SciBX: Science-Business eXchange - Issue - nature.com science feeds SciBX: Science-Business eXchange from Nature and Biocentury contains articles that highlight, analyse and report on the scientific and commercial potential of the most important translational research papers from across the life science literature thus highlighting the most important developments in translational science. SciBX provides a unique and essential scientific and commercial perspective on breakthrough science. http://www.nature.com/scibx/current_issue/ Nature Publishing Group en © 2009 Nature Publishing Group SciBX: Science-Business eXchange 1945-3477 © 2009 Nature Publishing Group permissions@nature.com SciBX: Science-Business eXchange http://www.nature.com/includes/rj_globnavimages/scibx_logo.gif http://www.nature.com/scibx/ A top-notch inhibitor http://feeds.nature.com/~r/scibx/rss/current/~3/lLFsRAhTzag/scibx.2009.1649 The previously intractable Notch pathway looks to be opening as a Harvard team has described a way to specifically inhibit Notch signaling and UCSD researchers have identified a role for NOTCH3 in pulmonary arterial hypertension. Also, Aileron Therapeutics has moved the Harvard technology into preclinical programs for a range of indications beyond cancer. A top-notch inhibitor

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1649

Author: Tim Fulmer

]]> A top-notch inhibitor Tim Fulmer doi:10.1038/scibx.2009.1649 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1649 http://dx.doi.org/10.1038/scibx.2009.1649 2 45 Cover Story http://dx.doi.org/10.1038/scibx.2009.1649 gp130's sensitive side http://feeds.nature.com/~r/scibx/rss/current/~3/N5u4aNt0v7w/scibx.2009.1651 Medical University Innsbruck researchers suggest that inhibiting the gp130 pathway could help manage certain types of pain as well as exert a therapeutic effect in cancer and inflammation. The key will be to block the pathway without disrupting the body's natural immune response. gp130's sensitive side

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1651

Author: Lauren Martz

]]> gp130's sensitive side Lauren Martz doi:10.1038/scibx.2009.1651 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1651 http://dx.doi.org/10.1038/scibx.2009.1651 2 45 Targets and Mechanisms http://dx.doi.org/10.1038/scibx.2009.1651 APC mutants for ALS http://feeds.nature.com/~r/scibx/rss/current/~3/-bPwWq-R26c/scibx.2009.1650 University of Rochester researchers suggest mutant forms of activated protein C could improve outcomes in ALS, and they point to a possible role of microglia in the etiology of the disease. The results could expand the number of indications addressed by ZZ Biotech's portfolio of APC mutants. APC mutants for ALS

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1650

Author: Lev Osherovich

]]> APC mutants for ALS Lev Osherovich doi:10.1038/scibx.2009.1650 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1650 http://dx.doi.org/10.1038/scibx.2009.1650 2 45 Targets and Mechanisms http://dx.doi.org/10.1038/scibx.2009.1650 Warming up to lung transplants http://feeds.nature.com/~r/scibx/rss/current/~3/XC_u9UtMpho/scibx.2009.1652 University of Toronto researchers have combined ex vivo IL-10 gene therapy with an organ preservation system from Vitrolife AB to repair damage in donor lungs and make them suitable for transplant. The approach could expand the supply of donor lungs and be applied to other donor organs. Warming up to lung transplants

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1652

Author: Kai-Jye Lou

]]> Warming up to lung transplants Kai-Jye Lou doi:10.1038/scibx.2009.1652 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1652 http://dx.doi.org/10.1038/scibx.2009.1652 2 45 Tools http://dx.doi.org/10.1038/scibx.2009.1652 MicroRNA-29b (miRNA-29b) http://feeds.nature.com/~r/scibx/rss/current/~3/5fWz4JPiuec/scibx.2009.1653 A study in cell culture and in mice suggests that miRNA-29b mimetics could help treat AML. MicroRNA-29b (miRNA-29b)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1653

]]> MicroRNA-29b (miRNA-29b) doi:10.1038/scibx.2009.1653 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1653 http://dx.doi.org/10.1038/scibx.2009.1653 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1653 Mdm2 p53 binding protein homolog (MDM2) http://feeds.nature.com/~r/scibx/rss/current/~3/fVoTcjewoFs/scibx.2009.1654 In vitro and mouse studies suggest that antagonizing MDM2 could help treat chemotherapy-resistant neuroblastoma. Mdm2 p53 binding protein homolog (MDM2)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1654

]]> Mdm2 p53 binding protein homolog (MDM2) doi:10.1038/scibx.2009.1654 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1654 http://dx.doi.org/10.1038/scibx.2009.1654 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1654 Integrin α5 (CD49e); radixin (RDX); Ras homolog gene family member (RHOA) http://feeds.nature.com/~r/scibx/rss/current/~3/mSNqvWUur-8/scibx.2009.1655 In vitro and mouse studies suggest that inhibiting CD49e, RDX or RHOA could help prevent breast cancer metastasis. Integrin α5 (CD49e); radixin (RDX); Ras homolog gene family member (RHOA)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1655

]]> Integrin α5 (CD49e); radixin (RDX); Ras homolog gene family member (RHOA) doi:10.1038/scibx.2009.1655 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1655 http://dx.doi.org/10.1038/scibx.2009.1655 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1655 Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) http://feeds.nature.com/~r/scibx/rss/current/~3/f2TAS33_eq4/scibx.2009.1656 A study in cell culture suggests that inhibiting the protease MALT1 could help treat diffuse large B cell lymphoma. Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1656

]]> Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) doi:10.1038/scibx.2009.1656 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1656 http://dx.doi.org/10.1038/scibx.2009.1656 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1656 Microtubules http://feeds.nature.com/~r/scibx/rss/current/~3/HBJw4ylK4XE/scibx.2009.1657 An in vitro and cell culture study suggests that zampanolide, a macrolide compound isolated from a Tongan sea sponge, could help treat cancer. Microtubules

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1657

]]> Microtubules doi:10.1038/scibx.2009.1657 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1657 http://dx.doi.org/10.1038/scibx.2009.1657 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1657 Notch transcription factor complex http://feeds.nature.com/~r/scibx/rss/current/~3/gS99SBOCrV0/scibx.2009.1658 A study in mice and in cell culture suggests that an α-helical peptide antagonist of the notch transcriptional complex could help treat cancer. Notch transcription factor complex

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1658

]]> Notch transcription factor complex doi:10.1038/scibx.2009.1658 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1658 http://dx.doi.org/10.1038/scibx.2009.1658 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1658 Estrogen receptor http://feeds.nature.com/~r/scibx/rss/current/~3/UML4XW_pNIU/scibx.2009.1659 A study in mice suggests that selective estrogen receptor antagonists could help treat and prevent cervical cancer. Estrogen receptor

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1659

]]> Estrogen receptor doi:10.1038/scibx.2009.1659 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1659 http://dx.doi.org/10.1038/scibx.2009.1659 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1659 Janus kinase 2 (JAK2); histone deacetylase (HDAC) http://feeds.nature.com/~r/scibx/rss/current/~3/nz7rvUKwZok/scibx.2009.1660 In vitro studies suggest that combining HDAC inhibitors with JAK2 inhibitors could help treat myeloproliferative cancers. Janus kinase 2 (JAK2); histone deacetylase (HDAC)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1660

]]> Janus kinase 2 (JAK2); histone deacetylase (HDAC) doi:10.1038/scibx.2009.1660 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1660 http://dx.doi.org/10.1038/scibx.2009.1660 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1660 Wingless-type MMTV integration site family member 5A (WNT5A) http://feeds.nature.com/~r/scibx/rss/current/~3/JKi8jP-tmR0/scibx.2009.1661 A study in cell culture identified an N-butyloxycarbonyl hexapeptide inhibitor of WNT5A that could help prevent melanoma-associated metastasis. Wingless-type MMTV integration site family member 5A (WNT5A)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1661

]]> Wingless-type MMTV integration site family member 5A (WNT5A) doi:10.1038/scibx.2009.1661 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1661 http://dx.doi.org/10.1038/scibx.2009.1661 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1661 Angiotensin-converting enzyme (ACE); endothelin converting enzyme 1 (ECE1); membrane metallo-endopeptidase (MME; NEP; CD10) http://feeds.nature.com/~r/scibx/rss/current/~3/RC5SQBbn1DQ/scibx.2009.1662 In vitro and rat studies suggest that dual ACE and ECE1 inhibitors could help treat hypertension. Angiotensin-converting enzyme (ACE); endothelin converting enzyme 1 (ECE1); membrane metallo-endopeptidase (MME; NEP; CD10)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1662

]]> Angiotensin-converting enzyme (ACE); endothelin converting enzyme 1 (ECE1); membrane metallo-endopeptidase (MME; NEP; CD10) doi:10.1038/scibx.2009.1662 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1662 http://dx.doi.org/10.1038/scibx.2009.1662 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1662 Not applicable http://feeds.nature.com/~r/scibx/rss/current/~3/mA_aSKGcUnM/scibx.2009.1663 In vitro and rat studies suggest that losartan-antioxidant hybrid compounds are more effective than losartan at controlling hypertension. Not applicable

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1663

]]> Not applicable doi:10.1038/scibx.2009.1663 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1663 http://dx.doi.org/10.1038/scibx.2009.1663 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1663 Androgen receptor http://feeds.nature.com/~r/scibx/rss/current/~3/1B7YwcS-ngw/scibx.2009.1664 Studies in mice suggest that inhibiting the androgen receptor could improve wound healing. Androgen receptor

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1664

]]> Androgen receptor doi:10.1038/scibx.2009.1664 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1664 http://dx.doi.org/10.1038/scibx.2009.1664 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1664 Syntaxin binding protein 2 (STXBP2; MUNC18–2) http://feeds.nature.com/~r/scibx/rss/current/~3/bNNEVK_6gck/scibx.2009.1665 Genetic studies in humans identified mutations in STXBP2 that could be biomarkers of the hematological disorder familial hemophagocytic lymphohistiocytosis type 5. Syntaxin binding protein 2 (STXBP2; MUNC18–2)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1665

]]> Syntaxin binding protein 2 (STXBP2; MUNC18–2) doi:10.1038/scibx.2009.1665 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1665 http://dx.doi.org/10.1038/scibx.2009.1665 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1665 C-type lectin domain family 7 member A (CLEC7A; DECTIN1) http://feeds.nature.com/~r/scibx/rss/current/~3/-zcGOKWtv6E/scibx.2009.1666 Genetic studies identified a mutation in DECTIN1 that could help predict susceptibility to recurrent mucocutaneous fungal infections. C-type lectin domain family 7 member A (CLEC7A; DECTIN1)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1666

]]> C-type lectin domain family 7 member A (CLEC7A; DECTIN1) doi:10.1038/scibx.2009.1666 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1666 http://dx.doi.org/10.1038/scibx.2009.1666 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1666 HCV NS3 protease http://feeds.nature.com/~r/scibx/rss/current/~3/dO8N7dT2X2o/scibx.2009.1667 In vitro and rat studies identified macrocyclic HCV NS3 protease inhibitors that could help treat HCV. HCV NS3 protease

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1667

]]> HCV NS3 protease doi:10.1038/scibx.2009.1667 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1667 http://dx.doi.org/10.1038/scibx.2009.1667 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1667 Not applicable http://feeds.nature.com/~r/scibx/rss/current/~3/l546if-4xAY/scibx.2009.1668 In vitro and in vivo studies suggest that a rhodacyanine analog could help treat visceral leishmaniasis. Not applicable

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1668

]]> Not applicable doi:10.1038/scibx.2009.1668 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1668 http://dx.doi.org/10.1038/scibx.2009.1668 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1668 Histone cluster 4, H4 (HIST4H4) http://feeds.nature.com/~r/scibx/rss/current/~3/UBKfj63h1NA/scibx.2009.1669 Studies in cell culture and in mice suggest that blocking HIST4H4 could help treat sepsis. Histone cluster 4, H4 (HIST4H4)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1669

]]> Histone cluster 4, H4 (HIST4H4) doi:10.1038/scibx.2009.1669 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1669 http://dx.doi.org/10.1038/scibx.2009.1669 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1669 Solute carrier family 6 member 3 (SLC6A3; DAT1) http://feeds.nature.com/~r/scibx/rss/current/~3/RJi8jyv87QY/scibx.2009.1670 Genetic association studies identified two loci that could help predict resistance to TB. Solute carrier family 6 member 3 (SLC6A3; DAT1)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1670

]]> Solute carrier family 6 member 3 (SLC6A3; DAT1) doi:10.1038/scibx.2009.1670 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1670 http://dx.doi.org/10.1038/scibx.2009.1670 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1670 Muscarinic acetylcholine receptor M1 (CHRM1; HM1) http://feeds.nature.com/~r/scibx/rss/current/~3/9fc7SQDLMNE/scibx.2009.1671 In vitro and mouse studies suggest that benzylquinolone carboxylic acid (BQCA) activates HM1 and could help treat cognitive impairment. Muscarinic acetylcholine receptor M1 (CHRM1; HM1)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1671

]]> Muscarinic acetylcholine receptor M1 (CHRM1; HM1) doi:10.1038/scibx.2009.1671 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1671 http://dx.doi.org/10.1038/scibx.2009.1671 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1671 NMDA receptor NR2A subtype (GRIN2A; NR2A) http://feeds.nature.com/~r/scibx/rss/current/~3/EZVmzd5l6rE/scibx.2009.1672 Studies in mice suggest that blocking phosphorylation of NR2A could help treat depression. NMDA receptor NR2A subtype (GRIN2A; NR2A)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1672

]]> NMDA receptor NR2A subtype (GRIN2A; NR2A) doi:10.1038/scibx.2009.1672 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1672 http://dx.doi.org/10.1038/scibx.2009.1672 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1672 Not applicable http://feeds.nature.com/~r/scibx/rss/current/~3/vN-cz0CesZ0/scibx.2009.1673 Studies in rats suggest that analogs of valproic acid could help treat neuropathic pain and epilepsy. Not applicable

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1673

]]> Not applicable doi:10.1038/scibx.2009.1673 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1673 http://dx.doi.org/10.1038/scibx.2009.1673 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1673 Adenosine A2A receptor (ADORA2A) http://feeds.nature.com/~r/scibx/rss/current/~3/RyOI5xLnEe0/scibx.2009.1674 Studies in rats suggest that agonizing ADORA2A could help treat neuropathic pain. Adenosine A2A receptor (ADORA2A)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1674

]]> Adenosine A2A receptor (ADORA2A) doi:10.1038/scibx.2009.1674 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1674 http://dx.doi.org/10.1038/scibx.2009.1674 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1674 IL-6; IL-6 signal transducer (IL-6ST; gp130; CD130) http://feeds.nature.com/~r/scibx/rss/current/~3/0doOBHcIgm0/scibx.2009.1675 Studies in mice suggest that inhibiting gp130 could help treat pain. IL-6; IL-6 signal transducer (IL-6ST; gp130; CD130)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1675

]]> IL-6; IL-6 signal transducer (IL-6ST; gp130; CD130) doi:10.1038/scibx.2009.1675 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1675 http://dx.doi.org/10.1038/scibx.2009.1675 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1675 Protein kinase Cδ (PRKCD); Src homology protein tyrosine phosphatase 1 (SHP-1; SHPTP1; PTPN6) http://feeds.nature.com/~r/scibx/rss/current/~3/QB6xgn2ZRK4/scibx.2009.1676 A study in cell culture and in mice suggests that antagonizing PKCD and SHP-1 could help treat diabetic retinopathy. Protein kinase Cδ (PRKCD); Src homology protein tyrosine phosphatase 1 (SHP-1; SHPTP1; PTPN6)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1676

]]> Protein kinase Cδ (PRKCD); Src homology protein tyrosine phosphatase 1 (SHP-1; SHPTP1; PTPN6) doi:10.1038/scibx.2009.1676 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1676 http://dx.doi.org/10.1038/scibx.2009.1676 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1676 CD80 (B7–1); cytotoxic T lymphocyte–associated protein 4 (CTLA4; CTLA-4; CD152) http://feeds.nature.com/~r/scibx/rss/current/~3/ZvIuFhPME3k/scibx.2009.1677 A study in cell culture suggests that antagonizing B7–1 on myeloid dendritic cells (DCs) could help treat inflammation associated with emphysema. CD80 (B7–1); cytotoxic T lymphocyte–associated protein 4 (CTLA4; CTLA-4; CD152)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1677

]]> CD80 (B7–1); cytotoxic T lymphocyte–associated protein 4 (CTLA4; CTLA-4; CD152) doi:10.1038/scibx.2009.1677 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1677 http://dx.doi.org/10.1038/scibx.2009.1677 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1677 Serum amyloid P component (SAP; APCS) http://feeds.nature.com/~r/scibx/rss/current/~3/8hoD73bgyd0/scibx.2009.1678 Studies in mice suggest that SAP could be useful for treating kidney fibrosis. Serum amyloid P component (SAP; APCS)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1678

]]> Serum amyloid P component (SAP; APCS) doi:10.1038/scibx.2009.1678 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1678 http://dx.doi.org/10.1038/scibx.2009.1678 2 45 Distillery: Therapeutics http://dx.doi.org/10.1038/scibx.2009.1678 Adoptive therapy to treat autoimmune diseases using engineered antigen-specific Tregs http://feeds.nature.com/~r/scibx/rss/current/~3/j9Pkxm-hqlQ/scibx.2009.1679 Adoptive therapy using Tregs engineered to target a specific antigen could help treat autoimmune diseases. Adoptive therapy to treat autoimmune diseases using engineered antigen-specific Tregs

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1679

]]> Adoptive therapy to treat autoimmune diseases using engineered antigen-specific Tregs doi:10.1038/scibx.2009.1679 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1679 http://dx.doi.org/10.1038/scibx.2009.1679 2 45 Distillery: Techniques http://dx.doi.org/10.1038/scibx.2009.1679 Glycoprotein 2 (GP2)-targeted antigens as mucosal vaccines http://feeds.nature.com/~r/scibx/rss/current/~3/RIunD2NXuTY/scibx.2009.1680 GP2-targeted antigen delivery could be useful for developing mucosal vaccines against a variety of pathogens. Glycoprotein 2 (GP2)-targeted antigens as mucosal vaccines

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1680

]]> Glycoprotein 2 (GP2)-targeted antigens as mucosal vaccines doi:10.1038/scibx.2009.1680 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1680 http://dx.doi.org/10.1038/scibx.2009.1680 2 45 Distillery: Techniques http://dx.doi.org/10.1038/scibx.2009.1680 IL-10–expressing adult neural stem cells for treatment of autoimmune encephalitis and multiple sclerosis (MS) http://feeds.nature.com/~r/scibx/rss/current/~3/ohqtyW_O04A/scibx.2009.1681 Expression of anti-inflammatory IL-10 in adult neural stem cells could improve the ability of implanted cells to treat autoimmune encephalitis and MS. IL-10–expressing adult neural stem cells for treatment of autoimmune encephalitis and multiple sclerosis (MS)

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1681

]]> IL-10–expressing adult neural stem cells for treatment of autoimmune encephalitis and multiple sclerosis (MS) doi:10.1038/scibx.2009.1681 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1681 http://dx.doi.org/10.1038/scibx.2009.1681 2 45 Distillery: Techniques http://dx.doi.org/10.1038/scibx.2009.1681 Near-infrared imaging of β-amyloid (Aβ) deposits with curcumin-derived compounds http://feeds.nature.com/~r/scibx/rss/current/~3/Jj5cXSiO-98/scibx.2009.1682 A curcumin-derived imaging agent could help detect Aβ aggregates to diagnose Alzheimer's disease (AD). Near-infrared imaging of β-amyloid (Aβ) deposits with curcumin-derived compounds

SciBX: Science-Business eXchange 2, (2009). doi:10.1038/scibx.2009.1682

]]> Near-infrared imaging of β-amyloid (Aβ) deposits with curcumin-derived compounds doi:10.1038/scibx.2009.1682 SciBX: Science-Business eXchange 2, (2009) 2009-11-19 SciBX: Science-Business eXchange 2009-11-19 10.1038/scibx.2009.1682 http://dx.doi.org/10.1038/scibx.2009.1682 2 45 Distillery: Techniques http://dx.doi.org/10.1038/scibx.2009.1682