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| Open AccessMyosin-independent stiffness sensing by fibroblasts is regulated by the viscoelasticity of flowing actin
Extracellular matrix stiffness induces differential tension within integrinbased adhesions but it is not known if this is solely from myosin activity. Here, it is shown that 3T3 fibroblasts still transmit stiffness-dependent traction even with the absence of myosin contractility.
- Nikhil Mittal
- , Etienne B. Michels
- & Sangyoon J. Han
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Article
| Open AccessA catch bond mechanism with looped adhesive tethers for self-strengthening materials
Catch bonds exist in some protein-ligand complexes and are of interest for their increased lifetime under greater mechanical force. Here, a mathematical model for nanoparticles tethered with macromolecules shows catch-bond behavior, which may be useful for designing synthetic materials.
- Kerim C. Dansuk
- , Subhadeep Pal
- & Sinan Keten