Signaling Gateway - Update - nature.com science feeds News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 Nature Signaling Update http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ Featured Article: Tumour metastasis: miR-9 under spotlight http://feeds.nature.com/~r/signaling-gateway/rss/update/~3/RSgXSag2whM/ miR-9 is a MYC-induced microRNA that suppresses E-cadherin expression and upregulates beta-catenin signaling, leading to induced tumour cell migration and metastasis.<img src="http://feeds.feedburner.com/~r/signaling-gateway/rss/update/~4/RSgXSag2whM" height="1" width="1"/> http://www.signaling-gateway.org/update/featured/ Selected Update: Small RNAs: An epigenetic silencing influence http://www.signaling-gateway.org/update/updates/201003/nrg2755.html New evidence has emerged that in moss, miRNAs can silence gene expression at the transcriptional level by interacting with DNA, leading to methylation. Selected Update: Autophagy: Doubling up http://www.signaling-gateway.org/update/updates/201003/nrm2850.html The COG complex directly participates in double-membrane vesicle formation. Selected Update: Tumorigenesis: Bad neighbours http://www.signaling-gateway.org/update/updates/201003/nrc2821.html Cooperative signalling between two tumour clones expressing different oncogenic mutations is reported. Research Library: Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction http://www.nature.com/ncb/journal/v12/n3/full/ncb2026.html Research Library: Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons http://www.nature.com/neuro/journal/v13/n3/full/nn.2505.html Research Library: Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion http://www.nature.com/nsmb/journal/v17/n3/full/nsmb.1764.html Molecule Page: Adap1 http://www.signaling-gateway.org/molecule/query?afcsid=A000614 ADAP1 is a phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3)/IP4 binding protein that regulates actin cytoskeleton organization and membrane trafficking by acting as a GTPase activating protein (GAP) of ADP-ribosylation factor 6 (ARF6). It also associates with casein kinase Ialpha (CKIalpha), Ran binding protein in microtubule-organizing center (RanBPM), nardilysin, kinesin motor protein (KIF13B), protein kinase C (PKC) and nucleolin. ADAP1 localization and activity have been shown to be regulated by phosphoinositol 3-kinase (PI3K), protein kinase C (PKC) isoforms and the kinesin motor protein KIF13B. It has also been implicated in regulation of Ca2+ transport in mitochondria. Molecule Page: Follicle stimulating hormone receptor http://www.signaling-gateway.org/molecule/query?afcsid=A000953 The follicle stimulating hormone receptor (FSHR) is a key regulatory site in the gonads that mediates the cellular effects of the pituitary glycoprotein FSH. Granulosa cell proliferation, estrogen synthesis, and expression of the luteinizing hormone receptor are dependent on FSH stimulation. In males, the persistence of Sertoli cells during gonadal development is dependent on FSHR activation, whereas its role in adult spermatogenesis is still controversial. Binding of FSH to the cognate receptor entails activation of adenylyl cyclases via Gs-coupling. News: Nature Methods: Nature Methods http://www.nature.com/nmeth/journal/v7/n3s/index.html The March issue of Nature Methods presents an online supplement that contains a series of five commissioned Reviews discussing the challenges of visualizing biological data and the visualization tools available to biologists working with genomes, alignments and phylogenies, macromolecular structures, images and systems biology data.