Nature Medicine Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation. Aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings, the journal publishes the latest advances in cancer biology, vascular biology, neuroscience, inflammatory disease, infectious disease and metabolic disorders, among other fields. Reviews, Perspectives and other commissioned content clarify and give context to these biomedical research advances, and the News section reports on the latest developments in drug research and development. http://feeds.nature.com/nm/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Medicine © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Medicine https://www.nature.com/uploads/product/nm/rss.gif http://feeds.nature.com/nm/rss/current <![CDATA[New AI regulation in the EU seeks to reduce risk without assessing public benefit]]> https://www.nature.com/articles/s41591-024-02874-2 Nature Medicine, Published online: 18 March 2024; doi:10.1038/s41591-024-02874-2

The European Union’s new AI Act focuses on risk without considering benefits, which could hinder the development of new technology while failing to protect the public.]]>
Barbara PrainsackNikolaus Forgó doi:10.1038/s41591-024-02874-2 Nature Medicine, Published online: 2024-03-18; | doi:10.1038/s41591-024-02874-2 2024-03-18 Nature Medicine 10.1038/s41591-024-02874-2 https://www.nature.com/articles/s41591-024-02874-2
<![CDATA[Telehealth enables safe medication abortion in shifting health and legal contexts]]> https://www.nature.com/articles/s41591-024-02876-0 Nature Medicine, Published online: 15 March 2024; doi:10.1038/s41591-024-02876-0

Telehealth provision of medication abortion is safe and effective, but ensuring equitable access is challenging in the USA — and further compounded by an upcoming Supreme Court case.]]>
Dana M. JohnsonAbigail R. A. AikenTerri-Ann Thompson doi:10.1038/s41591-024-02876-0 Nature Medicine, Published online: 2024-03-15; | doi:10.1038/s41591-024-02876-0 2024-03-15 Nature Medicine 10.1038/s41591-024-02876-0 https://www.nature.com/articles/s41591-024-02876-0
<![CDATA[<b>Prolonged benefits of bariatric surgery for patients with Type 2 Diabetes</b>]]> https://www.nature.com/articles/d41591-024-00017-1 Nature Medicine, Published online: 15 March 2024; doi:10.1038/d41591-024-00017-1

People with type 2 diabetes who underwent bariatric surgery compared to medical or lifestyle interventions had better long-term outcomes, such as greater diabetes remission and less reliance on medication.]]>
Prolonged benefits of bariatric surgery for patients with Type 2 Diabetes]]> Sonia Muliyil doi:10.1038/d41591-024-00017-1 Nature Medicine, Published online: 2024-03-15; | doi:10.1038/d41591-024-00017-1 2024-03-15 Nature Medicine 10.1038/d41591-024-00017-1 https://www.nature.com/articles/d41591-024-00017-1
<![CDATA[<b>A timeline of biomarker changes before Alzheimer’s disease</b>]]> https://www.nature.com/articles/d41591-024-00018-0 Nature Medicine, Published online: 15 March 2024; doi:10.1038/d41591-024-00018-0

Longitudinal data from the China Cognition and Aging Study map the sequential biomarker changes that begin almost two decades before clinical onset of Alzheimer’s disease.]]>
A timeline of biomarker changes before Alzheimer’s disease]]> Karen O’Leary doi:10.1038/d41591-024-00018-0 Nature Medicine, Published online: 2024-03-15; | doi:10.1038/d41591-024-00018-0 2024-03-15 Nature Medicine 10.1038/d41591-024-00018-0 https://www.nature.com/articles/d41591-024-00018-0
<![CDATA[Deciphering the genetic architecture of pain intensity]]> https://www.nature.com/articles/s41591-024-02881-3 Nature Medicine, Published online: 14 March 2024; doi:10.1038/s41591-024-02881-3

Chronic pain is common, with more than one in five adult Americans reporting having pain daily or on most days. A multi-ancestry genomic analysis in 598,339 military veterans in the USA identifies 126 genetic variants associated with pain intensity, highlights shared genetic risk with substance use and psychiatric disorders, and reveals enrichment in GABAergic neurons as a key molecular contributor to experiencing pain.]]>
doi:10.1038/s41591-024-02881-3 Nature Medicine, Published online: 2024-03-14; | doi:10.1038/s41591-024-02881-3 2024-03-14 Nature Medicine 10.1038/s41591-024-02881-3 https://www.nature.com/articles/s41591-024-02881-3
<![CDATA[Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial]]> https://www.nature.com/articles/s41591-024-02864-4 Nature Medicine, Published online: 14 March 2024; doi:10.1038/s41591-024-02864-4

The PRODIGITAL-D trial in adults aged 60+ years from socioeconomically deprived areas of Brazil showed that a 6-week self-help mobile messaging psychosocial intervention was effective in improving depression recovery at 3 months compared to a single message control intervention.]]>
Marcia ScazufcaCarina Akemi NakamuraNadine SewardThiago Vinicius Nadaleto DidoneFelipe Azevedo MorettiMarcelo Oliveira da CostaCaio Hudson Queiroz de SouzaGabriel Macias de OliveiraMonica Souza dos SantosLuara Aragoni PereiraMariana Mendes de Sá MartinsPepijn van de VenWilliam HollingworthTim J. PetersRicardo Araya doi:10.1038/s41591-024-02864-4 Nature Medicine, Published online: 2024-03-14; | doi:10.1038/s41591-024-02864-4 2024-03-14 Nature Medicine 10.1038/s41591-024-02864-4 https://www.nature.com/articles/s41591-024-02864-4
<![CDATA[Acquired blood mutations cause acute kidney injury via dysregulated inflammation]]> https://www.nature.com/articles/s41591-024-02861-7 Nature Medicine, Published online: 13 March 2024; doi:10.1038/s41591-024-02861-7

Acute kidney injury affects one in five hospitalized patients and can lead to lasting kidney damage or death. We show that clonal hematopoiesis of indeterminate potential — a common age-related condition caused by blood cell mutations — increases the risk of acute kidney injury in multiple cohorts of human patients and in mouse models.]]>
doi:10.1038/s41591-024-02861-7 Nature Medicine, Published online: 2024-03-13; | doi:10.1038/s41591-024-02861-7 2024-03-13 Nature Medicine 10.1038/s41591-024-02861-7 https://www.nature.com/articles/s41591-024-02861-7
<![CDATA[Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results]]> https://www.nature.com/articles/s41591-024-02893-z Nature Medicine, Published online: 13 March 2024; doi:10.1038/s41591-024-02893-z

In an interim analysis of an ongoing phase 1 trial of CAR T cells targeting EGFR and IL13Ra2 in patients with multifocal, recurrent glioblastoma, intrathecal delivery is feasible and well tolerated, with some reductions seen in tumor size.]]>
Stephen J. BagleyMeghan LogunJoseph A. FraiettaXin WangArati S. DesaiLinda J. BagleyAli NabavizadehDanuta JarochaRene MartinsEileen MaloneyLester LledoCarly SteinAmy MarshallRachel LeskowitzJulie K. JadlowskyShannon ChristensenBike Su OnerGabriela PlesaAndrea BrennanVanessa GonzalezFang ChenYusha SunWhitney GladneyDavid BarrettMacLean P. NasrallahWei-Ting HwangGuo-Li MingHongjun SongDonald L. SiegelCarl H. JuneElizabeth O. HexnerZev A. BinderDonald M. O’Rourke doi:10.1038/s41591-024-02893-z Nature Medicine, Published online: 2024-03-13; | doi:10.1038/s41591-024-02893-z 2024-03-13 Nature Medicine 10.1038/s41591-024-02893-z https://www.nature.com/articles/s41591-024-02893-z