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Letter |
Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments
It is widely accepted that contraction of skeletal muscle and the heart involves structural changes in actin-containing thin filaments to allow binding of myosin motors from neighbouring thick filaments, thus driving filament sliding; here, X-ray diffraction of single skeletal muscle cells reveals that this thin-filament mechanism can regulate muscle contraction against low load, but high-load contraction requires a second permissive step involving a structural change in the thick filament.
- Marco Linari
- , Elisabetta Brunello
- & Malcolm Irving