Seung Tae Kim
    • , Razvan Cristescu
    • , Adam J. Bass
    • , Kyoung-Mee Kim
    • , Justin I. Odegaard
    • , Kyung Kim
    • , Xiao Qiao Liu
    • , Xinwei Sher
    • , Hun Jung
    • , Mijin Lee
    • , Sujin Lee
    • , Se Hoon Park
    • , Joon Oh Park
    • , Young Suk Park
    • , Ho Yeong Lim
    • , Hyuk Lee
    • , Mingew Choi
    • , AmirAli Talasaz
    • , Peter Soonmo Kang
    • , Jonathan Cheng
    • , Andrey Loboda
    • , Jeeyun Lee
    •  & Won Ki Kang
  • Article |

    Mapping of the clonal structure of bone marrow cells in patients with acute myeloid leukemia treated with the IDH2 inhibitor enasidenib reveals heterogeneity in the cellular differentiation response and in mechanisms of relapse.

    • Lynn Quek
    • , Muriel D. David
    • , Alison Kennedy
    • , Marlen Metzner
    • , Michael Amatangelo
    • , Alan Shih
    • , Bilyana Stoilova
    • , Cyril Quivoron
    • , Maël Heiblig
    • , Christophe Willekens
    • , Véronique Saada
    • , Samar Alsafadi
    • , M. S. Vijayabaskar
    • , Andy Peniket
    • , Oliver A. Bernard
    • , Sam Agresta
    • , Katharine Yen
    • , Kyle MacBeth
    • , Eytan Stein
    • , George S. Vassiliou
    • , Ross Levine
    • , Stephane De Botton
    • , Anjan Thakurta
    • , Virginie Penard-Lacronique
    •  & Paresh Vyas
  • Letter |

    In utero GBA gene therapy extends lifespan and provides long-lasting phenotypic amelioration in a mouse model of neuronopathic Gaucher disease. Fetal ultrasound-guided in utero gene vector delivery is also achieved in the non-human primate brain.

    • Giulia Massaro
    • , Citra N. Z. Mattar
    • , Andrew M. S. Wong
    • , Ernestas Sirka
    • , Suzanne M. K. Buckley
    • , Bronwen R. Herbert
    • , Stefan Karlsson
    • , Dany P. Perocheau
    • , Derek Burke
    • , Simon Heales
    • , Angela Richard-Londt
    • , Sebastian Brandner
    • , Mylene Huebecker
    • , David A. Priestman
    • , Frances M. Platt
    • , Kevin Mills
    • , Arijit Biswas
    • , Jonathan D. Cooper
    • , Jerry K. Y. Chan
    • , Seng H. Cheng
    • , Simon N. Waddington
    •  & Ahad A. Rahim
  • News & Views |

    Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.

    • Fyodor D. Urnov
  • News & Views |

    An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.

    • Nathalie M. Delzenne
    •  & Laure B. Bindels
  • News & Views |

    The number, identity, and burden of mutations in clonal hematopoiesis are associated with the risk and timing of progression to acute myeloid leukemia.

    • Rob S. Sellar
    • , Siddhartha Jaiswal
    •  & Benjamin L. Ebert
  • Article |

    Somatic mutations detected years before diagnosis increase the odds of development of acute myeloid leukemia in women.

    • Pinkal Desai
    • , Nuria Mencia-Trinchant
    • , Oleksandr Savenkov
    • , Michael S. Simon
    • , Gloria Cheang
    • , Sangmin Lee
    • , Michael Samuel
    • , Ellen K. Ritchie
    • , Monica L. Guzman
    • , Karla V. Ballman
    • , Gail J. Roboz
    •  & Duane C. Hassane
  • Article |

    Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.

    • Ming Xu
    • , Tamar Pirtskhalava
    • , Joshua N. Farr
    • , Bettina M. Weigand
    • , Allyson K. Palmer
    • , Megan M. Weivoda
    • , Christina L. Inman
    • , Mikolaj B. Ogrodnik
    • , Christine M. Hachfeld
    • , Daniel G. Fraser
    • , Jennifer L. Onken
    • , Kurt O. Johnson
    • , Grace C. Verzosa
    • , Larissa G. P. Langhi
    • , Moritz Weigl
    • , Nino Giorgadze
    • , Nathan K. LeBrasseur
    • , Jordan D. Miller
    • , Diana Jurk
    • , Ravinder J. Singh
    • , David B. Allison
    • , Keisuke Ejima
    • , Gene B. Hubbard
    • , Yuji Ikeno
    • , Hajrunisa Cubro
    • , Vesna D. Garovic
    • , Xiaonan Hou
    • , S. John Weroha
    • , Paul D. Robbins
    • , Laura J. Niedernhofer
    • , Sundeep Khosla
    • , Tamara Tchkonia
    •  & James L. Kirkland
  • News Feature |

    First-of-its-kind US trial hopes to bring hospital treatment to the home.

    • Shraddha Chakradhar
  • News & Views |

    Studies in KRAS-mutant lung and pancreatic adenocarcinoma and in KRAS-amplified gastric carcinoma reveal that SHP2 inhibition augments the antitumor effect of MEK inhibitor treatment.

    • Trang T. Mai
    •  & Piro Lito
  • Q&A |

    The pathological hallmarks of Alzheimer’s disease (AD) include extracellular beta-amyloid plaques, neurofibrillary tangles, neuronal loss and tau deposits in brain. Therapies targeting these known hallmarks are yet to yield any meaningful benefit in clinical trials. We spoke to four researchers in the fields of AD research and therapy development to find out where they think the fields should head next.

    • Hannah Stower
  • Article |

    An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.

    • Lukas Bunse
    • , Stefan Pusch
    • , Theresa Bunse
    • , Felix Sahm
    • , Khwab Sanghvi
    • , Mirco Friedrich
    • , Dalia Alansary
    • , Jana K. Sonner
    • , Edward Green
    • , Katrin Deumelandt
    • , Michael Kilian
    • , Cyril Neftel
    • , Stefanie Uhlig
    • , Tobias Kessler
    • , Anna von Landenberg
    • , Anna S. Berghoff
    • , Kelly Marsh
    • , Mya Steadman
    • , Dongwei Zhu
    • , Brandon Nicolay
    • , Benedikt Wiestler
    • , Michael O. Breckwoldt
    • , Ruslan Al-Ali
    • , Simone Karcher-Bausch
    • , Matthias Bozza
    • , Iris Oezen
    • , Magdalena Kramer
    • , Jochen Meyer
    • , Antje Habel
    • , Jessica Eisel
    • , Gernot Poschet
    • , Michael Weller
    • , Matthias Preusser
    • , Minou Nadji-Ohl
    • , Niklas Thon
    • , Michael C. Burger
    • , Patrick N. Harter
    • , Miriam Ratliff
    • , Richard Harbottle
    • , Axel Benner
    • , Daniel Schrimpf
    • , Jürgen Okun
    • , Christel Herold-Mende
    • , Sevin Turcan
    • , Stefan Kaulfuss
    • , Holger Hess‐Stumpp
    • , Karen Bieback
    • , Daniel P. Cahill
    • , Karl H. Plate
    • , Daniel Hänggi
    • , Marion Dorsch
    • , Mario L. Suvà
    • , Barbara A. Niemeyer
    • , Andreas von Deimling
    • , Wolfgang Wick
    •  & Michael Platten
  • Article |

    How heavy a person is and how much active brown fat they have depends on their father and the season in which they were conceived.

    • Wenfei Sun
    • , Hua Dong
    • , Anton S. Becker
    • , Dianne H. Dapito
    • , Salvatore Modica
    • , Gerald Grandl
    • , Lennart Opitz
    • , Vissarion Efthymiou
    • , Leon G. Straub
    • , Gitalee Sarker
    • , Miroslav Balaz
    • , Lucia Balazova
    • , Aliki Perdikari
    • , Elke Kiehlmann
    • , Sara Bacanovic
    • , Caroline Zellweger
    • , Daria Peleg-Raibstein
    • , Pawel Pelczar
    • , Wolf Reik
    • , Irene A. Burger
    • , Ferdinand von Meyenn
    •  & Christian Wolfrum
  • News Feature |

    Nationwide trials pair children with targeted cancer therapies.

    • Shraddha Chakradhar
  • News & Views |

    A glucagon-like peptide receptor 1 (GLP-1R) agonist inhibits the conversion of astrocytes into a neurotoxic phenotype and protects against neurodegeneration, shedding light on the pathogenesis of Parkinson’s disease.

    • Lena Brundin
    • , Liza Bergkvist
    •  & Patrik Brundin
  • Resource |

    A comprehensive single-cell analysis of the lung cancer microenvironment reveals marked heterogeneity of transcriptional networks that defines novel clinically relevant stromal cell populations.

    • Diether Lambrechts
    • , Els Wauters
    • , Bram Boeckx
    • , Sara Aibar
    • , David Nittner
    • , Oliver Burton
    • , Ayse Bassez
    • , Herbert Decaluwé
    • , Andreas Pircher
    • , Kathleen Van den Eynde
    • , Birgit Weynand
    • , Erik Verbeken
    • , Paul De Leyn
    • , Adrian Liston
    • , Johan Vansteenkiste
    • , Peter Carmeliet
    • , Stein Aerts
    •  & Bernard Thienpont
  • Article |

    A molecularly defined set of sensory fibers expressing MrgprA3 mediate ocular itch via specific anatomical projections to the conjunctiva, which can be targeted therapeutically in rodent models.

    • Cheng-Chiu Huang
    • , Weishan Yang
    • , Changxiong Guo
    • , Haowu Jiang
    • , Fengxian Li
    • , Maolei Xiao
    • , Steve Davidson
    • , Guang Yu
    • , Bo Duan
    • , Tianwen Huang
    • , Andrew J. W. Huang
    •  & Qin Liu