NatureNature Reviews Nephrology - AOP - nature.com science feeds Nature Reviews Nephrology provides physicians and academics with authoritative and topical discussions of key developments in the field. http://www.nature.com/nrneph/current_issue/ Nature Publishing Group en © Nature Publishing Group Nature Reviews Nephrology 1759-5061 1759-507X © Nature Publishing Group permissions@nature.com Nature Reviews Nephrology http://www.nature.com/includes/rj_globnavimages/nrneph_logo.gif http://www.nature.com/nrneph/ Direct renin inhibition and the kidney http://feeds.nature.com/~r/nrneph/rss/aop/~3/C5mHwUZC1BI/nrneph.2009.201 Direct renin inhibition is a novel strategy for the blockade of the renin–angiotensin system. In this Review, Hollenberg discusses the evidence indicating that direct renin inhibitors might block the renin–angiotensin system in the kidney more effectively than either angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers. The author also discusses the therapeutic implications of this evidence and possible mechanisms that underlie the renal effects of direct renin inhibition. Direct renin inhibition and the kidney

Nature Reviews Nephrology. doi:10.1038/nrneph.2009.201

Author: Norman K. Hollenberg

]]> Direct renin inhibition and the kidney Norman K. Hollenberg doi:10.1038/nrneph.2009.201 Nature Reviews Nephrology 2009-11-24 Nature Reviews Nephrology 2009-11-24 10.1038/nrneph.2009.201 http://dx.doi.org/10.1038/nrneph.2009.201 Review http://dx.doi.org/10.1038/nrneph.2009.201 The growing problem of intradialytic hypertension http://feeds.nature.com/~r/nrneph/rss/aop/~3/pDE3oLwKow4/nrneph.2009.200 Intradialytic hypertension is not an uncommon complication in hemodialysis patients, and seems to be associated with adverse outcomes. This complex phenomenon is not well understood, and many uncertainties exist regarding its pathophysiologic mechanisms and appropriate treatment strategies. Many of the therapeutic approaches currently used come from expert recommendations rather than from the results of randomized clinical trials. In this Review, Locatelli et al. describe the possible pathophysiologic mechanisms of intradialytic hypertension, and consider potential treatment and management strategies. The growing problem of intradialytic hypertension

Nature Reviews Nephrology. doi:10.1038/nrneph.2009.200

Authors: Francesco Locatelli, Andrea Cavalli & Benedetta Tucci

]]> The growing problem of intradialytic hypertension Francesco Locatelli Andrea Cavalli Benedetta Tucci doi:10.1038/nrneph.2009.200 Nature Reviews Nephrology 2009-11-24 Nature Reviews Nephrology 2009-11-24 10.1038/nrneph.2009.200 http://dx.doi.org/10.1038/nrneph.2009.200 Review http://dx.doi.org/10.1038/nrneph.2009.200 Bone disease after renal transplantation http://feeds.nature.com/~r/nrneph/rss/aop/~3/4S2TifcrvIk/nrneph.2009.192 Disturbances in bone metabolism are common in patients after renal transplantation and represent important causes of morbidity and mortality. This Review discusses the etiological factors that contribute to bone metabolic disturbances in renal transplant recipients—pre-existing renal osteodystrophy, the effects of transplant-specific therapies on bone metabolism, and the effects of reduced renal function after transplantation. The clinical implications of bone disease in these patients are also considered. Bone disease after renal transplantation

Nature Reviews Nephrology. doi:10.1038/nrneph.2009.192

Authors: Hartmut H. Malluche, Marie-Claude Monier-Faugere & Johann Herberth

]]> Bone disease after renal transplantation Hartmut H. Malluche Marie-Claude Monier-Faugere Johann Herberth doi:10.1038/nrneph.2009.192 Nature Reviews Nephrology 2009-11-17 Nature Reviews Nephrology 2009-11-17 10.1038/nrneph.2009.192 http://dx.doi.org/10.1038/nrneph.2009.192 Review http://dx.doi.org/10.1038/nrneph.2009.192 Prehypertension: epidemiology, consequences and treatment http://feeds.nature.com/~r/nrneph/rss/aop/~3/_zhhd6mJX-M/nrneph.2009.191 A prehypertension classification of blood pressure, encompassing a blood pressure range previously regarded to be normal that has been associated with an increased risk of hypertension mortality compared with lower blood pressure, has been established. In this Review, Pimenta and Oparil discuss the epidemiology of prehypertension, the relationship with cardiovascular morbidity and mortality, and the treatment of prehypertensive patients. Prehypertension: epidemiology, consequences and treatment

Nature Reviews Nephrology. doi:10.1038/nrneph.2009.191

Authors: Eduardo Pimenta & Suzanne Oparil

]]> Prehypertension: epidemiology, consequences and treatment Eduardo Pimenta Suzanne Oparil doi:10.1038/nrneph.2009.191 Nature Reviews Nephrology 2009-11-17 Nature Reviews Nephrology 2009-11-17 10.1038/nrneph.2009.191 http://dx.doi.org/10.1038/nrneph.2009.191 Review http://dx.doi.org/10.1038/nrneph.2009.191