Nature Reviews Neurology - AOP - nature.com science feeds Nature Reviews Neurology provides physicians and academics with authoritative and topical discussions of key developments in the field. http://www.nature.com/nrneurol/current_issue/ Nature Publishing Group en © Nature Publishing Group Nature Reviews Neurology 1759-4758 1759-4766 © Nature Publishing Group permissions@nature.com Nature Reviews Neurology http://www.nature.com/includes/rj_globnavimages/nrneurol_logo.gif http://www.nature.com/nrneurol/ Changing perspectives regarding late-life dementia http://feeds.nature.com/~r/nrneurol/rss/aop/~3/x8k6I2ZgGXM/nrneurol.2009.175 The view of cognitive impairment in elderly individuals has evolved over the centuries, from a normal inevitable part of aging, through demonic possession and hardening of blood vessels, to Alzheimer disease. As Fotuhi et al. discuss in this article, individuals over 80 years of age rarely have 'pure Alzheimer disease' or 'pure vascular dementia'. The authors present a new framework, known as the dynamic polygon hypothesis, which reflects the complex interplay of factors that contribute to cognitive impairment in the oldest old. Changing perspectives regarding late-life dementia

Nature Reviews Neurology. doi:10.1038/nrneurol.2009.175

Authors: Majid Fotuhi, Vladimir Hachinski & Peter J. Whitehouse

]]> Changing perspectives regarding late-life dementia Majid Fotuhi Vladimir Hachinski Peter J. Whitehouse doi:10.1038/nrneurol.2009.175 Nature Reviews Neurology 2009-11-17 Nature Reviews Neurology 2009-11-17 10.1038/nrneurol.2009.175 http://dx.doi.org/10.1038/nrneurol.2009.175 Review http://dx.doi.org/10.1038/nrneurol.2009.175