Nature Structural & Molecular Biology Nature Structural and Molecular Biology reflects the growing integration of structural and molecular studies. The journal places a strong emphasis on understanding the molecular mechanisms underlying biological processes. Specific areas include (but are not limited to) DNA replication, repair and recombination; chromatin structure and remodeling; transcription; translation; folding, processing, transport and degradation of proteins and RNA; signal transduction and membrane processes. http://feeds.nature.com/nsmb/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Structural & Molecular Biology © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Structural & Molecular Biology https://www.nature.com/uploads/product/nsmb/rss.gif http://feeds.nature.com/nsmb/rss/current <![CDATA[Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine]]> https://www.nature.com/articles/s41594-024-01238-1 Nature Structural & Molecular Biology, Published online: 27 March 2024; doi:10.1038/s41594-024-01238-1

Precise protein synthesis is achieved by tRNA modifications. Here the authors revealed that modified cytidines in tRNAIle use their long side chains to make additional interactions with mRNA for stable tRNA binding on the ribosome.]]>
Naho AkiyamaKensuke IshiguroTakeshi YokoyamaKenjyo MiyauchiAsuteka NagaoMikako ShirouzuTsutomu Suzuki doi:10.1038/s41594-024-01238-1 Nature Structural & Molecular Biology, Published online: 2024-03-27; | doi:10.1038/s41594-024-01238-1 2024-03-27 Nature Structural & Molecular Biology 10.1038/s41594-024-01238-1 https://www.nature.com/articles/s41594-024-01238-1
<![CDATA[Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance]]> https://www.nature.com/articles/s41594-024-01236-3 Nature Structural & Molecular Biology, Published online: 27 March 2024; doi:10.1038/s41594-024-01236-3

Rybak and Gagnon elucidate the mechanism of AUG codon avoidance by the minor isoleucine tRNA in Escherichia coli. The lysidinylated C34 in the anticodon loop of tRNAIle weakens interactions with the mRNA and destabilizes the EF-Tu ternary complex.]]>
Mariia Yu. RybakMatthieu G. Gagnon doi:10.1038/s41594-024-01236-3 Nature Structural & Molecular Biology, Published online: 2024-03-27; | doi:10.1038/s41594-024-01236-3 2024-03-27 Nature Structural & Molecular Biology 10.1038/s41594-024-01236-3 https://www.nature.com/articles/s41594-024-01236-3
<![CDATA[Molecular stripping underpins derepression of a toxin–antitoxin system]]> https://www.nature.com/articles/s41594-024-01253-2 Nature Structural & Molecular Biology, Published online: 27 March 2024; doi:10.1038/s41594-024-01253-2

Transcription of toxin–antitoxin modules is regulated by conditional cooperativity, where the toxin enables or disrupts antitoxin-driven repression. Here, the authors solve the structural basis for the conditional cooperativity of Salmonella TacAT3.]]>
Grzegorz J. GrabeRachel T. GiorgioMiłosz WieczórBridget GollanMolly SargenModesto OrozcoStephen A. HareSophie Helaine doi:10.1038/s41594-024-01253-2 Nature Structural & Molecular Biology, Published online: 2024-03-27; | doi:10.1038/s41594-024-01253-2 2024-03-27 Nature Structural & Molecular Biology 10.1038/s41594-024-01253-2 https://www.nature.com/articles/s41594-024-01253-2
<![CDATA[Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1]]> https://www.nature.com/articles/s41594-024-01258-x Nature Structural & Molecular Biology, Published online: 25 March 2024; doi:10.1038/s41594-024-01258-x

Cryo-EM studies reveal that RYBP–PRC1 uses two distinct interfaces for binding unmodified and H2Aub1-modified nucleosomes. These binding modes enable the complex to generate H2Aub1 chromatin domains by a read–write mechanism.]]>
Maria CiapponiElena KarlukovaSven SchkölzigerChristian BendaJürg Müller doi:10.1038/s41594-024-01258-x Nature Structural & Molecular Biology, Published online: 2024-03-25; | doi:10.1038/s41594-024-01258-x 2024-03-25 Nature Structural & Molecular Biology 10.1038/s41594-024-01258-x https://www.nature.com/articles/s41594-024-01258-x
<![CDATA[Author Correction: Structure and interactions of the endogenous human Commander complex]]> https://www.nature.com/articles/s41594-024-01273-y Nature Structural & Molecular Biology, Published online: 19 March 2024; doi:10.1038/s41594-024-01273-y

Author Correction: Structure and interactions of the endogenous human Commander complex]]>
Saara LaulumaaEsa-Pekka KumpulaJuha T. HuiskonenMarkku Varjosalo doi:10.1038/s41594-024-01273-y Nature Structural & Molecular Biology, Published online: 2024-03-19; | doi:10.1038/s41594-024-01273-y 2024-03-19 Nature Structural & Molecular Biology 10.1038/s41594-024-01273-y https://www.nature.com/articles/s41594-024-01273-y
<![CDATA[Musings on art and science]]> https://www.nature.com/articles/s41594-024-01266-x Nature Structural & Molecular Biology, Published online: 18 March 2024; doi:10.1038/s41594-024-01266-x

In addition to the usual dose of compelling science, our March issue features thoughtful reflections on the last 30 years from readers, as well as past and present editors. Perhaps influenced by these pieces or by our stunning cover — or maybe it is just the changing seasons — we are in an introspective mood this month.]]>
doi:10.1038/s41594-024-01266-x Nature Structural & Molecular Biology, Published online: 2024-03-18; | doi:10.1038/s41594-024-01266-x 2024-03-18 Nature Structural & Molecular Biology 10.1038/s41594-024-01266-x https://www.nature.com/articles/s41594-024-01266-x
<![CDATA[Looking back at 30 years of <i>Nature Structural & Molecular Biology</i>]]> https://www.nature.com/articles/s41594-024-01248-z Nature Structural & Molecular Biology, Published online: 18 March 2024; doi:10.1038/s41594-024-01248-z

Over the past 30 years, Nature Structural & Molecular Biology (NSMB) has covered an enormous breadth of subjects in the broad field of molecular and structural biology. Here, some of the journal’s past and present editors recount their editorial experience at NSMB and some of the more memorable papers they worked on.]]>
Nature Structural & Molecular Biology]]> Guy RiddihoughChristopher SurridgeAndreas G. LadurnerRosemary K. ClyneMaria HodgesArianne HeinrichsKatarzyna MarcinkiewiczFlorian UllrichCarolina PerdigotoSara OsmanKatarzyna CiazynskaDimitris Typas doi:10.1038/s41594-024-01248-z Nature Structural & Molecular Biology, Published online: 2024-03-18; | doi:10.1038/s41594-024-01248-z 2024-03-18 Nature Structural & Molecular Biology 10.1038/s41594-024-01248-z https://www.nature.com/articles/s41594-024-01248-z
<![CDATA[The impact of DNA methylation on CTCF-mediated 3D genome organization]]> https://www.nature.com/articles/s41594-024-01241-6 Nature Structural & Molecular Biology, Published online: 18 March 2024; doi:10.1038/s41594-024-01241-6

In this Review, the authors present an overview of our current understanding of the relationship between DNA methylation and three-dimensional chromatin architecture, discussing the extent to which DNA methylation may regulate the folding of the genome.]]>
Ana Monteagudo-SánchezDaan NoordermeerMaxim V. C. Greenberg doi:10.1038/s41594-024-01241-6 Nature Structural & Molecular Biology, Published online: 2024-03-18; | doi:10.1038/s41594-024-01241-6 2024-03-18 Nature Structural & Molecular Biology 10.1038/s41594-024-01241-6 https://www.nature.com/articles/s41594-024-01241-6