Nature Reviews Cardiology - Issue - nature.com science feeds Nature Reviews Cardiology provides physicians and academics with authoritative and topical discussions of key developments in the field. http://www.nature.com/nrcardio/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group Nature Reviews Cardiology 1759-5002 1759-5010 © 2009 Nature Publishing Group permissions@nature.com Nature Reviews Cardiology http://www.nature.com/includes/rj_globnavimages/nrcardio_logo.gif http://www.nature.com/nrcardio/ The dual challenge of BP control http://feeds.nature.com/~r/nrcardio/rss/current/~3/6L5FijBJGGs/nrcardio.2009.202 Hypertension is a huge global health concern. In 2002, the WHO reported that this condition was the cause of 7.1 million deaths (13% of the total) and represented 4.5% of the disease burden worldwide. Crucially, elevated blood pressure was the risk factor associated with the The dual challenge of BP control

Nature Reviews Cardiology 6, 729 (2009). doi:10.1038/nrcardio.2009.202

Authors: Valentin Fuster & Alexandra King

Hypertension is a huge global health concern. In 2002, the WHO reported that this condition was the cause of 7.1 million deaths (13% of the total) and represented 4.5% of the disease burden worldwide. Crucially, elevated blood pressure was the risk factor associated with the

]]> The dual challenge of BP control Valentin Fuster Alexandra King doi:10.1038/nrcardio.2009.202 Nature Reviews Cardiology 6, 729 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.202 http://dx.doi.org/10.1038/nrcardio.2009.202 6 12 Editorial 729 730 http://dx.doi.org/10.1038/nrcardio.2009.202 Acute coronary syndromes: A new factor Xa inhibitor for acute coronary syndrome http://feeds.nature.com/~r/nrcardio/rss/current/~3/7vNPPwgdsG0/nrcardio.2009.176 Acute coronary syndromes: A new factor Xa inhibitor for acute coronary syndrome

Nature Reviews Cardiology 6, 731 (2009). doi:10.1038/nrcardio.2009.176

Author: Sharmini Rajanayagam

]]> Acute coronary syndromes: A new factor Xa inhibitor for acute coronary syndrome Sharmini Rajanayagam doi:10.1038/nrcardio.2009.176 Nature Reviews Cardiology 6, 731 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.176 http://dx.doi.org/10.1038/nrcardio.2009.176 6 12 Research Highlight 731 731 http://dx.doi.org/10.1038/nrcardio.2009.176 Acute coronary syndromes: Bivalirudin improves 1-year survival in patients with STEMI undergoing PCI http://feeds.nature.com/~r/nrcardio/rss/current/~3/zG7kWCHdECA/nrcardio.2009.178 Acute coronary syndromes: Bivalirudin improves 1-year survival in patients with STEMI undergoing PCI

Nature Reviews Cardiology 6, 732 (2009). doi:10.1038/nrcardio.2009.178

Author: Alexandra King

]]> Acute coronary syndromes: Bivalirudin improves 1-year survival in patients with STEMI undergoing PCI Alexandra King doi:10.1038/nrcardio.2009.178 Nature Reviews Cardiology 6, 732 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.178 http://dx.doi.org/10.1038/nrcardio.2009.178 6 12 Research Highlight 732 732 http://dx.doi.org/10.1038/nrcardio.2009.178 Statins reduce the occurrence of AF http://feeds.nature.com/~r/nrcardio/rss/current/~3/a8guSVuPqvs/nrcardio.2009.180 Statins reduce the occurrence of AF

Nature Reviews Cardiology 6, 732 (2009). doi:10.1038/nrcardio.2009.180

Author: Sharmini Rajanayagam

]]> Statins reduce the occurrence of AF Sharmini Rajanayagam doi:10.1038/nrcardio.2009.180 Nature Reviews Cardiology 6, 732 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.180 http://dx.doi.org/10.1038/nrcardio.2009.180 6 12 Research Highlight 732 732 http://dx.doi.org/10.1038/nrcardio.2009.180 Interventional cardiology: Clinical benefits of thrombectomy http://feeds.nature.com/~r/nrcardio/rss/current/~3/DcJL1KDvK38/nrcardio.2009.177 Interventional cardiology: Clinical benefits of thrombectomy

Nature Reviews Cardiology 6, 733 (2009). doi:10.1038/nrcardio.2009.177

Author: Sharmini Rajanayagam

]]> Interventional cardiology: Clinical benefits of thrombectomy Sharmini Rajanayagam doi:10.1038/nrcardio.2009.177 Nature Reviews Cardiology 6, 733 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.177 http://dx.doi.org/10.1038/nrcardio.2009.177 6 12 Research Highlight 733 733 http://dx.doi.org/10.1038/nrcardio.2009.177 Hypertension: Low-salt diet vital for patients with resistant hypertension http://feeds.nature.com/~r/nrcardio/rss/current/~3/o7Lq5uoJ-y4/nrcardio.2009.179 Hypertension: Low-salt diet vital for patients with resistant hypertension

Nature Reviews Cardiology 6, 733 (2009). doi:10.1038/nrcardio.2009.179

Author: Alexandra King

]]> Hypertension: Low-salt diet vital for patients with resistant hypertension Alexandra King doi:10.1038/nrcardio.2009.179 Nature Reviews Cardiology 6, 733 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.179 http://dx.doi.org/10.1038/nrcardio.2009.179 6 12 Research Highlight 733 733 http://dx.doi.org/10.1038/nrcardio.2009.179 Low-dose β-blocker for POTS http://feeds.nature.com/~r/nrcardio/rss/current/~3/tpcVIFgTxgo/nrcardio.2009.181 Low-dose β-blocker for POTS

Nature Reviews Cardiology 6, 733 (2009). doi:10.1038/nrcardio.2009.181

Author: Bryony M. Mearns

]]> Low-dose β-blocker for POTS Bryony M. Mearns doi:10.1038/nrcardio.2009.181 Nature Reviews Cardiology 6, 733 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.181 http://dx.doi.org/10.1038/nrcardio.2009.181 6 12 Research Highlight 733 733 http://dx.doi.org/10.1038/nrcardio.2009.181 Vascular disease: Metabolic syndrome increases risk of peripheral artery disease in women http://feeds.nature.com/~r/nrcardio/rss/current/~3/ACk6xB6vPEQ/nrcardio.2009.194 Vascular disease: Metabolic syndrome increases risk of peripheral artery disease in women

Nature Reviews Cardiology 6, 734 (2009). doi:10.1038/nrcardio.2009.194

Author: Alexandra King

]]> Vascular disease: Metabolic syndrome increases risk of peripheral artery disease in women Alexandra King doi:10.1038/nrcardio.2009.194 Nature Reviews Cardiology 6, 734 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.194 http://dx.doi.org/10.1038/nrcardio.2009.194 6 12 Research Highlight 734 734 http://dx.doi.org/10.1038/nrcardio.2009.194 Public health: Pollution and cardiovascular risk http://feeds.nature.com/~r/nrcardio/rss/current/~3/-RrzOccVmXs/nrcardio.2009.195 Public health: Pollution and cardiovascular risk

Nature Reviews Cardiology 6, 734 (2009). doi:10.1038/nrcardio.2009.195

Author: Sharmini Rajanayagam

]]> Public health: Pollution and cardiovascular risk Sharmini Rajanayagam doi:10.1038/nrcardio.2009.195 Nature Reviews Cardiology 6, 734 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.195 http://dx.doi.org/10.1038/nrcardio.2009.195 6 12 Research Highlight 734 734 http://dx.doi.org/10.1038/nrcardio.2009.195 Predicting response to CRT in patients with HF http://feeds.nature.com/~r/nrcardio/rss/current/~3/BI8_UMtDASw/nrcardio.2009.183 Predicting response to CRT in patients with HF

Nature Reviews Cardiology 6, 735 (2009). doi:10.1038/nrcardio.2009.183

Author: Bryony M. Mearns

]]> Predicting response to CRT in patients with HF Bryony M. Mearns doi:10.1038/nrcardio.2009.183 Nature Reviews Cardiology 6, 735 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.183 http://dx.doi.org/10.1038/nrcardio.2009.183 6 12 Research Highlight 735 735 http://dx.doi.org/10.1038/nrcardio.2009.183 Interventional cardiology: A bright future for biodegradable polymer DESs? http://feeds.nature.com/~r/nrcardio/rss/current/~3/CJpqGhaumXA/nrcardio.2009.182 Interventional cardiology: A bright future for biodegradable polymer DESs?

Nature Reviews Cardiology 6, 736 (2009). doi:10.1038/nrcardio.2009.182

Author: Alexandra King

]]> Interventional cardiology: A bright future for biodegradable polymer DESs? Alexandra King doi:10.1038/nrcardio.2009.182 Nature Reviews Cardiology 6, 736 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.182 http://dx.doi.org/10.1038/nrcardio.2009.182 6 12 Research Highlight 736 736 http://dx.doi.org/10.1038/nrcardio.2009.182 Sad news this year for Nat. Rev. Cardiol. http://feeds.nature.com/~r/nrcardio/rss/current/~3/KKVhZHXIUAc/nrcardio.2009.200 During the course of 2009 the Nature Reviews Cardiology editorial team were shocked and saddened to learn of the deaths of two of our esteemed advisory board members, Philip Poole-Wilson and Helmut Drexler. In addition to interactions with them in their roles on the Sad news this year for Nat. Rev. Cardiol.

Nature Reviews Cardiology 6, 736 (2009). doi:10.1038/nrcardio.2009.200

During the course of 2009 the Nature Reviews Cardiology editorial team were shocked and saddened to learn of the deaths of two of our esteemed advisory board members, Philip Poole-Wilson and Helmut Drexler. In addition to interactions with them in their roles on the

]]> Sad news this year for Nat. Rev. Cardiol. doi:10.1038/nrcardio.2009.200 Nature Reviews Cardiology 6, 736 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.200 http://dx.doi.org/10.1038/nrcardio.2009.200 6 12 Research Highlight 736 736 http://dx.doi.org/10.1038/nrcardio.2009.200 Antiplatelet therapy: Ticagrelor in ACS—what does PLATO teach us? http://feeds.nature.com/~r/nrcardio/rss/current/~3/wJDx53jnKos/nrcardio.2009.192 The novel antiplatelet agent ticagrelor was evaluated against clopidogrel in the PLATO trial of patients with acute coronary syndromes. This article discusses the main findings and importance of this study, including the reduction in mortality associated with ticagrelor therapy. Antiplatelet therapy: Ticagrelor in ACS—what does PLATO teach us?

Nature Reviews Cardiology 6, 737 (2009). doi:10.1038/nrcardio.2009.192

Author: Deepak L. Bhatt

The novel antiplatelet agent ticagrelor was evaluated against clopidogrel in the PLATO trial of patients with acute coronary syndromes. This article discusses the main findings and importance of this study, including the reduction in mortality associated with ticagrelor therapy.

]]> Antiplatelet therapy: Ticagrelor in ACS—what does PLATO teach us? Deepak L. Bhatt doi:10.1038/nrcardio.2009.192 Nature Reviews Cardiology 6, 737 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.192 http://dx.doi.org/10.1038/nrcardio.2009.192 6 12 News and Views 737 738 http://dx.doi.org/10.1038/nrcardio.2009.192 Surgery: Open or endoscopic vein graft harvesting—this is the question! http://feeds.nature.com/~r/nrcardio/rss/current/~3/YJQi-QmRwkg/nrcardio.2009.190 Endoscopic harvesting of saphenous veins for use in CABG surgery has become standard practice worldwide. This strategy reduces postoperative infection and hospital stay, and increases patients' satisfaction when compared with open harvest. However, long-term follow-up data provided by Lopes et al. indicate that widespread use of this technique must be urgently reviewed. Surgery: Open or endoscopic vein graft harvesting—this is the question!

Nature Reviews Cardiology 6, 738 (2009). doi:10.1038/nrcardio.2009.190

Authors: Nishith N. Patel & Gianni D. Angelini

Endoscopic harvesting of saphenous veins for use in CABG surgery has become standard practice worldwide. This strategy reduces postoperative infection and hospital stay, and increases patients' satisfaction when compared with open harvest. However, long-term follow-up data provided by Lopes et al. indicate that widespread use of this technique must be urgently reviewed.

]]> Surgery: Open or endoscopic vein graft harvesting—this is the question! Nishith N. Patel Gianni D. Angelini doi:10.1038/nrcardio.2009.190 Nature Reviews Cardiology 6, 738 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.190 http://dx.doi.org/10.1038/nrcardio.2009.190 6 12 News and Views 738 740 http://dx.doi.org/10.1038/nrcardio.2009.190 Acute coronary syndromes: Troponin triumphant? http://feeds.nature.com/~r/nrcardio/rss/current/~3/ZrByPSxGB7k/nrcardio.2009.193 New methods of cardiac troponin measurement accurately characterize patients as they present to the emergency department. Decisions on admission or discharge within 1–2 h of initial assessment (rather than 6–12 h thereafter), therefore, have become feasible. This development has potential for a major influence on how patients with chest pain are managed. Acute coronary syndromes: Troponin triumphant?

Nature Reviews Cardiology 6, 740 (2009). doi:10.1038/nrcardio.2009.193

Author: Paul O. Collinson

New methods of cardiac troponin measurement accurately characterize patients as they present to the emergency department. Decisions on admission or discharge within 1–2 h of initial assessment (rather than 6–12 h thereafter), therefore, have become feasible. This development has potential for a major influence on how patients with chest pain are managed.

]]> Acute coronary syndromes: Troponin triumphant? Paul O. Collinson doi:10.1038/nrcardio.2009.193 Nature Reviews Cardiology 6, 740 (2009) Nature Reviews Cardiology 10.1038/nrcardio.2009.193 http://dx.doi.org/10.1038/nrcardio.2009.193 6 12 News and Views 740 741 http://dx.doi.org/10.1038/nrcardio.2009.193 Diagnosis and management of pericardial diseases http://feeds.nature.com/~r/nrcardio/rss/current/~3/l44eQ1zliZc/nrcardio.2009.185 The management of pericardial diseases is largely empirical because of the relative lack of randomized trials that involve patients with these conditions. A first attempt to bring together and organize current knowledge resulted in the publication of the first guidelines on the management of pericardial Diagnosis and management of pericardial diseases

Nature Reviews Cardiology 6, 743 (2009). doi:10.1038/nrcardio.2009.185

Authors: Massimo Imazio, Antonio Brucato, Rita Trinchero & Yehuda Adler

The management of pericardial diseases is largely empirical because of the relative lack of randomized trials that involve patients with these conditions. A first attempt to bring together and organize current knowledge resulted in the publication of the first guidelines on the management of pericardial

]]> Diagnosis and management of pericardial diseases Massimo Imazio Antonio Brucato Rita Trinchero Yehuda Adler doi:10.1038/nrcardio.2009.185 Nature Reviews Cardiology 6, 743 (2009) 2009-10-27 Nature Reviews Cardiology 2009-10-27 10.1038/nrcardio.2009.185 http://dx.doi.org/10.1038/nrcardio.2009.185 6 12 Review 743 751 http://dx.doi.org/10.1038/nrcardio.2009.185 Omega-3 fatty acids: cardiovascular benefits, sources and sustainability http://feeds.nature.com/~r/nrcardio/rss/current/~3/MOzvPFytE88/nrcardio.2009.188 The evidence for the cardioprotective nature of omega-3 fatty acids is abundant, and currently available data indicate that patients with known coronary heart disease should consume at least 1 g daily of long-chain omega-3 fatty acids from either oily fish or fish-oil supplements, and that Omega-3 fatty acids: cardiovascular benefits, sources and sustainability

Nature Reviews Cardiology 6, 753 (2009). doi:10.1038/nrcardio.2009.188

Authors: John H. Lee, James H. O'Keefe, Carl J. Lavie & William S. Harris

The evidence for the cardioprotective nature of omega-3 fatty acids is abundant, and currently available data indicate that patients with known coronary heart disease should consume at least 1 g daily of long-chain omega-3 fatty acids from either oily fish or fish-oil supplements, and that

]]> Omega-3 fatty acids: cardiovascular benefits, sources and sustainability John H. Lee James H. O'Keefe Carl J. Lavie William S. Harris doi:10.1038/nrcardio.2009.188 Nature Reviews Cardiology 6, 753 (2009) 2009-10-27 Nature Reviews Cardiology 2009-10-27 10.1038/nrcardio.2009.188 http://dx.doi.org/10.1038/nrcardio.2009.188 6 12 Review 753 758 http://dx.doi.org/10.1038/nrcardio.2009.188 Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy http://feeds.nature.com/~r/nrcardio/rss/current/~3/D_JSYW3mt6Y/nrcardio.2009.189 Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy

Nature Reviews Cardiology 6, 759 (2009). doi:10.1038/nrcardio.2009.189

Authors: Niti R. Aggarwal, Matthew W. Martinez, Bernard J. Gersh & Panithaya Chareonthaitawee

Cardiac resynchronization has emerged as a highly effective therapy for heart failure. However, up to 40% of patients do not benefit from this treatment. In this Review, we discuss the potential role of MRI and nuclear molecular imaging in providing additional insights into the response

]]> Role of cardiac MRI and nuclear imaging in cardiac resynchronization therapy Niti R. Aggarwal Matthew W. Martinez Bernard J. Gersh Panithaya Chareonthaitawee doi:10.1038/nrcardio.2009.189 Nature Reviews Cardiology 6, 759 (2009) 2009-11-03 Nature Reviews Cardiology 2009-11-03 10.1038/nrcardio.2009.189 http://dx.doi.org/10.1038/nrcardio.2009.189 6 12 Review 759 770 http://dx.doi.org/10.1038/nrcardio.2009.189 Cellular and molecular mechanisms of thoracic aortic aneurysms http://feeds.nature.com/~r/nrcardio/rss/current/~3/vrmEqiPsccE/nrcardio.2009.191 Thoracic aortic aneurysms (TAA) increase the risk of aortic dissection or rupture and represent an important source of morbidity and mortality. Inherited forms of the disease, including Marfan syndrome, have been recognized for a long time but were considered degenerative diseases characterized by cystic medial Cellular and molecular mechanisms of thoracic aortic aneurysms

Nature Reviews Cardiology 6, 771 (2009). doi:10.1038/nrcardio.2009.191

Authors: Ismail El-Hamamsy & Magdi H. Yacoub

Thoracic aortic aneurysms (TAA) increase the risk of aortic dissection or rupture and represent an important source of morbidity and mortality. Inherited forms of the disease, including Marfan syndrome, have been recognized for a long time but were considered degenerative diseases characterized by cystic medial

]]> Cellular and molecular mechanisms of thoracic aortic aneurysms Ismail El-Hamamsy Magdi H. Yacoub doi:10.1038/nrcardio.2009.191 Nature Reviews Cardiology 6, 771 (2009) 2009-11-03 Nature Reviews Cardiology 2009-11-03 10.1038/nrcardio.2009.191 http://dx.doi.org/10.1038/nrcardio.2009.191 6 12 Review 771 786 http://dx.doi.org/10.1038/nrcardio.2009.191