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In this Review, Miller and Arias summarize recent advances in understanding ESKAPE pathogens, focusing on their molecular epidemiology, clinical impact, emerging mechanisms of resistance and novel therapeutic approaches.
In this Review, Lyons, Tino and colleagues explore the evolution of microbial life on Earth and examine the diversity of early microbial metabolic pathways, their associations with biogeochemical cycles and how they shaped and responded to changing surface environments over billions of years.
In this Review, Mather et al. discuss the role of genome-based approaches in deepening our understanding of both enduring and emerging bacterial foodborne pathogens in the context of evolving global food systems and environmental changes.
In this Review, Özçam and Lynch examine recent findings reporting the interaction between the gut and the airway microbiomes and explore the role of gut–airway crosstalk in human health and respiratory diseases.
In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved activity, and discuss their application in microbiome modulation and clinical potential.
In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence in bacteria, and how host niche, bacterial species and antibiotic mode of action combine to govern these mechanisms.
In this Review, Chan et al. explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and key treatments currently used in clinical settings for COVID-19.
In this Review, Uberoi, McCready-Vangi and Grice explore the diversity of microorganisms present in wounds and examine the mechanisms through which they invade skin tissues, impair skin repair and cause infection.
In this Review, Snyder et al. discuss the global impacts of food spoilage, mechanisms and causative agents, and strategies and emerging tools to control microbial food spoilage.
In this Review, Pai and colleagues examine the global landscape of drug-resistant tuberculosis, exploring its epidemiology, causes, risk factors, stigma and associated mental health burden as well as discussing the most recent developments in diagnostics, treatment and preventive regimens.
In the Review, Jensen and Unemo examine the epidemiology and clinical features, treatment options, and antimicrobial resistance of Neisseria gonorrhoeae and Mycoplasma genitalium, while briefly covering Chlamydia trachomatis and Treponema pallidum.
In this Review, Jiao, Robinson and colleagues examine recent advances related to the microbial carbon pump, exploring its role in the carbon cycle and climate change, and proposing future research directions and approaches to ocean negative carbon emissions.
In this Review, de Souza and Weaver discuss the potential effects on vector-borne diseases of climate change, weather and other anthropogenic factors, including land use, human mobility and behaviour, as possible contributors to the redistribution of vectors and spread of vector-borne diseases worldwide.
In this Review, Voolstra, Raina, Peixoto and colleagues discuss our current knowledge of the function and role of the bacterial microbiome in coral health and disease, and elucidate the response of the host-associated bacteria to global change, which bears implications for coral reef conservation.
In this Review, Ledvina and Whiteley highlight the key similarities between eukaryotic and bacterial innate immune systems, exploring conserved immune components and signalling strategies, as well as conserved mechanisms for pathogen restriction.
Finding a cure for HIV-1 infection, once considered elusive, now represents a major priority for the global microbiology research community. In this article, Armani-Tourret, Lichterfeld and colleagues highlight recent advances in understanding immunological vulnerabilities of virally infected cells that persist lifelong and represent the major barrier to a cure.
In this Review, Rosenthal, Asua and Conrad summarize our current knowledge of artemisinin partial resistance and focus on the emergence of resistance in Africa, including its epidemiology and transmission dynamics, and mechanisms of resistance.
In this Review, Jones, Marken and Silver develop a conceptual framework for synthetic microbiology organized into three domains — factory, farm and field — to explore the utility of synthetic microbiology in addressing sustainability challenges, and examine several examples of microbial engineering applications relevant to each domain.
In this Review, Thiel and colleagues summarize our emerging knowledge of the SARS-CoV-2 intracellular life cycle and the molecular functions of the viral proteins, as well as their interaction with the host cell.
In this Review, Roussin-Léveillée, Mackey and colleagues examine microorganism interaction with and manipulation of the plant apoplast. Effector-driven extracellular niche establishment is conceptualized as foundational to plant pathogenesis and frames the discussion of the complex interplay between pathogen virulence, host immunity and the physiological dynamics shaping plant–microorganism interactions.