Volume 10 Issue 11, November 2004

Editorial

Withdrawal syndrome

Editorial 01 Nov 2004

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News

Scientists seeking HIV in all the wrong places

HIV's abundance in the gut may mean vaccines should be refocused.

Helen Pearson
News 01 Nov 2004
Spain breaks financial pact with pharmaceutical industry

New law requires companies to fund public biomedical research.

Xavier Bosch
News 01 Nov 2004
Scientists stumped by test that promises tailored treatment

Genetic test can predict individuals' response to drugs, but what do the results mean?

Alla Katsnelson
News 01 Nov 2004
Database draws attention to not-so-Nobel intentions

Nobel Prize nominations run along national, gender lines

Peter Vermij
News 01 Nov 2004
Israeli researchers eye simple test for multiple sclerosis

Test could save years of needless therapy for those with benign disease

Tania Hershman
News 01 Nov 2004
Reports of SIDS-virus link greatly exaggerated, experts say

Newly discovered virus seems widespread, but relatively benign.

Douglas Sipp
News 01 Nov 2004
Chiron flu flap suggests vaccine industry needs shot in the arm

The US must adopt long-term solutions for its vaccine problems

Emily Singer
News 01 Nov 2004
Genetics may aggravate India's growing AIDS problem

Could Indians' genes render western vaccines ineffective?

K.S. Jayaraman
News 01 Nov 2004
News In Brief

News 01 Nov 2004
Profile: David Ho

Credited with some of the biggest breakthroughs in tackling HIV/AIDS, David Ho has been a star from the beginning. But in a field fraught with controversy, fame may have come at a cost.

Apoorva Mandavilli
News 01 Nov 2004
News Feature: Eye in the sky

A small group of epidemiologists is abandoning pen and paper for digital maps with multiple dimensions to track infectious disease outbreaks. Alan Dove takes stock of a field in transition.

Alan Dove
News 01 Nov 2004

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Correspondence

Translation of cancer immunotherapies

James J. Mulé
Jeffrey S. Weber
Correspondence 01 Nov 2004
Translation of cancer immunotherapies

Drew Pardoll
James Allison
Correspondence 01 Nov 2004
Translation of cancer immunotherapies

Jonathan Skipper
Eric W Hoffman
Lloyd J Old
Correspondence 01 Nov 2004
Translation of cancer immunotherapies

Drew Pardoll
James Allison
Correspondence 01 Nov 2004
Active tissue factor in blood?

Saulius Butenas
Kenneth G Mann
Correspondence 01 Nov 2004
Active tissue factor in blood?

Vladimir Y. Bogdanov
James Hathcock
Yale Nemerson
Correspondence 01 Nov 2004
New paradigms, animal models may lift antidepressant research

David W. Schulz
Correspondence 01 Nov 2004

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Book Review

The 'German synthetics'

Lawrence Robbins
Book Review 01 Nov 2004

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News & Views

Can nicotine treat sepsis?

The acetylcholine receptor modulates interactions between the nervous system and the immune system. An acetylcholine receptor agonist, nicotine, is now harnessed to dampen inflammation and reduce mortality in a mouse model of sepsis (pages 1216–1221).

Michael A Matthay
Lorraine B Ware
News & Views 01 Nov 2004
Hypertension with a grain of salt

It is common knowledge that high salt intake can contribute to high blood pressure, but the reasons have not been clear. Fresh insight emerges from mouse studies showing how smooth muscle cells in blood vessels respond to changes in salt balance (pages 1193–1199).

Ursula Danilczyk
Josef Penninger
News & Views 01 Nov 2004
H. pylori's inside job

Charlotte Schubert
News & Views 01 Nov 2004
Transplantation tolerance: babies take the first step

Babies will accept transplants from donors of different blood groups, a situation that is catastrophic in adults. The basis for this acceptance is now examined and found to hinge on B-cell tolerance (pages 1227–1233).

Jagdeep S Obhrai
Fadi G Lakkis
News & Views 01 Nov 2004
Stem cells bank on ATM machine

Hematopoietic stem cells maintain the capacity for self-renewal despite the hazard of oxidative damage. Studies in mice show that this hazard is held in check by the ataxia telangiectasia mutated gene, operating through some well-known tumor suppressors.

Anthony D Whetton
News & Views 01 Nov 2004
Turning up the heat in the fat cell

Obesity researchers have inched closer to a long-sought goal: creating a fat cell that burns up calories without causing obesity. The trick is to knock out a protein better known for its role in cancer, the inositol-phosphatase Pten (pages 1208–1215).

Domenico Accili
Luca Valenti
News & Views 01 Nov 2004
Transporter of a malaria catastrophe

Amantadine, a proton-channel blocker used to treat influenza, also inhibits growth of the malaria parasite Plasmodium falciparum. The drug is most active against parasite strains resistant to the increasingly ineffective drug chloroquine. The molecular basis of this enhanced activity is now examined, opening the door to new ways to attack chloroquine resistance.

Thomas E Wellems
News & Views 01 Nov 2004
Research highlights

News & Views 01 Nov 2004
From plankton to pathogen recognition

Two studies in the mid-1990s cracked a mystery of innate immunity–how foreign invaders are recognized. One study found that signaling through Toll-like receptor 4 activated the immune response. Another identified the signal: lipopolysaccharide (LPS), a cell envelope component of Gram-negative bacteria. The discoveries brought full circle observations that began with starfish in the 1880s.

Robert L Modlin
Genhong Cheng
News & Views 01 Nov 2004
Historical Research Highlights

News & Views 01 Nov 2004