Browse Articles

  • Q&A |

    We discussed with five scientists what the sources and roles of real-world evidence are, how we can use such data in clinical trials and how these data can be converted into useful information that can impact patient management and regulatory decisions in oncology.

    • Hannah Stower
  • Letter |

    A longitudinal survey of maternal antiviral antibodies in newborns provides a blueprint for understanding infectious disease susceptibility and vaccine development, and inform vaccine scheduling in newborn children.

    • Christian Pou
    • , Dieudonné Nkulikiyimfura
    • , Ewa Henckel
    • , Axel Olin
    • , Tadepally Lakshmikanth
    • , Jaromir Mikes
    • , Jun Wang
    • , Yang Chen
    • , Anna Karin Bernhardsson
    • , Anna Gustafsson
    • , Kajsa Bohlin
    •  & Petter Brodin
  • Letter |

    In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.

    • Luanluan Sun
    • , Robert Clarke
    • , Derrick Bennett
    • , Yu Guo
    • , Robin G. Walters
    • , Michael Hill
    • , Sarah Parish
    • , Iona Y. Millwood
    • , Zheng Bian
    • , Yiping Chen
    • , Canqing Yu
    • , Jun Lv
    • , Rory Collins
    • , Junshi Chen
    • , Richard Peto
    • , Liming Li
    • , Zhengming Chen
    • , Junshi Chen
    • , Zhengming Chen
    • , Robert Clarke
    • , Rory Collins
    • , Yu Guo
    • , Liming Li
    • , Jun Lv
    • , Richard Peto
    • , Robin Walters
    • , Daniel Avery
    • , Derrick Bennett
    • , Ruth Boxall
    • , Fiona Bragg
    • , Yumei Chang
    • , Yiping Chen
    • , Zhengming Chen
    • , Robert Clarke
    • , Huaidong Du
    • , Simon Gilbert
    • , Alex Hacker
    • , Michael Holmes
    • , Christiana Kartsonaki
    • , Rene Kerosi
    • , Garry Lancaster
    • , Kuang Lin
    • , John McDonnell
    • , Iona Millwood
    • , Qunhua Nie
    • , Jayakrishnan Radhakrishnan
    • , Paul Ryder
    • , Sam Sansome
    • , Dan Schmidt
    • , Rajani Sohoni
    • , Iain Turnbull
    • , Robin Walters
    • , Jenny Wang
    • , Lin Wang
    • , Neil Wright
    • , Ling Yang
    • , Xiaoming Yang
    • , Zheng Bian
    • , Yu Guo
    • , Xiao Han
    • , Can Hou
    • , Biao Jing
    • , Chao Liu
    • , Jun Lv
    • , Pei Pei
    • , Yunlong Tan
    • , Canqing Yu
    • , Zengchang Pang
    • , Ruqin Gao
    • , Shanpeng Li
    • , Shaojie Wang
    • , Yongmei Liu
    • , Ranran Du
    • , Yajing Zang
    • , Liang Cheng
    • , Xiaocao Tian
    • , Hua Zhang
    • , Yaoming Zhai
    • , Feng Ning
    • , Xiaohui Sun
    • , Feifei Li
    • , Silu Lv
    • , Junzheng Wang
    • , Wei Hou
    • , Mingyuan Zeng
    • , Ge Jiang
    • , Xue Zhou
    • , Liqiu Yang
    • , Hui He
    • , Bo Yu
    • , Yanjie Li
    • , Qinai Xu
    • , Quan Kang
    • , Ziyan Guo
    • , Dan Wang
    • , Ximin Hu
    • , Hongmei Wang
    • , Jinyan Chen
    • , Yan Fu
    • , Zhenwang Fu
    • , Xiaohuan Wang
    • , Min Weng
    • , Zhendong Guo
    • , Shukuan Wu
    • , Yilei Li
    • , Huimei Li
    • , Zhifang Fu
    • , Ming Wu
    • , Yonglin Zhou
    • , Jinyi Zhou
    • , Ran Tao
    • , Jie Yang
    • , Jian Su
    • , Fang Liu
    • , Jun Zhang
    • , Yihe Hu
    • , Yan Lu
    • , Liangcai Ma
    • , Aiyu Tang
    • , Shuo Zhang
    • , Jianrong Jin
    • , Jingchao Liu
    • , Zhenzhu Tang
    • , Naying Chen
    • , Ying Huang
    • , Mingqiang Li
    • , Jinhuai Meng
    • , Rong Pan
    • , Qilian Jiang
    • , Jian Lan
    • , Yun Liu
    • , Liuping Wei
    • , Liyuan Zhou
    • , Ningyu Chen
    • , Ping Wang
    • , Fanwen Meng
    • , Yulu Qin
    • , Sisi Wang
    • , Xianping Wu
    • , Ningmei Zhang
    • , Xiaofang Chen
    • , Weiwei Zhou
    • , Guojin Luo
    • , Jianguo Li
    • , Xiaofang Chen
    • , Xunfu Zhong
    • , Jiaqiu Liu
    • , Qiang Sun
    • , Pengfei Ge
    • , Xiaolan Ren
    • , Caixia Dong
    • , Hui Zhang
    • , Enke Mao
    • , Xiaoping Wang
    • , Tao Wang
    • , Xi Zhang
    • , Ding Zhang
    • , Gang Zhou
    • , Shixian Feng
    • , Liang Chang
    • , Lei Fan
    • , Yulian Gao
    • , Tianyou He
    • , Huarong Sun
    • , Pan He
    • , Chen Hu
    • , Xukui Zhang
    • , Huifang Wu
    • , Min Yu
    • , Ruying Hu
    • , Hao Wang
    • , Yijian Qian
    • , Chunmei Wang
    • , Kaixu Xie
    • , Lingli Chen
    • , Yidan Zhang
    • , Dongxia Pan
    • , Qijun Gu
    • , Yuelong Huang
    • , Biyun Chen
    • , Li Yin
    • , Huilin Liu
    • , Zhongxi Fu
    • , Qiaohua Xu
    • , Xin Xu
    • , Hao Zhang
    • , Huajun Long
    • , Xianzhi Li
    • , Libo Zhang
    •  & Zhe Qiu
  • Letter |

    iPSC-derived brain organoids from patients with neurodevelopmental disease reveal dysfunction in neural progenitors underlying impaired migration of developing neurons in periventricular heterotopia.

    • Johannes Klaus
    • , Sabina Kanton
    • , Christina Kyrousi
    • , Ane Cristina Ayo-Martin
    • , Rossella Di Giaimo
    • , Stephan Riesenberg
    • , Adam C. O’Neill
    • , J. Gray Camp
    • , Chiara Tocco
    • , Malgorzata Santel
    • , Ejona Rusha
    • , Micha Drukker
    • , Mariana Schroeder
    • , Magdalena Götz
    • , Stephen P. Robertson
    • , Barbara Treutlein
    •  & Silvia Cappello
  • Publisher Correction |

    • Bahtiyar Yilmaz
    • , Pascal Juillerat
    • , Ove Øyås
    • , Charlotte Ramon
    • , Francisco Damian Bravo
    • , Yannick Franc
    • , Nicolas Fournier
    • , Pierre Michetti
    • , Christoph Mueller
    • , Markus Geuking
    • , Valerie E. H. Pittet
    • , Michel H. Maillard
    • , Gerhard Rogler
    • , Karim Abdelrahman
    • , Gentiana Ademi
    • , Patrick Aepli
    • , Amman Thomas
    • , Claudia Anderegg
    • , Anca-Teodora Antonino
    • , Eva Archanioti
    • , Eviano Arrigoni
    • , Diana Bakker de Jong
    • , Bruno Balsiger
    • , Polat Bastürk
    • , Peter Bauerfeind
    • , Andrea Becocci
    • , Dominique Belli
    • , José M. Bengoa
    • , Luc Biedermann
    • , Janek Binek
    • , Mirjam Blattmann
    • , Stephan Boehm
    • , Tujana Boldanova
    • , Jan Borovicka
    • , Christian P. Braegger
    • , Stephan Brand
    • , Lukas Brügger
    • , Simon Brunner
    • , Patrick Bühr
    • , Bernard Burnand
    • , Sabine Burk
    • , Emanuel Burri
    • , Sophie Buyse
    • , Dahlia-Thao Cao
    • , Ove Carstens
    • , Dominique H. Criblez
    • , Sophie Cunningham
    • , Fabrizia D’Angelo
    • , Philippe de Saussure
    • , Lukas Degen
    • , Joakim Delarive
    • , Christopher Doerig
    • , Barbara Dora
    • , Susan Drerup
    • , Mara Egger
    • , Ali El-Wafa
    • , Matthias Engelmann
    • , Jessica Ezri
    • , Christian Felley
    • , Markus Fliegner
    • , Nicolas Fournier
    • , Montserrat Fraga
    • , Yannick Franc
    • , Pascal Frei
    • , Remus Frei
    • , Michael Fried
    • , Florian Froehlich
    • , Raoul Ivano Furlano
    • , Luca Garzoni
    • , Martin Geyer
    • , Laurent Girard
    • , Marc Girardin
    • , Delphine Golay
    • , Ignaz Good
    • , Ulrike Graf Bigler
    • , Beat Gysi
    • , Johannes Haarer
    • , Marcel Halama
    • , Janine Haldemann
    • , Pius Heer
    • , Benjamin Heimgartner
    • , Beat Helbling
    • , Peter Hengstler
    • , Denise Herzog
    • , Cyrill Hess
    • , Roxane Hessler
    • , Klaas Heyland
    • , Thomas Hinterleitner
    • , Claudia Hirschi
    • , Petr Hruz
    • , Pascal Juillerat
    • , Carolina Khalid-de Bakker
    • , Stephan Kayser
    • , Céline Keller
    • , Christina Knellwolf (-Grieger)
    • , Christoph Knoblauch
    • , Henrik Köhler
    • , Rebekka Koller
    • , Claudia Krieger(-Grübel)
    • , Patrizia Künzler
    • , Rachel Kusche
    • , Frank Serge Lehmann
    • , Andrew J. Macpherson
    • , Michel H. Maillard
    • , Michael Manz
    • , Astrid Marot
    • , Rémy Meier
    • , Christa Meyenberger
    • , Pamela Meyer
    • , Pierre Michetti
    • , Benjamin Misselwitz
    • , Patrick Mosler
    • , Christian Mottet
    • , Christoph Müller
    • , Beat Müllhaupt
    • , Leilla Musso
    • , Michaela Neagu
    • , Cristina Nichita
    • , Jan Niess
    • , Andreas Nydegger
    • , Nicole Obialo
    • , Diana Ollo
    • , Cassandra Oropesa
    • , Ulrich Peter
    • , Daniel Peternac
    • , Laetitia Marie Petit
    • , Valérie Pittet
    • , Daniel Pohl
    • , Marc Porzner
    • , Claudia Preissler
    • , Nadia Raschle
    • , Ronald Rentsch
    • , Alexandre Restellini
    • , Sophie Restellini
    • , Jean-Pierre Richterich
    • , Frederic Ris
    • , Branislav Risti
    • , Marc Alain Ritz
    • , Gerhard Rogler
    • , Nina Röhrich
    • , Jean-Benoît Rossel
    • , Vanessa Rueger
    • , Monica Rusticeanu
    • , Markus Sagmeister
    • , Gaby Saner
    • , Bernhard Sauter
    • , Mikael Sawatzki
    • , Michael Scharl
    • , Martin Schelling
    • , Susanne Schibli
    • , Hugo Schlauri
    • , Dominique Schluckebier
    • , Daniela Schmid
    • , Sybille Schmid (-Uebelhart)
    • , Jean-François Schnegg
    • , Alain Schoepfer
    • , Vivianne Seematter
    • , Frank Seibold
    • , Mariam Seirafi
    • , Gian-Marco Semadeni
    • , Arne Senning
    • , Christiane Sokollik
    • , Joachim Sommer
    • , Johannes Spalinger
    • , Holger Spangenberger
    • , Philippe Stadler
    • , Peter Staub
    • , Dominic Staudenmann
    • , Volker Stenz
    • , Michael Steuerwald
    • , Alex Straumann
    • , Bruno Strebel
    • , Andreas Stulz
    • , Michael Sulz
    • , Aurora Tatu
    • , Michela Tempia-Caliera
    • , Joël Thorens
    • , Kaspar Truninger
    • , Radu Tutuian
    • , Patrick Urfer
    • , Stephan Vavricka
    • , Francesco Viani
    • , Jürg Vögtlin
    • , Roland Von Känel
    • , Dominique Vouillamoz
    • , Rachel Vulliamy
    • , Paul Wiesel
    • , Reiner Wiest
    • , Stefanie Wöhrle
    • , Samuel Zamora
    • , Silvan Zander
    • , Tina Wylie
    • , Jonas Zeitz
    • , Dorothee Zimmermann
    • , Reiner Wiest
    • , Jörg Stelling
    •  & Andrew J. Macpherson
  • Article |

    Defects in the regulation of leptin gene expression can lead to a hypoleptinemic, leptin-responsive form of obesity.

    • Olof S. Dallner
    • , Jill M. Marinis
    • , Yi-Hsueh. Lu
    • , Kivanc Birsoy
    • , Emory Werner
    • , Gulya Fayzikhodjaeva
    • , Brian D. Dill
    • , Henrik Molina
    • , Arden Moscati
    • , Zoltán Kutalik
    • , Pedro Marques-Vidal
    • , Tuomas O. Kilpeläinen
    • , Niels Grarup
    • , Allan Linneberg
    • , Yinxin Zhang
    • , Roger Vaughan
    • , Ruth J. F. Loos
    • , Mitchell A. Lazar
    •  & Jeffrey M. Friedman
  • Editorial |

    Cancer surveillance programs have reported a global downward trend in cancer mortality rates for most common tumor types. However, startling geographic inequalities exist, and some cancers continue to pose a challenge. Ensuring global access to high-quality diagnostic and treatment approaches is needed to make decreasing cancer deaths a more widespread trend.

  • Turning Points |

    Samra Turajlic is a consultant medical oncologist at the Royal Marsden National Health Service Foundation Trust and a clinician–scientist at the Francis Crick Institute.

    • Samra Turajlic
  • Review Article |

    The microbiome influences response to cancer therapy, including cancer immunotherapy, and also plays a role in therapeutic toxicity.

    • Beth A. Helmink
    • , M. A. Wadud Khan
    • , Amanda Hermann
    • , Vancheswaran Gopalakrishnan
    •  & Jennifer A. Wargo
  • News Feature |

    Cancer registries that track tumors as they spread could reveal how these growths metastasize

    • Brianna Abbott
  • Turning Points |

    Georgina V. Long is co-medical director of Melanoma Institute Australia and Chair of Melanoma Medical Oncology and Translational Research. She is the first woman president of the Society for Melanoma Research.

    • Georgina V. Long
  • News & Views |

    Application of immunoprofiling of human peripheral blood samples from an aging cohort identifies changes in the immune system that inform our understanding of age-associated complex diseases.

    • Soumya Raychaudhuri
    •  & Rajat M. Gupta
  • Article |

    An integrated high-dimensional measurement of immune age describes a person’s immune status better than chronological age and predicts all-cause mortality.

    • Ayelet Alpert
    • , Yishai Pickman
    • , Michael Leipold
    • , Yael Rosenberg-Hasson
    • , Xuhuai Ji
    • , Renaud Gaujoux
    • , Hadas Rabani
    • , Elina Starosvetsky
    • , Ksenya Kveler
    • , Steven Schaffert
    • , David Furman
    • , Oren Caspi
    • , Uri Rosenschein
    • , Purvesh Khatri
    • , Cornelia L. Dekker
    • , Holden T. Maecker
    • , Mark M. Davis
    •  & Shai S. Shen-Orr
  • News & Views |

    Transcriptional signatures and immune cell infiltrates associated with immune activation distinguish patients with glioblastoma who initially respond to immune checkpoint blockade from those who do not.

    • Hirotaka Ito
    • , Hiroshi Nakashima
    •  & E. Antonio Chiocca
  • Letter |

    QPCTL is a modifier of CD47-SIRPα binding and its blockade enhances macrophage- and neutrophil-mediated antibody dependent cellular cytotoxicity towards tumor cells.

    • Meike E. W. Logtenberg
    • , J. H. Marco Jansen
    • , Matthijs Raaben
    • , Mireille Toebes
    • , Katka Franke
    • , Arianne M. Brandsma
    • , Hanke L. Matlung
    • , Astrid Fauster
    • , Raquel Gomez-Eerland
    • , Noor A. M. Bakker
    • , Simone van der Schot
    • , Koen A. Marijt
    • , Martijn Verdoes
    • , John B. A. G. Haanen
    • , Joost H. van den Berg
    • , Jacques Neefjes
    • , Timo K. van den Berg
    • , Thijn R. Brummelkamp
    • , Jeanette H. W. Leusen
    • , Ferenc A. Scheeren
    •  & Ton N. Schumacher
  • Letter |

    Targeted inhibition of RAF–MEK–ERK signaling induces autophagy through the LKB1–AMPK axis, creating a therapeutic vulnerability that can be exploited for treating patients with pancreatic cancer and potentially other RAS-mutant tumors.

    • Conan G. Kinsey
    • , Soledad A. Camolotto
    • , Amelie M. Boespflug
    • , Katrin P. Gullien
    • , Mona Foth
    • , Amanda Truong
    • , Sophia S. Schuman
    • , Jill E. Shea
    • , Michael T. Seipp
    • , Jeffrey T. Yap
    • , Lance D. Burrell
    • , David H. Lum
    • , Jonathan R. Whisenant
    • , G. Weldon Gilcrease III
    • , Courtney C. Cavalieri
    • , Kaitrin M. Rehbein
    • , Stephanie L. Cutler
    • , Kajsa E. Affolter
    • , Alana L. Welm
    • , Bryan E. Welm
    • , Courtney L. Scaife
    • , Eric L. Snyder
    •  & Martin McMahon
  • Letter |

    Rearrangements in MAP3K8 respond to MEK inhibition and represent the most common genetic driver in pediatric spitzoid melanoma, and in some adult melanomas lacking other MAPK alterations and for which clinical testing is warranted.

    • Scott Newman
    • , Liying Fan
    • , Allison Pribnow
    • , Antonina Silkov
    • , Stephen V. Rice
    • , Seungjae Lee
    • , Ying Shao
    • , Bridget Shaner
    • , Heather Mulder
    • , Joy Nakitandwe
    • , Sheila Shurtleff
    • , Elizabeth M. Azzato
    • , Gang Wu
    • , Xin Zhou
    • , Raymond Barnhill
    • , John Easton
    • , Kim E. Nichols
    • , David W. Ellison
    • , James R. Downing
    • , Alberto Pappo
    • , Philip M. Potter
    • , Jinghui Zhang
    •  & Armita Bahrami
  • Article |

    Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors.

    • Kirsten L. Bryant
    • , Clint A. Stalnecker
    • , Daniel Zeitouni
    • , Jennifer E. Klomp
    • , Sen Peng
    • , Andrey P. Tikunov
    • , Venugopal Gunda
    • , Mariaelena Pierobon
    • , Andrew M. Waters
    • , Samuel D. George
    • , Garima Tomar
    • , Björn Papke
    • , G. Aaron Hobbs
    • , Liang Yan
    • , Tikvah K. Hayes
    • , J. Nathaniel Diehl
    • , Gennifer D. Goode
    • , Nina V. Chaika
    • , Yingxue Wang
    • , Guo-Fang Zhang
    • , Agnieszka K. Witkiewicz
    • , Erik S. Knudsen
    • , Emanuel F. Petricoin III
    • , Pankaj K. Singh
    • , Jeffrey M. Macdonald
    • , Nhan L. Tran
    • , Costas A. Lyssiotis
    • , Haoqiang Ying
    • , Alec C. Kimmelman
    • , Adrienne D. Cox
    •  & Channing J. Der
  • Article |

    Blockade of sialic acid-binding protein Siglec-15 expressed in cancer and tumor-infiltrating myeloid cells reverses immunesupression and represents a novel target for cancer immunotherapy independent from the PD-1/PD-L1 axis.

    • Jun Wang
    • , Jingwei Sun
    • , Linda N. Liu
    • , Dallas B. Flies
    • , Xinxin Nie
    • , Maria Toki
    • , Jianping Zhang
    • , Chang Song
    • , Melissa Zarr
    • , Xu Zhou
    • , Xue Han
    • , Kristina A. Archer
    • , Thomas O’Neill
    • , Roy S. Herbst
    • , Agedi N. Boto
    • , Miguel F. Sanmamed
    • , Solomon Langermann
    • , David L. Rimm
    •  & Lieping Chen
  • News & Views |

    The analysis of autopsy material from individuals with multiple sclerosis with single-cell transcriptomics and 14C carbon dating calls for a reevaluation of mature oligodendrocytes in myelin repair.

    • Klaus-Armin Nave
    •  & Hannelore Ehrenreich
  • News & Views |

    Non-invasive prenatal diagnostics allow for the successful identification of paternally inherited and de novo mongenic diseases using circulating cell-free DNA.

    • Nancy B. Spinner
    •  & Ian D. Krantz
  • Letter |

    Neoadjuvant PD-1 blockade in patients with resectable melanoma followed by adjuvant maintenance results in early immunological effects driving clinical benefit and reveals transcriptional and genomic mechanisms of response.

    • Alexander C. Huang
    • , Robert J. Orlowski
    • , Xiaowei Xu
    • , Rosemarie Mick
    • , Sangeeth M. George
    • , Patrick K. Yan
    • , Sasikanth Manne
    • , Adam A. Kraya
    • , Bradley Wubbenhorst
    • , Liza Dorfman
    • , Kurt D’Andrea
    • , Brandon M. Wenz
    • , Shujing Liu
    • , Lakshmi Chilukuri
    • , Andrew Kozlov
    • , Mary Carberry
    • , Lydia Giles
    • , Melanie W. Kier
    • , Felix Quagliarello
    • , Suzanne McGettigan
    • , Kristin Kreider
    • , Lakshmanan Annamalai
    • , Qing Zhao
    • , Robin Mogg
    • , Wei Xu
    • , Wendy M. Blumenschein
    • , Jennifer H. Yearley
    • , Gerald P. Linette
    • , Ravi K. Amaravadi
    • , Lynn M. Schuchter
    • , Ramin S. Herati
    • , Bertram Bengsch
    • , Katherine L. Nathanson
    • , Michael D. Farwell
    • , Giorgos C. Karakousis
    • , E. John Wherry
    •  & Tara C. Mitchell
  • Letter |

    Clinical insights from patients with a rare genetic skeletal disorder led to the discovery of the first case of a pathogenic gain-of-function miRNA mutation.

    • Giedre Grigelioniene
    • , Hiroshi I. Suzuki
    • , Fulya Taylan
    • , Fatemeh Mirzamohammadi
    • , Zvi U. Borochowitz
    • , Ugur M. Ayturk
    • , Shay Tzur
    • , Eva Horemuzova
    • , Anna Lindstrand
    • , Mary Ann Weis
    • , Gintautas Grigelionis
    • , Anna Hammarsjö
    • , Elin Marsk
    • , Ann Nordgren
    • , Magnus Nordenskjöld
    • , David R. Eyre
    • , Matthew L. Warman
    • , Gen Nishimura
    • , Phillip A. Sharp
    •  & Tatsuya Kobayashi
  • Publisher Correction |

    • Jinglan Zhang
    • , Jianli Li
    • , Jennifer B. Saucier
    • , Yanming Feng
    • , Yanjun Jiang
    • , Jefferson Sinson
    • , Anne K. McCombs
    • , Eric S. Schmitt
    • , Sandra Peacock
    • , Stella Chen
    • , Hongzheng Dai
    • , Xiaoyan Ge
    • , Guoli Wang
    • , Chad A. Shaw
    • , Hui Mei
    • , Amy Breman
    • , Fan Xia
    • , Yaping Yang
    • , Anne Purgason
    • , Alan Pourpak
    • , Zhao Chen
    • , Xia Wang
    • , Yue Wang
    • , Shashikant Kulkarni
    • , Kwong Wai Choy
    • , Ronald J. Wapner
    • , Ignatia B. Van den Veyver
    • , Arthur Beaudet
    • , Sheetal Parmar
    • , Lee-Jun Wong
    •  & Christine M. Eng
  • Brief Communication |

    AAV-mediated CRISPR/Cas9 therapy extends life span and ameliorates disease-related phenotypes in a mouse model of Hutchinson–Gilford progeria syndrome.

    • Olaya Santiago-Fernández
    • , Fernando G. Osorio
    • , Víctor Quesada
    • , Francisco Rodríguez
    • , Sammy Basso
    • , Daniel Maeso
    • , Loïc Rolas
    • , Anna Barkaway
    • , Sussan Nourshargh
    • , Alicia R. Folgueras
    • , José M. P. Freije
    •  & Carlos López-Otín
  • Letter |

    In the mdx mouse model of Duchenne muscular dystrophy, single intravenous administration of AAV-CRISPR–Cas9 vectors provides efficient genome editing and restoration of dystrophin expression lasting for one year.

    • Christopher E. Nelson
    • , Yaoying Wu
    • , Matthew P. Gemberling
    • , Matthew L. Oliver
    • , Matthew A. Waller
    • , Joel D. Bohning
    • , Jacqueline N. Robinson-Hamm
    • , Karen Bulaklak
    • , Ruth M. Castellanos Rivera
    • , Joel H. Collier
    • , Aravind Asokan
    •  & Charles A. Gersbach
  • Letter |

    Genomic, transcriptomic, and microenvironmental analyses of samples from patients with glioblastoma treated with nivolumab or pembrolizumab identifies features associated with treatment response that may help in refining patient stratification.

    • Junfei Zhao
    • , Andrew X. Chen
    • , Robyn D. Gartrell
    • , Andrew M. Silverman
    • , Luis Aparicio
    • , Tim Chu
    • , Darius Bordbar
    • , David Shan
    • , Jorge Samanamud
    • , Aayushi Mahajan
    • , Ioan Filip
    • , Rose Orenbuch
    • , Morgan Goetz
    • , Jonathan T. Yamaguchi
    • , Michael Cloney
    • , Craig Horbinski
    • , Rimas V. Lukas
    • , Jeffrey Raizer
    • , Ali I. Rae
    • , Jinzhou Yuan
    • , Peter Canoll
    • , Jeffrey N. Bruce
    • , Yvonne M. Saenger
    • , Peter Sims
    • , Fabio M. Iwamoto
    • , Adam M. Sonabend
    •  & Raul Rabadan
  • Article |

    Neoadjuvant pembrolizumab promotes a survival benefit with intratumoral and systemic immune responses in patients with recurrent glioblastoma.

    • Timothy F. Cloughesy
    • , Aaron Y. Mochizuki
    • , Joey R. Orpilla
    • , Willy Hugo
    • , Alexander H. Lee
    • , Tom B. Davidson
    • , Anthony C. Wang
    • , Benjamin M. Ellingson
    • , Julie A. Rytlewski
    • , Catherine M. Sanders
    • , Eric S. Kawaguchi
    • , Lin Du
    • , Gang Li
    • , William H. Yong
    • , Sarah C. Gaffey
    • , Adam L. Cohen
    • , Ingo K. Mellinghoff
    • , Eudocia Q. Lee
    • , David A. Reardon
    • , Barbara J. O’Brien
    • , Nicholas A. Butowski
    • , Phioanh L. Nghiemphu
    • , Jennifer L. Clarke
    • , Isabel C. Arrillaga-Romany
    • , Howard Colman
    • , Thomas J. Kaley
    • , John F. de Groot
    • , Linda M. Liau
    • , Patrick Y. Wen
    •  & Robert M. Prins
  • Letter |

    A natural language processing system can support physicians in diagnostic assessments by extracting clinical information from electronic medical records to accurately predict diagnosis in pediatric patients.

    • Huiying Liang
    • , Brian Y. Tsui
    • , Hao Ni
    • , Carolina C. S. Valentim
    • , Sally L. Baxter
    • , Guangjian Liu
    • , Wenjia Cai
    • , Daniel S. Kermany
    • , Xin Sun
    • , Jiancong Chen
    • , Liya He
    • , Jie Zhu
    • , Pin Tian
    • , Hua Shao
    • , Lianghong Zheng
    • , Rui Hou
    • , Sierra Hewett
    • , Gen Li
    • , Ping Liang
    • , Xuan Zang
    • , Zhiqi Zhang
    • , Liyan Pan
    • , Huimin Cai
    • , Rujuan Ling
    • , Shuhua Li
    • , Yongwang Cui
    • , Shusheng Tang
    • , Hong Ye
    • , Xiaoyan Huang
    • , Waner He
    • , Wenqing Liang
    • , Qing Zhang
    • , Jianmin Jiang
    • , Wei Yu
    • , Jianqun Gao
    • , Wanxing Ou
    • , Yingmin Deng
    • , Qiaozhen Hou
    • , Bei Wang
    • , Cuichan Yao
    • , Yan Liang
    • , Shu Zhang
    • , Yaou Duan
    • , Runze Zhang
    • , Sarah Gibson
    • , Charlotte L. Zhang
    • , Oulan Li
    • , Edward D. Zhang
    • , Gabriel Karin
    • , Nathan Nguyen
    • , Xiaokang Wu
    • , Cindy Wen
    • , Jie Xu
    • , Wenqin Xu
    • , Bochu Wang
    • , Winston Wang
    • , Jing Li
    • , Bianca Pizzato
    • , Caroline Bao
    • , Daoman Xiang
    • , Wanting He
    • , Suiqin He
    • , Yugui Zhou
    • , Weldon Haw
    • , Michael Goldbaum
    • , Adriana Tremoulet
    • , Chun-Nan Hsu
    • , Hannah Carter
    • , Long Zhu
    • , Kang Zhang
    •  & Huimin Xia
  • Letter |

    Neoadjuvant nivolumab treatment in patients with glioblastoma induces intratumoral immune activation and underscores the need for rationale-based combination approaches for improving clinical responses.

    • Kurt A. Schalper
    • , Maria E. Rodriguez-Ruiz
    • , Ricardo Diez-Valle
    • , Alvaro López-Janeiro
    • , Angelo Porciuncula
    • , Miguel A. Idoate
    • , Susana Inogés
    • , Carlos de Andrea
    • , Ascensión López-Diaz de Cerio
    • , Sonia Tejada
    • , Pedro Berraondo
    • , Franz Villarroel-Espindola
    • , Jungmin Choi
    • , Alfonso Gúrpide
    • , Miriam Giraldez
    • , Iosune Goicoechea
    • , Jaime Gallego Perez-Larraya
    • , Miguel F. Sanmamed
    • , Jose L. Perez-Gracia
    •  & Ignacio Melero
  • News Feature |

    Careful sorting of probiotics may finally pave the way for an FDA approval.

    • Shraddha Chakradhar
  • Turning Points |

    Eran Elinav is an immunologist at the Weizmann Institute of Science in Rehovot, Israel. He has earned many distinctions, including being named a Howard Hughes Medical Institute and Bill and Melinda Gates Foundation research scholar in 2017.

    • Eran Elinav
  • Perspective |

    The emerging field of precision epidemiology allows the personalized diagnosis, tracking and treatment of infectious diseases.

    • Jason T. Ladner
    • , Nathan D. Grubaugh
    • , Oliver G. Pybus
    •  & Kristian G. Andersen
  • Editorial |

    As the world reckons with the news of the first use of genome editing in the human germline, researchers, clinicians, ethicists and policy makers must work across international boundaries to outline a transparent path forward for the responsible translation of this technology in the future.