Nature Medicine - Issue - nature.com science feeds Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category. http://www.nature.com/nm/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group Nature Medicine 1078-8956 1546-170X © 2009 Nature Publishing Group permissions@nature.com Nature Medicine http://www.nature.com/includes/rj_globnavimages/nm_logo.gif http://www.nature.com/nm/ Patently naive http://feeds.nature.com/~r/nm/rss/current/~3/e9B_y9MIUT4/nm1109-1229 Intellectual-property protection is a key driver of innovation, and researchers are always keen to file patents to shield their discoveries. Yet scientists often have an uninformed view of the value of their intellectual property. This naiveté slows down translational research. Advertisment

Patently naive

Nature Medicine 15, 1229 (2009). doi:10.1038/nm1109-1229

Intellectual-property protection is a key driver of innovation, and researchers are always keen to file patents to shield their discoveries. Yet scientists often have an uninformed view of the value of their intellectual property. This naiveté slows down translational research.

]]> Patently naive doi:10.1038/nm1109-1229 Nature Medicine 15, 1229 (2009) Nature Medicine 10.1038/nm1109-1229 http://dx.doi.org/10.1038/nm1109-1229 15 11 Editorial 1229 1229 http://dx.doi.org/10.1038/nm1109-1229 Wireless medical devices advance, weather balloons aside http://feeds.nature.com/~r/nm/rss/current/~3/ArZMkx0WC9Q/nm1109-1231 Wireless medical devices advance, weather balloons aside

Nature Medicine 15, 1231 (2009). doi:10.1038/nm1109-1231

Author: Jon Evans

]]> Wireless medical devices advance, weather balloons aside Jon Evans doi:10.1038/nm1109-1231 Nature Medicine 15, 1231 (2009) Nature Medicine 10.1038/nm1109-1231 http://dx.doi.org/10.1038/nm1109-1231 15 11 News 1231 1231 http://dx.doi.org/10.1038/nm1109-1231 Efforts to improve vaccine stabilization heat up http://feeds.nature.com/~r/nm/rss/current/~3/TIKeMKLyPzc/nm1109-1232 Efforts to improve vaccine stabilization heat up

Nature Medicine 15, 1232 (2009). doi:10.1038/nm1109-1232

Author: Meredith Wadman

]]> Efforts to improve vaccine stabilization heat up Meredith Wadman doi:10.1038/nm1109-1232 Nature Medicine 15, 1232 (2009) Nature Medicine 10.1038/nm1109-1232 http://dx.doi.org/10.1038/nm1109-1232 15 11 News 1232 1232 http://dx.doi.org/10.1038/nm1109-1232 Researchers come together to study natural HIV resistance http://feeds.nature.com/~r/nm/rss/current/~3/mqC7UIIqesA/nm1109-1233 Researchers come together to study natural HIV resistance

Nature Medicine 15, 1233 (2009). doi:10.1038/nm1109-1233

Author: Cassandra Willyard

]]> Researchers come together to study natural HIV resistance Cassandra Willyard doi:10.1038/nm1109-1233 Nature Medicine 15, 1233 (2009) Nature Medicine 10.1038/nm1109-1233 http://dx.doi.org/10.1038/nm1109-1233 15 11 News 1233 1233 http://dx.doi.org/10.1038/nm1109-1233 News in brief http://feeds.nature.com/~r/nm/rss/current/~3/IE72YB_7dx8/nm1109-1234 News in brief

Nature Medicine 15, 1234 (2009). doi:10.1038/nm1109-1234

]]> News in brief doi:10.1038/nm1109-1234 Nature Medicine 15, 1234 (2009) Nature Medicine 10.1038/nm1109-1234 http://dx.doi.org/10.1038/nm1109-1234 15 11 News 1234 1235 http://dx.doi.org/10.1038/nm1109-1234 Straight talk with...Joan Scott http://feeds.nature.com/~r/nm/rss/current/~3/WeedQgijDSk/nm1109-1236 The Genetics & Public Policy Center (GPPC), located within the Johns Hopkins Berman Institute of Bioethics in Washington, DC, monitors advances in human genetics, including genetic testing, and their translation into clinical medicine. In September 2009, Joan Scott was named the new director of the center. Scott spoke with Genevive Bjorn about the twists and turns of using information from the double helix. Straight talk with...Joan Scott

Nature Medicine 15, 1236 (2009). doi:10.1038/nm1109-1236

Author: Genevive Bjorn

]]> Straight talk with...Joan Scott Genevive Bjorn doi:10.1038/nm1109-1236 Nature Medicine 15, 1236 (2009) Nature Medicine 10.1038/nm1109-1236 http://dx.doi.org/10.1038/nm1109-1236 15 11 News 1236 1237 http://dx.doi.org/10.1038/nm1109-1236 Australian committees set to advise on translational medicine http://feeds.nature.com/~r/nm/rss/current/~3/KUaQ0tMEiyo/nm1109-1238a Australian committees set to advise on translational medicine

Nature Medicine 15, 1238 (2009). doi:10.1038/nm1109-1238a

Author: Simon Grose

]]> Australian committees set to advise on translational medicine Simon Grose doi:10.1038/nm1109-1238a Nature Medicine 15, 1238 (2009) Nature Medicine 10.1038/nm1109-1238a http://dx.doi.org/10.1038/nm1109-1238a 15 11 News 1238 1238 http://dx.doi.org/10.1038/nm1109-1238a In debate over AIDS vaccine success, every detail counts http://feeds.nature.com/~r/nm/rss/current/~3/N7isawYEoJY/nm1109-1238b In debate over AIDS vaccine success, every detail counts

Nature Medicine 15, 1238 (2009). doi:10.1038/nm1109-1238b

Author: Roxanne Khamsi

]]> In debate over AIDS vaccine success, every detail counts Roxanne Khamsi doi:10.1038/nm1109-1238b Nature Medicine 15, 1238 (2009) Nature Medicine 10.1038/nm1109-1238b http://dx.doi.org/10.1038/nm1109-1238b 15 11 News 1238 1238 http://dx.doi.org/10.1038/nm1109-1238b Biomedical patents: Overturning preconceptions http://feeds.nature.com/~r/nm/rss/current/~3/cU5o52jaujw/nm1109-1239a Biomedical patents: Overturning preconceptions

Nature Medicine 15, 1239 (2009). doi:10.1038/nm1109-1239a

]]> Biomedical patents: Overturning preconceptions doi:10.1038/nm1109-1239a Nature Medicine 15, 1239 (2009) Nature Medicine 10.1038/nm1109-1239a http://dx.doi.org/10.1038/nm1109-1239a 15 11 News 1239 1239 http://dx.doi.org/10.1038/nm1109-1239a Sluggish generics entry prompts calls for European patent reform http://feeds.nature.com/~r/nm/rss/current/~3/rcJRHSUe2yw/nm1109-1239b Sluggish generics entry prompts calls for European patent reform

Nature Medicine 15, 1239 (2009). doi:10.1038/nm1109-1239b

Author: Lucas Laursen

]]> Sluggish generics entry prompts calls for European patent reform Lucas Laursen doi:10.1038/nm1109-1239b Nature Medicine 15, 1239 (2009) Nature Medicine 10.1038/nm1109-1239b http://dx.doi.org/10.1038/nm1109-1239b 15 11 News 1239 1239 http://dx.doi.org/10.1038/nm1109-1239b Pharma 'patent trolls' remain mostly the stuff of myth http://feeds.nature.com/~r/nm/rss/current/~3/GDbFuuY0fHo/nm1109-1240a Pharma 'patent trolls' remain mostly the stuff of myth

Nature Medicine 15, 1240 (2009). doi:10.1038/nm1109-1240a

Author: Stu Hutson

]]> Pharma 'patent trolls' remain mostly the stuff of myth Stu Hutson doi:10.1038/nm1109-1240a Nature Medicine 15, 1240 (2009) Nature Medicine 10.1038/nm1109-1240a http://dx.doi.org/10.1038/nm1109-1240a 15 11 News 1240 1240 http://dx.doi.org/10.1038/nm1109-1240a Researchers ponder a patent-free world http://feeds.nature.com/~r/nm/rss/current/~3/H9gikUfpajI/nm1109-1240b Researchers ponder a patent-free world

Nature Medicine 15, 1240 (2009). doi:10.1038/nm1109-1240b

Author: Lauren Cahoon

]]> Researchers ponder a patent-free world Lauren Cahoon doi:10.1038/nm1109-1240b Nature Medicine 15, 1240 (2009) Nature Medicine 10.1038/nm1109-1240b http://dx.doi.org/10.1038/nm1109-1240b 15 11 News 1240 1241 http://dx.doi.org/10.1038/nm1109-1240b 'Machine or transformation test' put to the test itself http://feeds.nature.com/~r/nm/rss/current/~3/XsUCJeQb3Lo/nm1109-1241 'Machine or transformation test' put to the test itself

Nature Medicine 15, 1241 (2009). doi:10.1038/nm1109-1241

Author: Mike May

]]> 'Machine or transformation test' put to the test itself Mike May doi:10.1038/nm1109-1241 Nature Medicine 15, 1241 (2009) Nature Medicine 10.1038/nm1109-1241 http://dx.doi.org/10.1038/nm1109-1241 15 11 News 1241 1241 http://dx.doi.org/10.1038/nm1109-1241 Biosimilars legislation awakens data exclusivity debate http://feeds.nature.com/~r/nm/rss/current/~3/zUua2y-s9hE/nm1109-1242a Biosimilars legislation awakens data exclusivity debate

Nature Medicine 15, 1242 (2009). doi:10.1038/nm1109-1242a

Author: Stu Hutson

]]> Biosimilars legislation awakens data exclusivity debate Stu Hutson doi:10.1038/nm1109-1242a Nature Medicine 15, 1242 (2009) Nature Medicine 10.1038/nm1109-1242a http://dx.doi.org/10.1038/nm1109-1242a 15 11 News 1242 1242 http://dx.doi.org/10.1038/nm1109-1242a Online resource aims to smooth the biomed patent search http://feeds.nature.com/~r/nm/rss/current/~3/Xy8vi4e5cq0/nm1109-1242b Online resource aims to smooth the biomed patent search

Nature Medicine 15, 1242 (2009). doi:10.1038/nm1109-1242b

Author: Simon Grose

]]> Online resource aims to smooth the biomed patent search Simon Grose doi:10.1038/nm1109-1242b Nature Medicine 15, 1242 (2009) Nature Medicine 10.1038/nm1109-1242b http://dx.doi.org/10.1038/nm1109-1242b 15 11 News 1242 1242 http://dx.doi.org/10.1038/nm1109-1242b Pharma positions to survive the impending patent cliff http://feeds.nature.com/~r/nm/rss/current/~3/yyWn66WpuRU/nm1109-1243a Pharma positions to survive the impending patent cliff

Nature Medicine 15, 1243 (2009). doi:10.1038/nm1109-1243a

Author: Mike May

]]> Pharma positions to survive the impending patent cliff Mike May doi:10.1038/nm1109-1243a Nature Medicine 15, 1243 (2009) Nature Medicine 10.1038/nm1109-1243a http://dx.doi.org/10.1038/nm1109-1243a 15 11 News 1243 1243 http://dx.doi.org/10.1038/nm1109-1243a Prometheus v. Mayo case in the spotlight http://feeds.nature.com/~r/nm/rss/current/~3/z0ThFt-sOb8/nm1109-1243b Prometheus v. Mayo case in the spotlight

Nature Medicine 15, 1243 (2009). doi:10.1038/nm1109-1243b

Author: Lauren Cahoon

]]> Prometheus v. Mayo case in the spotlight Lauren Cahoon doi:10.1038/nm1109-1243b Nature Medicine 15, 1243 (2009) Nature Medicine 10.1038/nm1109-1243b http://dx.doi.org/10.1038/nm1109-1243b 15 11 News 1243 1243 http://dx.doi.org/10.1038/nm1109-1243b Rock the cradle http://feeds.nature.com/~r/nm/rss/current/~3/D8G6nhT5ozk/nm1109-1244 Rock the cradle

Nature Medicine 15, 1244 (2009). doi:10.1038/nm1109-1244

Author: Teresa K Woodruff

]]> Rock the cradle Teresa K Woodruff doi:10.1038/nm1109-1244 Nature Medicine 15, 1244 (2009) Nature Medicine 10.1038/nm1109-1244 http://dx.doi.org/10.1038/nm1109-1244 15 11 Book Review 1244 1244 http://dx.doi.org/10.1038/nm1109-1244 Sepsis: the dark side of histones http://feeds.nature.com/~r/nm/rss/current/~3/RsFQvZ4hC9I/nm1109-1245 Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis. Sepsis: the dark side of histones

Nature Medicine 15, 1245 (2009). doi:10.1038/nm1109-1245

Authors: Catherine Chaput & Arturo Zychlinsky

Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis.

]]> Sepsis: the dark side of histones Catherine Chaput Arturo Zychlinsky doi:10.1038/nm1109-1245 Nature Medicine 15, 1245 (2009) Nature Medicine 10.1038/nm1109-1245 http://dx.doi.org/10.1038/nm1109-1245 15 11 News and Views 1245 1246 http://dx.doi.org/10.1038/nm1109-1245 Autoimmunity: apoptotic fats grease transcription http://feeds.nature.com/~r/nm/rss/current/~3/vPp8DT-pzmM/nm1109-1246 Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272). When this process goes awry, autoimmunity can result. Autoimmunity: apoptotic fats grease transcription

Nature Medicine 15, 1246 (2009). doi:10.1038/nm1109-1246

Author: Keith B Elkon

Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272). When this process goes awry, autoimmunity can result.

]]> Autoimmunity: apoptotic fats grease transcription Keith B Elkon doi:10.1038/nm1109-1246 Nature Medicine 15, 1246 (2009) Nature Medicine 10.1038/nm1109-1246 http://dx.doi.org/10.1038/nm1109-1246 15 11 News and Views 1246 1248 http://dx.doi.org/10.1038/nm1109-1246 Eye vessels saved by rescuing their pericyte partners http://feeds.nature.com/~r/nm/rss/current/~3/ONbCETS8_wY/nm1109-1248 High blood sugar can lead to diabetic retinopathy and subsequent blindness. Glucose is now found to quench a growth factor that keeps pericytes alive. Without these key support cells, the retinal vasculature degenerates (pages 1298–1306). Eye vessels saved by rescuing their pericyte partners

Nature Medicine 15, 1248 (2009). doi:10.1038/nm1109-1248

Author: David Antonetti

High blood sugar can lead to diabetic retinopathy and subsequent blindness. Glucose is now found to quench a growth factor that keeps pericytes alive. Without these key support cells, the retinal vasculature degenerates (pages 1298–1306).

]]> Eye vessels saved by rescuing their pericyte partners David Antonetti doi:10.1038/nm1109-1248 Nature Medicine 15, 1248 (2009) Nature Medicine 10.1038/nm1109-1248 http://dx.doi.org/10.1038/nm1109-1248 15 11 News and Views 1248 1249 http://dx.doi.org/10.1038/nm1109-1248 Drug may put brakes on Parkinson's disease http://feeds.nature.com/~r/nm/rss/current/~3/bXUPCWB15CU/nm1109-1250 Drug may put brakes on Parkinson's disease

Nature Medicine 15, 1250 (2009). doi:10.1038/nm1109-1250

]]> Drug may put brakes on Parkinson's disease doi:10.1038/nm1109-1250 Nature Medicine 15, 1250 (2009) Nature Medicine 10.1038/nm1109-1250 http://dx.doi.org/10.1038/nm1109-1250 15 11 Community Corner 1250 1250 http://dx.doi.org/10.1038/nm1109-1250 Attacking the flu: Neutralizing antibodies may lead to 'universal' vaccine http://feeds.nature.com/~r/nm/rss/current/~3/uYVqf25HajY/nm1109-1251 Flu remains a major killer because of imperfect vaccines and widespread resistance to existing antivirals—problems particularly acute during a pandemic. New findings at the bedside and at the bench could lead to improvements on both fronts. Grace Chen and Kanta Subbarao discuss the implications of research identifying human antibodies than can neutralize a range of viral subtypes. The findings may help lead to a 'universal' vaccine against these diverse and rapidly evolving viruses. Estanislao Nistal-Villán and Adolfo García-Sastre examine two recent studies that reveal the crystal structure of a promising viral drug target, the unique endonuclease domain of the viral polymerase. The findings open the door to the rational design of new influenza virus inhibitors. Attacking the flu: Neutralizing antibodies may lead to 'universal' vaccine

Nature Medicine 15, 1251 (2009). doi:10.1038/nm1109-1251

Authors: Grace L Chen & Kanta Subbarao

Flu remains a major killer because of imperfect vaccines and widespread resistance to existing antivirals—problems particularly acute during a pandemic. New findings at the bedside and at the bench could lead to improvements on both fronts. Grace Chen and Kanta Subbarao discuss the implications of research identifying human antibodies than can neutralize a range of viral subtypes. The findings may help lead to a 'universal' vaccine against these diverse and rapidly evolving viruses. Estanislao Nistal-Villán and Adolfo García-Sastre examine two recent studies that reveal the crystal structure of a promising viral drug target, the unique endonuclease domain of the viral polymerase. The findings open the door to the rational design of new influenza virus inhibitors.

]]> Attacking the flu: Neutralizing antibodies may lead to 'universal' vaccine Grace L Chen Kanta Subbarao doi:10.1038/nm1109-1251 Nature Medicine 15, 1251 (2009) Nature Medicine 10.1038/nm1109-1251 http://dx.doi.org/10.1038/nm1109-1251 15 11 Between Bedside and Bench 1251 1252 http://dx.doi.org/10.1038/nm1109-1251 Attacking the flu: New prospects for the rational design of antivirals http://feeds.nature.com/~r/nm/rss/current/~3/GJ2yXbGDxOs/nm1109-1253 Attacking the flu: New prospects for the rational design of antivirals

Nature Medicine 15, 1253 (2009). doi:10.1038/nm1109-1253

Authors: Estanislao Nistal-Villán & Adolfo García-Sastre

]]> Attacking the flu: New prospects for the rational design of antivirals Estanislao Nistal-Villán Adolfo García-Sastre doi:10.1038/nm1109-1253 Nature Medicine 15, 1253 (2009) Nature Medicine 10.1038/nm1109-1253 http://dx.doi.org/10.1038/nm1109-1253 15 11 Between Bedside and Bench 1253 1254 http://dx.doi.org/10.1038/nm1109-1253 Research Highlights http://feeds.nature.com/~r/nm/rss/current/~3/bO5dFW6Ebd0/nm1109-1256 Research Highlights

Nature Medicine 15, 1256 (2009). doi:10.1038/nm1109-1256

]]> Research Highlights doi:10.1038/nm1109-1256 Nature Medicine 15, 1256 (2009) Nature Medicine 10.1038/nm1109-1256 http://dx.doi.org/10.1038/nm1109-1256 15 11 Research Highlights 1256 1257 http://dx.doi.org/10.1038/nm1109-1256 Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines http://feeds.nature.com/~r/nm/rss/current/~3/u6ZM99yTH5M/nm.2036 Soman Abraham and his colleagues report a new mechanism of immune suppression used by Salmonella. The bacteria traffic to lymph nodes, where Salmonella lipopolysaccharide triggers the downmodulation of certain chemokines, disrupting the cellular organization of the lymph node and impairing adaptive immunity. Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

Nature Medicine 15, 1259 (2009). doi:10.1038/nm.2036

Authors: Ashley L St John & Soman N Abraham

]]> Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines Ashley L St John Soman N Abraham doi:10.1038/nm.2036 Nature Medicine 15, 1259 (2009) 2009-10-25 Nature Medicine 2009-10-25 10.1038/nm.2036 http://dx.doi.org/10.1038/nm.2036 15 11 Article 1259 1265 http://dx.doi.org/10.1038/nm.2036 PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance http://feeds.nature.com/~r/nm/rss/current/~3/B-8-rOQjj5c/nm.2048 Macrophages coordinate the disposal of apoptotic cells. Ajay Chawla and his colleagues show that PPAR-δ, a sensor of fatty acids, is involved in this process. Ingestion of apoptotic cells by macrophages prompts the upregulation of PPAR-δ, which then responds by enhancing the expression of opsonins. Lack of PPAR-δ reduces apoptotic cell clearance and predisposes to autoimmunity (pages 1246–1248). PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Nature Medicine 15, 1266 (2009). doi:10.1038/nm.2048

Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni, Khoa D Nguyen, Lawrence Steinman, Sara A Michie & Ajay Chawla

]]> PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance Lata Mukundan Justin I Odegaard Christine R Morel Jose E Heredia Julia W Mwangi Roberto R Ricardo-Gonzalez Y P Sharon Goh Alex Red Eagle Shannon E Dunn Jennifer U H Awakuni Khoa D Nguyen Lawrence Steinman Sara A Michie Ajay Chawla doi:10.1038/nm.2048 Nature Medicine 15, 1266 (2009) 2009-10-18 Nature Medicine 2009-10-18 10.1038/nm.2048 http://dx.doi.org/10.1038/nm.2048 15 11 Article 1266 1272 http://dx.doi.org/10.1038/nm.2048 Dual roles for hepatic lectin receptors in the clearance of chilled platelets http://feeds.nature.com/~r/nm/rss/current/~3/6r_6O5A0pbc/nm.2030 Unlike other types of blood components, refrigeration of platelets leads to their rapid clearance from the circulation after transfusion. Platelets must therefore be stored at room temperature, a serious limitation to their use for transfusions. Viktoria Rumjantseva et al. now dissect two platelet clearance pathways by which exposed carbohydrate residues on platelets are recognized by receptors on liver macrophages and hepatocytes, which differentially control the clearance of short-term– and long-term–refrigerated platelets. Dual roles for hepatic lectin receptors in the clearance of chilled platelets

Nature Medicine 15, 1273 (2009). doi:10.1038/nm.2030

Authors: Viktoria Rumjantseva, Prabhjit K Grewal, Hans H Wandall, Emma C Josefsson, Anne Louise Sørensen, Göran Larson, Jamey D Marth, John H Hartwig & Karin M Hoffmeister

]]> Dual roles for hepatic lectin receptors in the clearance of chilled platelets Viktoria Rumjantseva Prabhjit K Grewal Hans H Wandall Emma C Josefsson Anne Louise Sørensen Göran Larson Jamey D Marth John H Hartwig Karin M Hoffmeister doi:10.1038/nm.2030 Nature Medicine 15, 1273 (2009) 2009-09-27 Nature Medicine 2009-09-27 10.1038/nm.2030 http://dx.doi.org/10.1038/nm.2030 15 11 Article 1273 1280 http://dx.doi.org/10.1038/nm.2030 Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy http://feeds.nature.com/~r/nm/rss/current/~3/CSJg9b6v7a0/nm.2037 David Hassel et al. show that mutations affecting the protein nexilin underlie an unusual type of dilated cardiomyopathy characterized by disrupted Z-disk structures in cardiac muscle. Functional studies in zebrafish revealed that nexilin has an essential role in maintaining Z-disk stability and suggested that the disease-causing nexilin mutations found in humans encode proteins that act in a dominant-negative fashion. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

Nature Medicine 15, 1281 (2009). doi:10.1038/nm.2037

Authors: David Hassel, Tillman Dahme, Jeanette Erdmann, Benjamin Meder, Andreas Huge, Monika Stoll, Steffen Just, Alexander Hess, Philipp Ehlermann, Dieter Weichenhan, Matthias Grimmler, Henrike Liptau, Roland Hetzer, Vera Regitz-Zagrosek, Christine Fischer, Peter Nürnberg, Heribert Schunkert, Hugo A Katus & Wolfgang Rottbauer

]]> Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy David Hassel Tillman Dahme Jeanette Erdmann Benjamin Meder Andreas Huge Monika Stoll Steffen Just Alexander Hess Philipp Ehlermann Dieter Weichenhan Matthias Grimmler Henrike Liptau Roland Hetzer Vera Regitz-Zagrosek Christine Fischer Peter Nürnberg Heribert Schunkert Hugo A Katus Wolfgang Rottbauer doi:10.1038/nm.2037 Nature Medicine 15, 1281 (2009) 2009-11-01 Nature Medicine 2009-11-01 10.1038/nm.2037 http://dx.doi.org/10.1038/nm.2037 15 11 Article 1281 1288 http://dx.doi.org/10.1038/nm.2037 Notch3 signaling promotes the development of pulmonary arterial hypertension http://feeds.nature.com/~r/nm/rss/current/~3/_LidEwbznyI/nm.2021 Notch signaling is known to modulate the phenotype of vascular smooth muscle cells. Xiaodong Li et al. now provide evidence for the importance of signaling through the NOTCH3 receptor and its downstream target HES-5 in pulmonary arterial smooth muscle cells for the development of pulmonary arterial hypertension, and they demonstrate the therapeutic potential of targeting this signaling pathway in a mouse model of pulmonary hypertension. Notch3 signaling promotes the development of pulmonary arterial hypertension

Nature Medicine 15, 1289 (2009). doi:10.1038/nm.2021

Authors: Xiaodong Li, Xiaoxue Zhang, Robin Leathers, Ayako Makino, Chengqun Huang, Pouria Parsa, Jesus Macias, Jason X-J Yuan, Stuart W Jamieson & Patricia A Thistlethwaite

]]> Notch3 signaling promotes the development of pulmonary arterial hypertension Xiaodong Li Xiaoxue Zhang Robin Leathers Ayako Makino Chengqun Huang Pouria Parsa Jesus Macias Jason X-J Yuan Stuart W Jamieson Patricia A Thistlethwaite doi:10.1038/nm.2021 Nature Medicine 15, 1289 (2009) 2009-10-25 Nature Medicine 2009-10-25 10.1038/nm.2021 http://dx.doi.org/10.1038/nm.2021 15 11 Article 1289 1297 http://dx.doi.org/10.1038/nm.2021 Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy http://feeds.nature.com/~r/nm/rss/current/~3/8urBBpDAx80/nm.2052 Vascular defects resulting from pericyte cell death are thought to be a major underlying cause of diabetic retinopathy. Pedro Geraldes et al. investigate the signaling mechanisms by which hyperglycemia leads to pericyte death and delineate a pathway by which PKC-δ activation decreases antiapoptotic PDGF receptor signaling (pages 1248–1249). Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

Nature Medicine 15, 1298 (2009). doi:10.1038/nm.2052

Authors: Pedro Geraldes, Junko Hiraoka-Yamamoto, Motonobu Matsumoto, Allen Clermont, Michael Leitges, Andre Marette, Lloyd P Aiello, Timothy S Kern & George L King

]]> Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy Pedro Geraldes Junko Hiraoka-Yamamoto Motonobu Matsumoto Allen Clermont Michael Leitges Andre Marette Lloyd P Aiello Timothy S Kern George L King doi:10.1038/nm.2052 Nature Medicine 15, 1298 (2009) 2009-11-01 Nature Medicine 2009-11-01 10.1038/nm.2052 http://dx.doi.org/10.1038/nm.2052 15 11 Article 1298 1306 http://dx.doi.org/10.1038/nm.2052 Foxo1 integrates insulin signaling with mitochondrial function in the liver http://feeds.nature.com/~r/nm/rss/current/~3/uOuNBGwMwDI/nm.2049 Hepatic insulin resistance is often associated with mitochondrial dysfunction, leading to defects in cellular activity. Morris White and his colleagues have now found that continued activity of the transcription factor Foxo1, which is normally inhibited by insulin signaling, is at the crux of this dysfunction, and, when it is genetically deleted, proper mitochondrial function in two models of insulin resistance is restored. Foxo1 integrates insulin signaling with mitochondrial function in the liver

Nature Medicine 15, 1307 (2009). doi:10.1038/nm.2049

Authors: Zhiyong Cheng, Shaodong Guo, Kyle Copps, Xiaochen Dong, Ramya Kollipara, Joseph T Rodgers, Ronald A Depinho, Pere Puigserver & Morris F White

]]> Foxo1 integrates insulin signaling with mitochondrial function in the liver Zhiyong Cheng Shaodong Guo Kyle Copps Xiaochen Dong Ramya Kollipara Joseph T Rodgers Ronald A Depinho Pere Puigserver Morris F White doi:10.1038/nm.2049 Nature Medicine 15, 1307 (2009) 2009-10-18 Nature Medicine 2009-10-18 10.1038/nm.2049 http://dx.doi.org/10.1038/nm.2049 15 11 Letter 1307 1311 http://dx.doi.org/10.1038/nm.2049 Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency http://feeds.nature.com/~r/nm/rss/current/~3/bQV4nm8j5CM/nm.2051 Viral gene expression can be regulated by chromatin methylation and demethylation. Thomas Kristie and his colleagues have identified a histone demethylase that is required to remove repressive methylation from the immediate early promoters of two α-herpesviruses. Monoamine oxidase inhibitors, which block this demethylase, prevented lytic replication and reactivation from latency. Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency

Nature Medicine 15, 1312 (2009). doi:10.1038/nm.2051

Authors: Yu Liang, Jodi L Vogel, Aarthi Narayanan, Hua Peng & Thomas M Kristie

]]> Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency Yu Liang Jodi L Vogel Aarthi Narayanan Hua Peng Thomas M Kristie doi:10.1038/nm.2051 Nature Medicine 15, 1312 (2009) 2009-10-25 Nature Medicine 2009-10-25 10.1038/nm.2051 http://dx.doi.org/10.1038/nm.2051 15 11 Letter 1312 1317 http://dx.doi.org/10.1038/nm.2051 Extracellular histones are major mediators of death in sepsis http://feeds.nature.com/~r/nm/rss/current/~3/-KVvy4lKWA4/nm.2053 Extracellular histones released in response to inflammatory challenge contribute to organ failure and death during sepsis. Histone-specific antibodies and activated protein C had beneficial effects in animal models of sepsis, pointing to extracellular histones as therapeutics targets for sepsis and other inflammatory conditions (pages 1245–1246). Extracellular histones are major mediators of death in sepsis

Nature Medicine 15, 1318 (2009). doi:10.1038/nm.2053

Authors: Jun Xu, Xiaomei Zhang, Rosana Pelayo, Marc Monestier, Concetta T Ammollo, Fabrizio Semeraro, Fletcher B Taylor, Naomi L Esmon, Florea Lupu & Charles T Esmon

]]> Extracellular histones are major mediators of death in sepsis Jun Xu Xiaomei Zhang Rosana Pelayo Marc Monestier Concetta T Ammollo Fabrizio Semeraro Fletcher B Taylor Naomi L Esmon Florea Lupu Charles T Esmon doi:10.1038/nm.2053 Nature Medicine 15, 1318 (2009) 2009-10-25 Nature Medicine 2009-10-25 10.1038/nm.2053 http://dx.doi.org/10.1038/nm.2053 15 11 Letter 1318 1321 http://dx.doi.org/10.1038/nm.2053 Major histocompatibility complex genotyping with massively parallel pyrosequencing http://feeds.nature.com/~r/nm/rss/current/~3/5Aqzu7Aoe4c/nm.2038 Nonhuman primates are key preclinical models for infectious disease, vaccine development and transplantation research, but their use has been hampered by the complexity and diversity of their major histocompatibility complex (MHC) class I genotypes. Wiseman and his colleagues provide a cost-effective solution to this problem using a next-generation pyrosequencing approach to high-resolution MHC genotyping in various nonhuman primates, identifying both known and new MHC class I alleles. Major histocompatibility complex genotyping with massively parallel pyrosequencing

Nature Medicine 15, 1322 (2009). doi:10.1038/nm.2038

Authors: Roger W Wiseman, Julie A Karl, Benjamin N Bimber, Claire E O'Leary, Simon M Lank, Jennifer J Tuscher, Ann M Detmer, Pascal Bouffard, Natalya Levenkova, Cynthia L Turcotte, Edward Szekeres, Chris Wright, Timothy Harkins & David H O'Connor

]]> Major histocompatibility complex genotyping with massively parallel pyrosequencing Roger W Wiseman Julie A Karl Benjamin N Bimber Claire E O'Leary Simon M Lank Jennifer J Tuscher Ann M Detmer Pascal Bouffard Natalya Levenkova Cynthia L Turcotte Edward Szekeres Chris Wright Timothy Harkins David H O'Connor doi:10.1038/nm.2038 Nature Medicine 15, 1322 (2009) 2009-10-11 Nature Medicine 2009-10-11 10.1038/nm.2038 http://dx.doi.org/10.1038/nm.2038 15 11 Technical Report 1322 1326 http://dx.doi.org/10.1038/nm.2038 Matrix-insensitive protein assays push the limits of biosensors in medicine http://feeds.nature.com/~r/nm/rss/current/~3/Jw6ZCjxzN7E/nm.2032 Despite progress in the biosensor field, a platform that allows the sensitive detection of disease-specific proteins in a diverse range of clinical samples such as saliva, serum and urine has proved elusive. Here, Richard Gaster and his colleagues introduce a magnetic nanosensing protein detection platform that offers quantitative multiplex protein detection at attomolar concentrations over a large linear dynamic range and in a range of biological fluids. Matrix-insensitive protein assays push the limits of biosensors in medicine

Nature Medicine 15, 1327 (2009). doi:10.1038/nm.2032

Authors: Richard S Gaster, Drew A Hall, Carsten H Nielsen, Sebastian J Osterfeld, Heng Yu, Kathleen E Mach, Robert J Wilson, Boris Murmann, Joseph C Liao, Sanjiv S Gambhir & Shan X Wang

]]> Matrix-insensitive protein assays push the limits of biosensors in medicine Richard S Gaster Drew A Hall Carsten H Nielsen Sebastian J Osterfeld Heng Yu Kathleen E Mach Robert J Wilson Boris Murmann Joseph C Liao Sanjiv S Gambhir Shan X Wang doi:10.1038/nm.2032 Nature Medicine 15, 1327 (2009) 2009-10-11 Nature Medicine 2009-10-11 10.1038/nm.2032 http://dx.doi.org/10.1038/nm.2032 15 11 Technical Report 1327 1332 http://dx.doi.org/10.1038/nm.2032 Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis http://feeds.nature.com/~r/nm/rss/current/~3/tAId_Mu1S7o/nm1109-1333a Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Nature Medicine 15, 1333 (2009). doi:10.1038/nm1109-1333a

Authors: Tony Muchamuel, Michael Basler, Monette A Aujay, Erika Suzuki, Khalid W Kalim, Christoph Lauer, Catherine Sylvain, Eileen R Ring, Jamie Shields, Jing Jiang, Peter Shwonek, Francesco Parlati, Susan D Demo, Mark K Bennett, Christopher J Kirk & Marcus Groettrup

]]> Erratum: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis Tony Muchamuel Michael Basler Monette A Aujay Erika Suzuki Khalid W Kalim Christoph Lauer Catherine Sylvain Eileen R Ring Jamie Shields Jing Jiang Peter Shwonek Francesco Parlati Susan D Demo Mark K Bennett Christopher J Kirk Marcus Groettrup doi:10.1038/nm1109-1333a Nature Medicine 15, 1333 (2009) Nature Medicine 10.1038/nm1109-1333a http://dx.doi.org/10.1038/nm1109-1333a 15 11 Erratum 1333 1333 http://dx.doi.org/10.1038/nm1109-1333a Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells http://feeds.nature.com/~r/nm/rss/current/~3/PRTsfH48MJY/nm1109-1333b Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

Nature Medicine 15, 1333 (2009). doi:10.1038/nm1109-1333b

Authors: Natalie A Hutnick, Diane G Carnathan, Sheri A Dubey, George Makedonas, Kara S Cox, Lisa Kierstead, Sarah J Ratcliffe, Michael N Robertson, Danilo R Casimiro, Hildegund C J Ertl & Michael R Betts

]]> Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells Natalie A Hutnick Diane G Carnathan Sheri A Dubey George Makedonas Kara S Cox Lisa Kierstead Sarah J Ratcliffe Michael N Robertson Danilo R Casimiro Hildegund C J Ertl Michael R Betts doi:10.1038/nm1109-1333b Nature Medicine 15, 1333 (2009) Nature Medicine 10.1038/nm1109-1333b http://dx.doi.org/10.1038/nm1109-1333b 15 11 Corrigendum 1333 1333 http://dx.doi.org/10.1038/nm1109-1333b