Featured
-
-
News |
Weight-loss drug wins US approval
Obesity treatment shows promise for patients with diabetes despite concerns that it could cause heart complications.
- Brendan Borrell
-
Article |
Large-scale prediction and testing of drug activity on side-effect targets
A large-scale computational effort is used to predict the activity of 656 drugs against 73 protein targets that have been associated with adverse drug reactions; the abdominal pain side effect of the synthetic oestrogen chlorotrianisene is shown to be mediated through its inhibition of cyclooxygenase-1.
- Eugen Lounkine
- , Michael J. Keiser
- & Laszlo Urban
-
News |
Debate on diabetes drugs gathers pace
Petition unveils unnerving reports on potential carcinogenicity of GLP-1 mimics.
- Amy Maxmen
-
Outlook |
Drugs: An injection of hope
For decades, drugs have barely managed to slow the progression of multiple sclerosis. Therapies are now emerging that may even help to reverse the disease — but are they worth the risk?
- Duncan Graham-Rowe
-
News |
How marijuana makes you forget
Drug affects previously overlooked brain cells that have a crucial role in memory formation.
- Mo Costandi
-
Research Highlights |
Chemo spans generations
-
News |
Cancer drugs affect mouse genomes for generations
DNA mutations continue to accumulate in offspring of treated mice.
- Heidi Ledford
-
Outlook |
Perspective: Herbal dangers
Traditional plant-based remedies are not risk-free. Doctors and patients need to be informed about the possible side effects, says Masatomo Sakurai.
- Masatomo Sakurai
-
News |
US lawsuit extends thalidomide's reach
Drug blamed for a broader range of harmful effects.
- Meredith Wadman
-
Comment |
Stop the killing of beneficial bacteria
Concerns about antibiotics focus on bacterial resistance — but permanent changes to our protective flora could have more serious consequences, says Martin Blaser.
- Martin Blaser
-
Research Highlights |
Diabetes drug affects the brain
-
News & Views |
Context is key in the gut
The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220
- Craig L. Maynard
- & Casey T. Weaver
-
News |
Antipsychotic drugs could shrink patients' brains
Experts say findings should not dramatically change current prescription practices.
- David Cyranoski
-
News |
Exposure to seasonal flu weakened armour against H1N1
Faulty antibodies from previous infections boosted severity of swine flu in the middle-aged.
- Janelle Weaver
-
Books & Arts |
Developmental biology: The whole nine months
Michael Sargent examines the evidence that pre-birth experiences shape our lives.
- Michael Sargent
-
News |
Diabetes drugs offered fresh start
As FDA advisers vote for restrictions on Avandia, researchers reveal a way to make such drugs safer.
- Heidi Ledford
-
News |
Evidence mounts against diabetes drug
Studies continue to find heart-attack risk.
- Heidi Ledford
-
News |
Strange lesions after stem-cell therapy
Unproven treatment results in mysterious masses.
- David Cyranoski
-
Research Highlights |
Neuroscience: Drug shrinks brain
-
News |
Antipsychotic deflates the brain
Drug for schizophrenia causes side effects by shrinking part of the brain.
- Amy Maxmen
-
News |
A direct hit for thalidomide
The drug stunts limb development in zebrafish and chicks by binding to a protein called cereblon.
- Janet Fang
-
Brief Communications Arising |
Chronic DLL4 blockade induces vascular neoplasms
- Minhong Yan
- , Christopher A. Callahan
- & Greg D. Plowman
Human drugs make fish flounder