Browse Articles

  • Article |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Letter |

    Exposure to a farm-like house dust microbiome is associated with protection against asthma development in children living in urban environments.

    • Pirkka V. Kirjavainen
    • , Anne M. Karvonen
    • , Rachel I. Adams
    • , Martin Täubel
    • , Marjut Roponen
    • , Pauli Tuoresmäki
    • , Georg Loss
    • , Balamuralikrishna Jayaprakash
    • , Martin Depner
    • , Markus Johannes Ege
    • , Harald Renz
    • , Petra Ina Pfefferle
    • , Bianca Schaub
    • , Roger Lauener
    • , Anne Hyvärinen
    • , Rob Knight
    • , Dick J. J. Heederik
    • , Erika von Mutius
    •  & Juha Pekkanen
  • Publisher Correction |

    • Leonie Voorwerk
    • , Maarten Slagter
    • , Hugo M. Horlings
    • , Karolina Sikorska
    • , Koen K. van de Vijver
    • , Michiel de Maaker
    • , Iris Nederlof
    • , Roelof J. C. Kluin
    • , Sarah Warren
    • , SuFey Ong
    • , Terry G. Wiersma
    • , Nicola S. Russell
    • , Ferry Lalezari
    • , Philip C. Schouten
    • , Noor A. M. Bakker
    • , Steven L. C. Ketelaars
    • , Dennis Peters
    • , Charlotte A. H. Lange
    • , Erik van Werkhoven
    • , Harm van Tinteren
    • , Ingrid A. M. Mandjes
    • , Inge Kemper
    • , Suzanne Onderwater
    • , Myriam Chalabi
    • , Sofie Wilgenhof
    • , John B. A. G. Haanen
    • , Roberto Salgado
    • , Karin E. de Visser
    • , Gabe S. Sonke
    • , Lodewyk F. A. Wessels
    • , Sabine C. Linn
    • , Ton N. Schumacher
    • , Christian U. Blank
    •  & Marleen Kok
  • Editorial |

    The National Institutes of Health Human Microbiome Project is coming to a close, offering an opportunity to reflect on its legacy and the urgent need to understand the microbiome of underrepresented populations.

  • Turning Points |

    Vijay Sankaran is a practicing pediatric hematologist and researcher at Boston Children’s Hospital, the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard. His laboratory uses insights from human genetics to study blood cell production in health and disease.

    • Vijay G. Sankaran
  • Turning Points |

    Karishma Kaushik’s research at University of Pune focuses on chronic wound infections, from probing the complex wound infection microenvironment to enabling personalized therapeutic approaches. She is a recipient of the Ramalingaswami Re-entry Fellowship, a program funded by the Government of India to support the research of early-career scientists and their return to the country from abroad.

    • Karishma Kaushik
  • Letter |

    Triple therapy combining BRAF and MEK inhibitors with immune checkpoint blockade may benefit a subset of patients with BRAFV600-mutated metastatic melanoma.

    • Antoni Ribas
    • , Donald Lawrence
    • , Victoria Atkinson
    • , Sachin Agarwal
    • , Wilson H. Miller Jr
    • , Matteo S. Carlino
    • , Rosalie Fisher
    • , Georgina V. Long
    • , F. Stephen Hodi
    • , Jennifer Tsoi
    • , Catherine S. Grasso
    • , Bijoyesh Mookerjee
    • , Qing Zhao
    • , Razi Ghori
    • , Blanca Homet Moreno
    • , Nageatte Ibrahim
    •  & Omid Hamid
  • Letter |

    A randomized phase 2 trial testing triple combination of BRAF, MEK and PD-1 inhibition as first-line therapy in patients with BRAF-mutant melanoma shows durable responses and encouraging progression-free survival.

    • Paolo Antonio Ascierto
    • , Pier Francesco Ferrucci
    • , Rosalie Fisher
    • , Michele Del Vecchio
    • , Victoria Atkinson
    • , Henrik Schmidt
    • , Jacob Schachter
    • , Paola Queirolo
    • , Georgina V. Long
    • , Anna Maria Di Giacomo
    • , Inge Marie Svane
    • , Michal Lotem
    • , Gil Bar-Sela
    • , Felix Couture
    • , Bijoyesh Mookerjee
    • , Razi Ghori
    • , Nageatte Ibrahim
    • , Blanca Homet Moreno
    •  & Antoni Ribas
  • Letter |

    Treatment with BRAF and/or MEK inhibitors followed by addition of anti-PD-L1 in BRAF-mutant melanoma patients is safe and shows promising anti-tumor activity.

    • Ryan J. Sullivan
    • , Omid Hamid
    • , Rene Gonzalez
    • , Jeffrey R. Infante
    • , Manish R. Patel
    • , F. Stephen Hodi
    • , Karl D. Lewis
    • , Hussein A. Tawbi
    • , Genevive Hernandez
    • , Matthew J. Wongchenko
    • , YiMeng Chang
    • , Louise Roberts
    • , Marcus Ballinger
    • , Yibing Yan
    • , Edward Cha
    •  & Patrick Hwu
  • Letter |

    Colorectal cancer stages are associated with distinct microbial and metabolomic profiles that could shed light on cancer progression.

    • Shinichi Yachida
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Takeshi Nakajima
    • , Taku Sakamoto
    • , Hikaru Watanabe
    • , Keigo Masuda
    • , Yuichiro Nishimoto
    • , Masaru Kubo
    • , Fumie Hosoda
    • , Hirofumi Rokutan
    • , Minori Matsumoto
    • , Hiroyuki Takamaru
    • , Masayoshi Yamada
    • , Takahisa Matsuda
    • , Motoki Iwasaki
    • , Taiki Yamaji
    • , Tatsuo Yachida
    • , Tomoyoshi Soga
    • , Ken Kurokawa
    • , Atsushi Toyoda
    • , Yoshitoshi Ogura
    • , Tetsuya Hayashi
    • , Masanori Hatakeyama
    • , Hitoshi Nakagama
    • , Yutaka Saito
    • , Shinji Fukuda
    • , Tatsuhiro Shibata
    •  & Takuji Yamada
  • Turning Points |

    Takanori Takebe is an assistant professor at the Cincinnati Children’s Hospital Medical Center and a professor at Tokyo Medical and Dental University, Japan. His research aims to develop mini organ technologies derived from human stem cells and use those in patients with rare congenital metabolic disorders.

    • Takanori Takebe
  • Brief Communication |

    A deep residual learning framework identifies microsatellite instability in histology slides from patients with cancer and can be used to guide immunotherapy.

    • Jakob Nikolas Kather
    • , Alexander T. Pearson
    • , Niels Halama
    • , Dirk Jäger
    • , Jeremias Krause
    • , Sven H. Loosen
    • , Alexander Marx
    • , Peter Boor
    • , Frank Tacke
    • , Ulf Peter Neumann
    • , Heike I. Grabsch
    • , Takaki Yoshikawa
    • , Hermann Brenner
    • , Jenny Chang-Claude
    • , Michael Hoffmeister
    • , Christian Trautwein
    •  & Tom Luedde
  • Brief Communication |

    Individuals homozygous for the CCR5-∆32 allele have a 21% increase in mortality rate in the UK Biobank cohort. In light of the CRISPR-baby scandal, this work highlights the need for understanding the unintended consequences of introducing mutations in humans.

    • Xinzhu Wei
    •  & Rasmus Nielsen
  • Letter |

    A diagnostic tool based on blood RNA-seq is shown to identify causal genes and variants linked to clinical phenotypes in individuals with rare diseases for which whole-exome genetic sequencing was uninformative.

    • Laure Frésard
    • , Craig Smail
    • , Nicole M. Ferraro
    • , Nicole A. Teran
    • , Xin Li
    • , Kevin S. Smith
    • , Devon Bonner
    • , Kristin D. Kernohan
    • , Shruti Marwaha
    • , Zachary Zappala
    • , Brunilda Balliu
    • , Joe R. Davis
    • , Boxiang Liu
    • , Cameron J. Prybol
    • , Jennefer N. Kohler
    • , Diane B. Zastrow
    • , Chloe M. Reuter
    • , Dianna G. Fisk
    • , Megan E. Grove
    • , Jean M. Davidson
    • , Taila Hartley
    • , Ruchi Joshi
    • , Benjamin J. Strober
    • , Sowmithri Utiramerur
    • , David R. Adams
    • , Aaron Aday
    • , Mercedes E. Alejandro
    • , Patrick Allard
    • , Euan A. Ashley
    • , Mahshid S. Azamian
    • , Carlos A. Bacino
    • , Eva Baker
    • , Ashok Balasubramanyam
    • , Hayk Barseghyan
    • , Gabriel F. Batzli
    • , Alan H. Beggs
    • , Babak Behnam
    • , Hugo J. Bellen
    • , Jonathan A. Bernstein
    • , Gerard T. Berry
    • , Anna Bican
    • , David P. Bick
    • , Camille L. Birch
    • , Devon Bonner
    • , Braden E. Boone
    • , Bret L. Bostwick
    • , Lauren C. Briere
    • , Elly Brokamp
    • , Donna M. Brown
    • , Matthew Brush
    • , Elizabeth A. Burke
    • , Lindsay C. Burrage
    • , Manish J. Butte
    • , Shan Chen
    • , Gary D. Clark
    • , Terra R. Coakley
    • , Joy D. Cogan
    • , Heather A. Colley
    • , Cynthia M. Cooper
    • , Heidi Cope
    • , William J. Craigen
    • , Precilla D’Souza
    • , Mariska Davids
    • , Jean M. Davidson
    • , Jyoti G. Dayal
    • , Esteban C. Dell’Angelica
    • , Shweta U. Dhar
    • , Katrina M. Dipple
    • , Laurel A. Donnell-Fink
    • , Naghmeh Dorrani
    • , Daniel C. Dorset
    • , Emilie D. Douine
    • , David D. Draper
    • , Annika M. Dries
    • , Laura Duncan
    • , David J. Eckstein
    • , Lisa T. Emrick
    • , Christine M. Eng
    • , Gregory M. Enns
    • , Ascia Eskin
    • , Cecilia Esteves
    • , Tyra Estwick
    • , Liliana Fernandez
    • , Carlos Ferreira
    • , Elizabeth L. Fieg
    • , Paul G. Fisher
    • , Brent L. Fogel
    • , Noah D. Friedman
    • , William A. Gahl
    • , Emily Glanton
    • , Rena A. Godfrey
    • , Alica M. Goldman
    • , David B. Goldstein
    • , Sarah E. Gould
    • , Jean-Philippe F. Gourdine
    • , Catherine A. Groden
    • , Andrea L. Gropman
    • , Melissa Haendel
    • , Rizwan Hamid
    • , Neil A. Hanchard
    • , Frances High
    • , Ingrid A. Holm
    • , Jason Hom
    • , Ellen M. Howerton
    • , Yong Huang
    • , Fariha Jamal
    • , Yong-hui Jiang
    • , Jean M. Johnston
    • , Angela L. Jones
    • , Lefkothea Karaviti
    • , David M. Koeller
    • , Isaac S. Kohane
    • , Jennefer N. Kohler
    • , Donna M. Krasnewich
    • , Susan Korrick
    • , Mary Koziura
    • , Joel B. Krier
    • , Jennifer E. Kyle
    • , Seema R. Lalani
    • , C. Christopher Lau
    • , Jozef Lazar
    • , Kimberly LeBlanc
    • , Brendan H. Lee
    • , Hane Lee
    • , Shawn E. Levy
    • , Richard A. Lewis
    • , Sharyn A. Lincoln
    • , Sandra K. Loo
    • , Joseph Loscalzo
    • , Richard L. Maas
    • , Ellen F. Macnamara
    • , Calum A. MacRae
    • , Valerie V. Maduro
    • , Marta M. Majcherska
    • , May Christine V. Malicdan
    • , Laura A. Mamounas
    • , Teri A. Manolio
    • , Thomas C. Markello
    • , Ronit Marom
    • , Martin G. Martin
    • , Julian A. Martínez-Agosto
    • , Shruti Marwaha
    • , Thomas May
    • , Allyn McConkie-Rosell
    • , Colleen E. McCormack
    • , Alexa T. McCray
    • , Jason D. Merker
    • , Thomas O. Metz
    • , Matthew Might
    • , Paolo M. Moretti
    • , Marie Morimoto
    • , John J. Mulvihill
    • , David R. Murdock
    • , Jennifer L. Murphy
    • , Donna M. Muzny
    • , Michele E. Nehrebecky
    • , Stan F. Nelson
    • , J. Scott Newberry
    • , John H. Newman
    • , Sarah K. Nicholas
    • , Donna Novacic
    • , Jordan S. Orange
    • , James P. Orengo
    • , J. Carl Pallais
    • , Christina GS. Palmer
    • , Jeanette C. Papp
    • , Neil H. Parker
    • , Loren DM. Pena
    • , John A. Phillips III
    • , Jennifer E. Posey
    • , John H. Postlethwait
    • , Lorraine Potocki
    • , Barbara N. Pusey
    • , Genecee Renteria
    • , Chloe M. Reuter
    • , Lynette Rives
    • , Amy K. Robertson
    • , Lance H. Rodan
    • , Jill A. Rosenfeld
    • , Jacinda B. Sampson
    • , Susan L. Samson
    • , Kelly Schoch
    • , Daryl A. Scott
    • , Lisa Shakachite
    • , Prashant Sharma
    • , Vandana Shashi
    • , Rebecca Signer
    • , Edwin K. Silverman
    • , Janet S. Sinsheimer
    • , Kevin S. Smith
    • , Rebecca C. Spillmann
    • , Joan M. Stoler
    • , Nicholas Stong
    • , Jennifer A. Sullivan
    • , David A. Sweetser
    • , Queenie K.-G. Tan
    • , Cynthia J. Tifft
    • , Camilo Toro
    • , Alyssa A. Tran
    • , Tiina K. Urv
    • , Eric Vilain
    • , Tiphanie P. Vogel
    • , Daryl M. Waggott
    • , Colleen E. Wahl
    • , Nicole M. Walley
    • , Chris A. Walsh
    • , Melissa Walker
    • , Jijun Wan
    • , Michael F. Wangler
    • , Patricia A. Ward
    • , Katrina M. Waters
    • , Bobbie-Jo M. Webb-Robertson
    • , Monte Westerfield
    • , Matthew T. Wheeler
    • , Anastasia L. Wise
    • , Lynne A. Wolfe
    • , Elizabeth A. Worthey
    • , Shinya Yamamoto
    • , John Yang
    • , Yaping Yang
    • , Amanda J. Yoon
    • , Guoyun Yu
    • , Diane B. Zastrow
    • , Chunli Zhao
    • , Allison Zheng
    • , Kym Boycott
    • , Alex MacKenzie
    • , Jacek Majewski
    • , Michael Brudno
    • , Dennis Bulman
    • , David Dyment
    • , Lars Lind
    • , Erik Ingelsson
    • , Alexis Battle
    • , Gill Bejerano
    • , Jonathan A. Bernstein
    • , Euan A. Ashley
    • , Kym M. Boycott
    • , Jason D. Merker
    • , Matthew T. Wheeler
    •  & Stephen B. Montgomery
  • Letter |

    Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.

    • Sophia Ng
    • , Raffael Nachbagauer
    • , Angel Balmaseda
    • , Daniel Stadlbauer
    • , Sergio Ojeda
    • , Mayuri Patel
    • , Arvind Rajabhathor
    • , Roger Lopez
    • , Andrea F. Guglia
    • , Nery Sanchez
    • , Fatima Amanat
    • , Lionel Gresh
    • , Guillermina Kuan
    • , Florian Krammer
    •  & Aubree Gordon
  • News & Views |

    Assessment of more than 400,000 people over the age of 40 demonstrates that homozygosity for a CCR5 variant that prevents HIV-1 infection comes at the cost of increased rates of mortality.

    • Jeremy Luban
  • Correspondence |

    • Eli Y. Adashi
    • , Arthur L. Caplan
    • , Alexander Capron
    • , Audrey R. Chapman
    • , Mildred Cho
    • , Ellen Wright Clayton
    • , I. Glenn Cohen
    • , Robert Cook-Deegan
    • , Ruth R. Faden
    • , Theodore Friedmann
    • , Lawrence O. Gostin
    • , Henry T. Greely
    • , Josephine Johnston
    • , Eric Juengst
    • , Patricia A. King
    • , Lori P. Knowles
    • , Anne Drapkin Lyerly
    • , Amy L. McGuire
    • , Jonathan D. Moreno
    • , Karen Rothenberg
    • , Robert D. Truog
    •  & LeRoy Walters
  • Article | | open

    As part of the second phase of Human Microbiome Project, the Multi-Omic Microbiome Study: Pregnancy Initiative presents a community resource to help better understand how microbiome and host profiles change throughout pregnancy as well as to identify new opportunities for assessment of the risk of preterm birth.

    • Jennifer M. Fettweis
    • , Myrna G. Serrano
    • , J. Paul Brooks
    • , David J. Edwards
    • , Philippe H. Girerd
    • , Hardik I. Parikh
    • , Bernice Huang
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Abigail L. Glascock
    • , Jie Xu
    • , Nicole R. Jimenez
    • , Stephany C. Vivadelli
    • , Stephen S. Fong
    • , Nihar U. Sheth
    • , Sophonie Jean
    • , Vladimir Lee
    • , Yahya A. Bokhari
    • , Ana M. Lara
    • , Shreni D. Mistry
    • , Robert A. Duckworth III
    • , Steven P. Bradley
    • , Vishal N. Koparde
    • , X. Valentine Orenda
    • , Sarah H. Milton
    • , Sarah K. Rozycki
    • , Andrey V. Matveyev
    • , Michelle L. Wright
    • , Snehalata V. Huzurbazar
    • , Eugenie M. Jackson
    • , Ekaterina Smirnova
    • , Jonas Korlach
    • , Yu-Chih Tsai
    • , Molly R. Dickinson
    • , Jamie L. Brooks
    • , Jennifer I. Drake
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , N. Romesh Wijesooriya
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    •  & Gregory A. Buck
  • Article |

    Ancestry and socioeconomic factors influence predictable changes in the vaginal microbiome that occur early in pregnancy in women who experience normal term birth.

    • Myrna G. Serrano
    • , Hardik I. Parikh
    • , J. Paul Brooks
    • , David J. Edwards
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Bernice Huang
    • , Philippe H. Girerd
    • , Yahya A. Bokhari
    • , Steven P. Bradley
    • , Jamie L. Brooks
    • , Molly R. Dickinson
    • , Jennifer I. Drake
    • , Robert A. Duckworth III
    • , Stephen S. Fong
    • , Abigail L. Glascock
    • , Sophonie Jean
    • , Nicole R. Jimenez
    • , Joseph Khoury
    • , Vishal N. Koparde
    • , Ana M. Lara
    • , Vladimir Lee
    • , Andrey V. Matveyev
    • , Sarah H. Milton
    • , Shreni D. Mistry
    • , Sarah K. Rozycki
    • , Nihar U. Sheth
    • , Ekaterina Smirnova
    • , Stephany C. Vivadelli
    • , N. Romesh Wijesooriya
    • , Jie Xu
    • , Ping Xu
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    • , Jennifer M. Fettweis
    •  & Gregory A. Buck
  • Comment |

    A crucial consideration for the clinical application of any burgeoning science is when the understanding of that field can be implemented without the risk of unforeseen harm. In our opinion, the need for caution is particularly urgent with respect to increasingly prevalent applications of microbiome science to medicine.

    • Kjersti Aagaard
    •  & Elizabeth Hohmann
  • Publisher Correction |

    • Zhenxun Wang
    • , Lian Yee Yip
    • , Jia Hui Jane Lee
    • , Zhengwei Wu
    • , Hui Yi Chew
    • , Pooi Kiat William Chong
    • , Chin Chye Teo
    • , Heather Yin-Kuan Ang
    • , Kai Lay Esther Peh
    • , Ju Yuan
    • , Siming Ma
    • , Li Shi Kimberly Choo
    • , Nurhidayah Basri
    • , Xia Jiang
    • , Qiang Yu
    • , Axel M. Hillmer
    • , Wan Teck Lim
    • , Tony Kiat Hon Lim
    • , Angela Takano
    • , Eng Huat Tan
    • , Daniel Shao Weng Tan
    • , Ying Swan Ho
    • , Bing Lim
    •  & Wai Leong Tam
  • Article | | open

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
  • News Feature |

    Researchers studying insect-borne disease hope to bring down the exorbitant cost of mosquitoes.

    • Monique Brouillette
  • Letter |

    A pick-the-winner clinical trial design in patients with metastatic triple-negative breast cancer shows that immune induction with doxorubicin or cisplatin may improve clinical responses to PD-1 blockade and induce a more favorable tumor microenvironment.

    • Leonie Voorwerk
    • , Maarten Slagter
    • , Hugo M. Horlings
    • , Karolina Sikorska
    • , Koen K. van de Vijver
    • , Michiel de Maaker
    • , Iris Nederlof
    • , Roelof J. C. Kluin
    • , Sarah Warren
    • , SuFey Ong
    • , Terry G. Wiersma
    • , Nicola S. Russell
    • , Ferry Lalezari
    • , Philip C. Schouten
    • , Noor A. M. Bakker
    • , Steven L. C. Ketelaars
    • , Dennis Peters
    • , Charlotte A. H. Lange
    • , Erik van Werkhoven
    • , Harm van Tinteren
    • , Ingrid A. M. Mandjes
    • , Inge Kemper
    • , Suzanne Onderwater
    • , Myriam Chalabi
    • , Sofie Wilgenhof
    • , John B. A. G. Haanen
    • , Roberto Salgado
    • , Karin E. de Visser
    • , Gabe S. Sonke
    • , Lodewyk F. A. Wessels
    • , Sabine C. Linn
    • , Ton N. Schumacher
    • , Christian U. Blank
    •  & Marleen Kok
  • Article |

    The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

    • Hanadie Yousef
    • , Cathrin J. Czupalla
    • , Davis Lee
    • , Michelle B. Chen
    • , Ashley N. Burke
    • , Kristy A. Zera
    • , Judith Zandstra
    • , Elisabeth Berber
    • , Benoit Lehallier
    • , Vidhu Mathur
    • , Ramesh V. Nair
    • , Liana N. Bonanno
    • , Andrew C. Yang
    • , Todd Peterson
    • , Husein Hadeiba
    • , Taylor Merkel
    • , Jakob Körbelin
    • , Markus Schwaninger
    • , Marion S. Buckwalter
    • , Stephen R. Quake
    • , Eugene C. Butcher
    •  & Tony Wyss-Coray
  • Editorial |

    Immune interventions capable of preventing or eradicating HIV infection have yet to achieve broad success in humans. Renewed vigor in the clinical trial arena may bring us closer to that goal.

  • Resource |

    Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anticancer therapy

    • Haoxin Li
    • , Shaoyang Ning
    • , Mahmoud Ghandi
    • , Gregory V. Kryukov
    • , Shuba Gopal
    • , Amy Deik
    • , Amanda Souza
    • , Kerry Pierce
    • , Paula Keskula
    • , Desiree Hernandez
    • , Julie Ann
    • , Dojna Shkoza
    • , Verena Apfel
    • , Yilong Zou
    • , Francisca Vazquez
    • , Jordi Barretina
    • , Raymond A. Pagliarini
    • , Giorgio G. Galli
    • , David E. Root
    • , William C. Hahn
    • , Aviad Tsherniak
    • , Marios Giannakis
    • , Stuart L. Schreiber
    • , Clary B. Clish
    • , Levi A. Garraway
    •  & William R. Sellers
  • Turning Points |

    Max Nieuwdorp is an internist, endocrinologist and vascular medicine specialist at Amsterdam University Medical Centers. He chairs the Diabetes Center there and is chief of the Department and Laboratory of Vascular Medicine.

    • Max Nieuwdorp