Cardiac hypertrophy articles within Nature

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• Article
  01 November 2023 | Open Access

  Structure of the native myosin filament in the relaxed cardiac sarcomere

  A cryo-electron tomography study reports the structure of thick myosin filaments of mouse cardiac muscle in the relaxed state in situ and the MyBP-C links that connect them with the surrounding thin actin filaments.

  • Davide Tamborrini
  • , Zhexin Wang
  •  & Stefan Raunser

• Article | 05 August 2020

  Position-specific oxidation of miR-1 encodes cardiac hypertrophy

  The 8-oxoguanine modification of the microRNA miR-1 results in redirected recognition and silencing of target genes and leads to cardiac hypertrophy in mice.

  • Heeyoung Seok
  • , Haejeong Lee
  •  & Sung Wook Chi

• Letter | 30 January 2019

  PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

  Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.

  • Mark J. Ranek
  • , Kristen M. Kokkonen-Simon
  •  & David A. Kass

• Letter | 18 March 2015

  Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

  The inhibition, in mice, of the phosphodiesterase PDE9A, which specifically regulates natriuretic-peptide-coupled cGMP signalling, is independent of nitric oxide and is upregulated in failing human hearts, and can reverse pre-established stress-induced heart disease.

  • Dong I. Lee
  • , Guangshuo Zhu
  •  & David A. Kass

• Letter | 05 October 2011

  Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

  • Chris McDermott-Roe
  • , Junmei Ye
  •  & Stuart A. Cook