Browse Articles

  • Brief Communication |

    Preliminary evidence from two cases suggests that fecal microbiota transplantation may provide a viable treatment option for a severe adverse effect of immune checkpoint blockade therapy in patients with cancer.

    • Yinghong Wang
    • , Diana H. Wiesnoski
    • , Beth A. Helmink
    • , Vancheswaran Gopalakrishnan
    • , Kati Choi
    • , Hebert L. DuPont
    • , Zhi-Dong Jiang
    • , Hamzah Abu-Sbeih
    • , Christopher A. Sanchez
    • , Chia-Chi Chang
    • , Edwin R. Parra
    • , Alejandro Francisco-Cruz
    • , Gottumukkala S. Raju
    • , John R. Stroehlein
    • , Matthew T. Campbell
    • , Jianjun Gao
    • , Sumit K. Subudhi
    • , Dipen M. Maru
    • , Jorge M. Blando
    • , James P. Allison
    • , Padmanee Sharma
    • , Michael T. Tetzlaff
    • , Jennifer A. Wargo
    •  & Robert R. Jenq
  • Article |

    Targeting of mitochondrial metabolism in combination with BCL-2 inhibition eradicates leukemia stem cells and induces long-lasting responses in patients with acute myeloid leukemia.

    • Daniel A. Pollyea
    • , Brett M. Stevens
    • , Courtney L. Jones
    • , Amanda Winters
    • , Shanshan Pei
    • , Mohammad Minhajuddin
    • , Angelo D’Alessandro
    • , Rachel Culp-Hill
    • , Kent A. Riemondy
    • , Austin E. Gillen
    • , Jay R. Hesselberth
    • , Diana Abbott
    • , Derek Schatz
    • , Jonathan A. Gutman
    • , Enkhtsetseg Purev
    • , Clayton Smith
    •  & Craig T. Jordan
  • Article |

    Obesity promotes tumor growth yet simultaneously increases susceptibility to PD-1-targeted cancer immunotherapy.

    • Ziming Wang
    • , Ethan G. Aguilar
    • , Jesus I. Luna
    • , Cordelia Dunai
    • , Lam T. Khuat
    • , Catherine T. Le
    • , Annie Mirsoian
    • , Christine M. Minnar
    • , Kevin M. Stoffel
    • , Ian R. Sturgill
    • , Steven K. Grossenbacher
    • , Sita S. Withers
    • , Robert B. Rebhun
    • , Dennis J. Hartigan-O’Connor
    • , Gema Méndez-Lagares
    • , Alice F. Tarantal
    • , R. Rivkah Isseroff
    • , Thomas S. Griffith
    • , Kurt A. Schalper
    • , Alexander Merleev
    • , Asim Saha
    • , Emanual Maverakis
    • , Karen Kelly
    • , Raid Aljumaily
    • , Sami Ibrahimi
    • , Sarbajit Mukherjee
    • , Michael Machiorlatti
    • , Sara K. Vesely
    • , Dan L. Longo
    • , Bruce R. Blazar
    • , Robert J. Canter
    • , William J. Murphy
    •  & Arta M. Monjazeb
  • Letter |

    Single-cell RNA-seq of a mouse model of multiple sclerosis uncovers new oligodendrocyte populations and putative disease markers and suggests new mechanisms underlying the pathogenesis of the disease.

    • Ana Mendanha Falcão
    • , David van Bruggen
    • , Sueli Marques
    • , Mandy Meijer
    • , Sarah Jäkel
    • , Eneritz Agirre
    • , Samudyata
    • , Elisa M. Floriddia
    • , Darya P. Vanichkina
    • , Charles ffrench-Constant
    • , Anna Williams
    • , André Ortlieb Guerreiro-Cacais
    •  & Gonçalo Castelo-Branco
  • News & Views |

    Stratifying tuberculosis (TB) disease into minimal, moderate or severe disease may allow treatment duration to be tailored to disease severity. Minimal poor adherence is associated with poor treatment outcomes.

    • Gavin J. Churchyard
  • News & Views |

    In humans, niche-specific gastrointestinal microbiomes influence the colonization success of probiotic microbes. Microbiome reconstitution following antimicrobial perturbation is most successful using preperturbation autofecal microbial transplant.

    • Elze Rackaityte
    •  & Susan V. Lynch
  • Perspective |

    A neoadjuvant approach using combined anti-CTLA4/anti-PD1 treatment prior to lymph node surgery is evaluated in two phase I trials of later stage melanoma finding this a therapeutic angle worth pursuing.

    • Caroline Robert
  • Editorial |

    Recent news stories about conflict of interest in biomedical research have shaken up public and private institutions alike, but their focus was on clinical research. Amidst the renewed focus on conflicts of interest in clinical work, let’s not disregard the fact that financial conflicts also pose a concern to basic and preclinical research.

  • News & Views |

    Reinforcement learning is applied to two large databases of electronic health records for patients admitted to an intensive care unit to identify individualized treatment strategies for correcting hypotension in sepsis.

    • Suchi Saria
  • Letter |

    Radiotherapy-induced abscopal responses enhance the efficacy of anti-CTLA-4 in patients with non-small-cell lung cancer.

    • Silvia C. Formenti
    • , Nils-Petter Rudqvist
    • , Encouse Golden
    • , Benjamin Cooper
    • , Erik Wennerberg
    • , Claire Lhuillier
    • , Claire Vanpouille-Box
    • , Kent Friedman
    • , Lucas Ferrari de Andrade
    • , Kai W. Wucherpfennig
    • , Adriana Heguy
    • , Naoko Imai
    • , Sacha Gnjatic
    • , Ryan O. Emerson
    • , Xi Kathy Zhou
    • , Tuo Zhang
    • , Abraham Chachoua
    •  & Sandra Demaria
  • Letter |

    Skin from individuals with a rare immunodeficiency harbors more eukaryotic viruses than healthy skin, highlighting the role of immune surveillance in modulating the skin microbiome.

    • Osnat Tirosh
    • , Sean Conlan
    • , Clay Deming
    • , Shih-Queen Lee-Lin
    • , Xin Huang
    • , Beatrice B. Barnabas
    • , Gerard G. Bouffard
    • , Shelise Y. Brooks
    • , Holly Marfani
    • , Lyudmila Dekhtyar
    • , Xiaobin Guan
    • , Joel Han
    • , Shi-ling Ho
    • , Richelle Legaspi
    • , Quino L. Maduro
    • , Catherine A. Masiello
    • , Jennifer C. McDowell
    • , Casandra Montemayor
    • , James C. Mullikin
    • , Morgan Park
    • , Nancy L. Riebow
    • , Karen Schandler
    • , Chanthra Scharer
    • , Brian Schmidt
    • , Christina Sison
    • , Sirintorn Stantripop
    • , James W. Thomas
    • , Pamela J. Thomas
    • , Meghana Vemulapalli
    • , Alice C. Young
    • , Helen C. Su
    • , Alexandra F. Freeman
    • , Julia A. Segre
    •  & Heidi H. Kong
  • Article |

    A novel orphan noncoding RNA species with tumor-specific expression across breast cancer subtypes promotes metastatic progression and holds potential for patient diagnosis.

    • Lisa Fish
    • , Steven Zhang
    • , Johnny X. Yu
    • , Bruce Culbertson
    • , Alicia Y. Zhou
    • , Andrei Goga
    •  & Hani Goodarzi
  • Article | | open

    Analysis of tuberculosis drug trials identifies features to stratify patients for longer or shorter treatment duration than the standard of care, in order to improve therapeutic outcomes.

    • Marjorie Z. Imperial
    • , Payam Nahid
    • , Patrick P. J. Phillips
    • , Geraint R. Davies
    • , Katherine Fielding
    • , Debra Hanna
    • , David Hermann
    • , Robert S. Wallis
    • , John L. Johnson
    • , Christian Lienhardt
    •  & Rada M. Savic
  • Article |

    Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

    • Lulu Sun
    • , Cen Xie
    • , Guang Wang
    • , Yue Wu
    • , Qing Wu
    • , Xuemei Wang
    • , Jia Liu
    • , Yangyang Deng
    • , Jialin Xia
    • , Bo Chen
    • , Songyang Zhang
    • , Chuyu Yun
    • , Guan Lian
    • , Xiujuan Zhang
    • , Heng Zhang
    • , William H. Bisson
    • , Jingmin Shi
    • , Xiaoxia Gao
    • , Pupu Ge
    • , Cuihua Liu
    • , Kristopher W. Krausz
    • , Robert G. Nichols
    • , Jingwei Cai
    • , Bipin Rimal
    • , Andrew D. Patterson
    • , Xian Wang
    • , Frank J. Gonzalez
    •  & Changtao Jiang
  • News Feature |

    The microbiome may have an influence on addiction

    • Wudan Yan
  • News Feature |

    A long-neglected virus returns to the top of researchers’ to-do lists.

    • Amanda B. Keener
  • Article |

    Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.

    • Jorge Sepulcre
    • , Michel J. Grothe
    • , Federico d’Oleire Uquillas
    • , Laura Ortiz-Terán
    • , Ibai Diez
    • , Hyun-Sik Yang
    • , Heidi I. L. Jacobs
    • , Bernard J. Hanseeuw
    • , Quanzheng Li
    • , Georges El-Fakhri
    • , Reisa A. Sperling
    •  & Keith A. Johnson
  • Article |

    The translation initiation complex mediates tumor immune escape in melanoma by controlling STAT1 mRNA levels and T lymphocyte–induced PD-L1 expression.

    • Michaël Cerezo
    • , Ramdane Guemiri
    • , Sabine Druillennec
    • , Isabelle Girault
    • , Hélène Malka-Mahieu
    • , Shensi Shen
    • , Delphine Allard
    • , Sylvain Martineau
    • , Caroline Welsch
    • , Sandrine Agoussi
    • , Charlène Estrada
    • , Julien Adam
    • , Cristina Libenciuc
    • , Emilie Routier
    • , Séverine Roy
    • , Laurent Désaubry
    • , Alexander M. Eggermont
    • , Nahum Sonenberg
    • , Jean Yves Scoazec
    • , Alain Eychène
    • , Stéphan Vagner
    •  & Caroline Robert
  • News & Views |

    Mutationally activated BRAF-V600E influences the behavior of different types of cells in the brain and leads to promotion of seizures as well as brain tumors, indicating how both can be pharmacologically targeted in the clinic.

    • Jean M. Mulcahy Levy
    •  & Martin McMahon
  • Author Correction |

    • Rodabe N. Amaria
    • , Sangeetha M. Reddy
    • , Hussein A. Tawbi
    • , Michael A. Davies
    • , Merrick I. Ross
    • , Isabella C. Glitza
    • , Janice N. Cormier
    • , Carol Lewis
    • , Wen-Jen Hwu
    • , Ehab Hanna
    • , Adi Diab
    • , Michael K. Wong
    • , Richard Royal
    • , Neil Gross
    • , Randal Weber
    • , Stephen Y. Lai
    • , Richard Ehlers
    • , Jorge Blando
    • , Denái R. Milton
    • , Scott Woodman
    • , Robin Kageyama
    • , Daniel K. Wells
    • , Patrick Hwu
    • , Sapna P. Patel
    • , Anthony Lucci
    • , Amy Hessel
    • , Jeffrey E. Lee
    • , Jeffrey Gershenwald
    • , Lauren Simpson
    • , Elizabeth M. Burton
    • , Liberty Posada
    • , Lauren Haydu
    • , Linghua Wang
    • , Shaojun Zhang
    • , Alexander J. Lazar
    • , Courtney W. Hudgens
    • , Vancheswaran Gopalakrishnan
    • , Alexandre Reuben
    • , Miles C. Andrews
    • , Christine N. Spencer
    • , Victor Prieto
    • , Padmanee Sharma
    • , James Allison
    • , Michael T. Tetzlaff
    •  & Jennifer A. Wargo
  • Publisher Correction |

    • Rodabe N. Amaria
    • , Sangeetha M. Reddy
    • , Hussein A. Tawbi
    • , Michael A. Davies
    • , Merrick I. Ross
    • , Isabella C. Glitza
    • , Janice N. Cormier
    • , Carol Lewis
    • , Wen-Jen Hwu
    • , Ehab Hanna
    • , Adi Diab
    • , Michael K. Wong
    • , Richard Royal
    • , Neil Gross
    • , Randal Weber
    • , Stephen Y. Lai
    • , Richard Ehlers
    • , Jorge Blando
    • , Denái R. Milton
    • , Scott Woodman
    • , Robin Kageyama
    • , Daniel K. Wells
    • , Patrick Hwu
    • , Sapna P. Patel
    • , Anthony Lucci
    • , Amy Hessel
    • , Jeffrey E. Lee
    • , Jeffrey Gershenwald
    • , Lauren Simpson
    • , Elizabeth M. Burton
    • , Liberty Posada
    • , Lauren Haydu
    • , Linghua Wang
    • , Shaojun Zhang
    • , Alexander J. Lazar
    • , Courtney W. Hudgens
    • , Vancheswaran Gopalakrishnan
    • , Alexandre Reuben
    • , Miles C. Andrews
    • , Christine N. Spencer
    • , Victor Prieto
    • , Padmanee Sharma
    • , James Allison
    • , Michael T. Tetzlaff
    •  & Jennifer A. Wargo
  • Resource |

    A resource of preclinical pediatric brain tumor models with detailed molecular characterization provides a platform for the community to test novel therapeutic approaches.

    • Sebastian Brabetz
    • , Sarah E. S. Leary
    • , Susanne N. Gröbner
    • , Madison W. Nakamoto
    • , Huriye Şeker-Cin
    • , Emily J. Girard
    • , Bonnie Cole
    • , Andrew D. Strand
    • , Karina L. Bloom
    • , Volker Hovestadt
    • , Norman L. Mack
    • , Fiona Pakiam
    • , Benjamin Schwalm
    • , Andrey Korshunov
    • , Gnana Prakash Balasubramanian
    • , Paul A. Northcott
    • , Kyle D. Pedro
    • , Joyoti Dey
    • , Stacey Hansen
    • , Sally Ditzler
    • , Peter Lichter
    • , Lukas Chavez
    • , David T. W. Jones
    • , Jan Koster
    • , Stefan M. Pfister
    • , Marcel Kool
    •  & James M. Olson
  • Resource |

    A quantitative proteomic approach overcomes a major bottleneck in translational immunology, namely the identification of autologous and bacterial immunodominant major histocompatibility complex class II epitopes based on genomic sequences.

    • Daniel B. Graham
    • , Chengwei Luo
    • , Daniel J. O’Connell
    • , Ariel Lefkovith
    • , Eric M. Brown
    • , Moran Yassour
    • , Mukund Varma
    • , Jennifer G. Abelin
    • , Kara L. Conway
    • , Guadalupe J. Jasso
    • , Caline G. Matar
    • , Steven A. Carr
    •  & Ramnik J. Xavier
  • News Feature |

    Virologists say sewage systems are flush with opportunity.

    • Colin Barras
  • Letter |

    AAV-mediated base editing corrects an autosomal recessive mutation in the Pahenu2 gene and ameliorates molecular deficits in a mouse model of metabolic liver disease.

    • Lukas Villiger
    • , Hiu Man Grisch-Chan
    • , Helen Lindsay
    • , Femke Ringnalda
    • , Chiara B. Pogliano
    • , Gabriella Allegri
    • , Ralph Fingerhut
    • , Johannes Häberle
    • , Joao Matos
    • , Mark D. Robinson
    • , Beat Thöny
    •  & Gerald Schwank
  • Article |

    Targeting different aspects of mutant CFTR structural defects with combination therapy leads to more potent rescue of function than that following single therapy.

    • Guido Veit
    • , Haijin Xu
    • , Elise Dreano
    • , Radu G. Avramescu
    • , Miklos Bagdany
    • , Lenore K. Beitel
    • , Ariel Roldan
    • , Mark A. Hancock
    • , Cecilia Lay
    • , Wei Li
    • , Katelin Morin
    • , Sandra Gao
    • , Puiying A. Mak
    • , Edward Ainscow
    • , Anthony P. Orth
    • , Peter McNamara
    • , Aleksander Edelman
    • , Saul Frenkiel
    • , Elias Matouk
    • , Isabelle Sermet-Gaudelus
    • , William G. Barnes
    •  & Gergely L. Lukacs
  • Letter |

    A biocompatible device built from naturally dissolving components and controlled by wireless technology enables programmable electrical stimulation of injured rodent peripheral nerves to accelerate regeneration and recovery.

    • Jahyun Koo
    • , Matthew R. MacEwan
    • , Seung-Kyun Kang
    • , Sang Min Won
    • , Manu Stephen
    • , Paul Gamble
    • , Zhaoqian Xie
    • , Ying Yan
    • , Yu-Yu Chen
    • , Jiho Shin
    • , Nathan Birenbaum
    • , Sangjin Chung
    • , Sung Bong Kim
    • , Jawad Khalifeh
    • , Daniel V. Harburg
    • , Kelsey Bean
    • , Michael Paskett
    • , Jeonghyun Kim
    • , Zohny S. Zohny
    • , Seung Min Lee
    • , Ruoyao Zhang
    • , Kaijing Luo
    • , Bowen Ji
    • , Anthony Banks
    • , Hyuck Mo Lee
    • , Younggang Huang
    • , Wilson Z. Ray
    •  & John A. Rogers
  • Letter |

    Viral-mediated base editing in utero enables therapeutic editing of two metabolic genes in mice.

    • Avery C. Rossidis
    • , John D. Stratigis
    • , Alexandra C. Chadwick
    • , Heather A. Hartman
    • , Nicholas J. Ahn
    • , Haiying Li
    • , Kshitiz Singh
    • , Barbara E. Coons
    • , Li Li
    • , Wenjian Lv
    • , Philip W. Zoltick
    • , Deepthi Alapati
    • , William Zacharias
    • , Rajan Jain
    • , Edward E. Morrisey
    • , Kiran Musunuru
    •  & William H. Peranteau
  • News & Views |

    Informing physicians who prescribe opioids about opioid-linked deaths in their practice reduces future opioid prescribing.

    • Nora D. Volkow
    •  & Ruben Baler
  • Article |

    Systemic administration of human PBGD mRNA encapsulated in lipid nanoparticles ameliorates disease phenotypes in mouse and rabbit models of acute hepatic porphyria and is safe in nonhuman primates.

    • Lei Jiang
    • , Pedro Berraondo
    • , Daniel Jericó
    • , Lin T. Guey
    • , Ana Sampedro
    • , Andrea Frassetto
    • , Kerry E. Benenato
    • , Kristine Burke
    • , Eva Santamaría
    • , Manuel Alegre
    • , Álvaro Pejenaute
    • , Mayur Kalariya
    • , William Butcher
    • , Ji-Sun Park
    • , Xuling Zhu
    • , Staci Sabnis
    • , E. Sathyajith Kumarasinghe
    • , Timothy Salerno
    • , Matthew Kenney
    • , Christine M. Lukacs
    • , Matías A. Ávila
    • , Paolo G. V. Martini
    •  & Antonio Fontanellas
  • Letter |

    Neoadjuvant combination treatment with nivolumab and ipilimumab in patients with high-risk melanoma results in higher response rates than nivolumab monotherapy and warrants future optimization of dosing regimens to preserve efficacy while limiting toxicity.

    • Rodabe N. Amaria
    • , Sangeetha M. Reddy
    • , Hussein A. Tawbi
    • , Michael A. Davies
    • , Merrick I. Ross
    • , Isabella C. Glitza
    • , Janice N. Cormier
    • , Carol Lewis
    • , Wen-Jen Hwu
    • , Ehab Hanna
    • , Adi Diab
    • , Michael K. Wong
    • , Richard Royal
    • , Neil Gross
    • , Randal Weber
    • , Stephen Y. Lai
    • , Richard Ehlers
    • , Jorge Blando
    • , Denái R. Milton
    • , Scott Woodman
    • , Robin Kageyama
    • , Daniel K. Wells
    • , Patrick Hwu
    • , Sapna P. Patel
    • , Anthony Lucci
    • , Amy Hessel
    • , Jeffrey E. Lee
    • , Jeffrey Gershenwald
    • , Lauren Simpson
    • , Elizabeth M. Burton
    • , Liberty Posada
    • , Lauren Haydu
    • , Linghua Wang
    • , Shaojun Zhang
    • , Alexander J. Lazar
    • , Courtney W. Hudgens
    • , Vancheswaran Gopalakrishnan
    • , Alexandre Reuben
    • , Miles C. Andrews
    • , Christine N. Spencer
    • , Victor Prieto
    • , Padmanee Sharma
    • , James Allison
    • , Michael T. Tetzlaff
    •  & Jennifer A. Wargo
  • Letter |

    The long-term follow-up results of a phase 1/2 retinal gene therapy clinical trial for choroideremia ( NCT01461213 ) support the safety and efficacy of the treatment.

    • Kanmin Xue
    • , Jasleen K Jolly
    • , Alun R. Barnard
    • , Anna Rudenko
    • , Anna P. Salvetti
    • , Maria I. Patrício
    • , Thomas L. Edwards
    • , Markus Groppe
    • , Harry O. Orlans
    • , Tanya Tolmachova
    • , Graeme C. Black
    • , Andrew R. Webster
    • , Andrew J. Lotery
    • , Graham E. Holder
    • , Susan M. Downes
    • , Miguel C. Seabra
    •  & Robert E. MacLaren
  • Letter |

    Large tumors induce anemia and expansion of CD45+ immature erythroid cells, which represent a major immunosuppressive population in the spleen, contributing to systemic suppression of T cell immunity in late-stage cancer.

    • Lintao Zhao
    • , Ran He
    • , Haixia Long
    • , Bo Guo
    • , Qingzhu Jia
    • , Diyuan Qin
    • , Si-Qi Liu
    • , Zhongyu Wang
    • , Tong Xiang
    • , Jue Zhang
    • , Yulong Tan
    • , Jiani Huang
    • , Junying Chen
    • , Fang Wang
    • , Minglu Xiao
    • , Jianbao Gao
    • , Xinxin Yang
    • , Hao Zeng
    • , Xinxin Wang
    • , Chunyan Hu
    • , Peter B. Alexander
    • , Alistair L. J. Symonds
    • , Jia Yu
    • , Yisong Wan
    • , Qi-Jing Li
    • , Lilin Ye
    •  & Bo Zhu