Nature Reviews Endocrinology Nature Reviews Endocrinology is a peer-reviewed journal for endocrinologists and affiliated healthcare professionals. The journal delivers timely interpretations of key developments in endocrinology and related areas of study. Nature Reviews Endocrinology is published monthly in print and online, and includes commissioned news, commentary and opinion pieces and comprehensive narrative reviews. Articles are subject to rigorous peer-review and/ or review by in-house editors. Topics covered include prevention, diagnosis and treatment of disorders of the endocrine system and related metabolic and nutritional disorders, including diabetes and the metabolic syndrome, male and female reproductive endocrinology, thyroid, parathyroid, pituitary and adrenal disease, neuroendocrinology, bone and mineral metabolism and other areas of clinical endocrinology. http://feeds.nature.com/nrendo/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Endocrinology © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Reviews Endocrinology https://www.nature.com/uploads/product/nrendo/rss.gif http://feeds.nature.com/nrendo/rss/current <![CDATA[Inceptor loss in mice with obesity]]> https://www.nature.com/articles/s41574-024-00980-2 Nature Reviews Endocrinology, Published online: 18 March 2024; doi:10.1038/s41574-024-00980-2

Inceptor loss in mice with obesity]]>
Shimona Starling doi:10.1038/s41574-024-00980-2 Nature Reviews Endocrinology, Published online: 2024-03-18; | doi:10.1038/s41574-024-00980-2 2024-03-18 Nature Reviews Endocrinology 10.1038/s41574-024-00980-2 https://www.nature.com/articles/s41574-024-00980-2
<![CDATA[Metabolic regulation of skeletal cell fate and function]]> https://www.nature.com/articles/s41574-024-00969-x Nature Reviews Endocrinology, Published online: 18 March 2024; doi:10.1038/s41574-024-00969-x

The skeleton is a metabolically active organ, with bone formation and maintenance relying on highly anabolic, nutrient-consuming processes. Here, the authors describe the current understanding of fuel selection and intermediary metabolic pathways in bone cells during bone formation and discuss how metabolic dysfunction can contribute to skeletal disease.]]>
Steve StegenGeert Carmeliet doi:10.1038/s41574-024-00969-x Nature Reviews Endocrinology, Published online: 2024-03-18; | doi:10.1038/s41574-024-00969-x 2024-03-18 Nature Reviews Endocrinology 10.1038/s41574-024-00969-x https://www.nature.com/articles/s41574-024-00969-x
<![CDATA[The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism]]> https://www.nature.com/articles/s41574-024-00966-0 Nature Reviews Endocrinology, Published online: 14 March 2024; doi:10.1038/s41574-024-00966-0

This Review discusses the effect of antibiotic-induced perturbations of the gut microbiome on host metabolic health. The authors outline factors that might influence the response to antibiotic use and highlight prebiotic strategies that could improve microbial composition and modulate microbial recovery.]]>
Lars M. M. VliexJohn PendersArjen NautaErwin G. ZoetendalEllen E. Blaak doi:10.1038/s41574-024-00966-0 Nature Reviews Endocrinology, Published online: 2024-03-14; | doi:10.1038/s41574-024-00966-0 2024-03-14 Nature Reviews Endocrinology 10.1038/s41574-024-00966-0 https://www.nature.com/articles/s41574-024-00966-0
<![CDATA[Antibodies drive adipose tissue ageing]]> https://www.nature.com/articles/s41574-024-00974-0 Nature Reviews Endocrinology, Published online: 13 March 2024; doi:10.1038/s41574-024-00974-0

Antibodies drive adipose tissue ageing]]>
Shimona Starling doi:10.1038/s41574-024-00974-0 Nature Reviews Endocrinology, Published online: 2024-03-13; | doi:10.1038/s41574-024-00974-0 2024-03-13 Nature Reviews Endocrinology 10.1038/s41574-024-00974-0 https://www.nature.com/articles/s41574-024-00974-0
<![CDATA[Thyroid-function reference ranges in the diagnosis of thyroid dysfunction in adults]]> https://www.nature.com/articles/s41574-024-00972-2 Nature Reviews Endocrinology, Published online: 08 March 2024; doi:10.1038/s41574-024-00972-2

Applying a uniform reference range across all adults for serum levels of thyroid stimulating hormone and thyroid hormones makes establishing a diagnosis of thyroid dysfunction challenging and could lead to potentially unnecessary treatment. For the results of thyroid function tests to be meaningful, the reference ranges should reflect individual variation in thyroid function.]]>
Salman Razvi doi:10.1038/s41574-024-00972-2 Nature Reviews Endocrinology, Published online: 2024-03-08; | doi:10.1038/s41574-024-00972-2 2024-03-08 Nature Reviews Endocrinology 10.1038/s41574-024-00972-2 https://www.nature.com/articles/s41574-024-00972-2
<![CDATA[Controlling brown adipose tissue size through EPAC1]]> https://www.nature.com/articles/s41574-024-00971-3 Nature Reviews Endocrinology, Published online: 04 March 2024; doi:10.1038/s41574-024-00971-3

A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPAC1 controls the size of brown and beige adipose tissue. This finding opens the door for the development of pharmacological interventions to prevent the decline of brown adipose tissue in obesity and ageing, and thereby improve metabolic health.]]>
Francesc VillarroyaMarta Giralt doi:10.1038/s41574-024-00971-3 Nature Reviews Endocrinology, Published online: 2024-03-04; | doi:10.1038/s41574-024-00971-3 2024-03-04 Nature Reviews Endocrinology 10.1038/s41574-024-00971-3 https://www.nature.com/articles/s41574-024-00971-3
<![CDATA[Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism]]> https://www.nature.com/articles/s41574-024-00957-1 Nature Reviews Endocrinology, Published online: 29 February 2024; doi:10.1038/s41574-024-00957-1

This Review highlights how cryo-electron microscopy has revolutionized our understanding of G protein-coupled receptor (GPCR) functions. Specific examples are outlined that provide insights into GPCR biology and drug discovery in endocrinology and metabolism.]]>
Jia DuanXin-Heng HeShu-Jie LiH. Eric Xu doi:10.1038/s41574-024-00957-1 Nature Reviews Endocrinology, Published online: 2024-02-29; | doi:10.1038/s41574-024-00957-1 2024-02-29 Nature Reviews Endocrinology 10.1038/s41574-024-00957-1 https://www.nature.com/articles/s41574-024-00957-1
<![CDATA[An historical step in our understanding of hypothalamic oestrogen feedback]]> https://www.nature.com/articles/s41574-024-00968-y Nature Reviews Endocrinology, Published online: 28 February 2024; doi:10.1038/s41574-024-00968-y

An historical step in our understanding of hypothalamic oestrogen feedback]]>
Erik Hrabovszky doi:10.1038/s41574-024-00968-y Nature Reviews Endocrinology, Published online: 2024-02-28; | doi:10.1038/s41574-024-00968-y 2024-02-28 Nature Reviews Endocrinology 10.1038/s41574-024-00968-y https://www.nature.com/articles/s41574-024-00968-y