Nature Medicine Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation. Aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings, the journal publishes the latest advances in cancer biology, vascular biology, neuroscience, inflammatory disease, infectious disease and metabolic disorders, among other fields. Reviews, Perspectives and other commissioned content clarify and give context to these biomedical research advances, and the News section reports on the latest developments in drug research and development. http://feeds.nature.com/nm/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Medicine © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Medicine https://www.nature.com/uploads/product/nm/rss.gif http://feeds.nature.com/nm/rss/current <![CDATA[<b>Microplastics at heart of the problem</b>]]> https://www.nature.com/articles/d41591-024-00021-5 Nature Medicine, Published online: 27 March 2024; doi:10.1038/d41591-024-00021-5

Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.]]>
Microplastics at heart of the problem]]> Sonia Muliyil doi:10.1038/d41591-024-00021-5 Nature Medicine, Published online: 2024-03-27; | doi:10.1038/d41591-024-00021-5 2024-03-27 Nature Medicine 10.1038/d41591-024-00021-5 https://www.nature.com/articles/d41591-024-00021-5
<![CDATA[A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results]]> https://www.nature.com/articles/s41591-024-02851-9 Nature Medicine, Published online: 27 March 2024; doi:10.1038/s41591-024-02851-9

In an interim analysis of a phase 1/2 trial, a heterologous prime boost vaccine comprised of a chimpanzee adenovirus and self-amplifying mRNA that encodes neoantigens derived from common oncogenic driver mutations in combination with immune checkpoint blockade was safe and elicited neoantigen-specific T cell responses in patients with advanced solid tumors.]]>
Amy R. RappaportChrisann KyiMonica LaneMeghan G. HartMelissa L. JohnsonBrian S. HenickChih-Yi LiaoAmit MahipalArdaman ShergillAlexander I. SpiraJonathan W. GoldmanCiaran D. ScallanDesiree SchenkChristine D. PalmerMatthew J. DavisSonia KounlavouthLindsey KempAaron YangYaojun John LiMolly LikesAnnie ShenGregory R. BoucherMilana EgorovaRobert L. VeresJ. Aaron EspinosaJason R. JaroslavskyLauren D. Kraemer TardifLindsey AcrebucheChristopher PucciaLeiliane SousaRita ZhouKyounghwa BaeJ. Randolph HechtDavid P. CarboneBenny JohnsonAndrew AllenAndrew R. FergusonKarin Jooss doi:10.1038/s41591-024-02851-9 Nature Medicine, Published online: 2024-03-27; | doi:10.1038/s41591-024-02851-9 2024-03-27 Nature Medicine 10.1038/s41591-024-02851-9 https://www.nature.com/articles/s41591-024-02851-9
<![CDATA[<b>Combination treatment for immune-mediated HIV remission</b>]]> https://www.nature.com/articles/d41591-024-00020-6 Nature Medicine, Published online: 26 March 2024; doi:10.1038/d41591-024-00020-6

In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.]]>
Combination treatment for immune-mediated HIV remission]]> Karen O’Leary doi:10.1038/d41591-024-00020-6 Nature Medicine, Published online: 2024-03-26; | doi:10.1038/d41591-024-00020-6 2024-03-26 Nature Medicine 10.1038/d41591-024-00020-6 https://www.nature.com/articles/d41591-024-00020-6
<![CDATA[Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease]]> https://www.nature.com/articles/s41591-024-02896-w Nature Medicine, Published online: 26 March 2024; doi:10.1038/s41591-024-02896-w

In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood pressure-lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality.]]>
Anubha AgarwalPriya M. MehtaTyler JacobsonNilay S. ShahJiancheng YeJingJing ZhuQ. Eileen WaffordEhete BahiruAngharad N. de CatesShah EbrahimDorairaj PrabhakaranAnthony RodgersMark D. Huffman doi:10.1038/s41591-024-02896-w Nature Medicine, Published online: 2024-03-26; | doi:10.1038/s41591-024-02896-w 2024-03-26 Nature Medicine 10.1038/s41591-024-02896-w https://www.nature.com/articles/s41591-024-02896-w
<![CDATA[Risk factors associated with heatwave mortality in Chinese adults over 65 years]]> https://www.nature.com/articles/s41591-024-02880-4 Nature Medicine, Published online: 25 March 2024; doi:10.1038/s41591-024-02880-4

In a prospective cohort of Chinese participants aged 65 years and older, heatwaves doubled the risk of mortality, especially in adults with functional impairments and dependency on daily living activities.]]>
Di XiLinxin LiuMin ZhangCunrui HuangKatrin G. BurkartKristie EbiYi ZengJohn S. Ji doi:10.1038/s41591-024-02880-4 Nature Medicine, Published online: 2024-03-25; | doi:10.1038/s41591-024-02880-4 2024-03-25 Nature Medicine 10.1038/s41591-024-02880-4 https://www.nature.com/articles/s41591-024-02880-4
<![CDATA[Promoting gender equity in the scientific and health workforce is essential to improve women’s health]]> https://www.nature.com/articles/s41591-024-02872-4 Nature Medicine, Published online: 22 March 2024; doi:10.1038/s41591-024-02872-4

Women’s health can be improved by increasing the representation of women in leadership roles in science, medicine and public health.]]>
Cristiani Vieira MachadoCristina Araripe FerreiraMaria Auxiliadora de Souza Mendes Gomes doi:10.1038/s41591-024-02872-4 Nature Medicine, Published online: 2024-03-22; | doi:10.1038/s41591-024-02872-4 2024-03-22 Nature Medicine 10.1038/s41591-024-02872-4 https://www.nature.com/articles/s41591-024-02872-4
<![CDATA[Off-label use of artificial intelligence models in healthcare]]> https://www.nature.com/articles/s41591-024-02870-6 Nature Medicine, Published online: 22 March 2024; doi:10.1038/s41591-024-02870-6

In healthcare, many artificial intelligence models could be used in settings other than those for which they were approved. But such off-label use must include an empirical or mechanistic evaluation to ensure patient safety.]]>
Meera KrishnamoorthyMichael W. SjodingJenna Wiens doi:10.1038/s41591-024-02870-6 Nature Medicine, Published online: 2024-03-22; | doi:10.1038/s41591-024-02870-6 2024-03-22 Nature Medicine 10.1038/s41591-024-02870-6 https://www.nature.com/articles/s41591-024-02870-6
<![CDATA[Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data]]> https://www.nature.com/articles/s41591-024-02879-x Nature Medicine, Published online: 21 March 2024; doi:10.1038/s41591-024-02879-x

Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data]]>
Tracey L. WeissgerberMałgorzata Anna GazdaGustav NilsonneGerben ter RietKelly D. CobeyJulia Prieß-BuchheitJorge NoroRobert SchulzJoeri K. TijdinkEvgeny BobrovAlexandra Bannach-BrownDelwen L. FranzenUgo MoschiniFlorian NaudetUlrich MansmannMaia Salholz-HillelAnita BandrowskiMalcolm R. Macleod doi:10.1038/s41591-024-02879-x Nature Medicine, Published online: 2024-03-21; | doi:10.1038/s41591-024-02879-x 2024-03-21 Nature Medicine 10.1038/s41591-024-02879-x https://www.nature.com/articles/s41591-024-02879-x