Bone marrow transplantation articles within Nature

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• Article | 25 November 2020

  The gut microbiota is associated with immune cell dynamics in humans

  Influence of the gut microbiome on the human immune system is revealed by systems analysis of vast clinical data from decades of electronic health records paired with massive longitudinal microbiome sequencing.

  • Jonas Schluter
  • , Jonathan U. Peled
  •  & Joao B. Xavier

• Letter | 09 December 2015

  Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

  Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

  • Caroline A. Lindemans
  • , Marco Calafiore
  •  & Alan M. Hanash

• Letter | 02 March 2014

  Direct measurement of local oxygen concentration in the bone marrow of live animals

  Here, using two-photon phosphorescence lifetime microscopy, the local oxygen tension in the bone marrow of live mice is found to be quite low, with spatiotemporal variations depending on the blood vessel type, distance to the endosteum, and changes in cellularity after stress.

  • Joel A. Spencer
  • , Francesca Ferraro
  •  & Charles P. Lin

• News | 18 March 2012

  Bone-marrow transplant reverses Rett syndrome in mice

  Rare autism spectrum disorder is partially caused by faulty immune cells in the brain.

  • Ewen Callaway

• News | 07 March 2012

  Drug-free organ transplants without tissue matching

  Bone-marrow transfer could end the need for lifelong immunosupression.

  • Elie Dolgin

• Letter | 08 June 2011

  In vivo imaging of T_reg cells providing immune privilege to the haematopoietic stem-cell niche

  • Joji Fujisaki
  • , Juwell Wu
  •  & Charles P. Lin

• News | 27 May 2010

  Key to psychological disorder may lie in the immune system

  Bone-marrow transplants cure obsessive-compulsive behaviour in mice.

  • Janelle Weaver

• Article | 13 January 2010

  Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

  GNF-2 is a recently discovered, selective allosteric Bcr–Abl inhibitor. Solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange mass spectrometry are now used to show that GNF-2 binds to the myristate-binding site of Abl, leading to changes in the structural dynamics of the ATP-binding site. The results show that the combination of allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.

  • Jianming Zhang
  • , Francisco J. Adrián
  •  & Nathanael S. Gray