Browse Articles

  • Perspective |

    In this Opinion article, Martijn van den Heuvel and Olaf Sporns examine alterations in structural and functional brain connectivity across brain disorders. They propose a common landscape for such alterations that is based on principles of network organization.

    • Martijn P. van den Heuvel
    •  & Olaf Sporns
  • Research Highlight |

    Certain cellular functions in artificially reperfused pig brains can be restored and maintained several hours after initial loss of cerebral blood flow.

    • Natasha Bray
  • Review Article |

    The short-term retention of working memory is accompanied by neural delay activity. Sreenivasan and D’Esposito describe how delay activity can be assessed, discuss where in the brain it occurs and why, and examine the possible mechanisms that underlie it.

    • Kartik K. Sreenivasan
    •  & Mark D’Esposito
  • Research Highlight |

    In monkeys, some neurons in the amygdala may simulate a social partner’s decision-making process in a reward-based decision-making task.

    • Darran Yates
  • Research Highlight |

    Certain lasting antidepressant effects of ketamine in a mouse model of depression depend on the restoration of dendritic spines in the prefrontal cortex.

    • Natasha Bray
  • Review Article |

    Spinal neural circuits are established through the navigation of multiple types of neuronal axon to their appropriate synaptic targets. Chédotal reviews the cellular and molecular mechanisms that control this complex wiring, incorporating recent discoveries of new guidance factors.

    • Alain Chédotal
  • Research Highlight |

    Grid cells in the rat medial entorhinal cortex distort their firing patterns local to a reward in the environment.

    • Natasha Bray
  • Review Article |

    Much of the mammalian nervous system is innervated by neurons that express and release 5-hydroxytryptamine (5-HT). In this Review, Okaty, Commons and Dymecki explore the diversity in the properties and function of the 5-HT neuronal system.

    • Benjamin W. Okaty
    • , Kathryn G. Commons
    •  & Susan M. Dymecki
  • Research Highlight |

    Sensory stimulus-induced gamma oscillations reduce pathology and cognitive dysfunction in mouse models of Alzheimer disease.

    • Darran Yates
  • Research Highlight |

    An intracellular molecule acts in a context-dependent manner to suppress responses to irrelevant guidance cues during axon development.

    • Katherine Whalley
  • Perspective |

    How is the processing of auditory information by the cortex organized? Scott and colleagues describe differences in the connectivity and properties of the rostral and caudal auditory cortex and propose links to the functional specializations of the rostral and caudal auditory streams.

    • Kyle Jasmin
    • , César F. Lima
    •  & Sophie K. Scott
  • Review Article |

    Recent studies indicate that cerebellar dysfunction contributes to the aetiology of many neurodevelopmental disorders. In this review, Gallo and colleagues cover recent discoveries in basic cerebellar research, linking them to human imaging and preclinical work on complex brain disorders with motor and non-motor deficits.

    • Aaron Sathyanesan
    • , Joy Zhou
    • , Joseph Scafidi
    • , Detlef H. Heck
    • , Roy V. Sillitoe
    •  & Vittorio Gallo
  • Research Highlight |

    Neurons expressing corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus of mice show increases and decreases in activity in response to aversive and appetitive stimuli.

    • Natasha Bray
  • Research Highlight |

    In ‘singing’ mice, the motor cortex controls the timing of rapid vocal exchanges to enable turn-taking during social interaction.

    • Katherine Whalley
  • Perspective |

    In this Opinion, Yonelinas et al. propose that the hippocampus binds together item-related and content-related information to form memories. They compare the evidence for this contextual binding theory with that for another theory of memory, standard systems consolidation theory.

    • Andrew P. Yonelinas
    • , Charan Ranganath
    • , Arne D. Ekstrom
    •  & Brian J. Wiltgen
  • Review Article |

    There is growing evidence for activity-dependent plasticity at inhibitory GABAergic synapses. In this Review, Chiu and colleagues propose that an array of molecular mechanisms promotes the parallel regulation of synapses formed by distinct presynaptic interneurons innervating perisomatic or dendritic targets.

    • Chiayu Q. Chiu
    • , Andrea Barberis
    •  & Michael J. Higley
  • Research Highlight |

    Targeted ultrasound stimulation can specifically modulate the functional connectivity profiles of targeted structures — including deep structures — in the macaque brain, with effects lasting for up to 2 hours following stimulation.

    • Natasha Bray
  • Review Article |

    Here, Hong and Lieber review recent developments in electrode technologies for the recording of single-unit spiking activity. They focus on advances in electrodes with high spatial integration, long-term stability and multifunctional capacities.

    • Guosong Hong
    •  & Charles M. Lieber
  • Review Article |

    Electrical synapses comprise intercellular channels termed gap junctions and are found in vertebrate and invertebrate nervous systems. In this Review, Pepe Alcamí and Alberto Pereda examine the properties of electrical synapses that influence neural circuit dynamics without modifying gap junction conductance.

    • Pepe Alcamí
    •  & Alberto E. Pereda
  • Correspondence |

    • Roberto Cabeza
    • , Marilyn Albert
    • , Sylvie Belleville
    • , Fergus I. M Craik
    • , Audrey Duarte
    • , Cheryl L. Grady
    • , Ulman Lindenberger
    • , Lars Nyberg
    • , Denise C. Park
    • , Patricia A. Reuter-Lorenz
    • , Michael D. Rugg
    • , Jason Steffener
    •  & M. Natasha Rajah
  • Correspondence |

    • Yaakov Stern
    • , Gaël Chételat
    • , Christian Habeck
    • , Eider M. Arenaza-Urquijo
    • , Prashanthi Vemuri
    • , Ainara Estanga
    • , David Bartrés-Faz
    • , Marc Cantillon
    • , Sean A.P. Clouston
    • , Jeremy A. Elman
    • , Brian T. Gold
    • , Richard Jones
    • , Gerd Kempermann
    • , Yen Ying Lim
    • , Anita van Loenhoud
    • , Pablo Martínez-Lage
    • , Silvia Morbelli
    • , Ozioma Okonkwo
    • , Rik Ossenkoppele
    • , Corinne Pettigrew
    • , Allyson C. Rosen
    • , Nikolaos Scarmeas
    • , Anja Soldan
    • , Chinedu Udeh-Momoh
    • , Michael Valenzuela
    •  & Eero Vuoksimaa
  • Research Highlight |

    The sexually dimorphic responses of male and female mice to their young are regulated by the activity of a specific population of neurons in the medial amygdala.

    • Katherine Whalley
  • Review Article |

    The role of glia in supporting and modulating neuronal activity has been an active area of research. In this Review, Patel et al. discuss the evidence and mechanisms whereby reactivated glia contribute to the development and progression of epilepsy.

    • Dipan C. Patel
    • , Bhanu P. Tewari
    • , Lata Chaunsali
    •  & Harald Sontheimer
  • Research Highlight |

    The neural ensembles within the prelimbic cortex representing remote (long-term) memories undergo time-dependent reorganization.

    • Sian Lewis