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Crystallographic, biochemical and computational studies of the hairpin ribozyme define its structure and reveal likely components of an enzyme active site that is comprised entirely of ribonucleotides.
Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.
Structures of the Puf domains from the Drosophila Pum and human Pum1 proteins reveal a novel function for a known structural repeat motif and exciting possibilities for the combinatorial assembly of complexes that regulate gene expression post-transcriptionally.