Nature Reviews Neurology Nature Reviews Neurology is a peer-reviewed journal for neurologists and affiliated health care professionals. The journal delivers timely interpretations of key scientific developments in neurology and related areas of study. Nature Reviews Neurology is published monthly in print and online and includes commissioned news, commentary and opinion pieces and comprehensive reviews. Articles are subject to rigorous peer-review and/or review by in-house editors. Topics covered include pathogenesis, prevention, diagnosis and treatment of disease or impaired function of the central and peripheral nervous systems, including neurodevelopmental, neurodegenerative and neuropsychiatric disorders. http://feeds.nature.com/nrneurol/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Neurology © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Reviews Neurology https://www.nature.com/uploads/product/nrneurol/rss.gif http://feeds.nature.com/nrneurol/rss/current <![CDATA[Neurological care for LGBT+ people]]> https://www.nature.com/articles/s41582-024-00944-0 Nature Reviews Neurology, Published online: 18 March 2024; doi:10.1038/s41582-024-00944-0

In this Review, the authors discuss the unique neurological health disparities faced by sexual and gender minority (LGBT+) people. The Review presents clinical considerations alongside language and practice recommendations to promote inclusive care, and highlights the gaps in need of further research.]]>
Salvatore Giovanni VolpeJoya AhmadRoshni Abee PatelNicole Rosendale doi:10.1038/s41582-024-00944-0 Nature Reviews Neurology, Published online: 2024-03-18; | doi:10.1038/s41582-024-00944-0 2024-03-18 Nature Reviews Neurology 10.1038/s41582-024-00944-0 https://www.nature.com/articles/s41582-024-00944-0
<![CDATA[Towards the era of biological biomarkers for Parkinson disease]]> https://www.nature.com/articles/s41582-024-00950-2 Nature Reviews Neurology, Published online: 07 March 2024; doi:10.1038/s41582-024-00950-2

Since its instigation in cancer research in the 1930s, the disease-staging concept has become a crucial tool in clinical research and medical practice. Two new papers have proposed biological staging and classification systems based on α-synuclein pathology for Parkinson disease and related conditions.]]>
Nobutaka Hattori doi:10.1038/s41582-024-00950-2 Nature Reviews Neurology, Published online: 2024-03-07; | doi:10.1038/s41582-024-00950-2 2024-03-07 Nature Reviews Neurology 10.1038/s41582-024-00950-2 https://www.nature.com/articles/s41582-024-00950-2
<![CDATA[Metabolic changes in status epilepticus]]> https://www.nature.com/articles/s41582-024-00946-y Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00946-y

Status epilepticus is associated with changes in metabolic pathways, a new study has shown.]]>
Ian Fyfe doi:10.1038/s41582-024-00946-y Nature Reviews Neurology, Published online: 2024-03-05; | doi:10.1038/s41582-024-00946-y 2024-03-05 Nature Reviews Neurology 10.1038/s41582-024-00946-y https://www.nature.com/articles/s41582-024-00946-y
<![CDATA[α-Synuclein seeds in amyotrophic lateral sclerosis]]> https://www.nature.com/articles/s41582-024-00949-9 Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00949-9

New evidence that α-synuclein can contribute to the pathogenesis of amyotrophic lateral sclerosis has come from analysis of cerebrospinal fluid.]]>
Ian Fyfe doi:10.1038/s41582-024-00949-9 Nature Reviews Neurology, Published online: 2024-03-05; | doi:10.1038/s41582-024-00949-9 2024-03-05 Nature Reviews Neurology 10.1038/s41582-024-00949-9 https://www.nature.com/articles/s41582-024-00949-9
<![CDATA[Marker provides 10-year warning of dementia]]> https://www.nature.com/articles/s41582-024-00947-x Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00947-x

Changes in plasma levels of specific proteins could predict the development of dementia more than 10 years before clinical diagnosis.]]>
Ian Fyfe doi:10.1038/s41582-024-00947-x Nature Reviews Neurology, Published online: 2024-03-05; | doi:10.1038/s41582-024-00947-x 2024-03-05 Nature Reviews Neurology 10.1038/s41582-024-00947-x https://www.nature.com/articles/s41582-024-00947-x
<![CDATA[Parkinson disease pathology in inflammatory bowel disease]]> https://www.nature.com/articles/s41582-024-00945-z Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00945-z

A new study has found evidence of α-synuclein aggregates — a key pathological hallmark of Parkinson disease — in the gut and brain in people and animals with inflammatory bowel disease.]]>
Heather Wood doi:10.1038/s41582-024-00945-z Nature Reviews Neurology, Published online: 2024-03-05; | doi:10.1038/s41582-024-00945-z 2024-03-05 Nature Reviews Neurology 10.1038/s41582-024-00945-z https://www.nature.com/articles/s41582-024-00945-z
<![CDATA[Mitochondrial DNA marks multiple sclerosis]]> https://www.nature.com/articles/s41582-024-00948-w Nature Reviews Neurology, Published online: 05 March 2024; doi:10.1038/s41582-024-00948-w

Mitochondrial DNA has been identified as a potential biomarker of multiple sclerosis disease activity and treatment response.]]>
Ian Fyfe doi:10.1038/s41582-024-00948-w Nature Reviews Neurology, Published online: 2024-03-05; | doi:10.1038/s41582-024-00948-w 2024-03-05 Nature Reviews Neurology 10.1038/s41582-024-00948-w https://www.nature.com/articles/s41582-024-00948-w
<![CDATA[Biomarker-based staging of Alzheimer disease: rationale and clinical applications]]> https://www.nature.com/articles/s41582-024-00942-2 Nature Reviews Neurology, Published online: 01 March 2024; doi:10.1038/s41582-024-00942-2

Recent clinical trials have highlighted the need for Alzheimer disease (AD) staging rather than simply noting the presence or absence of AD pathology. This article reviews current biomarker-based AD staging systems and outlines hypothetical frameworks to stage AD severity using fluid biomarkers.]]>
Joseph TherriaultSuzanne E. SchindlerGemma SalvadóTharick A. PascoalAndréa Lessa BenedetNicholas J. AshtonThomas K. KarikariLiana ApostolovaMelissa E. MurrayInge VerberkJacob W. VogelRenaud La JoieSerge GauthierCharlotte TeunissenGil D. RabinoviciHenrik ZetterbergRandall J. BatemanPhilip ScheltensKaj BlennowReisa SperlingOskar HanssonClifford R. Jack JrPedro Rosa-Neto doi:10.1038/s41582-024-00942-2 Nature Reviews Neurology, Published online: 2024-03-01; | doi:10.1038/s41582-024-00942-2 2024-03-01 Nature Reviews Neurology 10.1038/s41582-024-00942-2 https://www.nature.com/articles/s41582-024-00942-2