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The binding of psychedelics to the BDNF receptor TrkB boosts plasticity in cultured neurons and underlies the antidepressant-like effects of these compounds in mice.
The increase in blood corticosterone triggered by the release of proinflammatory cytokines is shown to involve vagal regulation of a parabrachial nucleus–paraventricular nucleus pathway.
Alternative splicing dysregulation contributes to the molecular pathology of a wide range of neurodegenerative diseases. In this Review, Nikom and Zheng discuss the latest advances in RNA-based therapeutic strategies developed to target the underlying splicing mechanisms.
Oligodendrocytes secrete extracellular vesicles, which deliver cargo to axons where they regulate key cellular processes. In this Review, Krämer-Albers and Werner discuss the mechanisms by which extracellular vesicles promote neuronal health and their potential to be utilized therapeutically.
The contribution of visual information to the representation of space in the brain is well known and recent research in rodents has indicated that spatial signals can also influence visual processing. In this Review, Saleem and Busse describe what is known about these bidirectional interactions and their importance in the control of visuo-spatial behaviour.
Various theories exist for the function of the dentate gyrus in learning and memory. In this Perspective article, Rangel and colleagues compare a number of these theories and discuss how they may be further tested to develop a better understanding of dentate gyrus function.
