Nature Reviews Nephrology Nature Reviews Nephrology is a peer-reviewed journal for nephrologists and affiliated health-care professionals. The journal delivers timely interpretations of key scientific developments in nephrology and related areas of study. Nature Reviews Nephrology is published monthly in print and online and includes news pieces written in-house, commissioned commentaries and opinion pieces and comprehensive reviews. Articles are subject to rigorous peer-review and/or review by in-house editors. Topics covered include all areas concerned with the prevention, diagnosis and treatment of disorders of the kidney in adults and children, including hypertension, infection, inflammation, dialysis, chronic uremia, renal failure, transplantation, applied physiology, epidemiology, pathology, immunology and genetics. http://feeds.nature.com/nrneph/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Nephrology © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Reviews Nephrology https://www.nature.com/uploads/product/nrneph/rss.gif http://feeds.nature.com/nrneph/rss/current <![CDATA[Drug stewardship in chronic kidney disease to achieve effective and safe medication use]]> https://www.nature.com/articles/s41581-024-00823-3 Nature Reviews Nephrology, Published online: 15 March 2024; doi:10.1038/s41581-024-00823-3

Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can be susceptible to the adverse effects of medications. This Review discusses the principles of drug stewardship — that is, the effective, safe and sustainable use of medications — for people with chronic kidney disease.]]>
Rasheeda K. HallRümeyza KazancıoğluTeerawat ThanachayanontGermaine WongDharshana SabanayagamMarisa BattistellaSofia B. AhmedLesley A. InkerErin F. BarretoEdouard L. FuCatherine M. ClaseJuan J. Carrero doi:10.1038/s41581-024-00823-3 Nature Reviews Nephrology, Published online: 2024-03-15; | doi:10.1038/s41581-024-00823-3 2024-03-15 Nature Reviews Nephrology 10.1038/s41581-024-00823-3 https://www.nature.com/articles/s41581-024-00823-3
<![CDATA[Role of biophysics and mechanobiology in podocyte physiology]]> https://www.nature.com/articles/s41581-024-00815-3 Nature Reviews Nephrology, Published online: 05 March 2024; doi:10.1038/s41581-024-00815-3

In this Review, the authors examine the biophysical and biomechanical properties that influence podocyte physiology as they integrate and adapt to stimuli from their dynamic environment within the glomerular capillaries. The authors also discuss how dysregulation and loss of biomechanical resilience in podocytes can contribute to kidney disease.]]>
Jonathan HaydakEvren U. Azeloglu doi:10.1038/s41581-024-00815-3 Nature Reviews Nephrology, Published online: 2024-03-05; | doi:10.1038/s41581-024-00815-3 2024-03-05 Nature Reviews Nephrology 10.1038/s41581-024-00815-3 https://www.nature.com/articles/s41581-024-00815-3
<![CDATA[Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group]]> https://www.nature.com/articles/s41581-024-00818-0 Nature Reviews Nephrology, Published online: 05 March 2024; doi:10.1038/s41581-024-00818-0

Care for patients with tuberous sclerosis complex (TSC) should be coordinated by a multidisciplinary team. This Consensus Statement, which involved input from nephrologists, urologists, geneticists, radiologists, interventional radiologists and pathologists as well as patient representatives, provides an overview of TSC-associated kidney manifestations and outlines current recommendations for the management of kidney involvement in TSC.]]>
Djalila MekahliRoman-Ulrich MüllerMatko MarlaisTanja WlodkowskiStefanie HaeberleMarta López de ArgumedoCarsten BergmannLuc BreysemCarla FladrowskiElizabeth P. HenskePeter JanssensFrançois JouretJohn Christopher KingswoodJean-Baptiste LattoufMarc LilienGeert MaleuxMicaela RozenbergStefan SiemerOlivier DevuystFranz SchaeferDavid J. KwiatkowskiOlivier RouvièreJohn Bissler doi:10.1038/s41581-024-00818-0 Nature Reviews Nephrology, Published online: 2024-03-05; | doi:10.1038/s41581-024-00818-0 2024-03-05 Nature Reviews Nephrology 10.1038/s41581-024-00818-0 https://www.nature.com/articles/s41581-024-00818-0
<![CDATA[Innovating dialysis through computational modelling of hollow-fibre haemodialysers]]> https://www.nature.com/articles/s41581-024-00826-0 Nature Reviews Nephrology, Published online: 04 March 2024; doi:10.1038/s41581-024-00826-0

Haemodialyser technology has not advanced much in decades, despite its unresolved shortcomings. Sophisticated new computational tools such as high-fidelity surrogate in silico dialyser models could reduce the time and expense of exploring alternative designs, dialysis dose and operating conditions compared with the current gold standard in vitro studies.]]>
Ruhit SinhaMichael V. RoccoPirouz DaeihaghAnne E. Staples doi:10.1038/s41581-024-00826-0 Nature Reviews Nephrology, Published online: 2024-03-04; | doi:10.1038/s41581-024-00826-0 2024-03-04 Nature Reviews Nephrology 10.1038/s41581-024-00826-0 https://www.nature.com/articles/s41581-024-00826-0
<![CDATA[The renal glucagon receptor is essential to kidney metabolic and homeostatic functions]]> https://www.nature.com/articles/s41581-024-00825-1 Nature Reviews Nephrology, Published online: 29 February 2024; doi:10.1038/s41581-024-00825-1

The renal glucagon receptor is essential to kidney metabolic and homeostatic functions]]>
Ellen F. Carney doi:10.1038/s41581-024-00825-1 Nature Reviews Nephrology, Published online: 2024-02-29; | doi:10.1038/s41581-024-00825-1 2024-02-29 Nature Reviews Nephrology 10.1038/s41581-024-00825-1 https://www.nature.com/articles/s41581-024-00825-1
<![CDATA[A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells]]> https://www.nature.com/articles/s41581-024-00824-2 Nature Reviews Nephrology, Published online: 28 February 2024; doi:10.1038/s41581-024-00824-2

A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells]]>
Ellen F. Carney doi:10.1038/s41581-024-00824-2 Nature Reviews Nephrology, Published online: 2024-02-28; | doi:10.1038/s41581-024-00824-2 2024-02-28 Nature Reviews Nephrology 10.1038/s41581-024-00824-2 https://www.nature.com/articles/s41581-024-00824-2
<![CDATA[Pericyte–stem cell crosstalk in ccRCC]]> https://www.nature.com/articles/s41581-024-00822-4 Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00822-4

Pericyte–stem cell crosstalk in ccRCC]]>
Susan J. Allison doi:10.1038/s41581-024-00822-4 Nature Reviews Nephrology, Published online: 2024-02-26; | doi:10.1038/s41581-024-00822-4 2024-02-26 Nature Reviews Nephrology 10.1038/s41581-024-00822-4 https://www.nature.com/articles/s41581-024-00822-4
<![CDATA[Organ trafficking — a continuing challenge]]> https://www.nature.com/articles/s41581-024-00821-5 Nature Reviews Nephrology, Published online: 26 February 2024; doi:10.1038/s41581-024-00821-5

Global inequities and inequalities, human and health-care crises, transplantation successes in the face of limited organ availability, and desperate donors and recipients underlie the backstory of organ trafficking, namely the exploitation of the most vulnerable. Despite the framework set out by the Declaration of Istanbul for the ethical donation and transplantation of organs, organ trafficking remains a global challenge.]]>
Thomas F. MuellerSanjay Nagral doi:10.1038/s41581-024-00821-5 Nature Reviews Nephrology, Published online: 2024-02-26; | doi:10.1038/s41581-024-00821-5 2024-02-26 Nature Reviews Nephrology 10.1038/s41581-024-00821-5 https://www.nature.com/articles/s41581-024-00821-5