Nature Reviews Endocrinology - Issue - nature.com science feeds Nature Reviews Endocrinology provides physicians and academics with authoritative and topical discussions of key developments in the field. http://www.nature.com/nrendo/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group Nature Reviews Endocrinology 1759-5029 1759-5037 © 2009 Nature Publishing Group permissions@nature.com Nature Reviews Endocrinology http://www.nature.com/includes/rj_globnavimages/nrendo_logo.gif http://www.nature.com/nrendo/ Obesity: New database charts the course of childhood weight gain in Europe http://feeds.nature.com/~r/nrendo/rss/current/~3/TQQu4kmG1UA/nrendo.2009.189 Obesity: New database charts the course of childhood weight gain in Europe

Nature Reviews Endocrinology 5, 639 (2009). doi:10.1038/nrendo.2009.189

Author: Vicky Heath

]]> Obesity: New database charts the course of childhood weight gain in Europe Vicky Heath doi:10.1038/nrendo.2009.189 Nature Reviews Endocrinology 5, 639 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.189 http://dx.doi.org/10.1038/nrendo.2009.189 5 12 Research Highlight 639 639 http://dx.doi.org/10.1038/nrendo.2009.189 Immunotherapy and obesity http://feeds.nature.com/~r/nrendo/rss/current/~3/suAsdOLjYcA/nrendo.2009.203 Immunotherapy and obesity

Nature Reviews Endocrinology 5, 640 (2009). doi:10.1038/nrendo.2009.203

Author: Linda Koch

]]> Immunotherapy and obesity Linda Koch doi:10.1038/nrendo.2009.203 Nature Reviews Endocrinology 5, 640 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.203 http://dx.doi.org/10.1038/nrendo.2009.203 5 12 Research Highlight 640 640 http://dx.doi.org/10.1038/nrendo.2009.203 Diabetes: Early blockade of the renin–angiotensin system in type 1 diabetes mellitus http://feeds.nature.com/~r/nrendo/rss/current/~3/-D0t3R0jHnI/nrendo.2009.204 Diabetes: Early blockade of the renin–angiotensin system in type 1 diabetes mellitus

Nature Reviews Endocrinology 5, 640 (2009). doi:10.1038/nrendo.2009.204

Author: Julianna Vig

]]> Diabetes: Early blockade of the renin–angiotensin system in type 1 diabetes mellitus Julianna Vig doi:10.1038/nrendo.2009.204 Nature Reviews Endocrinology 5, 640 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.204 http://dx.doi.org/10.1038/nrendo.2009.204 5 12 Research Highlight 640 640 http://dx.doi.org/10.1038/nrendo.2009.204 Bone: Thiazolidinediones increase fracture risk http://feeds.nature.com/~r/nrendo/rss/current/~3/zIxuhubALG0/nrendo.2009.205 Bone: Thiazolidinediones increase fracture risk

Nature Reviews Endocrinology 5, 641 (2009). doi:10.1038/nrendo.2009.205

Author: Carol Wilson

]]> Bone: Thiazolidinediones increase fracture risk Carol Wilson doi:10.1038/nrendo.2009.205 Nature Reviews Endocrinology 5, 641 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.205 http://dx.doi.org/10.1038/nrendo.2009.205 5 12 Research Highlight 641 641 http://dx.doi.org/10.1038/nrendo.2009.205 In brief http://feeds.nature.com/~r/nrendo/rss/current/~3/sxwYiLOJhBE/nrendo.2009.217 Reproductive endocrinologyHigh dietary fiber consumption is associated with a decrease in reproductive hormone concentrations, according to the BioCycle study. Investigators assessed the dietary fiber consumption of 250 healthy, premenopausal women over two menstrual cycles and found that a 5 g increase in total fiber In brief

Nature Reviews Endocrinology 5, 641 (2009). doi:10.1038/nrendo.2009.217

Reproductive endocrinologyHigh dietary fiber consumption is associated with a decrease in reproductive hormone concentrations, according to the BioCycle study. Investigators assessed the dietary fiber consumption of 250 healthy, premenopausal women over two menstrual cycles and found that a 5 g increase in total fiber

]]> In brief doi:10.1038/nrendo.2009.217 Nature Reviews Endocrinology 5, 641 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.217 http://dx.doi.org/10.1038/nrendo.2009.217 5 12 Research Highlight 641 641 http://dx.doi.org/10.1038/nrendo.2009.217 Diabetes: Maternal weight and type 1 diabetes mellitus in children http://feeds.nature.com/~r/nrendo/rss/current/~3/98qRuqWSFec/nrendo.2009.187 Diabetes: Maternal weight and type 1 diabetes mellitus in children

Nature Reviews Endocrinology 5, 642 (2009). doi:10.1038/nrendo.2009.187

Author: Linda Koch

]]> Diabetes: Maternal weight and type 1 diabetes mellitus in children Linda Koch doi:10.1038/nrendo.2009.187 Nature Reviews Endocrinology 5, 642 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.187 http://dx.doi.org/10.1038/nrendo.2009.187 5 12 Research Highlight 642 642 http://dx.doi.org/10.1038/nrendo.2009.187 Bone: Bisphosphonates in Paget disease of bone http://feeds.nature.com/~r/nrendo/rss/current/~3/5Wm3k-fvpp8/nrendo.2009.188 Bone: Bisphosphonates in Paget disease of bone

Nature Reviews Endocrinology 5, 642 (2009). doi:10.1038/nrendo.2009.188

Author: Linda Koch

]]> Bone: Bisphosphonates in Paget disease of bone Linda Koch doi:10.1038/nrendo.2009.188 Nature Reviews Endocrinology 5, 642 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.188 http://dx.doi.org/10.1038/nrendo.2009.188 5 12 Research Highlight 642 642 http://dx.doi.org/10.1038/nrendo.2009.188 FTO genotype primes obesity risk http://feeds.nature.com/~r/nrendo/rss/current/~3/yknEq5rh3mU/nrendo.2009.207 FTO genotype primes obesity risk

Nature Reviews Endocrinology 5, 643 (2009). doi:10.1038/nrendo.2009.207

Author: Carol Wilson

]]> FTO genotype primes obesity risk Carol Wilson doi:10.1038/nrendo.2009.207 Nature Reviews Endocrinology 5, 643 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.207 http://dx.doi.org/10.1038/nrendo.2009.207 5 12 Research Highlight 643 643 http://dx.doi.org/10.1038/nrendo.2009.207 Reproductive endocrinology: Adiponectin levels distinguish various phenotypes of polycystic ovary syndrome http://feeds.nature.com/~r/nrendo/rss/current/~3/wTj3baL0mag/nrendo.2009.208 Reproductive endocrinology: Adiponectin levels distinguish various phenotypes of polycystic ovary syndrome

Nature Reviews Endocrinology 5, 644 (2009). doi:10.1038/nrendo.2009.208

Author: Julianna Vig

]]> Reproductive endocrinology: Adiponectin levels distinguish various phenotypes of polycystic ovary syndrome Julianna Vig doi:10.1038/nrendo.2009.208 Nature Reviews Endocrinology 5, 644 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.208 http://dx.doi.org/10.1038/nrendo.2009.208 5 12 Research Highlight 644 644 http://dx.doi.org/10.1038/nrendo.2009.208 Bone: Osteoprotegerin and bone loss http://feeds.nature.com/~r/nrendo/rss/current/~3/dR27P-Irt2c/nrendo.2009.209 Bone: Osteoprotegerin and bone loss

Nature Reviews Endocrinology 5, 644 (2009). doi:10.1038/nrendo.2009.209

Author: Linda Koch

]]> Bone: Osteoprotegerin and bone loss Linda Koch doi:10.1038/nrendo.2009.209 Nature Reviews Endocrinology 5, 644 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.209 http://dx.doi.org/10.1038/nrendo.2009.209 5 12 Research Highlight 644 644 http://dx.doi.org/10.1038/nrendo.2009.209 Surgery: How safe is bariatric surgery? http://feeds.nature.com/~r/nrendo/rss/current/~3/gdLmGcSirgo/nrendo.2009.221 The use of bariatric surgery for the treatment of morbid obesity has increased dramatically over the past decade, which has raised concerns about safety, efficacy and cost-effectiveness. A new study by the Longitudinal Assessment of Bariatric Surgery consortium has assessed the safety of these increasingly frequent procedures. Surgery: How safe is bariatric surgery?

Nature Reviews Endocrinology 5, 645 (2009). doi:10.1038/nrendo.2009.221

Authors: Jacob A. Greenberg & Malcolm K. Robinson

The use of bariatric surgery for the treatment of morbid obesity has increased dramatically over the past decade, which has raised concerns about safety, efficacy and cost-effectiveness. A new study by the Longitudinal Assessment of Bariatric Surgery consortium has assessed the safety of these increasingly frequent procedures.

]]> Surgery: How safe is bariatric surgery? Jacob A. Greenberg Malcolm K. Robinson doi:10.1038/nrendo.2009.221 Nature Reviews Endocrinology 5, 645 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.221 http://dx.doi.org/10.1038/nrendo.2009.221 5 12 News and Views 645 646 http://dx.doi.org/10.1038/nrendo.2009.221 Diabetes: Diabetes risk after gestational diabetes mellitus http://feeds.nature.com/~r/nrendo/rss/current/~3/-6cIgcVG3GA/nrendo.2009.199 Women with gestational diabetes mellitus have a substantial risk for progression to a permanent diabetic state, according to researchers in the UK. Could early identification of women at high risk for disease progression lead to improved intervention and preventative measures? Diabetes: Diabetes risk after gestational diabetes mellitus

Nature Reviews Endocrinology 5, 646 (2009). doi:10.1038/nrendo.2009.199

Author: David Simmons

Women with gestational diabetes mellitus have a substantial risk for progression to a permanent diabetic state, according to researchers in the UK. Could early identification of women at high risk for disease progression lead to improved intervention and preventative measures?

]]> Diabetes: Diabetes risk after gestational diabetes mellitus David Simmons doi:10.1038/nrendo.2009.199 Nature Reviews Endocrinology 5, 646 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.199 http://dx.doi.org/10.1038/nrendo.2009.199 5 12 News and Views 646 648 http://dx.doi.org/10.1038/nrendo.2009.199 Inflammation: Where is the SPARC in adipose-tissue inflammation? http://feeds.nature.com/~r/nrendo/rss/current/~3/uWmtSTXSQDM/nrendo.2009.220 Although low-grade inflammation of adipose tissue is thought to be central to the development of insulin resistance in individuals with obesity, the underlying cause of this inflammatory state remains elusive. A new study by Kos and colleagues suggests that the glycoprotein SPARC limits adipose-tissue expansion and promotes inflammation and insulin resistance. Inflammation: Where is the SPARC in adipose-tissue inflammation?

Nature Reviews Endocrinology 5, 648 (2009). doi:10.1038/nrendo.2009.220

Authors: Mourad Naïmi & Emmanuel Van Obberghen

Although low-grade inflammation of adipose tissue is thought to be central to the development of insulin resistance in individuals with obesity, the underlying cause of this inflammatory state remains elusive. A new study by Kos and colleagues suggests that the glycoprotein SPARC limits adipose-tissue expansion and promotes inflammation and insulin resistance.

]]> Inflammation: Where is the SPARC in adipose-tissue inflammation? Mourad Naïmi Emmanuel Van Obberghen doi:10.1038/nrendo.2009.220 Nature Reviews Endocrinology 5, 648 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.220 http://dx.doi.org/10.1038/nrendo.2009.220 5 12 News and Views 648 649 http://dx.doi.org/10.1038/nrendo.2009.220 Thyroid gland: Use of glucocorticoids in amiodarone-induced thyrotoxicosis http://feeds.nature.com/~r/nrendo/rss/current/~3/9GFcmkr8ZLE/nrendo.2009.218 The incidence of type 2 amiodarone-induced thyrotoxicosis (AIT) is increasing. A new study provides evidence that glucocorticoid therapy is safe, effective and associated with prompt restoration of euthyroidism in previously untreated type 2 AIT. The outcome of initial combined glucocorticoid and thionamide therapy can also help differentiate between type 1 and type 2 AIT. Thyroid gland: Use of glucocorticoids in amiodarone-induced thyrotoxicosis

Nature Reviews Endocrinology 5, 650 (2009). doi:10.1038/nrendo.2009.218

Author: Mark P. J. Vanderpump

The incidence of type 2 amiodarone-induced thyrotoxicosis (AIT) is increasing. A new study provides evidence that glucocorticoid therapy is safe, effective and associated with prompt restoration of euthyroidism in previously untreated type 2 AIT. The outcome of initial combined glucocorticoid and thionamide therapy can also help differentiate between type 1 and type 2 AIT.

]]> Thyroid gland: Use of glucocorticoids in amiodarone-induced thyrotoxicosis Mark P. J. Vanderpump doi:10.1038/nrendo.2009.218 Nature Reviews Endocrinology 5, 650 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.218 http://dx.doi.org/10.1038/nrendo.2009.218 5 12 News and Views 650 651 http://dx.doi.org/10.1038/nrendo.2009.218 Diabetes: Diabetes therapy and cancer risk http://feeds.nature.com/~r/nrendo/rss/current/~3/aScL0o4cdAg/nrendo.2009.219 The results of two independent, observational studies suggest that antidiabetic medications might have differential effects on cancer risk in patients with diabetes mellitus. Should these findings influence our approach to diabetes treatment? Diabetes: Diabetes therapy and cancer risk

Nature Reviews Endocrinology 5, 651 (2009). doi:10.1038/nrendo.2009.219

Author: Riccardo Vigneri

The results of two independent, observational studies suggest that antidiabetic medications might have differential effects on cancer risk in patients with diabetes mellitus. Should these findings influence our approach to diabetes treatment?

]]> Diabetes: Diabetes therapy and cancer risk Riccardo Vigneri doi:10.1038/nrendo.2009.219 Nature Reviews Endocrinology 5, 651 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.219 http://dx.doi.org/10.1038/nrendo.2009.219 5 12 News and Views 651 652 http://dx.doi.org/10.1038/nrendo.2009.219 Therapy: Evidence-based treatment of Graves ophthalmopathy http://feeds.nature.com/~r/nrendo/rss/current/~3/riEDcRoSF70/nrendo.2009.222 Graves ophthalmopathy is a disfiguring and often incapacitating disease that is difficult to treat. A meta-analysis has compared the efficacy and tolerability of available treatment modalities and shows, among other findings, that intravenous pulse corticosteroid therapy is the most efficacious treatment when immunosuppression is indicated. Therapy: Evidence-based treatment of Graves ophthalmopathy

Nature Reviews Endocrinology 5, 653 (2009). doi:10.1038/nrendo.2009.222

Author: Wilmar M. Wiersinga

Graves ophthalmopathy is a disfiguring and often incapacitating disease that is difficult to treat. A meta-analysis has compared the efficacy and tolerability of available treatment modalities and shows, among other findings, that intravenous pulse corticosteroid therapy is the most efficacious treatment when immunosuppression is indicated.

]]> Therapy: Evidence-based treatment of Graves ophthalmopathy Wilmar M. Wiersinga doi:10.1038/nrendo.2009.222 Nature Reviews Endocrinology 5, 653 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.222 http://dx.doi.org/10.1038/nrendo.2009.222 5 12 News and Views 653 654 http://dx.doi.org/10.1038/nrendo.2009.222 Type 1 diabetes mellitus and multiple sclerosis: common etiological features http://feeds.nature.com/~r/nrendo/rss/current/~3/oQHnmBJakaU/nrendo.2009.216 Type 1 diabetes mellitus and multiple sclerosis have been largely seen as different, organ-specific diseases, which are managed by different medical specialties. Research studies on these diseases have for the most part followed independent tracks. In this Review, we highlight the latest epidemiological and genetic Type 1 diabetes mellitus and multiple sclerosis: common etiological features

Nature Reviews Endocrinology 5, 655 (2009). doi:10.1038/nrendo.2009.216

Authors: Adam E. Handel, Lahiru Handunnetthi, George C. Ebers & Sreeram V. Ramagopalan

Type 1 diabetes mellitus and multiple sclerosis have been largely seen as different, organ-specific diseases, which are managed by different medical specialties. Research studies on these diseases have for the most part followed independent tracks. In this Review, we highlight the latest epidemiological and genetic

]]> Type 1 diabetes mellitus and multiple sclerosis: common etiological features Adam E. Handel Lahiru Handunnetthi George C. Ebers Sreeram V. Ramagopalan doi:10.1038/nrendo.2009.216 Nature Reviews Endocrinology 5, 655 (2009) 2009-11-03 Nature Reviews Endocrinology 2009-11-03 10.1038/nrendo.2009.216 http://dx.doi.org/10.1038/nrendo.2009.216 5 12 Review 655 664 http://dx.doi.org/10.1038/nrendo.2009.216 Should we screen for emotional distress in type 2 diabetes mellitus? http://feeds.nature.com/~r/nrendo/rss/current/~3/VvHf3bPb3bA/nrendo.2009.214 Emotional problems such as depression, anxiety and diabetes-specific distress are common in patients with type 2 diabetes mellitus (T2DM) but often remain unrecognized and thus untreated. The present Review focuses on the extent of this problem and discusses whether we should screen for depression, anxiety Should we screen for emotional distress in type 2 diabetes mellitus?

Nature Reviews Endocrinology 5, 665 (2009). doi:10.1038/nrendo.2009.214

Author: François Pouwer

Emotional problems such as depression, anxiety and diabetes-specific distress are common in patients with type 2 diabetes mellitus (T2DM) but often remain unrecognized and thus untreated. The present Review focuses on the extent of this problem and discusses whether we should screen for depression, anxiety

]]> Should we screen for emotional distress in type 2 diabetes mellitus? François Pouwer doi:10.1038/nrendo.2009.214 Nature Reviews Endocrinology 5, 665 (2009) 2009-11-03 Nature Reviews Endocrinology 2009-11-03 10.1038/nrendo.2009.214 http://dx.doi.org/10.1038/nrendo.2009.214 5 12 Review 665 671 http://dx.doi.org/10.1038/nrendo.2009.214 Testosterone deficiency, insulin resistance and the metabolic syndrome http://feeds.nature.com/~r/nrendo/rss/current/~3/r3vQBgL_D_s/nrendo.2009.212 Changing lifestyles and an excess of food supply in developed countries have resulted in an increasing prevalence of overweight and obesity. As a consequence, a disorder of complex pathophysiology involving visceral adipose tissue as an endocrine organ, dyslipidemia, insulin resistance and hypertension has emerged—the so-called Testosterone deficiency, insulin resistance and the metabolic syndrome

Nature Reviews Endocrinology 5, 673 (2009). doi:10.1038/nrendo.2009.212

Author: Michael Zitzmann

Changing lifestyles and an excess of food supply in developed countries have resulted in an increasing prevalence of overweight and obesity. As a consequence, a disorder of complex pathophysiology involving visceral adipose tissue as an endocrine organ, dyslipidemia, insulin resistance and hypertension has emerged—the so-called

]]> Testosterone deficiency, insulin resistance and the metabolic syndrome Michael Zitzmann doi:10.1038/nrendo.2009.212 Nature Reviews Endocrinology 5, 673 (2009) 2009-10-27 Nature Reviews Endocrinology 2009-10-27 10.1038/nrendo.2009.212 http://dx.doi.org/10.1038/nrendo.2009.212 5 12 Review 673 681 http://dx.doi.org/10.1038/nrendo.2009.212 Insulin signaling regulating genes: effect on T2DM and cardiovascular risk http://feeds.nature.com/~r/nrendo/rss/current/~3/CW5heJTrupQ/nrendo.2009.215 Type 2 diabetes mellitus (T2DM) is a complex disorder that has a heterogeneous genetic and environmental background. In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of Insulin signaling regulating genes: effect on T2DM and cardiovascular risk

Nature Reviews Endocrinology 5, 682 (2009). doi:10.1038/nrendo.2009.215

Authors: Sabrina Prudente, Eleonora Morini & Vincenzo Trischitta

Type 2 diabetes mellitus (T2DM) is a complex disorder that has a heterogeneous genetic and environmental background. In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of

]]> Insulin signaling regulating genes: effect on T2DM and cardiovascular risk Sabrina Prudente Eleonora Morini Vincenzo Trischitta doi:10.1038/nrendo.2009.215 Nature Reviews Endocrinology 5, 682 (2009) Nature Reviews Endocrinology 10.1038/nrendo.2009.215 http://dx.doi.org/10.1038/nrendo.2009.215 5 12 Review 682 693 http://dx.doi.org/10.1038/nrendo.2009.215