Nature Materials - Issue - nature.com science feeds Nature Materials journal covers a range of topics within materials science, from materials engineering and structural materials (metals, alloys, ceramics, composites) to organic and soft materials (glasses, colloids, liquid crystals, polymers). http://www.nature.com/nmat/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group Nature Materials 1476-1122 1476-4660 © 2009 Nature Publishing Group permissions@nature.com Nature Materials http://www.nature.com/includes/rj_globnavimages/nmat_logo.gif http://www.nature.com/nmat/ A better world for science? http://feeds.nature.com/~r/nmat/rss/current/~3/a6mNUalepAc/nmat2582 Virtual worlds such as Second Life present an intriguing premise for scientific use. But are the benefits sufficiently clear for widespread uptake? A better world for science?

Nature Materials 8, 917 (2009). doi:10.1038/nmat2582

Virtual worlds such as Second Life present an intriguing premise for scientific use. But are the benefits sufficiently clear for widespread uptake?

]]> A better world for science? doi:10.1038/nmat2582 Nature Materials 8, 917 (2009) Nature Materials 10.1038/nmat2582 http://dx.doi.org/10.1038/nmat2582 8 12 Editorial 917 917 http://dx.doi.org/10.1038/nmat2582 Getting real about our virtual future http://feeds.nature.com/~r/nmat/rss/current/~3/loLkr14pjz4/nmat2580 Virtual worlds such as Second Life have been perceived as a social meeting point for a small following of devotees. A number of serious emerging mainstream applications may fundamentally alter this perception. Getting real about our virtual future

Nature Materials 8, 919 (2009). doi:10.1038/nmat2580

Author: Tim Jones

Virtual worlds such as Second Life have been perceived as a social meeting point for a small following of devotees. A number of serious emerging mainstream applications may fundamentally alter this perception.

]]> Getting real about our virtual future Tim Jones doi:10.1038/nmat2580 Nature Materials 8, 919 (2009) Nature Materials 10.1038/nmat2580 http://dx.doi.org/10.1038/nmat2580 8 12 Commentary 919 921 http://dx.doi.org/10.1038/nmat2580 Our choice from the recent literature http://feeds.nature.com/~r/nmat/rss/current/~3/gc7FKK0qxHw/nmat2581 Our choice from the recent literature

Nature Materials 8, 922 (2009). doi:10.1038/nmat2581

]]> Our choice from the recent literature doi:10.1038/nmat2581 Nature Materials 8, 922 (2009) Nature Materials 10.1038/nmat2581 http://dx.doi.org/10.1038/nmat2581 8 12 Research Highlights 922 922 http://dx.doi.org/10.1038/nmat2581 Tissue engineering: Function follows form http://feeds.nature.com/~r/nmat/rss/current/~3/GVXcFqNfH3c/nmat2577 At present, when intervertebral discs fail, the only existing treatments are fusion of neighbouring vertebrae or polymer and metal implants. A tissue-engineering approach using an electrospun-fibre laminated scaffold could provide functional equivalence with native tissues in both construction form and strength. Tissue engineering: Function follows form

Nature Materials 8, 923 (2009). doi:10.1038/nmat2577

Author: James C. Iatridis

At present, when intervertebral discs fail, the only existing treatments are fusion of neighbouring vertebrae or polymer and metal implants. A tissue-engineering approach using an electrospun-fibre laminated scaffold could provide functional equivalence with native tissues in both construction form and strength.

]]> Tissue engineering: Function follows form James C. Iatridis doi:10.1038/nmat2577 Nature Materials 8, 923 (2009) Nature Materials 10.1038/nmat2577 http://dx.doi.org/10.1038/nmat2577 8 12 News and Views 923 924 http://dx.doi.org/10.1038/nmat2577 Magnetic nanoparticles: When atoms move around http://feeds.nature.com/~r/nmat/rss/current/~3/yXaqAHcCg9w/nmat2575 The degree of atomic ordering in magnetic nanoparticles decreases strongly with the particles' size. The origin of such a phenomenon has been determined by high-resolution transmission electron microscopy and tomography, which shows how correct heat treatment can lead to atomic order also in very small nanoparticles. Magnetic nanoparticles: When atoms move around

Nature Materials 8, 924 (2009). doi:10.1038/nmat2575

Author: Kazuhisa Sato

The degree of atomic ordering in magnetic nanoparticles decreases strongly with the particles' size. The origin of such a phenomenon has been determined by high-resolution transmission electron microscopy and tomography, which shows how correct heat treatment can lead to atomic order also in very small nanoparticles.

]]> Magnetic nanoparticles: When atoms move around Kazuhisa Sato doi:10.1038/nmat2575 Nature Materials 8, 924 (2009) Nature Materials 10.1038/nmat2575 http://dx.doi.org/10.1038/nmat2575 8 12 News and Views 924 925 http://dx.doi.org/10.1038/nmat2575 Material witness: Well preserved http://feeds.nature.com/~r/nmat/rss/current/~3/XiqHCuela0U/nmat2579 Material witness: Well preserved

Nature Materials 8, 926 (2009). doi:10.1038/nmat2579

]]> Material witness: Well preserved doi:10.1038/nmat2579 Nature Materials 8, 926 (2009) Nature Materials 10.1038/nmat2579 http://dx.doi.org/10.1038/nmat2579 8 12 News and Views 926 926 http://dx.doi.org/10.1038/nmat2579 Nanocomposites: Nanoparticles in the right place http://feeds.nature.com/~r/nmat/rss/current/~3/Ue1525r1l-Y/nmat2576 Hybrid materials based on block copolymers and nanoparticles are a promising class of nanocomposites. Tailoring the block copolymer properties by using supramolecular chemistry allows control of the particle spatial organization and resulting composite properties. Nanocomposites: Nanoparticles in the right place

Nature Materials 8, 926 (2009). doi:10.1038/nmat2576

Authors: Raffaele Mezzenga & Janne Ruokolainen

Hybrid materials based on block copolymers and nanoparticles are a promising class of nanocomposites. Tailoring the block copolymer properties by using supramolecular chemistry allows control of the particle spatial organization and resulting composite properties.

]]> Nanocomposites: Nanoparticles in the right place Raffaele Mezzenga Janne Ruokolainen doi:10.1038/nmat2576 Nature Materials 8, 926 (2009) Nature Materials 10.1038/nmat2576 http://dx.doi.org/10.1038/nmat2576 8 12 News and Views 926 928 http://dx.doi.org/10.1038/nmat2576 Metamaterials: Acoustic lenses to shout about http://feeds.nature.com/~r/nmat/rss/current/~3/f_1CZ7iAQGA/nmat2573 An acoustic hyperlens that is able to magnify and image objects much smaller than the probing wavelength promises new applications in sonar imaging. Metamaterials: Acoustic lenses to shout about

Nature Materials 8, 928 (2009). doi:10.1038/nmat2573

Author: Ping Sheng

An acoustic hyperlens that is able to magnify and image objects much smaller than the probing wavelength promises new applications in sonar imaging.

]]> Metamaterials: Acoustic lenses to shout about Ping Sheng doi:10.1038/nmat2573 Nature Materials 8, 928 (2009) Nature Materials 10.1038/nmat2573 http://dx.doi.org/10.1038/nmat2573 8 12 News and Views 928 929 http://dx.doi.org/10.1038/nmat2573 Artificial photosynthesis: Solar to fuel http://feeds.nature.com/~r/nmat/rss/current/~3/27Hf3k1SmdQ/nmat2578 Artificial photosynthesis is an appealing strategy for producing sustainable fuels, if we can find the right materials to make it work efficiently. Scientists of all backgrounds are coming together to see if we can beat nature at her own game. Artificial photosynthesis: Solar to fuel

Nature Materials 8, 929 (2009). doi:10.1038/nmat2578

Authors: Andrea Listorti, James Durrant & Jim Barber

Artificial photosynthesis is an appealing strategy for producing sustainable fuels, if we can find the right materials to make it work efficiently. Scientists of all backgrounds are coming together to see if we can beat nature at her own game.

]]> Artificial photosynthesis: Solar to fuel Andrea Listorti James Durrant Jim Barber doi:10.1038/nmat2578 Nature Materials 8, 929 (2009) Nature Materials 10.1038/nmat2578 http://dx.doi.org/10.1038/nmat2578 8 12 News and Views 929 930 http://dx.doi.org/10.1038/nmat2578 Correction http://feeds.nature.com/~r/nmat/rss/current/~3/R9Z2PG7Om_c/nmat2586 Correction

Nature Materials 8, 930 (2009). doi:10.1038/nmat2586

]]> Correction doi:10.1038/nmat2586 Nature Materials 8, 930 (2009) Nature Materials 10.1038/nmat2586 http://dx.doi.org/10.1038/nmat2586 8 12 News and Views 930 930 http://dx.doi.org/10.1038/nmat2586 Experimental demonstration of an acoustic magnifying hyperlens http://feeds.nature.com/~r/nmat/rss/current/~3/AQ7_mlYX5wg/nmat2561 Like their optical counterparts, acoustic metamaterials are capable of manipulating sound waves in unusual ways. An acoustic hyperlens is now demonstrated that is capable of magnifying subwavelength acoustic waves, and could therefore find applications in medical imaging or underwater sonar. Experimental demonstration of an acoustic magnifying hyperlens

Nature Materials 8, 931 (2009). doi:10.1038/nmat2561

Authors: Jensen Li, Lee Fok, Xiaobo Yin, Guy Bartal & Xiang Zhang

Acoustic metamaterials can manipulate sound waves in surprising ways, which include collimation, focusing, cloaking, sonic screening and extraordinary transmission. Recent theories suggested that imaging below the diffraction limit using passive elements can be realized by acoustic superlenses or magnifying hyperlenses. These could markedly enhance the capabilities in underwater sonar sensing, medical ultrasound imaging and non-destructive materials testing. However, these proposed approaches suffer narrow working frequency bands and significant resonance-induced loss, which hinders them from successful experimental realization. Here, we report the experimental demonstration of an acoustic hyperlens that magnifies subwavelength objects by gradually converting evanescent components into propagating waves. The fabricated acoustic hyperlens relies on straightforward cutoff-free propagation and achieves deep-subwavelength resolution with low loss over a broad frequency bandwidth.

]]> Experimental demonstration of an acoustic magnifying hyperlens Jensen Li Lee Fok Xiaobo Yin Guy Bartal Xiang Zhang doi:10.1038/nmat2561 Nature Materials 8, 931 (2009) 2009-10-25 Nature Materials 2009-10-25 10.1038/nmat2561 http://dx.doi.org/10.1038/nmat2561 8 12 Letter 931 934 http://dx.doi.org/10.1038/nmat2561 Gold nanocages covered by smart polymers for controlled release with near-infrared light http://feeds.nature.com/~r/nmat/rss/current/~3/aWiSqx2DBdE/nmat2564 Heat-responsive polymers grafted onto gold nanocages serve as a nanoscale delivery system for biologically important compounds. Laser irradiation of the nanocages heats the polymers by means of the photothermal effect; the polymers then change conformation and compounds are released. The polymers return to their original configuration when the laser is switched off, stopping further release. Gold nanocages covered by smart polymers for controlled release with near-infrared light

Nature Materials 8, 935 (2009). doi:10.1038/nmat2564

Authors: Mustafa S. Yavuz, Yiyun Cheng, Jingyi Chen, Claire M. Cobley, Qiang Zhang, Matthew Rycenga, Jingwei Xie, Chulhong Kim, Kwang H. Song, Andrea G. Schwartz, Lihong V. Wang & Younan Xia

Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound for each effector. The ultraviolet light may cause damage to biological samples and is suitable only for in vitro studies because of its quick attenuation in tissue. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls. They can have strong absorption (for the photothermal effect) in the near-infrared while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a near-infrared laser. This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region.

]]> Gold nanocages covered by smart polymers for controlled release with near-infrared light Mustafa S. Yavuz Yiyun Cheng Jingyi Chen Claire M. Cobley Qiang Zhang Matthew Rycenga Jingwei Xie Chulhong Kim Kwang H. Song Andrea G. Schwartz Lihong V. Wang Younan Xia doi:10.1038/nmat2564 Nature Materials 8, 935 (2009) 2009-11-01 Nature Materials 2009-11-01 10.1038/nmat2564 http://dx.doi.org/10.1038/nmat2564 8 12 Letter 935 939 http://dx.doi.org/10.1038/nmat2564 Size and shape effects on the order–disorder phase transition in CoPt nanoparticles http://feeds.nature.com/~r/nmat/rss/current/~3/HpifDZo3GJQ/nmat2574 The structure of magnetic nanoparticles has a strong influence on the properties of these materials at present being considered for magnetic-storage applications. It is now shown that size and shape of magnetic nanoparticles such as CoPt affect the transition from an ordered to a disordered phase, highlighting the need to take morphology into account to understand the structural properties. Size and shape effects on the order–disorder phase transition in CoPt nanoparticles

Nature Materials 8, 940 (2009). doi:10.1038/nmat2574

Authors: D. Alloyeau, C. Ricolleau, C. Mottet, T. Oikawa, C. Langlois, Y. Le Bouar, N. Braidy & A. Loiseau

]]> Size and shape effects on the order–disorder phase transition in CoPt nanoparticles D. Alloyeau C. Ricolleau C. Mottet T. Oikawa C. Langlois Y. Le Bouar N. Braidy A. Loiseau doi:10.1038/nmat2574 Nature Materials 8, 940 (2009) 2009-11-15 Nature Materials 2009-11-15 10.1038/nmat2574 http://dx.doi.org/10.1038/nmat2574 8 12 Article 940 946 http://dx.doi.org/10.1038/nmat2574 Reduction of the bulk modulus at high pressure in CrN http://feeds.nature.com/~r/nmat/rss/current/~3/tpsgKpirlNk/nmat2549 Chromium nitride is very incompressible, making it ideal for industrial coatings. However, it is now shown that the material softens at high pressure and low temperature in connection with a phase transition from cubic to orthorhombic structure. The results could be fundamental in designing ways to improve the mechanical properties of superhard CrN. Reduction of the bulk modulus at high pressure in CrN

Nature Materials 8, 947 (2009). doi:10.1038/nmat2549

Authors: Francisco Rivadulla, Manuel Bañobre-López, Camilo X. Quintela, Alberto Piñeiro, Victor Pardo, Daniel Baldomir, Manuel Arturo López-Quintela, José Rivas, Carlos A. Ramos, Horacio Salva, Jian-Shi Zhou & John B. Goodenough

]]> Reduction of the bulk modulus at high pressure in CrN Francisco Rivadulla Manuel Bañobre-López Camilo X. Quintela Alberto Piñeiro Victor Pardo Daniel Baldomir Manuel Arturo López-Quintela José Rivas Carlos A. Ramos Horacio Salva Jian-Shi Zhou John B. Goodenough doi:10.1038/nmat2549 Nature Materials 8, 947 (2009) 2009-10-25 Nature Materials 2009-10-25 10.1038/nmat2549 http://dx.doi.org/10.1038/nmat2549 8 12 Article 947 951 http://dx.doi.org/10.1038/nmat2549 Large modulation of carrier transport by grain-boundary molecular packing and microstructure in organic thin films http://feeds.nature.com/~r/nmat/rss/current/~3/RExgwF2TxuM/nmat2570 Grain boundaries are already known to have a large effect on the charge-carrier mobility of molecular semiconductors. Several experimental and computational techniques now show that the orientation of grain boundaries in a perylene diimide semiconductor modulates carrier mobility by two orders of magnitude. The results provide important guidelines for producing device-optimized molecular semiconductors. Large modulation of carrier transport by grain-boundary molecular packing and microstructure in organic thin films

Nature Materials 8, 952 (2009). doi:10.1038/nmat2570

Authors: Jonathan Rivnay, Leslie H. Jimison, John E. Northrup, Michael F. Toney, Rodrigo Noriega, Shaofeng Lu, Tobin J. Marks, Antonio Facchetti & Alberto Salleo

]]> Large modulation of carrier transport by grain-boundary molecular packing and microstructure in organic thin films Jonathan Rivnay Leslie H. Jimison John E. Northrup Michael F. Toney Rodrigo Noriega Shaofeng Lu Tobin J. Marks Antonio Facchetti Alberto Salleo doi:10.1038/nmat2570 Nature Materials 8, 952 (2009) 2009-11-08 Nature Materials 2009-11-08 10.1038/nmat2570 http://dx.doi.org/10.1038/nmat2570 8 12 Article 952 958 http://dx.doi.org/10.1038/nmat2570 Morphology-dependent zeolite intergrowth structures leading to distinct internal and outer-surface molecular diffusion barriers http://feeds.nature.com/~r/nmat/rss/current/~3/RtjxS9NYI2o/nmat2530 Characterizing the internal architecture of zeolites is crucial for understanding their structure–function relationships, and for acid–base heterogeneous catalysis. Using a unique combination of diffraction and microscopy techniques provides a unified picture of the morphology of intergrowth structures and confirmation of surface barriers for molecular diffusion. Morphology-dependent zeolite intergrowth structures leading to distinct internal and outer-surface molecular diffusion barriers

Nature Materials 8, 959 (2009). doi:10.1038/nmat2530

Authors: Lukasz Karwacki, Marianne H. F. Kox, D. A. Matthijs de Winter, Martyn R. Drury, Johannes D. Meeldijk, Eli Stavitski, Wolfgang Schmidt, Machteld Mertens, Pablo Cubillas, Neena John, Ally Chan, Norma Kahn, Simon R. Bare, Michael Anderson, Jan Kornatowski & Bert M. Weckhuysen

]]> Morphology-dependent zeolite intergrowth structures leading to distinct internal and outer-surface molecular diffusion barriers Lukasz Karwacki Marianne H. F. Kox D. A. Matthijs de Winter Martyn R. Drury Johannes D. Meeldijk Eli Stavitski Wolfgang Schmidt Machteld Mertens Pablo Cubillas Neena John Ally Chan Norma Kahn Simon R. Bare Michael Anderson Jan Kornatowski Bert M. Weckhuysen doi:10.1038/nmat2530 Nature Materials 8, 959 (2009) 2009-09-20 Nature Materials 2009-09-20 10.1038/nmat2530 http://dx.doi.org/10.1038/nmat2530 8 12 Article 959 965 http://dx.doi.org/10.1038/nmat2530 Metastable and unstable cellular solidification of colloidal suspensions http://feeds.nature.com/~r/nmat/rss/current/~3/MGgFK20w-tE/nmat2571 Direct in situ high-resolution X-ray radiography and tomography observations now reveal instability and metastability domains in cellular solidification of colloidal suspensions and the transition to the stable phase. These results provide important insight into the study of morphological instabilities and could prove significant in the design of various types of nanostructure. Metastable and unstable cellular solidification of colloidal suspensions

Nature Materials 8, 966 (2009). doi:10.1038/nmat2571

Authors: Sylvain Deville, Eric Maire, Guillaume Bernard-Granger, Audrey Lasalle, Agnès Bogner, Catherine Gauthier, Jérôme Leloup & Christian Guizard

]]> Metastable and unstable cellular solidification of colloidal suspensions Sylvain Deville Eric Maire Guillaume Bernard-Granger Audrey Lasalle Agnès Bogner Catherine Gauthier Jérôme Leloup Christian Guizard doi:10.1038/nmat2571 Nature Materials 8, 966 (2009) 2009-11-08 Nature Materials 2009-11-08 10.1038/nmat2571 http://dx.doi.org/10.1038/nmat2571 8 12 Article 966 972 http://dx.doi.org/10.1038/nmat2571 Porous organic cages http://feeds.nature.com/~r/nmat/rss/current/~3/j7lrwqqCWac/nmat2545 Porous materials are technologically important for a wide range of applications, such as catalysis and separation. Covalently bonded organic cages can now be assembled into crystalline microporous materials, and their porosity is found to be intrinsic to their molecular cage structure. Porous organic cages

Nature Materials 8, 973 (2009). doi:10.1038/nmat2545

Authors: Tomokazu Tozawa, James T. A. Jones, Shashikala I. Swamy, Shan Jiang, Dave J. Adams, Stephen Shakespeare, Rob Clowes, Darren Bradshaw, Tom Hasell, Samantha Y. Chong, Chiu Tang, Stephen Thompson, Julia Parker, Abbie Trewin, John Bacsa, Alexandra M. Z. Slawin, Alexander Steiner & Andrew I. Cooper

]]> Porous organic cages Tomokazu Tozawa James T. A. Jones Shashikala I. Swamy Shan Jiang Dave J. Adams Stephen Shakespeare Rob Clowes Darren Bradshaw Tom Hasell Samantha Y. Chong Chiu Tang Stephen Thompson Julia Parker Abbie Trewin John Bacsa Alexandra M. Z. Slawin Alexander Steiner Andrew I. Cooper doi:10.1038/nmat2545 Nature Materials 8, 973 (2009) 2009-10-25 Nature Materials 2009-10-25 10.1038/nmat2545 http://dx.doi.org/10.1038/nmat2545 8 12 Article 973 978 http://dx.doi.org/10.1038/nmat2545 Small-molecule-directed nanoparticle assembly towards stimuli-responsive nanocomposites http://feeds.nature.com/~r/nmat/rss/current/~3/zUXZELWHXfQ/nmat2565 By including small molecules with block copolymers in polymer nanocomposites, various types of nanoparticle can be positioned within the composite with unprecedented precision over several length scales. Moreover, the spatial distribution of nanoparticles within the combined material can be varied by exposure to heat or light, creating a new route to stimuli-responsive materials. Small-molecule-directed nanoparticle assembly towards stimuli-responsive nanocomposites

Nature Materials 8, 979 (2009). doi:10.1038/nmat2565

Authors: Yue Zhao, Kari Thorkelsson, Alexander J. Mastroianni, Thomas Schilling, Joseph M. Luther, Benjamin J. Rancatore, Kazuyuki Matsunaga, Hiroshi Jinnai, Yue Wu, Daniel Poulsen, Jean M. J. Fréchet, A. Paul Alivisatos & Ting Xu

]]> Small-molecule-directed nanoparticle assembly towards stimuli-responsive nanocomposites Yue Zhao Kari Thorkelsson Alexander J. Mastroianni Thomas Schilling Joseph M. Luther Benjamin J. Rancatore Kazuyuki Matsunaga Hiroshi Jinnai Yue Wu Daniel Poulsen Jean M. J. Fréchet A. Paul Alivisatos Ting Xu doi:10.1038/nmat2565 Nature Materials 8, 979 (2009) 2009-10-18 Nature Materials 2009-10-18 10.1038/nmat2565 http://dx.doi.org/10.1038/nmat2565 8 12 Article 979 985 http://dx.doi.org/10.1038/nmat2565 Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus http://feeds.nature.com/~r/nmat/rss/current/~3/wMu3RdkU2Z4/nmat2558 Designing load-bearing tissues that match the mechanical performance of native ones adds extra challenges to tissue engineering. Electrospinning of biodegradable polymer fibres into oriented sheets enables the production of laminate scaffolds; when seeded with mesenchymal stem cells and cultured for 10 weeks, these scaffolds replicate the mechanical properties of native annulus fibrosus. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus

Nature Materials 8, 986 (2009). doi:10.1038/nmat2558

Authors: Nandan L. Nerurkar, Brendon M. Baker, Sounok Sen, Emily E. Wible, Dawn M. Elliott & Robert L. Mauck

]]> Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus Nandan L. Nerurkar Brendon M. Baker Sounok Sen Emily E. Wible Dawn M. Elliott Robert L. Mauck doi:10.1038/nmat2558 Nature Materials 8, 986 (2009) 2009-10-25 Nature Materials 2009-10-25 10.1038/nmat2558 http://dx.doi.org/10.1038/nmat2558 8 12 Article 986 992 http://dx.doi.org/10.1038/nmat2558 Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection http://feeds.nature.com/~r/nmat/rss/current/~3/z7Sfr-l2DpQ/nmat2569 When artificial polypeptides are conjugated to a variety of hydrophobic molecules such as chemotherapeutics, the resulting molecules spontaneously self-assemble into nanoparticles. Delivering the chemotherapeutics to a murine cancer model, the nanoparticles have a fourfold higher maximum tolerated dose than the free drug, and induce nearly complete tumour regression after a single dose. Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

Nature Materials 8, 993 (2009). doi:10.1038/nmat2569

Authors: J. Andrew MacKay, Mingnan Chen, Jonathan R. McDaniel, Wenge Liu, Andrew J. Simnick & Ashutosh Chilkoti

]]> Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection J. Andrew MacKay Mingnan Chen Jonathan R. McDaniel Wenge Liu Andrew J. Simnick Ashutosh Chilkoti doi:10.1038/nmat2569 Nature Materials 8, 993 (2009) 2009-11-08 Nature Materials 2009-11-08 10.1038/nmat2569 http://dx.doi.org/10.1038/nmat2569 8 12 Article 993 999 http://dx.doi.org/10.1038/nmat2569