Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Fluorescent indicators can provide quantitative insights into the spatiotemporal dynamics of signalling molecules released by brain circuits. However, a mismatch between the experimental context and the experimental imaging settings often introduces unexpected errors and biases in such measurements. Appreciating this mismatch should help to arrive at unbiased estimates.
The macaque homologue of the dorsal medial prefrontal cortex tracks the reliability of social information and determines whether this information is used to guide choices during decision making.
A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS) and shows a role for contactin-1 in assembly of the AIS extracellular matrix.
Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 infection are found to be associated with reduced serotonin levels.
In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippocampus-dependent memory deficits.
Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and cell-extrinsic mechanisms that govern neuronal postmitotic development and consider the factors that may contribute to species-specific maturation rates.
SARS-CoV-2 infection is associated with various neurological effects both during and after infection. In this Review, Meinhardt and colleagues discuss the possible impact of SARS-CoV-2 infection on different cell populations of the nervous system and the neurological alterations that result, thus facilitating the development of treatment options.
A prevailing notion in sleep research is that sleep homeostasis and circadian rhythmicity involve independent processes. In this Review, Franken and Dijk discuss evidence that suggests that sleep and circadian rhythmicity are interdependent and together support the homeostasis of brain function.
Neurobiological organizational principles suggest that a generative grammar exists in the brain. In this Perspective, Dragoi proposes how neural grammar enables specific experience-independent, internally generated patterns of activity acquired via spontaneous generative combination of pre-existing sequential motifs to support internally generated representations of experience in the hippocampus.
