Alternative splicing articles within Nature

Featured

• Article
  22 March 2023 | Open Access

  RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

  Analysis of messenger RNA splicing in a large cohort of pancreatic ductal adenocarcinoma tumours identifies differential splicing correlating with disease progression, associated with the the splicing regulator RBFOX2.

  • Amina Jbara
  • , Kuan-Ting Lin
  •  & Rotem Karni

• Article
  29 July 2020 | Open Access

  A large-scale binding and functional map of human RNA-binding proteins

  A combination of five assays is used to produce a catalogue of RNA elements to which RNA-binding proteins bind in human cells.

  • Eric L. Van Nostrand
  • , Peter Freese
  •  & Gene W. Yeo

• Letter | 09 October 2019

  Spliceosomal disruption of the non-canonical BAF complex in cancer

  A range of SF3B1 mutations promote tumorigenesis through the repression of BRD9, a core component of the non-canonical BAF complex, and correcting BRD9 mis-splicing in these SF3B1-mutant cells suppresses tumour growth.

  • Daichi Inoue
  • , Guo-Liang Chew
  •  & Robert K. Bradley

• Letter | 11 July 2018

  Prespliceosome structure provides insights into spliceosome assembly and regulation

  The cryo-electron microscopy structure of the Saccharomyces cerevisiae prespliceosome provides insights into splice-site selection and early spliceosome assembly events.

  • Clemens Plaschka
  • , Pei-Chun Lin
  •  & Kiyoshi Nagai

• Letter | 05 December 2016

  Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

  Precursor mRNA splicing homeostasis is a biomarker and predictor of life expectancy in Caenorhabditis elegans and defects in global pre-mRNA splicing associated with age are reduced by dietary restriction via splicing factor 1.

  • Caroline Heintz
  • , Thomas K. Doktor
  •  & William B. Mair

• Letter | 30 November 2016

  m⁶A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

  Two complementary studies describe how the pervasive N⁶-methyladenosine modification in mRNA can affect Drosophila sex determination, neuronal function and behaviour.

  • Irmgard U. Haussmann
  • , Zsuzsanna Bodi
  •  & Matthias Soller

• Letter | 05 June 2013

  MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

  This study identifies MBNL proteins as negative regulators of alternative splicing events that are differentially regulated between ES cells and other cell types; several lines of evidence show that these proteins repress an ES cell alternative splicing program and the reprogramming of somatic cells to induced pluripotent stem cells.

  • Hong Han
  • , Manuel Irimia
  •  & Benjamin J. Blencowe

• Letter | 23 May 2012

  Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi

  Translocation of glycolytic enzymes to peroxisomes in fungi suggests broader metabolic role for this organelle.

  • Johannes Freitag
  • , Julia Ast
  •  & Michael Bölker

• Article | 03 November 2011

  CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

  • Sanjeev Shukla
  • , Ersen Kavak
  •  & Shalini Oberdoerffer

• Letter | 03 August 2011

  Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats

  • Elena O. Gracheva
  • , Julio F. Cordero-Morales
  •  & David Julius

• Article | 25 May 2011

  Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

  • Shravan Kumar Mishra
  • , Tim Ammon
  •  & Stefan Jentsch

• Letter | 20 October 2010

  A methyl transferase links the circadian clock to the regulation of alternative splicing

  Various biological processes are entrained by the day–night cycle to occur at a specific time of day. One way the circadian system exerts these effects is through post-transcriptional regulation. These authors show that a protein that transfers methyl groups onto several spliceosome subunits, PRMT5, is regulated by the light–dark cycle. Methylation of these subunits affects alternative splicing of some genes, thus making them subject to circadian control.

  • Sabrina E. Sanchez
  • , Ezequiel Petrillo
  •  & Marcelo J. Yanovsky

• Article | 06 May 2010

  Deciphering the splicing code

  The coding capacity of the genome is greatly expanded by the process of alternative splicing, which enables a single gene to produce more than one distinct protein. Can the expression of these different proteins be predicted from sequence data? Here, modelling based on information theory has been used to develop a 'splicing code', which can predict, with good accuracy, tissue-dependent changes in alternative splicing.

  • Yoseph Barash
  • , John A. Calarco
  •  & Brendan J. Frey

• Review Article | 27 January 2010

  Expansion of the eukaryotic proteome by alternative splicing

  • Timothy W. Nilsen
  •  & Brenton R. Graveley