Nature Reviews Rheumatology - AOP - nature.com science feeds

Therapy: TNF inhibition suppresses angiogenic mechanisms implicated in RA

Ellen F. Carney — 2012-05-15

Therapy: TNF inhibition suppresses angiogenic mechanisms implicated in RA

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.77

Author: Ellen F. Carney

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Rheumatoid arthritis: How bad is obesity for RA?

Sarah Onuora — 2012-05-15

Rheumatoid arthritis: How bad is obesity for RA?

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.78

Author: Sarah Onuora

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Arthritogenic alphaviruses—an overview

Andreas Suhrbier — 2012-05-08

Alphaviruses can cause rheumatic manifestations (usually polyarthralgia and/or polyarthritis) in humans. Arthritogenic alphaviruses are distributed globally and include chikungunya virus, Ross River virus, Barmah Forest virus, Sindbis virus, o'nyong nyong virus and Mayaro virus. In this Review, the authors provide an overview of these viruses, describing epidemiology, pathogenesis, disease manifestations, diagnosis and interventions.

Management of rheumatic disease with comorbid HBV or HCV infection

Dimitrios Vassilopoulos — 2012-05-08

Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is a global health problem. Management of patients with co-existing rheumatic disease and viral hepatitis can be challenging, given that immunosuppressive and biologic agents used to treat rheumatic disease can have serious complications. This Review provides a guide to viral hepatitis for the rheumatologist, describing the characteristics, complications and treatment of chronic HBV or HCV infection in rheumatic disease.

Experimental arthritis: Pathogenic role of autotaxin and LPA

Emma Leah — 2012-05-01

Experimental arthritis: Pathogenic role of autotaxin and LPA

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.61

Author: Emma Leah

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Rheumatoid arthritis: Linking ACPA to bone loss in rheumatoid arthritis

Emma Leah — 2012-05-01

Rheumatoid arthritis: Linking ACPA to bone loss in rheumatoid arthritis

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.68

Author: Emma Leah

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Therapy: Shot at sciatica relief misses the mark

Sarah Onuora — 2012-05-01

Therapy: Shot at sciatica relief misses the mark

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.67

Author: Sarah Onuora

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Paediatric rheumatology: Corticosteroids as primary therapy in Kawasaki disease

Rebecca Reindel — 2012-05-01

Paediatric rheumatology: Corticosteroids as primary therapy in Kawasaki disease

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.65

Authors: Rebecca Reindel & Stanford T. Shulman

Coronary artery aneurysms affect a substantial proportion of patients with Kawasaki disease, especially when standard therapy fails. Adjunctive primary corticosteroid treatment reduces inflammation and might reduce the incidence of coronary artery disease in a subset of patients at high risk of this comorbidity, but reliably identifying such individuals is a challenge.

Follicular helper T cells in immunity and systemic autoimmunity

Joseph E. Craft — 2012-05-01

Aberrant T-cell help has been implicated in the expansion of self-reactive B-cell clones and subsequent autoantibody production in many systemic autoimmune diseases, including systemic lupus erythematosus. In this Review, Joseph Craft discusses the T-helper-cell populations, particularly follicular helper T cells, which are key regulators of B-cell survival and maturation during normal immune responses and in autoimmunity.

Topical and systemic medications for the treatment of primary Sjögren's syndrome

Manuel Ramos-Casals — 2012-05-01

Both sicca and systemic symptoms affect quality of life in patient with Sjögren's syndrome, and their management is complicated by the low level of evidence supporting the available therapeutic options. Here, the authors comprehensively review the data on the efficacy of treatments for the glandular and extraglandular manifestations of this disease. Ramos-Casals and colleagues also recommend treatment approaches tailored to different clinical scenarios that patients with Sjögren's syndrome can present.

Therapy: Tissue engineering: harnessing stem cells in cartilage repair

Katrina Ray — 2012-04-24

Therapy: Tissue engineering: harnessing stem cells in cartilage repair

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.62

Author: Katrina Ray

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Osteoarthritis: Probing knee OA as a system responding to a stimulus

Thomas P. Andriacchi — 2012-04-24

Osteoarthritis: Probing knee OA as a system responding to a stimulus

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.59

Author: Thomas P. Andriacchi

Systems level analysis using stimulus–response modelling could increase our understanding of the interplay between biochemical, structural and functional variables that influence the development and manifestation of osteoarthritis. Furthermore, surrogate markers of clinical responses identified might enable early diagnosis, improve therapy, and facilitate development of new treatments and end points.

Osteoarthritis: Omega-3 fatty acids and synovitis in osteoarthritic knees

Leslie G. Cleland — 2012-04-17

Osteoarthritis: Omega-3 fatty acids and synovitis in osteoarthritic knees

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.60

Authors: Leslie G. Cleland & Michael J. James

Recently reported associations between synovitis, cartilage damage and plasma levels of omega-3 and omega-6 fatty acids in patients with osteoarthritis suggest that fish oil supplements might be beneficial additions to the therapeutic regime in this disease; however, questions remain regarding the details of this approach, and controlled trials are required.

Diagnosis: Severity scoring system for paediatric FMF

Avi Livneh — 2012-04-17

Diagnosis: Severity scoring system for paediatric FMF

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.54

Author: Avi Livneh

Severity scoring systems for adult familial Mediterranean fever (FMF) are established and used as important clinical and analytical tools in disease management and research. A recent paper highlights the need for a paediatric FMF severity measure. How should such a score be built and what challenges might be faced?

Connective tissue diseases: Unravelling aetiology in male SLE—the X chromosome dose effect

Gisele Zandman-Goddard — 2012-04-17

Connective tissue diseases: Unravelling aetiology in male SLE—the X chromosome dose effect

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.44

Authors: Gisele Zandman-Goddard & Elena Peeva

New evidence suggesting an X chromosome effect underlies the development and progression of male systemic lupus erythematosus comes from a study of sex chromosome aneuploidy in men with this disease. The description of a number of immunoregulatory mechanisms encoded on the X chromosome support this hypothesis; however, further studies are warranted.

Hypoxia-driven pathways in bone development, regeneration and disease

Christa Maes — 2012-03-27

Oxygen is thought to be an indispensable regulatory signal in tissue development and homeostasis, via its controlling of specific genetic programs. Hypoxia-inducible transcription factors (HIFs), which are regulated by oxygen tension, are central mediators of the homeostatic response that enables cells to survive and differentiate in low-oxygen conditions. In this Review, the authors summarize the current knowledge of HIF signalling in cartilage, bone and blood, and pay particular attention to the complex relationship between HIF and VEGF in these tissues based on data collected from animal models, which can also be relevant in diseases like cancer and ischemia.

Advances and challenges in imaging in juvenile idiopathic arthritis

Silvia Magni-Manzoni — 2012-03-27

Advances and challenges in imaging in juvenile idiopathic arthritis

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2012.30

Authors: Silvia Magni-Manzoni, Clara Malattia, Stefano Lanni & Angelo Ravelli