Browse Articles

  • Article |

    Interdependence between YAP/TAZ and BRD4 drives transcriptional addiction in cancer cells and determines sensitivity to BET inhibition.

    • Francesca Zanconato
    • , Giusy Battilana
    • , Mattia Forcato
    • , Letizia Filippi
    • , Luca Azzolin
    • , Andrea Manfrin
    • , Erika Quaranta
    • , Daniele Di Biagio
    • , Gianluca Sigismondo
    • , Vincenza Guzzardo
    • , Pascale Lejeune
    • , Bernard Haendler
    • , Jeroen Krijgsveld
    • , Matteo Fassan
    • , Silvio Bicciato
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo
  • Article |

    A convolutional neural network model using feature extraction and machine-learning techniques provides a tool for classification of lung cancer histopathology images and predicting mutational status of driver oncogenes

    • Nicolas Coudray
    • , Paolo Santiago Ocampo
    • , Theodore Sakellaropoulos
    • , Navneet Narula
    • , Matija Snuderl
    • , David Fenyö
    • , Andre L. Moreira
    • , Narges Razavian
    •  & Aristotelis Tsirigos
  • Letter |

    In pediatric brain tumors that are accompanied by epileptic seizures, the BRAF somatic mutation V600E contributes to intrinsic epileptic properties in neurons, which can be suppressed by vemurafenib in mice.

    • Hyun Yong Koh
    • , Se Hoon Kim
    • , Jaeson Jang
    • , Hyungguk Kim
    • , Sungwook Han
    • , Jae Seok Lim
    • , Geurim Son
    • , Junjeong Choi
    • , Byung Ouk Park
    • , Won Do Heo
    • , Jinju Han
    • , Hyunjoo Jenny Lee
    • , Daeyoup Lee
    • , Hoon-Chul Kang
    • , Minho Shong
    • , Se-Bum Paik
    • , Dong Seok Kim
    •  & Jeong Ho Lee
  • Comment | | open

    To address a critical roadblock that can occur in translational and clinical research, the National Cancer Institute and the Food and Drug Administration, in coordination with the DREAM Challenges, are launching the first computational challenge using multi-omics datasets to detect and correct specimen mislabeling.

    • Emily Boja
    • , Živana Težak
    • , Bing Zhang
    • , Pei Wang
    • , Elaine Johanson
    • , Denise Hinton
    •  & Henry Rodriguez
  • News & Views |

    Preconception cold–induced alterations of sperm DNA methylation result in offspring with altered brown adipose tissue and improved adaptation to overnutrition and hypothermia.

    • Michael K. Skinner
  • Editorial |

    To facilitate access to and improve the discoverability of the data in our papers, Nature Medicine is making the data availability statement in our papers more prominent and its language more transparent.

  • News & Views |

    An in vivo cellular reprogramming strategy to generate epithelial cells from wound mesenchymal cells promotes healing and provides a new avenue for the treatment of nonhealing wounds.

    • Shruti Naik
  • News & Views |

    Impaired de novo NAD+ biosynthesis predisposes to acute kidney injury, and augmenting NAD+ metabolism with oral nicotinamide supplementation may prevent acute kidney injury.

    • Heerajnarain Bulluck
    •  & Derek J. Hausenloy
  • News & Views |

    Machine learning can be used for computer-aided diagnosis of acute neurological events and retinal disease and can be incorporated into conventional clinical workflows to improve health outcomes.

    • Charles J. Lynch
    •  & Conor Liston
  • Article |

    Distinct routes of immunization elicit different antibody isotypes and functions associated with protection against SIV infection that converge on phagocytosis as a candidate protective mechanism of independent SIV vaccines.

    • Margaret E. Ackerman
    • , Jishnu Das
    • , Srivamshi Pittala
    • , Thomas Broge
    • , Caitlyn Linde
    • , Todd J. Suscovich
    • , Eric P. Brown
    • , Todd Bradley
    • , Harini Natarajan
    • , Shu Lin
    • , Jessica K. Sassic
    • , Sean O’Keefe
    • , Nickita Mehta
    • , Derrick Goodman
    • , Magdalena Sips
    • , Joshua A. Weiner
    • , Georgia D. Tomaras
    • , Barton F. Haynes
    • , Douglas A. Lauffenburger
    • , Chris Bailey-Kellogg
    • , Mario Roederer
    •  & Galit Alter
  • Letter |

    The definition of a 'healthy' microbiome is impacted by geographic regional variations.

    • Yan He
    • , Wei Wu
    • , Hui-Min Zheng
    • , Pan Li
    • , Daniel McDonald
    • , Hua-Fang Sheng
    • , Mu-Xuan Chen
    • , Zi-Hui Chen
    • , Gui-Yuan Ji
    • , Zhong-Dai-Xi Zheng
    • , Prabhakar Mujagond
    • , Xiao-Jiao Chen
    • , Zu-Hua Rong
    • , Peng Chen
    • , Li-Yi Lyu
    • , Xian Wang
    • , Chong-Bin Wu
    • , Nan Yu
    • , Yan-Jun Xu
    • , Jia Yin
    • , Jeroen Raes
    • , Rob Knight
    • , Wen-Jun Ma
    •  & Hong-Wei Zhou
  • Article |

    The antidiabetic action of metformin raises heptocyte intracellular AMP levels, causing allosteric inhibition of fructose-1,6-bisphosphatase and thus reductions in gluconeogenesis.

    • Roger W. Hunter
    • , Curtis C. Hughey
    • , Louise Lantier
    • , Elias I. Sundelin
    • , Mark Peggie
    • , Elton Zeqiraj
    • , Frank Sicheri
    • , Niels Jessen
    • , David H. Wasserman
    •  & Kei Sakamoto
  • Letter |

    Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.

    • Mélanie Deschasaux
    • , Kristien E. Bouter
    • , Andrei Prodan
    • , Evgeni Levin
    • , Albert K. Groen
    • , Hilde Herrema
    • , Valentina Tremaroli
    • , Guido J. Bakker
    • , Ilias Attaye
    • , Sara-Joan Pinto-Sietsma
    • , Daniel H. van Raalte
    • , Marieke B. Snijder
    • , Mary Nicolaou
    • , Ron Peters
    • , Aeilko H. Zwinderman
    • , Fredrik Bäckhed
    •  & Max Nieuwdorp
  • Resource |

    In-depth methylation analysis of formalin-fixed paraffin-embedded glioblastoma samples demonstrates heterogeneity between primary and recurring tumors and enables prediction of composition of the tumor microenvironment and insights into progression.

    • Johanna Klughammer
    • , Barbara Kiesel
    • , Thomas Roetzer
    • , Nikolaus Fortelny
    • , Amelie Nemc
    • , Karl-Heinz Nenning
    • , Julia Furtner
    • , Nathan C. Sheffield
    • , Paul Datlinger
    • , Nadine Peter
    • , Martha Nowosielski
    • , Marco Augustin
    • , Mario Mischkulnig
    • , Thomas Ströbel
    • , Donat Alpar
    • , Bekir Ergüner
    • , Martin Senekowitsch
    • , Patrizia Moser
    • , Christian F. Freyschlag
    • , Johannes Kerschbaumer
    • , Claudius Thomé
    • , Astrid E. Grams
    • , Günther Stockhammer
    • , Melitta Kitzwoegerer
    • , Stefan Oberndorfer
    • , Franz Marhold
    • , Serge Weis
    • , Johannes Trenkler
    • , Johanna Buchroithner
    • , Josef Pichler
    • , Johannes Haybaeck
    • , Stefanie Krassnig
    • , Kariem Mahdy Ali
    • , Gord von Campe
    • , Franz Payer
    • , Camillo Sherif
    • , Julius Preiser
    • , Thomas Hauser
    • , Peter A. Winkler
    • , Waltraud Kleindienst
    • , Franz Würtz
    • , Tanisa Brandner-Kokalj
    • , Martin Stultschnig
    • , Stefan Schweiger
    • , Karin Dieckmann
    • , Matthias Preusser
    • , Georg Langs
    • , Bernhard Baumann
    • , Engelbert Knosp
    • , Georg Widhalm
    • , Christine Marosi
    • , Johannes A. Hainfellner
    • , Adelheid Woehrer
    •  & Christoph Bock
  • News Feature |

    Evolving research sheds light on a possibly unique form of depression among the elderly.

    • Nicole Wetsman
  • News Feature |

    A new class of therapeutics instruct the body to make its own drugs.

    • Amanda B. Keener
  • Publisher Correction |

    • Peter Savas
    • , Balaji Virassamy
    • , Chengzhong Ye
    • , Agus Salim
    • , Christopher P. Mintoff
    • , Franco Caramia
    • , Roberto Salgado
    • , David J. Byrne
    • , Zhi L. Teo
    • , Sathana Dushyanthen
    • , Ann Byrne
    • , Lironne Wein
    • , Stephen J. Luen
    • , Catherine Poliness
    • , Sophie S. Nightingale
    • , Anita S. Skandarajah
    • , David E. Gyorki
    • , Chantel M. Thornton
    • , Paul A. Beavis
    • , Stephen B. Fox
    • , Phillip K. Darcy
    • , Terence P. Speed
    • , Laura K. Mackay
    • , Paul J. Neeson
    •  & Sherene Loi
  • Article |

    Impaired NAD+ biosynthesis may be a common feature of high-risk hospitalizations for which NAD+ augmentation could improve therapeutic outcome.

    • Ali Poyan Mehr
    • , Mei T. Tran
    • , Kenneth M. Ralto
    • , David E. Leaf
    • , Vaughan Washco
    • , Joseph Messmer
    • , Adam Lerner
    • , Ajay Kher
    • , Steven H. Kim
    • , Charbel C. Khoury
    • , Shoshana J. Herzig
    • , Mary E. Trovato
    • , Noemie Simon-Tillaux
    • , Matthew R. Lynch
    • , Ravi I. Thadhani
    • , Clary B. Clish
    • , Kamal R. Khabbaz
    • , Eugene P. Rhee
    • , Sushrut S. Waikar
    • , Anders H. Berg
    •  & Samir M. Parikh
  • Article |

    iPSC-derived motor neurons from over 30 heterogeneous sporadic ALS cases exhibit pathologies correlated with clinical disease progression, are more similar to FUS/TDP-43 familial ALS than SOD1-ALS and are corrected by repurposing of ropinirole.

    • Koki Fujimori
    • , Mitsuru Ishikawa
    • , Asako Otomo
    • , Naoki Atsuta
    • , Ryoichi Nakamura
    • , Tetsuya Akiyama
    • , Shinji Hadano
    • , Masashi Aoki
    • , Hideyuki Saya
    • , Gen Sobue
    •  & Hideyuki Okano
  • Article |

    An algorithm-selected gene signature focused on tumor immune evasion and suppression predicts response to immune checkpoint blockade in melanoma, exceeding the accuracy of current clinical biomarkers.

    • Peng Jiang
    • , Shengqing Gu
    • , Deng Pan
    • , Jingxin Fu
    • , Avinash Sahu
    • , Xihao Hu
    • , Ziyi Li
    • , Nicole Traugh
    • , Xia Bu
    • , Bo Li
    • , Jun Liu
    • , Gordon J. Freeman
    • , Myles A. Brown
    • , Kai W. Wucherpfennig
    •  & X. Shirley Liu
  • Article |

    CRISPR–Cas9-mediated gene editing of TSC1 and TSC2 in human pluripotent stem cells is used to investigate the contribution of tuberous sclerosis complex–mechanistic target of rapamycin complex 1 signaling to human neural development in two-dimensional monolayer and three-dimensional spheroid models of the neurodevelopmental disorder tuberous sclerosis complex.

    • John D. Blair
    • , Dirk Hockemeyer
    •  & Helen S. Bateup
  • Letter |

    A gene signature identified in spontaneously regressing neuroblastoma identifies responders to immune checkpoint blockade among patients with melanoma with accuracy superior to previously reported biomarkers.

    • Noam Auslander
    • , Gao Zhang
    • , Joo Sang Lee
    • , Dennie T. Frederick
    • , Benchun Miao
    • , Tabea Moll
    • , Tian Tian
    • , Zhi Wei
    • , Sanna Madan
    • , Ryan J. Sullivan
    • , Genevieve Boland
    • , Keith Flaherty
    • , Meenhard Herlyn
    •  & Eytan Ruppin
  • Letter |

    A deep-learning algorithm is developed to provide rapid and accurate diagnosis of clinical 3D head CT-scan images to triage and prioritize urgent neurological events, thus potentially accelerating time to diagnosis and care in clinical settings.

    • Joseph J. Titano
    • , Marcus Badgeley
    • , Javin Schefflein
    • , Margaret Pain
    • , Andres Su
    • , Michael Cai
    • , Nathaniel Swinburne
    • , John Zech
    • , Jun Kim
    • , Joshua Bederson
    • , J. Mocco
    • , Burton Drayer
    • , Joseph Lehar
    • , Samuel Cho
    • , Anthony Costa
    •  & Eric K. Oermann
  • Article |

    A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.

    • Jeffrey De Fauw
    • , Joseph R. Ledsam
    • , Bernardino Romera-Paredes
    • , Stanislav Nikolov
    • , Nenad Tomasev
    • , Sam Blackwell
    • , Harry Askham
    • , Xavier Glorot
    • , Brendan O’Donoghue
    • , Daniel Visentin
    • , George van den Driessche
    • , Balaji Lakshminarayanan
    • , Clemens Meyer
    • , Faith Mackinder
    • , Simon Bouton
    • , Kareem Ayoub
    • , Reena Chopra
    • , Dominic King
    • , Alan Karthikesalingam
    • , Cían O. Hughes
    • , Rosalind Raine
    • , Julian Hughes
    • , Dawn A. Sim
    • , Catherine Egan
    • , Adnan Tufail
    • , Hugh Montgomery
    • , Demis Hassabis
    • , Geraint Rees
    • , Trevor Back
    • , Peng T. Khaw
    • , Mustafa Suleyman
    • , Julien Cornebise
    • , Pearse A. Keane
    •  & Olaf Ronneberger
  • Author Correction |

    • Yonathan Lissanu Deribe
    • , Yuting Sun
    • , Christopher Terranova
    • , Fatima Khan
    • , Juan Martinez-Ledesma
    • , Jason Gay
    • , Guang Gao
    • , Robert A. Mullinax
    • , Tin Khor
    • , Ningping Feng
    • , Yu-Hsi Lin
    • , Chia-Chin Wu
    • , Claudia Reyes
    • , Qian Peng
    • , Frederick Robinson
    • , Akira Inoue
    • , Veena Kochat
    • , Chang-Gong Liu
    • , John M. Asara
    • , Cesar Moran
    • , Florian Muller
    • , Jing Wang
    • , Bingliang Fang
    • , Vali Papadimitrakopoulou
    • , Ignacio I. Wistuba
    • , Kunal Rai
    • , Joseph Marszalek
    •  & P. Andrew Futreal
  • Article |

    Patients with glioblastoma experience lymphopenia and sequestration of T cells in the bone marrow, which is recapitulated in mice with brain tumors, where the reversible nature of this effect is demonstrated by an approach that enables the efficacy of other immunotherapeutics.

    • Pakawat Chongsathidkiet
    • , Christina Jackson
    • , Shohei Koyama
    • , Franziska Loebel
    • , Xiuyu Cui
    • , S. Harrison Farber
    • , Karolina Woroniecka
    • , Aladine A. Elsamadicy
    • , Cosette A. Dechant
    • , Hanna R. Kemeny
    • , Luis Sanchez-Perez
    • , Tooba A. Cheema
    • , Nicholas C. Souders
    • , James E. Herndon
    • , Jean-Valery Coumans
    • , Jeffrey I. Everitt
    • , Brian V. Nahed
    • , John H. Sampson
    • , Michael D. Gunn
    • , Robert L. Martuza
    • , Glenn Dranoff
    • , William T. Curry
    •  & Peter E. Fecci
  • Author Correction |

    • Gabrielle S. Wong
    • , Jin Zhou
    • , Jie Bin Liu
    • , Zhong Wu
    • , Xinsen Xu
    • , Tianxia Li
    • , David Xu
    • , Steven E. Schumacher
    • , Jens Puschhof
    • , James McFarland
    • , Charles Zou
    • , Austin Dulak
    • , Les Henderson
    • , Peng Xu
    • , Emily O’Day
    • , Rachel Rendak
    • , Wei-li Liao
    • , Fabiola Cecchi
    • , Todd Hembrough
    • , Sarit Schwartz
    • , Christopher Szeto
    • , Anil K. Rustgi
    • , Kwok-Kin Wong
    • , J. Alan Diehl
    • , Karin Jensen
    • , Francesco Graziano
    • , Annamaria Ruzzo
    • , Shaunt Fereshetian
    • , Philipp Mertins
    • , Steven A. Carr
    • , Rameen Beroukhim
    • , Kenichi Nakamura
    • , Eiji Oki
    • , Masayuki Watanabe
    • , Hideo Baba
    • , Yu Imamura
    • , Daniel Catenacci
    •  & Adam J. Bass
  • Publisher Correction |

    • Lesley Hoyles
    • , José-Manuel Fernández-Real
    • , Massimo Federici
    • , Matteo Serino
    • , James Abbott
    • , Julie Charpentier
    • , Christophe Heymes
    • , Jèssica Latorre Luque
    • , Elodie Anthony
    • , Richard H. Barton
    • , Julien Chilloux
    • , Antonis Myridakis
    • , Laura Martinez-Gili
    • , José Maria Moreno-Navarrete
    • , Fadila Benhamed
    • , Vincent Azalbert
    • , Vincent Blasco-Baque
    • , Josep Puig
    • , Gemma Xifra
    • , Wifredo Ricart
    • , Christopher Tomlinson
    • , Mark Woodbridge
    • , Marina Cardellini
    • , Francesca Davato
    • , Iris Cardolini
    • , Ottavia Porzio
    • , Paolo Gentileschi
    • , Frédéric Lopez
    • , Fabienne Foufelle
    • , Sarah A. Butcher
    • , Elaine Holmes
    • , Jeremy K. Nicholson
    • , Catherine Postic
    • , Rémy Burcelin
    •  & Marc-Emmanuel Dumas
  • Author Correction |

    • Wenfei Sun
    • , Hua Dong
    • , Anton S. Becker
    • , Dianne H. Dapito
    • , Salvatore Modica
    • , Gerald Grandl
    • , Lennart Opitz
    • , Vissarion Efthymiou
    • , Leon G. Straub
    • , Gitalee Sarker
    • , Miroslav Balaz
    • , Lucia Balazova
    • , Aliki Perdikari
    • , Elke Kiehlmann
    • , Sara Bacanovic
    • , Caroline Zellweger
    • , Daria Peleg-Raibstein
    • , Pawel Pelczar
    • , Wolf Reik
    • , Irene A. Burger
    • , Ferdinand von Meyenn
    •  & Christian Wolfrum
  • Publisher Correction |

    • Wenfei Sun
    • , Hua Dong
    • , Anton S. Becker
    • , Dianne H. Dapito
    • , Salvatore Modica
    • , Gerald Grandl
    • , Lennart Opitz
    • , Vissarion Efthymiou
    • , Leon G. Straub
    • , Gitalee Sarker
    • , Miroslav Balaz
    • , Lucia Balazova
    • , Aliki Perdikari
    • , Elke Kiehlmann
    • , Sara Bacanovic
    • , Caroline Zellweger
    • , Daria Peleg-Raibstein
    • , Pawel Pelczar
    • , Wolf Reik
    • , Irene A. Burger
    • , Ferdinand von Meyenn
    •  & Christian Wolfrum
  • Article |

    Early and prolonged administration of antiretroviral therapy to SIV-infected and post-exposure-vaccinated rhesus macaques was associated with absence or delay of detectable virus after therapy interruption.

    • Afam A. Okoye
    • , Scott G. Hansen
    • , Mukta Vaidya
    • , Yoshinori Fukazawa
    • , Haesun Park
    • , Derick M. Duell
    • , Richard Lum
    • , Colette M. Hughes
    • , Abigail B. Ventura
    • , Emily Ainslie
    • , Julia C. Ford
    • , David Morrow
    • , Roxanne M. Gilbride
    • , Alfred W. Legasse
    • , Joseph Hesselgesser
    • , Romas Geleziunas
    • , Yuan Li
    • , Kelli Oswald
    • , Rebecca Shoemaker
    • , Randy Fast
    • , William J. Bosche
    • , Bhavesh R. Borate
    • , Paul T. Edlefsen
    • , Michael K. Axthelm
    • , Louis J. Picker
    •  & Jeffrey D. Lifson
  • News & Views |

    The human heart contains two macrophage populations with distinct self-maintenance and inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling and systolic function in patients with heart failure.

    • Freya R. Svedberg
    •  & Martin Guilliams
  • Editorial |

    Concerns about potential unintended DNA changes that might accidentally arise from CRISPR gene editing have emerged to varying degrees with the advent of the technology. As new therapies move from bench to bedside, scientists need to redouble their efforts to document the spectrum of these off-target effects while also acknowledging the reality that a certain degree of risk is embedded in many promising and successful medical therapies.

  • Article |

    A blood-based DNA sequencing assay to infer tumor mutational burden in the absence of tumor biopsy predicts response to PD-L1 blockade in patients with non-small-cell lung cancer.

    • David R. Gandara
    • , Sarah M. Paul
    • , Marcin Kowanetz
    • , Erica Schleifman
    • , Wei Zou
    • , Yan Li
    • , Achim Rittmeyer
    • , Louis Fehrenbacher
    • , Geoff Otto
    • , Christine Malboeuf
    • , Daniel S. Lieber
    • , Doron Lipson
    • , Jacob Silterra
    • , Lukas Amler
    • , Todd Riehl
    • , Craig A. Cummings
    • , Priti S. Hegde
    • , Alan Sandler
    • , Marcus Ballinger
    • , David Fabrizio
    • , Tony Mok
    •  & David S. Shames
  • News & Views |

    Targeting senescent cells with repurposed FDA-approved drugs improves phenotypes of aging in mice.

    • Manuel Serrano
    •  & Nir Barzilai
  • Article |

    A bacterial screen yields a Cas9 variant that retains high on-target activity when delivered in the RNP format. As proof of principle, this Cas9 variant enables high-level correction of the sickle cell disease mutation in patient-derived HSPCs.

    • Christopher A. Vakulskas
    • , Daniel P. Dever
    • , Garrett R. Rettig
    • , Rolf Turk
    • , Ashley M. Jacobi
    • , Michael A. Collingwood
    • , Nicole M. Bode
    • , Matthew S. McNeill
    • , Shuqi Yan
    • , Joab Camarena
    • , Ciaran M. Lee
    • , So Hyun Park
    • , Volker Wiebking
    • , Rasmus O. Bak
    • , Natalia Gomez-Ospina
    • , Mara Pavel-Dinu
    • , Wenchao Sun
    • , Gang Bao
    • , Matthew H. Porteus
    •  & Mark A. Behlke