Action potential generation articles within Nature

Featured

  • Letter |

    In vivo whole-cell recordings combined with an intracellular N-methyl-d-aspartate receptor (NMDAR) blocker and membrane hyperpolarization are used to examine the contribution of dendritic NMDAR-dependent regenerative responses to the angular tuning of layer 4 neurons; the results show that active dendritic processing sharpens the sensory responses of cortical neurons in vivo.

    • Maria Lavzin
    • , Sophia Rapoport
    •  & Jackie Schiller

  • News & Views |

    Sodium channels in cell membranes have a crucial role in triggering bioelectrical events that lead to processes such as muscle contraction or hormone release. A crystal structure reveals how one such channel might work. See Article p.353

    • Richard Horn

  • News & Views |

    The organization of behaviour as sequences of actions requires proper initiation and termination of each action sequence. The neural circuit that signals instructions to start and stop is now revealed.

    • Paolo Calabresi
    •  & Massimiliano Di Filippo

  • News & Views |

    Neurons generate their output signal — the action potential — in a distinct region of the axon called the initial segment. The location and extent of this trigger zone can be modified by neural activity to control excitability.

    • Jan Gründemann
    •  & Michael Häusser

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