Alphaviruses articles within Nature

Featured

  • Article |

    Studies using viral coat glycoproteins show that alphaviruses can enter cells via the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), members of an evolutionarily conserved family of lipoprotein receptors.

    • Lars E. Clark
    • , Sarah A. Clark
    •  & Jonathan Abraham

  • Article |

    The cryo-electron microscopy structure of domain 1 of the LDLRAD3 receptor in complex with virus-like particles of Venezuelan equine encephalitis virus (VEEV) provides insights into the assembly and entry of VEEV and other alphaviruses.

    • Bingting Ma
    • , Cuiqing Huang
    •  & Xinzheng Zhang

  • Article |

    Cryo-electron microscopy structures of non-structural protein 1 (nsP1) of chikungunya virus reveal the mechanisms that underpin the association of viral replication machinery with virus-induced membranous organelles within host cells.

    • Rhian Jones
    • , Gabriel Bragagnolo
    •  & Juan Reguera

  • Article |

    LDLRAD3 is a receptor for infection with Venezuelan equine encephalitis virus, and in mouse models deletion of Ldlrad3 or treatment with a soluble LDLRAD3 decoy molecule abrogates infection and disease caused by this virus.

    • Hongming Ma
    • , Arthur S. Kim
    •  & Michael S. Diamond

  • Letter |

    FHL1 is a key factor expressed by humans and mice that is required for chikungunya virus infection and is therefore a promising target for the development of therapies against chikungunya virus.

    • Laurent Meertens
    • , Mohamed Lamine Hafirassou
    •  & Ali Amara

  • Letter |

    The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra8 monoclonal antibodies are shown to reduce rates of chikungunya virus infection in mice and a range of human cells.

    • Rong Zhang
    • , Arthur S. Kim
    •  & Michael S. Diamond

  • Letter |

    Here it is proposed that RNA viruses can adapt to use the antiviral properties of microRNAs to limit viral replication and suppress innate immunity in particular cell types, and this restriction can lead to exacerbation of disease severity.

    • Derek W. Trobaugh
    • , Christina L. Gardner
    •  & William B. Klimstra

  • News & Views |

    Alphaviruses infect their host by binding to cellular receptors and fusing with cell membranes. New studies define the receptor-binding protein of these viruses and its regulation of the membrane-fusion reaction. See Letters p.705 & p.709

    • Margaret Kielian

  • Letter |

    The E1 and E2 glycoproteins of alphaviruses form heterodimers and assemble into spikes on the virus surface, which mediate receptor binding and endocytosis. When the virion encounters acidic pH in the endosome E1 and E2 dissociate and E1 triggers fusion with the endosomal membrane. Two papers now provide the first crystal structures for glycoprotein complexes incorporating E2 at acidic and neutral pH, respectively. Together they provide insight into how fusion activation is controlled in alphaviruses.

    • Long Li
    • , Joyce Jose
    •  & Michael G. Rossmann

  • Letter |

    The E1 and E2 glycoproteins of alphaviruses form heterodimers and assemble into spikes on the virus surface, which mediate receptor binding and endocytosis. When the virion encounters acidic pH in the endosome E1 and E2 dissociate and E1 triggers fusion with the endosomal membrane. Two papers now provide the first crystal structures for glycoprotein complexes incorporating E2 at acidic and neutral pH, respectively. Together they provide insight into how fusion activation is controlled in alphaviruses.

    • James E. Voss
    • , Marie-Christine Vaney
    •  & Félix A. Rey

Browse broader subjects

Browse Alphaviruses across other nature.com journals