Nature Reviews Neuroscience - Issue - nature.com science feeds http://www.nature.com/nrn/current_issue/ Nature Publishing Group en © 2012 Nature Publishing Group Nature Reviews Neuroscience 1471-003X © 2012 Nature Publishing Group permissions@nature.com Nature Reviews Neuroscience http://www.nature.com/includes/rj_globnavimages/nrn_logo.gif http://www.nature.com/nrn/ In This Issue http://feeds.nature.com/~r/nrn/rss/current/~3/hK-aCrxs60s/nrn3193 As a result of both longer life expectancy and declining birth rates, in almost every developed country the number of people aged over 60 years is growing faster than the number in any other age group. This demographic shift is causing profound social and economic In This Issue

Nature Reviews Neuroscience 13, 147 (2012). doi:10.1038/nrn3193

As a result of both longer life expectancy and declining birth rates, in almost every developed country the number of people aged over 60 years is growing faster than the number in any other age group. This demographic shift is causing profound social and economic

]]> In This Issue doi:10.1038/nrn3193 Nature Reviews Neuroscience 13, 147 (2012) 2012-02-20 Nature Reviews Neuroscience 2012-02-20 10.1038/nrn3193 http://dx.doi.org/10.1038/nrn3193 13 3 In This Issue 147 147 http://dx.doi.org/10.1038/nrn3193 Neurodegenerative disease: Dishing up Alzheimer's disease http://feeds.nature.com/~r/nrn/rss/current/~3/vb0RsTP_HP8/nrn3201 This study uses a cell reprogramming approach to investigate mechanisms of Alzheimer's disease. Neurodegenerative disease: Dishing up Alzheimer's disease

Nature Reviews Neuroscience 13, 149 (2012). doi:10.1038/nrn3201

Author: Katherine Whalley

This study uses a cell reprogramming approach to investigate mechanisms of Alzheimer's disease.

]]> Neurodegenerative disease: Dishing up Alzheimer's disease Katherine Whalley doi:10.1038/nrn3201 Nature Reviews Neuroscience 13, 149 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3201 http://dx.doi.org/10.1038/nrn3201 13 3 Research Highlight 149 149 http://dx.doi.org/10.1038/nrn3201 Turning neural activity into words http://feeds.nature.com/~r/nrn/rss/current/~3/pcq0n9VDqZU/nrn3206 A paper published in PLoS Biology describes how researchers recorded neural population responses in non-primary auditory cortex of individuals listening to spoken words and then reconstructed the original spoken words from the population activity.The study shows that the superior temporal gyrus encodes certain Turning neural activity into words

Nature Reviews Neuroscience 13, 150 (2012). doi:10.1038/nrn3206

Author: Leonie Welberg

A paper published in PLoS Biology describes how researchers recorded neural population responses in non-primary auditory cortex of individuals listening to spoken words and then reconstructed the original spoken words from the population activity.The study shows that the superior temporal gyrus encodes certain

]]> Turning neural activity into words Leonie Welberg doi:10.1038/nrn3206 Nature Reviews Neuroscience 13, 150 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3206 http://dx.doi.org/10.1038/nrn3206 13 3 Research Highlight 150 150 http://dx.doi.org/10.1038/nrn3206 Reward: High expectations for GABA http://feeds.nature.com/~r/nrn/rss/current/~3/N_yMSs48JwI/nrn3194 GABA neurons encode the value of the expected reward — information that dopamine neurons need to compute prediction errors. Reward: High expectations for GABA

Nature Reviews Neuroscience 13, 150 (2012). doi:10.1038/nrn3194

Author: Leonie Welberg

GABA neurons encode the value of the expected reward — information that dopamine neurons need to compute prediction errors.

]]> Reward: High expectations for GABA Leonie Welberg doi:10.1038/nrn3194 Nature Reviews Neuroscience 13, 150 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3194 http://dx.doi.org/10.1038/nrn3194 13 3 Research Highlight 150 151 http://dx.doi.org/10.1038/nrn3194 Synaptic plasticity: Adding a piece to the LTP jigsaw http://feeds.nature.com/~r/nrn/rss/current/~3/xoc4NxiArc4/nrn3207 Complexin is involved in postsynaptic AMPA receptor exocytosis in long-term potentiation. Synaptic plasticity: Adding a piece to the LTP jigsaw

Nature Reviews Neuroscience 13, 150 (2012). doi:10.1038/nrn3207

Author: Man Tsuey Tse

Complexin is involved in postsynaptic AMPA receptor exocytosis in long-term potentiation.

]]> Synaptic plasticity: Adding a piece to the LTP jigsaw Man Tsuey Tse doi:10.1038/nrn3207 Nature Reviews Neuroscience 13, 150 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3207 http://dx.doi.org/10.1038/nrn3207 13 3 Research Highlight 150 151 http://dx.doi.org/10.1038/nrn3207 Addiction: Curtailing reward http://feeds.nature.com/~r/nrn/rss/current/~3/qDf3quznQtA/nrn3196 Histone deacetylases (HDACs), which regulate transcription, seem to modulate cocaine reward behaviours, but the underlying mechanisms are unclear. A new study shows that in rodent striatal neurons, cocaine and cyclic AMP signalling, which is upregulated by cocaine, induce HDAC5 nuclear translocation. Such translocation is dependent Addiction: Curtailing reward

Nature Reviews Neuroscience 13, 151 (2012). doi:10.1038/nrn3196

Author: Darran Yates

Histone deacetylases (HDACs), which regulate transcription, seem to modulate cocaine reward behaviours, but the underlying mechanisms are unclear. A new study shows that in rodent striatal neurons, cocaine and cyclic AMP signalling, which is upregulated by cocaine, induce HDAC5 nuclear translocation. Such translocation is dependent

]]> Addiction: Curtailing reward Darran Yates doi:10.1038/nrn3196 Nature Reviews Neuroscience 13, 151 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3196 http://dx.doi.org/10.1038/nrn3196 13 3 Research Highlight 151 151 http://dx.doi.org/10.1038/nrn3196 Cerebral cortex: Whisking up a change in state http://feeds.nature.com/~r/nrn/rss/current/~3/QutIFLghWlY/nrn3197 In mammals, quiet wakefulness and active behaviour are associated with synchronized and desynchronized patterns, respectively, of spontaneous cortical activity (termed cortical states). The mechanisms controlling cortical states are poorly understood. Poulet et al. showed that active whisking behaviour in mice, which is associated with Cerebral cortex: Whisking up a change in state

Nature Reviews Neuroscience 13, 151 (2012). doi:10.1038/nrn3197

Author: Darran Yates

In mammals, quiet wakefulness and active behaviour are associated with synchronized and desynchronized patterns, respectively, of spontaneous cortical activity (termed cortical states). The mechanisms controlling cortical states are poorly understood. Poulet et al. showed that active whisking behaviour in mice, which is associated with

]]> Cerebral cortex: Whisking up a change in state Darran Yates doi:10.1038/nrn3197 Nature Reviews Neuroscience 13, 151 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3197 http://dx.doi.org/10.1038/nrn3197 13 3 Research Highlight 151 151 http://dx.doi.org/10.1038/nrn3197 Neurodegeneration: Alternative neuronal loss http://feeds.nature.com/~r/nrn/rss/current/~3/XJ4vkEYUUvk/nrn3198 Although various RNA-processing proteins are implicated in neurodegenerative mechanisms, there is no firm evidence that defective RNA splicing causes neuronal loss. The pre-messenger RNA splicing machinery includes several uridine-rich small nuclear RNAs (U-snRNAs). Here, Jia et al. show that in mice, a mutation in Neurodegeneration: Alternative neuronal loss

Nature Reviews Neuroscience 13, 151 (2012). doi:10.1038/nrn3198

Author: Darran Yates

Although various RNA-processing proteins are implicated in neurodegenerative mechanisms, there is no firm evidence that defective RNA splicing causes neuronal loss. The pre-messenger RNA splicing machinery includes several uridine-rich small nuclear RNAs (U-snRNAs). Here, Jia et al. show that in mice, a mutation in

]]> Neurodegeneration: Alternative neuronal loss Darran Yates doi:10.1038/nrn3198 Nature Reviews Neuroscience 13, 151 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3198 http://dx.doi.org/10.1038/nrn3198 13 3 Research Highlight 151 151 http://dx.doi.org/10.1038/nrn3198 Gene expression: Transcriptional mapping http://feeds.nature.com/~r/nrn/rss/current/~3/FylVSs4V4NI/nrn3199 How the transcriptomes of various cell types in a specific brain area differ is unclear. Here, Siegert et al. created an atlas of cell type transcriptomes for the mouse retina and found that each cell type was associated with the expression of a specific Gene expression: Transcriptional mapping

Nature Reviews Neuroscience 13, 151 (2012). doi:10.1038/nrn3199

Author: Darran Yates

How the transcriptomes of various cell types in a specific brain area differ is unclear. Here, Siegert et al. created an atlas of cell type transcriptomes for the mouse retina and found that each cell type was associated with the expression of a specific

]]> Gene expression: Transcriptional mapping Darran Yates doi:10.1038/nrn3199 Nature Reviews Neuroscience 13, 151 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3199 http://dx.doi.org/10.1038/nrn3199 13 3 Research Highlight 151 151 http://dx.doi.org/10.1038/nrn3199 Dendrites: Ensuring appropriate coverage http://feeds.nature.com/~r/nrn/rss/current/~3/LoGs9NHPwTk/nrn3191 Two new studies highlight the contribution of dendrite–substrate interactions to dendritic morphogenesis in Drosophila melanogaster sensory neurons. Dendrites: Ensuring appropriate coverage

Nature Reviews Neuroscience 13, 152 (2012). doi:10.1038/nrn3191

Author: Monica Hoyos Flight

Two new studies highlight the contribution of dendrite–substrate interactions to dendritic morphogenesis in Drosophila melanogaster sensory neurons.

]]> Dendrites: Ensuring appropriate coverage Monica Hoyos Flight doi:10.1038/nrn3191 Nature Reviews Neuroscience 13, 152 (2012) 2012-02-01 Nature Reviews Neuroscience 2012-02-01 10.1038/nrn3191 http://dx.doi.org/10.1038/nrn3191 13 3 Research Highlight 152 153 http://dx.doi.org/10.1038/nrn3191 Cellular neurophysiology: ER cargo confinement influences dendritic plasticity http://feeds.nature.com/~r/nrn/rss/current/~3/vzJOiZh6zSk/nrn3195 The structural complexity of the ER restricts the diffusion of nascent proteins and influences the spatial scales of cargo transport to the dendritic membrane. Cellular neurophysiology: ER cargo confinement influences dendritic plasticity

Nature Reviews Neuroscience 13, 152 (2012). doi:10.1038/nrn3195

Author: Sian Lewis

The structural complexity of the ER restricts the diffusion of nascent proteins and influences the spatial scales of cargo transport to the dendritic membrane.

]]> Cellular neurophysiology: ER cargo confinement influences dendritic plasticity Sian Lewis doi:10.1038/nrn3195 Nature Reviews Neuroscience 13, 152 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3195 http://dx.doi.org/10.1038/nrn3195 13 3 Research Highlight 152 153 http://dx.doi.org/10.1038/nrn3195 Addiction: Brain changes in siblings of addicted individuals http://feeds.nature.com/~r/nrn/rss/current/~3/P0usEiWtUjQ/nrn3202 Drug addiction has been associated with structural brain changes, but do they precede addiction or are they the consequence of it? Here, the authors showed that compared with unrelated healthy controls, stimulant-dependent individuals and their biological siblings have impaired inhibitory control, reduced white matter integrity Addiction: Brain changes in siblings of addicted individuals

Nature Reviews Neuroscience 13, 153 (2012). doi:10.1038/nrn3202

Author: Leonie Welberg

Drug addiction has been associated with structural brain changes, but do they precede addiction or are they the consequence of it? Here, the authors showed that compared with unrelated healthy controls, stimulant-dependent individuals and their biological siblings have impaired inhibitory control, reduced white matter integrity

]]> Addiction: Brain changes in siblings of addicted individuals Leonie Welberg doi:10.1038/nrn3202 Nature Reviews Neuroscience 13, 153 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3202 http://dx.doi.org/10.1038/nrn3202 13 3 Research Highlight 153 153 http://dx.doi.org/10.1038/nrn3202 Neuroimmunology: Neural activity regulates T cell entry http://feeds.nature.com/~r/nrn/rss/current/~3/HDyEbH6-hmc/nrn3203 Peripheral CD4+ T cells have a central role in multiple sclerosis, but how these cells cross the blood–brain barrier is not understood. Here, the authors examined this issue in a mouse model of the disease. In mice with experimental autoimmune encephalomyelitis, CD4+ Neuroimmunology: Neural activity regulates T cell entry

Nature Reviews Neuroscience 13, 153 (2012). doi:10.1038/nrn3203

Author: Leonie Welberg

Peripheral CD4+ T cells have a central role in multiple sclerosis, but how these cells cross the blood–brain barrier is not understood. Here, the authors examined this issue in a mouse model of the disease. In mice with experimental autoimmune encephalomyelitis, CD4+

]]> Neuroimmunology: Neural activity regulates T cell entry Leonie Welberg doi:10.1038/nrn3203 Nature Reviews Neuroscience 13, 153 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3203 http://dx.doi.org/10.1038/nrn3203 13 3 Research Highlight 153 153 http://dx.doi.org/10.1038/nrn3203 Protein metabolism: No turnover for brain nuclear pore proteins http://feeds.nature.com/~r/nrn/rss/current/~3/vLYYCZn78-w/nrn3204 Although most proteins undergo turnover, a few extremely long-lived proteins (ELLPs) have been identified. To detect potential ELLPs in the rat brain, the authors fed rat pups a 15N-enriched diet until they were 6 weeks of age and a 14N-enriched diet thereafter. Twenty-five Protein metabolism: No turnover for brain nuclear pore proteins

Nature Reviews Neuroscience 13, 153 (2012). doi:10.1038/nrn3204

Author: Leonie Welberg

Although most proteins undergo turnover, a few extremely long-lived proteins (ELLPs) have been identified. To detect potential ELLPs in the rat brain, the authors fed rat pups a 15N-enriched diet until they were 6 weeks of age and a 14N-enriched diet thereafter. Twenty-five

]]> Protein metabolism: No turnover for brain nuclear pore proteins Leonie Welberg doi:10.1038/nrn3204 Nature Reviews Neuroscience 13, 153 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3204 http://dx.doi.org/10.1038/nrn3204 13 3 Research Highlight 153 153 http://dx.doi.org/10.1038/nrn3204 Techniques: Nanoscale imaging of dendritic spines http://feeds.nature.com/~r/nrn/rss/current/~3/gFmGkUxtLlo/nrn3205 Stimulated emission depletion (STED) microscopy has an extremely high (nanoscale) resolution, but this technique has not been applied in vivo in rodents. Here, the authors used STED microscopy to study neuron dynamics in vivo in the somatosensory cortex of adult mice. The images Techniques: Nanoscale imaging of dendritic spines

Nature Reviews Neuroscience 13, 153 (2012). doi:10.1038/nrn3205

Author: Leonie Welberg

Stimulated emission depletion (STED) microscopy has an extremely high (nanoscale) resolution, but this technique has not been applied in vivo in rodents. Here, the authors used STED microscopy to study neuron dynamics in vivo in the somatosensory cortex of adult mice. The images

]]> Techniques: Nanoscale imaging of dendritic spines Leonie Welberg doi:10.1038/nrn3205 Nature Reviews Neuroscience 13, 153 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3205 http://dx.doi.org/10.1038/nrn3205 13 3 Research Highlight 153 153 http://dx.doi.org/10.1038/nrn3205 Neurodegenerative disorders: Microglia get ready, set... http://feeds.nature.com/~r/nrn/rss/current/~3/CO_Np_pMYu0/nrn3189 Primed microglia are associated with accelerated decline in patients with neurodegenerative diseases, and a new study indicates that the dysregulation of certain proteins of the alternative complement pathway might trigger the priming process. Neurodegenerative disorders: Microglia get ready, set...

Nature Reviews Neuroscience 13, 154 (2012). doi:10.1038/nrn3189

Author: Sian Lewis

Primed microglia are associated with accelerated decline in patients with neurodegenerative diseases, and a new study indicates that the dysregulation of certain proteins of the alternative complement pathway might trigger the priming process.

]]> Neurodegenerative disorders: Microglia get ready, set... Sian Lewis doi:10.1038/nrn3189 Nature Reviews Neuroscience 13, 154 (2012) 2012-01-25 Nature Reviews Neuroscience 2012-01-25 10.1038/nrn3189 http://dx.doi.org/10.1038/nrn3189 13 3 Research Highlight 154 155 http://dx.doi.org/10.1038/nrn3189 Pain: A new trick for opioids? http://feeds.nature.com/~r/nrn/rss/current/~3/2nHOzG45T-E/nrn3190 An acute high dose of an opioid agonist may be able to reverse the synaptic plasticity associated with chronic pain. Pain: A new trick for opioids?

Nature Reviews Neuroscience 13, 154 (2012). doi:10.1038/nrn3190

Author: Katherine Whalley

An acute high dose of an opioid agonist may be able to reverse the synaptic plasticity associated with chronic pain.

]]> Pain: A new trick for opioids? Katherine Whalley doi:10.1038/nrn3190 Nature Reviews Neuroscience 13, 154 (2012) 2012-02-01 Nature Reviews Neuroscience 2012-02-01 10.1038/nrn3190 http://dx.doi.org/10.1038/nrn3190 13 3 Research Highlight 154 155 http://dx.doi.org/10.1038/nrn3190 Consciousness: Effective detection http://feeds.nature.com/~r/nrn/rss/current/~3/sfKhl3Q2Ex4/nrn3188 A new 'bedside' method that detects effective connectivity can discriminate between the vegetative state and the minimally conscious state. Consciousness: Effective detection

Nature Reviews Neuroscience 13, 155 (2012). doi:10.1038/nrn3188

Author: Leonie Welberg

A new 'bedside' method that detects effective connectivity can discriminate between the vegetative state and the minimally conscious state.

]]> Consciousness: Effective detection Leonie Welberg doi:10.1038/nrn3188 Nature Reviews Neuroscience 13, 155 (2012) 2012-01-25 Nature Reviews Neuroscience 2012-01-25 10.1038/nrn3188 http://dx.doi.org/10.1038/nrn3188 13 3 Research Highlight 155 155 http://dx.doi.org/10.1038/nrn3188 Understanding calcium waves and sparks in central neurons http://feeds.nature.com/~r/nrn/rss/current/~3/S8hF44_k-J0/nrn3168 All cells use changes in intracellular calcium concentration ([Ca2+]i) to regulate cell signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there are clear examples of both localized and widespread Ca2+ signals. [Ca2+]i Understanding calcium waves and sparks in central neurons

Nature Reviews Neuroscience 13, 157 (2012). doi:10.1038/nrn3168

Author: William N. Ross

All cells use changes in intracellular calcium concentration ([Ca2+]i) to regulate cell signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there are clear examples of both localized and widespread Ca2+ signals. [Ca2+]i

]]> Understanding calcium waves and sparks in central neurons William N. Ross doi:10.1038/nrn3168 Nature Reviews Neuroscience 13, 157 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3168 http://dx.doi.org/10.1038/nrn3168 13 3 Review 157 168 http://dx.doi.org/10.1038/nrn3168 Mechanisms of CaMKII action in long-term potentiation http://feeds.nature.com/~r/nrn/rss/current/~3/o8bJw606y28/nrn3192 Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds Mechanisms of CaMKII action in long-term potentiation

Nature Reviews Neuroscience 13, 169 (2012). doi:10.1038/nrn3192

Authors: John Lisman, Ryohei Yasuda & Sridhar Raghavachari

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for long periods, making it a probable mechanism for memory storage. LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII subsequently translocates to the synapse, where it binds

]]> Mechanisms of CaMKII action in long-term potentiation John Lisman Ryohei Yasuda Sridhar Raghavachari doi:10.1038/nrn3192 Nature Reviews Neuroscience 13, 169 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3192 http://dx.doi.org/10.1038/nrn3192 13 3 Review 169 182 http://dx.doi.org/10.1038/nrn3192 Assembly of a new growth cone after axotomy: the precursor to axon regeneration http://feeds.nature.com/~r/nrn/rss/current/~3/QPx1k357Mp4/nrn3176 The assembly of a new growth cone is a prerequisite for axon regeneration after injury. Creation of a new growth cone involves multiple processes, including calcium signalling, restructuring of the cytoskeleton, transport of materials, local translation of messenger RNAs and the insertion of new membrane Assembly of a new growth cone after axotomy: the precursor to axon regeneration

Nature Reviews Neuroscience 13, 183 (2012). doi:10.1038/nrn3176

Authors: Frank Bradke, James W. Fawcett & Micha E. Spira

The assembly of a new growth cone is a prerequisite for axon regeneration after injury. Creation of a new growth cone involves multiple processes, including calcium signalling, restructuring of the cytoskeleton, transport of materials, local translation of messenger RNAs and the insertion of new membrane

]]> Assembly of a new growth cone after axotomy: the precursor to axon regeneration Frank Bradke James W. Fawcett Micha E. Spira doi:10.1038/nrn3176 Nature Reviews Neuroscience 13, 183 (2012) 2012-02-15 Nature Reviews Neuroscience 2012-02-15 10.1038/nrn3176 http://dx.doi.org/10.1038/nrn3176 13 3 Review 183 193 http://dx.doi.org/10.1038/nrn3176 Direction selectivity in the retina: symmetry and asymmetry in structure and function http://feeds.nature.com/~r/nrn/rss/current/~3/KvmwlMQ70BE/nrn3165 Visual information is processed in the retina to a remarkable degree before it is transmitted to higher visual centres. Several types of retinal ganglion cells (the output neurons of the retina) respond preferentially to image motion in a particular direction, and each type of direction-selective Direction selectivity in the retina: symmetry and asymmetry in structure and function

Nature Reviews Neuroscience 13, 194 (2012). doi:10.1038/nrn3165

Authors: David I. Vaney, Benjamin Sivyer & W. Rowland Taylor

Visual information is processed in the retina to a remarkable degree before it is transmitted to higher visual centres. Several types of retinal ganglion cells (the output neurons of the retina) respond preferentially to image motion in a particular direction, and each type of direction-selective

]]> Direction selectivity in the retina: symmetry and asymmetry in structure and function David I. Vaney Benjamin Sivyer W. Rowland Taylor doi:10.1038/nrn3165 Nature Reviews Neuroscience 13, 194 (2012) 2012-02-08 Nature Reviews Neuroscience 2012-02-08 10.1038/nrn3165 http://dx.doi.org/10.1038/nrn3165 13 3 Review 194 208 http://dx.doi.org/10.1038/nrn3165 Recruiting adaptive cellular stress responses for successful brain ageing http://feeds.nature.com/~r/nrn/rss/current/~3/VUJW2XC9-wc/nrn3151 Successful ageing is determined in part by genetic background, but also by experiential factors associated with lifestyle and culture. Dietary, behavioural and pharmacological interventions have been identified as potential means to slow brain ageing and forestall neurodegenerative disease. Many of these interventions recruit adaptive cellular Recruiting adaptive cellular stress responses for successful brain ageing

Nature Reviews Neuroscience 13, 209 (2012). doi:10.1038/nrn3151

Authors: Alexis M. Stranahan & Mark P. Mattson

Successful ageing is determined in part by genetic background, but also by experiential factors associated with lifestyle and culture. Dietary, behavioural and pharmacological interventions have been identified as potential means to slow brain ageing and forestall neurodegenerative disease. Many of these interventions recruit adaptive cellular

]]> Recruiting adaptive cellular stress responses for successful brain ageing Alexis M. Stranahan Mark P. Mattson doi:10.1038/nrn3151 Nature Reviews Neuroscience 13, 209 (2012) 2012-01-18 Nature Reviews Neuroscience 2012-01-18 10.1038/nrn3151 http://dx.doi.org/10.1038/nrn3151 13 3 Perspectives 209 216 http://dx.doi.org/10.1038/nrn3151