Nature Reviews Cancer Nature Reviews Cancer publishes a dynamic and accessible mix of Reviews, Perspectives, Progress and Highlight articles on the most important primary research papers. All Reviews and Perspectives are carefully commissioned, written by leaders in the field and subject to rigorous peer-review – so that readers receive independent, high-quality and authoritative articles in each issue. The journal’s broad scope captures the essence of modern multidisciplinary cancer research – integrating cancer biology with new approaches to treatment, diagnosis and prevention. Non-specialists will benefit from the glossary and highlighted references, busy scientists will appreciate the ‘At-a-glance’ summaries, and experts will value the insight provided by top names in their field. Nature Reviews Cancer is the premier teaching and reference resource in cancer and has become the ‘must read’ review journal of cancer researchers worldwide. http://feeds.nature.com/nrc/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Cancer © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Reviews Cancer https://www.nature.com/uploads/product/nrc/rss.gif http://feeds.nature.com/nrc/rss/current <![CDATA[Trastuzumab: dreams, desperation and hope]]> https://www.nature.com/articles/s41568-024-00676-9 Nature Reviews Cancer, Published online: 15 March 2024; doi:10.1038/s41568-024-00676-9

In this World View, H. Michael Shepard describes his personal story behind the discovery of trastuzumab, 25 years since its FDA approval for HER2-overexpressing breast cancers.]]>
H. Michael Shepard doi:10.1038/s41568-024-00676-9 Nature Reviews Cancer, Published online: 2024-03-15; | doi:10.1038/s41568-024-00676-9 2024-03-15 Nature Reviews Cancer 10.1038/s41568-024-00676-9 https://www.nature.com/articles/s41568-024-00676-9
<![CDATA[New pathogen on the block]]> https://www.nature.com/articles/s41568-024-00682-x Nature Reviews Cancer, Published online: 11 March 2024; doi:10.1038/s41568-024-00682-x

Fu et al. provide data indicating a pathogenic role for Streptococcus anginosus in gastric cancer.]]>
Anna Dart doi:10.1038/s41568-024-00682-x Nature Reviews Cancer, Published online: 2024-03-11; | doi:10.1038/s41568-024-00682-x 2024-03-11 Nature Reviews Cancer 10.1038/s41568-024-00682-x https://www.nature.com/articles/s41568-024-00682-x
<![CDATA[Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity]]> https://www.nature.com/articles/s41568-024-00674-x Nature Reviews Cancer, Published online: 07 March 2024; doi:10.1038/s41568-024-00674-x

In this Review, Meier et al. discuss the molecular mechanisms of necroptosis, delineate how this form of immunogenic cell death activates antitumour immune responses and explore the opportunities and limitations of targeting necroptosis for anticancer therapy.]]>
Pascal MeierArnaud J. LegrandDieter AdamJohn Silke doi:10.1038/s41568-024-00674-x Nature Reviews Cancer, Published online: 2024-03-07; | doi:10.1038/s41568-024-00674-x 2024-03-07 Nature Reviews Cancer 10.1038/s41568-024-00674-x https://www.nature.com/articles/s41568-024-00674-x
<![CDATA[Catastrophic conformity]]> https://www.nature.com/articles/s41568-024-00678-7 Nature Reviews Cancer, Published online: 01 March 2024; doi:10.1038/s41568-024-00678-7

Recently published in Nature, Fan et al. demonstrate that accumulation of advanced glycation end-products in the extracellular matrix of the liver increases viscoelasticity to promote hepatocellular carcinoma growth, independent of stiffness.]]>
Gabrielle Brewer doi:10.1038/s41568-024-00678-7 Nature Reviews Cancer, Published online: 2024-03-01; | doi:10.1038/s41568-024-00678-7 2024-03-01 Nature Reviews Cancer 10.1038/s41568-024-00678-7 https://www.nature.com/articles/s41568-024-00678-7
<![CDATA[B-ring sterols to the rescue]]> https://www.nature.com/articles/s41568-024-00677-8 Nature Reviews Cancer, Published online: 01 March 2024; doi:10.1038/s41568-024-00677-8

Two independent studies published in Nature implicate distal cholesterol biosynthesis in the regulation of ferroptosis and show that 7-dehydrocholesterol (7-DHC) is an endogenous, anti-ferroptotic metabolite.]]>
Daniela Senft doi:10.1038/s41568-024-00677-8 Nature Reviews Cancer, Published online: 2024-03-01; | doi:10.1038/s41568-024-00677-8 2024-03-01 Nature Reviews Cancer 10.1038/s41568-024-00677-8 https://www.nature.com/articles/s41568-024-00677-8
<![CDATA[Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets]]> https://www.nature.com/articles/s41568-024-00666-x Nature Reviews Cancer, Published online: 29 February 2024; doi:10.1038/s41568-024-00666-x

This Review provides an overview of the complexity and significance of protein lipidation in cancer, outlines how targeting protein lipidation pathways offer promising avenues for developing cancer treatments, and discusses the current state of drugs targeting these pathways.]]>
Edward W. TateLior SodayAna Losada de la LastraMei WangHening Lin doi:10.1038/s41568-024-00666-x Nature Reviews Cancer, Published online: 2024-02-29; | doi:10.1038/s41568-024-00666-x 2024-02-29 Nature Reviews Cancer 10.1038/s41568-024-00666-x https://www.nature.com/articles/s41568-024-00666-x
<![CDATA[Extrachromosomal DNA in cancer]]> https://www.nature.com/articles/s41568-024-00669-8 Nature Reviews Cancer, Published online: 26 February 2024; doi:10.1038/s41568-024-00669-8

Extrachromosomal DNA (ecDNA) is now accepted as a major contributor to cancer pathogenesis. In this Review, Yan, Mischel and Chang highlight the recent advancements in ecDNA research, providing new insights into the biogenesis and maintenance of ecDNA, as well as its role in altering gene expression and promoting tumour heterogeneity.]]>
Xiaowei YanPaul MischelHoward Chang doi:10.1038/s41568-024-00669-8 Nature Reviews Cancer, Published online: 2024-02-26; | doi:10.1038/s41568-024-00669-8 2024-02-26 Nature Reviews Cancer 10.1038/s41568-024-00669-8 https://www.nature.com/articles/s41568-024-00669-8
<![CDATA[Black voices in cancer research and oncology]]> https://www.nature.com/articles/s41568-023-00662-7 Nature Reviews Cancer, Published online: 19 February 2024; doi:10.1038/s41568-023-00662-7

In this Viewpoint article, we asked five Black cancer researchers and clinicians to present their ideas on how we can attract and retain more diverse researchers to the cancer community and how we begin to close the gap in cancer disparities.]]>
Kilan C. Ashad-BishopOnyinye D. BalogunRuncie C. W. ChidebeLeah M. CookChristina Towers doi:10.1038/s41568-023-00662-7 Nature Reviews Cancer, Published online: 2024-02-19; | doi:10.1038/s41568-023-00662-7 2024-02-19 Nature Reviews Cancer 10.1038/s41568-023-00662-7 https://www.nature.com/articles/s41568-023-00662-7