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Volume 13 Issue 7, July 2006

Studies from Miller and Hahn map the path of the promoter, represented here by the Great Wall of China, across the faces of the eukaryotic Pol II subunits and the general transcription factors which crowd the DNA on either side of the TATA box. The photo was kindly provided by Guo Ximin. pp 603-610 | p 564

Volume 13 Issue 7

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News & Views

  • Two new studies on the structure of an enzyme involved the synthesis of mammalian NAD shed new light on the evolutionary and biochemical complexity of this fundamental metabolic pathway.

    • Andrea Mattevi
    News & Views

  • Yeast RNA polymerase II has been proposed to 'scan' template DNA for transcription start sites. A new study mapping promoter DNA trajectory through the preinitiation complex suggests a mechanism for how this occurs.

    • Michael Hampsey
    News & Views

  • SecA is an essential eubacterial protein in which the ATPase motor from DEAD-box RNA helicases has adapted to function as a processive polypeptide pump. A new report suggests that a disorder-order transition in the DEAD-box motor is responsible for distinctive thermodynamic features of SecA's conformationally coupled ATPase cycle.

    • Lorraine F Cavanaugh
    • Arthur G Palmer III
    • John F Hunt
    News & Views

  • Riboswitches provide an elegantly simple means of coupling metabolic sensing to genetic regulation. Recent work provides a wealth of structural insight into ligand binding by these RNAs.

    • Wade C Winkler
    • Charles E Dann III
    News & Views

  • Covalent modifications of histones play an important role in regulating chromatin structure and function, probably by serving as docking sites for effector proteins. The discovery that PHD fingers of two different proteins recognize trimethyl-Lys4 of histone H3 supports and extends this notion.

    • Yi Zhang
    News & Views
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