Browse Articles

  • Author Correction |

    • Neibla Priego
    • , Lucía Zhu
    • , Cátia Monteiro
    • , Manon Mulders
    • , David Wasilewski
    • , Wendy Bindeman
    • , Laura Doglio
    • , Liliana Martínez
    • , Elena Martínez-Saez
    • , Santiago Ramón y Cajal
    • , Diego Megías
    • , Elena Hernández-Encinas
    • , Carmen Blanco-Aparicio
    • , Lola Martínez
    • , Eduardo Zarzuela
    • , Javier Muñoz
    • , Coral Fustero-Torre
    • , Elena Piñeiro-Yáñez
    • , Aurelio Hernández-Laín
    • , Luca Bertero
    • , Valeria Poli
    • , Melchor Sanchez-Martinez
    • , Javier A. Menendez
    • , Riccardo Soffietti
    • , Joaquim Bosch-Barrera
    •  & Manuel Valiente
  • Article |

    Recovery of skilled motor function in rodents after stroke correlates with the restoration of low-frequency quasi-oscillatory activity in the motor cortex, and neuromodulatory electrical stimulation targeting this activity can further accelerate recovery.

    • Dhakshin S. Ramanathan
    • , Ling Guo
    • , Tanuj Gulati
    • , Gray Davidson
    • , April K. Hishinuma
    • , Seok-Joon Won
    • , Robert T. Knight
    • , Edward F. Chang
    • , Raymond A. Swanson
    •  & Karunesh Ganguly
  • Letter |

    CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells.

    • Robert J. Ihry
    • , Kathleen A. Worringer
    • , Max R. Salick
    • , Elizabeth Frias
    • , Daniel Ho
    • , Kraig Theriault
    • , Sravya Kommineni
    • , Julie Chen
    • , Marie Sondey
    • , Chaoyang Ye
    • , Ranjit Randhawa
    • , Tripti Kulkarni
    • , Zinger Yang
    • , Gregory McAllister
    • , Carsten Russ
    • , John Reece-Hoyes
    • , William Forrester
    • , Gregory R. Hoffman
    • , Ricardo Dolmetsch
    •  & Ajamete Kaykas
  • Article |

    Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.

    • Christina Yingxian Chen
    • , Matthew A. Caporizzo
    • , Kenneth Bedi
    • , Alexia Vite
    • , Alexey I. Bogush
    • , Patrick Robison
    • , Julie G. Heffler
    • , Alex K. Salomon
    • , Neil A. Kelly
    • , Apoorva Babu
    • , Michael P. Morley
    • , Kenneth B. Margulies
    •  & Benjamin L. Prosser
  • Article |

    Reactive astrocytes expressing STAT3 support the metastatic growth of tumor cells colonizing the brain and can be pharmacologically targeted to improve the clinical management of patients with secondary brain tumors.

    • Neibla Priego
    • , Lucía Zhu
    • , Cátia Monteiro
    • , Manon Mulders
    • , David Wasilewski
    • , Wendy Bindeman
    • , Laura Doglio
    • , Liliana Martínez
    • , Elena Martínez-Saez
    • , Santiago Ramón y Cajal
    • , Diego Megías
    • , Elena Hernández-Encinas
    • , Carmen Blanco-Aparicio
    • , Lola Martínez
    • , Eduardo Zarzuela
    • , Javier Muñoz
    • , Coral Fustero-Torre
    • , Elena Piñeiro-Yáñez
    • , Aurelio Hernández-Laín
    • , Luca Bertero
    • , Valeria Poli
    • , Melchor Sanchez-Martinez
    • , Javier A. Menendez
    • , Riccardo Soffietti
    • , Joaquim Bosch-Barrera
    •  & Manuel Valiente
  • Letter |

    Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

    • Seung Pil Yun
    • , Tae-In Kam
    • , Nikhil Panicker
    • , SangMin Kim
    • , Yumin Oh
    • , Jong-Sung Park
    • , Seung-Hwan Kwon
    • , Yong Joo Park
    • , Senthilkumar S. Karuppagounder
    • , Hyejin Park
    • , Sangjune Kim
    • , Nayeon Oh
    • , Nayoung Alice Kim
    • , Saebom Lee
    • , Saurav Brahmachari
    • , Xiaobo Mao
    • , Jun Hee Lee
    • , Manoj Kumar
    • , Daniel An
    • , Sung-Ung Kang
    • , Yunjong Lee
    • , Kang Choon Lee
    • , Dong Hee Na
    • , Donghoon Kim
    • , Sang Hun Lee
    • , Viktor V. Roschke
    • , Shane A. Liddelow
    • , Zoltan Mari
    • , Ben A. Barres
    • , Valina L. Dawson
    • , Seulki Lee
    • , Ted M. Dawson
    •  & Han Seok Ko
  • Article |

    Study of macrophage heterogeneity in human hearts reveals a subset of inflammatory macrophages that is associated with cardiac dysfunction in patients with heart failure.

    • Geetika Bajpai
    • , Caralin Schneider
    • , Nicole Wong
    • , Andrea Bredemeyer
    • , Maarten Hulsmans
    • , Matthias Nahrendorf
    • , Slava Epelman
    • , Daniel Kreisel
    • , Yongjian Liu
    • , Akinobu Itoh
    • , Thirupura S. Shankar
    • , Craig H. Selzman
    • , Stavros G. Drakos
    •  & Kory J. Lavine
  • Brief Communication |

    Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.

    • Donn J. Colby
    • , Lydie Trautmann
    • , Suteeraporn Pinyakorn
    • , Louise Leyre
    • , Amélie Pagliuzza
    • , Eugène Kroon
    • , Morgane Rolland
    • , Hiroshi Takata
    • , Supranee Buranapraditkun
    • , Jintana Intasan
    • , Nitiya Chomchey
    • , Roshell Muir
    • , Elias K. Haddad
    • , Sodsai Tovanabutra
    • , Sasiwimol Ubolyam
    • , Diane L. Bolton
    • , Brandie A. Fullmer
    • , Robert J. Gorelick
    • , Lawrence Fox
    • , Trevor A. Crowell
    • , Rapee Trichavaroj
    • , Robert O’Connell
    • , Nicolas Chomont
    • , Jerome H. Kim
    • , Nelson L. Michael
    • , Merlin L. Robb
    • , Nittaya Phanuphak
    •  & Jintanat Ananworanich
  • Article |

    A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative phosphorylation.

    • Jennifer R. Molina
    • , Yuting Sun
    • , Marina Protopopova
    • , Sonal Gera
    • , Madhavi Bandi
    • , Christopher Bristow
    • , Timothy McAfoos
    • , Pietro Morlacchi
    • , Jeffrey Ackroyd
    • , Ahmed-Noor A. Agip
    • , Gheath Al-Atrash
    • , John Asara
    • , Jennifer Bardenhagen
    • , Caroline C. Carrillo
    • , Christopher Carroll
    • , Edward Chang
    • , Stefan Ciurea
    • , Jason B. Cross
    • , Barbara Czako
    • , Angela Deem
    • , Naval Daver
    • , John Frederick de Groot
    • , Jian-Wen Dong
    • , Ningping Feng
    • , Guang Gao
    • , Jason Gay
    • , Mary Geck Do
    • , Jennifer Greer
    • , Virginia Giuliani
    • , Jing Han
    • , Lina Han
    • , Verlene K. Henry
    • , Judy Hirst
    • , Sha Huang
    • , Yongying Jiang
    • , Zhijun Kang
    • , Tin Khor
    • , Sergej Konoplev
    • , Yu-Hsi Lin
    • , Gang Liu
    • , Alessia Lodi
    • , Timothy Lofton
    • , Helen Ma
    • , Mikhila Mahendra
    • , Polina Matre
    • , Robert Mullinax
    • , Michael Peoples
    • , Alessia Petrocchi
    • , Jaime Rodriguez-Canale
    • , Riccardo Serreli
    • , Thomas Shi
    • , Melinda Smith
    • , Yoko Tabe
    • , Jay Theroff
    • , Stefano Tiziani
    • , Quanyun Xu
    • , Qi Zhang
    • , Florian Muller
    • , Ronald A. DePinho
    • , Carlo Toniatti
    • , Giulio F. Draetta
    • , Timothy P. Heffernan
    • , Marina Konopleva
    • , Philip Jones
    • , M. Emilia Di Francesco
    •  & Joseph R. Marszalek
  • Article |

    Tumor-infiltrating CD8+ T cells with high expression of PD-1 in non-small-cell lung cancer are distinct from exhausted T cells in chronic virus infection, have high tumor reactivity and associate with response to PD-1-targeted immunotherapy.

    • Daniela S. Thommen
    • , Viktor H. Koelzer
    • , Petra Herzig
    • , Andreas Roller
    • , Marcel Trefny
    • , Sarah Dimeloe
    • , Anna Kiialainen
    • , Jonathan Hanhart
    • , Catherine Schill
    • , Christoph Hess
    • , Spasenija Savic Prince
    • , Mark Wiese
    • , Didier Lardinois
    • , Ping-Chih Ho
    • , Christian Klein
    • , Vaios Karanikas
    • , Kirsten D. Mertz
    • , Ton N. Schumacher
    •  & Alfred Zippelius
  • Letter |

    In vivo shRNA screens in sensitized genetic backgrounds identify p53-activated target genes involved in DNA repair that enable its tumor suppressor function.

    • Ana Janic
    • , Liz J. Valente
    • , Matthew J. Wakefield
    • , Leon Di Stefano
    • , Liz Milla
    • , Stephen Wilcox
    • , Haoyu Yang
    • , Lin Tai
    • , Cassandra J. Vandenberg
    • , Andrew J. Kueh
    • , Shinsuke Mizutani
    • , Margs S. Brennan
    • , Robyn L. Schenk
    • , Lisa M. Lindqvist
    • , Anthony T. Papenfuss
    • , Liam O’Connor
    • , Andreas Strasser
    •  & Marco J. Herold
  • Article |

    SMARCA4 loss in non-small-cell lung cancer creates a metabolic dependency on oxidative phosphorylation that can be targeted using a new small-molecule inhibitor.

    • Yonathan Lissanu Deribe
    • , Yuting Sun
    • , Christopher Terranova
    • , Fatima Khan
    • , Juan Martinez-Ledesma
    • , Jason Gay
    • , Guang Gao
    • , Robert A. Mullinax
    • , Tin Khor
    • , Ningping Feng
    • , Yu-Hsi Lin
    • , Chia-Chin Wu
    • , Claudia Reyes
    • , Qian Peng
    • , Frederick Robinson
    • , Akira Inoue
    • , Veena Kochat
    • , Chang-Gong Liu
    • , John M. Asara
    • , Cesar Moran
    • , Florian Muller
    • , Jing Wang
    • , Bingliang Fang
    • , Vali Papadimitrakopoulou
    • , Ignacio I. Wistuba
    • , Kunal Rai
    • , Joseph Marszalek
    •  & P. Andrew Futreal
  • News & Views |

    A large retrospective study involving 62,565 Danish men shows that those who have been overweight in childhood have a lower risk of having type 2 diabetes in adulthood if they had remission of overweight before 13 years of age.

    • Daniel S. Hsia
    •  & Steven B. Heymsfield
  • Editorial |

    With the ongoing demand for assisted reproduction, the need and ability to study the fundamentals of human reproduction at a cellular level have never been greater. At this juncture, we join other Nature Research Journals in formalizing our ethical guidelines for papers in this growing field.

  • News Feature |

    Chronotherapy looks beyond to treating more than just cancer

    • Shraddha Chakradhar
  • Article |

    Accumulation of zinc in muscle cells resulting from transcriptional upregulation of metal transporter ZIP14 causes muscle atrophy and promotes cachexia in metastatic cancer.

    • Gang Wang
    • , Anup K. Biswas
    • , Wanchao Ma
    • , Manoj Kandpal
    • , Courtney Coker
    • , Paul M. Grandgenett
    • , Michael A. Hollingsworth
    • , Rinku Jain
    • , Kurenai Tanji
    • , Sara Lόpez-Pintado
    • , Alain Borczuk
    • , Doreen Hebert
    • , Supak Jenkitkasemwong
    • , Shintaro Hojyo
    • , Ramana V. Davuluri
    • , Mitchell D. Knutson
    • , Toshiyuki Fukada
    •  & Swarnali Acharyya
  • News Feature |

    After half a century, scientists still debate the best way to fatten up lab animals

    • Daniel Engber