Browse Articles

  • Article |

    Interactions between the MLL3 histone methyltransferase and the BAP1–UTX complex set the level of histone H3K27 methylation and suggest a new therapy for MLL3-mutant cancer.

    • Lu Wang
    • , Zibo Zhao
    • , Patrick A. Ozark
    • , Damiano Fantini
    • , Stacy A. Marshall
    • , Emily J. Rendleman
    • , Kira A. Cozzolino
    • , Nundia Louis
    • , Xingyao He
    • , Marc A. Morgan
    • , Yoh-hei Takahashi
    • , Clayton K. Collings
    • , Edwin R. Smith
    • , Panagiotis Ntziachristos
    • , Jeffrey N. Savas
    • , Lihua Zou
    • , Rintaro Hashizume
    • , Joshua J. Meeks
    •  & Ali Shilatifard
  • Article |

    In a mouse model of intellectual disability, the chromatin remodeling protein ATR-X is shown to bind to G-quadruplex DNA structures and modulate target gene expression, which can be pharmacologically targeted to restore neuronal and cognitive phenotypes in these animals.

    • Norifumi Shioda
    • , Yasushi Yabuki
    • , Kouya Yamaguchi
    • , Misaki Onozato
    • , Yue Li
    • , Kenji Kurosawa
    • , Hideyuki Tanabe
    • , Nobuhiko Okamoto
    • , Takumi Era
    • , Hiroshi Sugiyama
    • , Takahito Wada
    •  & Kohji Fukunaga
  • Article |

    Distinct monocyte subsets associate with different outcomes of SIV vaccines.

    • Monica Vaccari
    • , Slim Fourati
    • , Shari N. Gordon
    • , Dallas R. Brown
    • , Massimilano Bissa
    • , Luca Schifanella
    • , Isabela Silva de Castro
    • , Melvin N. Doster
    • , Veronica Galli
    • , Maria Omsland
    • , Dai Fujikawa
    • , Giacomo Gorini
    • , Namal P. M. Liyanage
    • , Hung V. Trinh
    • , Katherine M. McKinnon
    • , Kathryn E. Foulds
    • , Brandon F. Keele
    • , Mario Roederer
    • , Richard A. Koup
    • , Xiaoying Shen
    • , Georgia D. Tomaras
    • , Marcus P. Wong
    • , Karissa J. Munoz
    • , Johannes S. Gach
    • , Donald N. Forthal
    • , David C. Montefiori
    • , David J. Venzon
    • , Barbara K. Felber
    • , Margherita Rosati
    • , George N. Pavlakis
    • , Mangala Rao
    • , Rafick-Pierre Sekaly
    •  & Genoveffa Franchini
  • Article |

    Inhibition of immune cell–derived acetylcholine synthesis or of its signaling via CHRNA2 in beige adipocytes reduces thermogenesis and exacerbates diet-induced obesity, suggesting a new mode of immuno–fat communication in energy metabolism.

    • Heejin Jun
    • , Hui Yu
    • , Jianke Gong
    • , Juan Jiang
    • , Xiaona Qiao
    • , Eric Perkey
    • , Dong-il Kim
    • , Margo P. Emont
    • , Alexander G. Zestos
    • , Jung-Sun Cho
    • , Jianfeng Liu
    • , Robert T. Kennedy
    • , Ivan Maillard
    • , X. Z. Shawn Xu
    •  & Jun Wu
  • Resource |

    An integrated resource of (epi)genomic features in annotated chronic lymphocytic leukemia (CLL) primary samples uncovers subgroup-specific regulatory alterations associated with clinical behavior.

    • Renée Beekman
    • , Vicente Chapaprieta
    • , Núria Russiñol
    • , Roser Vilarrasa-Blasi
    • , Núria Verdaguer-Dot
    • , Joost H. A. Martens
    • , Martí Duran-Ferrer
    • , Marta Kulis
    • , François Serra
    • , Biola M. Javierre
    • , Steven W. Wingett
    • , Guillem Clot
    • , Ana C. Queirós
    • , Giancarlo Castellano
    • , Julie Blanc
    • , Marta Gut
    • , Angelika Merkel
    • , Simon Heath
    • , Anna Vlasova
    • , Sebastian Ullrich
    • , Emilio Palumbo
    • , Anna Enjuanes
    • , David Martín-García
    • , Sílvia Beà
    • , Magda Pinyol
    • , Marta Aymerich
    • , Romina Royo
    • , Montserrat Puiggros
    • , David Torrents
    • , Avik Datta
    • , Ernesto Lowy
    • , Myrto Kostadima
    • , Maša Roller
    • , Laura Clarke
    • , Paul Flicek
    • , Xabier Agirre
    • , Felipe Prosper
    • , Tycho Baumann
    • , Julio Delgado
    • , Armando López-Guillermo
    • , Peter Fraser
    • , Marie-Laure Yaspo
    • , Roderic Guigó
    • , Reiner Siebert
    • , Marc A. Martí-Renom
    • , Xose S. Puente
    • , Carlos López-Otín
    • , Ivo Gut
    • , Hendrik G. Stunnenberg
    • , Elias Campo
    •  & Jose I. Martin-Subero
  • Article |

    Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium.

    • Ren Xu
    • , Alisha Yallowitz
    • , An Qin
    • , Zhuhao Wu
    • , Dong Yeon Shin
    • , Jung-Min Kim
    • , Shawon Debnath
    • , Gang Ji
    • , Mathias P. Bostrom
    • , Xu Yang
    • , Chao Zhang
    • , Han Dong
    • , Pouneh Kermani
    • , Sarfaraz Lalani
    • , Na Li
    • , Yifang Liu
    • , Michael G. Poulos
    • , Amanda Wach
    • , Yi Zhang
    • , Kazuki Inoue
    • , Annarita Di Lorenzo
    • , Baohong Zhao
    • , Jason M. Butler
    • , Jae-Hyuck Shim
    • , Laurie H. Glimcher
    •  & Matthew B. Greenblatt
  • Article |

    Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.

    • Brooke Tata
    • , Nour El Houda Mimouni
    • , Anne-Laure Barbotin
    • , Samuel A. Malone
    • , Anne Loyens
    • , Pascal Pigny
    • , Didier Dewailly
    • , Sophie Catteau-Jonard
    • , Inger Sundström-Poromaa
    • , Terhi T. Piltonen
    • , Federica Dal Bello
    • , Claudio Medana
    • , Vincent Prevot
    • , Jerome Clasadonte
    •  & Paolo Giacobini
  • News & Views |

    Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.

    • Vijay Ramaswamy
    •  & Michael D Taylor
  • News Feature |

    New studies question how HIV persists in the body

    • Shraddha Chakradhar
  • News & Views |

    A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.

    • Paul Hiebert
    •  & Sabine Werner
  • Brief Communication |

    Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor–deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects.

    • Karine Clément
    • , Heike Biebermann
    • , I. Sadaf Farooqi
    • , Lex Van der Ploeg
    • , Barbara Wolters
    • , Christine Poitou
    • , Lia Puder
    • , Fred Fiedorek
    • , Keith Gottesdiener
    • , Gunnar Kleinau
    • , Nicolas Heyder
    • , Patrick Scheerer
    • , Ulrike Blume-Peytavi
    • , Irina Jahnke
    • , Shubh Sharma
    • , Jacek Mokrosinski
    • , Susanna Wiegand
    • , Anne Müller
    • , Katja Weiß
    • , Knut Mai
    • , Joachim Spranger
    • , Annette Grüters
    • , Oliver Blankenstein
    • , Heiko Krude
    •  & Peter Kühnen
  • Editorial |

    For more than two decades, Nature Medicine has been the prime venue for publication of outstanding work in the translational space. Now the journal’s scope is evolving to embrace the clinical research that meets the challenges and complexities of contemporary medicine.

  • Letter |

    Loss of mismatch-repair protein ARID1A in cancer correlates with high mutation load & checkpoint blockade response, complementing MSI-based prognosis.

    • Jianfeng Shen
    • , Zhenlin Ju
    • , Wei Zhao
    • , Lulu Wang
    • , Yang Peng
    • , Zhongqi Ge
    • , Zachary D. Nagel
    • , Jun Zou
    • , Chen Wang
    • , Prabodh Kapoor
    • , Xiangyi Ma
    • , Ding Ma
    • , Jiyong Liang
    • , Shumei Song
    • , Jinsong Liu
    • , Leona D. Samson
    • , Jaffer A. Ajani
    • , Guo-Min Li
    • , Han Liang
    • , Xuetong Shen
    • , Gordon B. Mills
    •  & Guang Peng
  • News Feature |

    Finding poetry in gene editing and ways to improve it

    • Peter Andrey Smith
  • Letter |

    Expression of PM20D1 is regulated by long-range chromatin interactions with an Alzheimer’s disease risk haplotype, and PM20D1 overexpression reduces AD-like pathology and cognitive impairment in a rodent model.

    • Jose V. Sanchez-Mut
    • , Holger Heyn
    • , Bianca A. Silva
    • , Lucie Dixsaut
    • , Paula Garcia-Esparcia
    • , Enrique Vidal
    • , Sergi Sayols
    • , Liliane Glauser
    • , Ana Monteagudo-Sánchez
    • , Jordi Perez-Tur
    • , Isidre Ferrer
    • , David Monk
    • , Bernard Schneider
    • , Manel Esteller
    •  & Johannes Gräff
  • News & Views |

    In triple-negative breast cancer, therapeutic response to carboplatin and docetaxel is similar. However, carboplatin therapy is superior to docetaxel in patients with germline BRCA1 or BRCA2 mutations, but ‘BRCAness’ does not predict sensitivity to carboplatin. 

    • Ana C. Garrido-Castro
    •  & Eric P. Winer
  • News & Views |

    An artificial intelligence (AI) using a deep-learning approach can classify retinal images from optical coherence tomography for early diagnosis of retinal diseases and has the potential to be used in other image-based medical diagnoses.

    • Daniel S. W. Ting
    • , Yong Liu
    • , Philippe Burlina
    • , Xinxing Xu
    • , Neil M. Bressler
    •  & Tien Y. Wong
  • Letter |

    The transcription factor ELK-1 is upregulated in patients with major depressive disorder, and selective inhibition of hippocampal ELK-1 produces rapid antidepressive effects in rodent models of depression.

    • Kallia Apazoglou
    • , Séverine Farley
    • , Victor Gorgievski
    • , Raoul Belzeaux
    • , Juan Pablo Lopez
    • , Julien Grenier
    • , El Chérif Ibrahim
    • , Marie-Anne El Khoury
    • , Yiu C. Tse
    • , Raphaele Mongredien
    • , Alexandre Barbé
    • , Carlos E. A. de Macedo
    • , Wojciech Jaworski
    • , Ariane Bochereau
    • , Alejandro Orrico
    • , Elsa Isingrini
    • , Chloé Guinaudie
    • , Lenka Mikasova
    • , Franck Louis
    • , Sophie Gautron
    • , Laurent Groc
    • , Charbel Massaad
    • , Ferah Yildirim
    • , Vincent Vialou
    • , Sylvie Dumas
    • , Fabio Marti
    • , Naguib Mechawar
    • , Elise Morice
    • , Tak P. Wong
    • , Jocelyne Caboche
    • , Gustavo Turecki
    • , Bruno Giros
    •  & Eleni T. Tzavara
  • Article |

    The phase 3 TNT Trial in subjects with triple-negative breast cancer supports the superiority of carboplatin over docetaxel in BRCA1/2-mutated tumors and a greater response to taxanes in the nonbasal subtype.

    • Andrew Tutt
    • , Holly Tovey
    • , Maggie Chon U. Cheang
    • , Sarah Kernaghan
    • , Lucy Kilburn
    • , Patrycja Gazinska
    • , Julie Owen
    • , Jacinta Abraham
    • , Sophie Barrett
    • , Peter Barrett-Lee
    • , Robert Brown
    • , Stephen Chan
    • , Mitchell Dowsett
    • , James M Flanagan
    • , Lisa Fox
    • , Anita Grigoriadis
    • , Alexander Gutin
    • , Catherine Harper-Wynne
    • , Matthew Q. Hatton
    • , Katherine A. Hoadley
    • , Jyoti Parikh
    • , Peter Parker
    • , Charles M. Perou
    • , Rebecca Roylance
    • , Vandna Shah
    • , Adam Shaw
    • , Ian E. Smith
    • , Kirsten M. Timms
    • , Andrew M. Wardley
    • , Gregory Wilson
    • , Cheryl Gillett
    • , Jerry S. Lanchbury
    • , Alan Ashworth
    • , Nazneen Rahman
    • , Mark Harries
    • , Paul Ellis
    • , Sarah E. Pinder
    •  & Judith M. Bliss
  • Letter |

    An IL-6/STAT3 signature and memory CD8 T cell subset in preinfusion chimeric antigen receptor–expressing T cells associate with response in patients with high-risk chronic lymphocytic leukemia.

    • Joseph A. Fraietta
    • , Simon F. Lacey
    • , Elena J. Orlando
    • , Iulian Pruteanu-Malinici
    • , Mercy Gohil
    • , Stefan Lundh
    • , Alina C. Boesteanu
    • , Yan Wang
    • , Roddy S. O’Connor
    • , Wei-Ting Hwang
    • , Edward Pequignot
    • , David E. Ambrose
    • , Changfeng Zhang
    • , Nicholas Wilcox
    • , Felipe Bedoya
    • , Corin Dorfmeier
    • , Fang Chen
    • , Lifeng Tian
    • , Harit Parakandi
    • , Minnal Gupta
    • , Regina M. Young
    • , F. Brad Johnson
    • , Irina Kulikovskaya
    • , Li Liu
    • , Jun Xu
    • , Sadik H. Kassim
    • , Megan M. Davis
    • , Bruce L. Levine
    • , Noelle V. Frey
    • , Donald L. Siegel
    • , Alexander C. Huang
    • , E. John Wherry
    • , Hans Bitter
    • , Jennifer L. Brogdon
    • , David L. Porter
    • , Carl H. June
    •  & J. Joseph Melenhorst
  • Resource |

    Comprehensive integration of mutational and structural alterations in clinically-annotated DLBCL patient samples provides a novel molecular classification of the disease.

    • Bjoern Chapuy
    • , Chip Stewart
    • , Andrew J. Dunford
    • , Jaegil Kim
    • , Atanas Kamburov
    • , Robert A. Redd
    • , Mike S. Lawrence
    • , Margaretha G. M. Roemer
    • , Amy J. Li
    • , Marita Ziepert
    • , Annette M. Staiger
    • , Jeremiah A. Wala
    • , Matthew D. Ducar
    • , Ignaty Leshchiner
    • , Ester Rheinbay
    • , Amaro Taylor-Weiner
    • , Caroline A. Coughlin
    • , Julian M. Hess
    • , Chandra S. Pedamallu
    • , Dimitri Livitz
    • , Daniel Rosebrock
    • , Mara Rosenberg
    • , Adam A. Tracy
    • , Heike Horn
    • , Paul van Hummelen
    • , Andrew L. Feldman
    • , Brian K. Link
    • , Anne J. Novak
    • , James R. Cerhan
    • , Thomas M. Habermann
    • , Reiner Siebert
    • , Andreas Rosenwald
    • , Aaron R. Thorner
    • , Matthew L. Meyerson
    • , Todd R. Golub
    • , Rameen Beroukhim
    • , Gerald G. Wulf
    • , German Ott
    • , Scott J. Rodig
    • , Stefano Monti
    • , Donna S. Neuberg
    • , Markus Loeffler
    • , Michael Pfreundschuh
    • , Lorenz Trümper
    • , Gad Getz
    •  & Margaret A. Shipp
  • Letter |

    A new technique enabling single-cell analysis of T cell receptor identity and epigenomic state uncovers heterogeneity in normal and leukemic T cells.

    • Ansuman T. Satpathy
    • , Naresha Saligrama
    • , Jason D. Buenrostro
    • , Yuning Wei
    • , Beijing Wu
    • , Adam J. Rubin
    • , Jeffrey M. Granja
    • , Caleb A. Lareau
    • , Rui Li
    • , Yanyan Qi
    • , Kevin R. Parker
    • , Maxwell R. Mumbach
    • , William S. Serratelli
    • , David G. Gennert
    • , Alicia N. Schep
    • , M. Ryan Corces
    • , Michael S. Khodadoust
    • , Youn H. Kim
    • , Paul A. Khavari
    • , William J. Greenleaf
    • , Mark M. Davis
    •  & Howard Y. Chang
  • Review Article |

    The tumor immune microenvironment influences tumor progression and response to immunotherapy; its further characterization will improve therapeutic outcome.

    • Mikhail Binnewies
    • , Edward W. Roberts
    • , Kelly Kersten
    • , Vincent Chan
    • , Douglas F. Fearon
    • , Miriam Merad
    • , Lisa M. Coussens
    • , Dmitry I. Gabrilovich
    • , Suzanne Ostrand-Rosenberg
    • , Catherine C. Hedrick
    • , Robert H. Vonderheide
    • , Mikael J. Pittet
    • , Rakesh K. Jain
    • , Weiping Zou
    • , T. Kevin Howcroft
    • , Elisa C. Woodhouse
    • , Robert A. Weinberg
    •  & Matthew F. Krummel
  • Article |

    Poziotinib is a candidate inhibitor for a subset of EGFR or HER2 mutant non–small cell lung cancers that lack effective therapy.

    • Jacqulyne P. Robichaux
    • , Yasir Y. Elamin
    • , Zhi Tan
    • , Brett W. Carter
    • , Shuxing Zhang
    • , Shengwu Liu
    • , Shuai Li
    • , Ting Chen
    • , Alissa Poteete
    • , Adriana Estrada-Bernal
    • , Anh T. Le
    • , Anna Truini
    • , Monique B. Nilsson
    • , Huiying Sun
    • , Emily Roarty
    • , Sarah B. Goldberg
    • , Julie R. Brahmer
    • , Mehmet Altan
    • , Charles Lu
    • , Vassiliki Papadimitrakopoulou
    • , Katerina Politi
    • , Robert C. Doebele
    • , Kwok-Kin Wong
    •  & John V. Heymach